EA201690879A1 - Новое триазолопиридиновое соединение - Google Patents

Новое триазолопиридиновое соединение

Info

Publication number
EA201690879A1
EA201690879A1 EA201690879A EA201690879A EA201690879A1 EA 201690879 A1 EA201690879 A1 EA 201690879A1 EA 201690879 A EA201690879 A EA 201690879A EA 201690879 A EA201690879 A EA 201690879A EA 201690879 A1 EA201690879 A1 EA 201690879A1
Authority
EA
Eurasian Patent Office
Prior art keywords
triazolopiridine
new
connection
group
present
Prior art date
Application number
EA201690879A
Other languages
English (en)
Inventor
Чафик Хамдоучи
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201690879A1 publication Critical patent/EA201690879A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles

Abstract

Согласно настоящему изобретению предложено соединение формулыгде Rвыбран из группы, состоящей из Н и СН; Rвыбран из группы, состоящей из Н и СН; Rвыбран из группы, состоящей из Н, C-Cалкила, O(CH)SOCH, О(СН)ОСН, О(СН)С(СН)ОН, CN и OCF, или его фармацевтическая соль, способы лечения диабета, промежуточные соединения и способ получения соединений согласно настоящему изобретению.
EA201690879A 2013-12-13 2014-12-04 Новое триазолопиридиновое соединение EA201690879A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361915774P 2013-12-13 2013-12-13
PCT/US2014/068487 WO2015088868A1 (en) 2013-12-13 2014-12-04 A novel triazolo-pyridine compound

Publications (1)

Publication Number Publication Date
EA201690879A1 true EA201690879A1 (ru) 2016-10-31

Family

ID=52144909

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690879A EA201690879A1 (ru) 2013-12-13 2014-12-04 Новое триазолопиридиновое соединение

Country Status (14)

Country Link
US (1) US9120793B2 (ru)
EP (1) EP3080093B1 (ru)
JP (1) JP6152227B2 (ru)
KR (1) KR20160077207A (ru)
CN (1) CN105814026B (ru)
AR (1) AR098522A1 (ru)
AU (1) AU2014364224B2 (ru)
BR (1) BR112016012123A8 (ru)
CA (1) CA2929317A1 (ru)
EA (1) EA201690879A1 (ru)
ES (1) ES2653522T3 (ru)
MX (1) MX2016007567A (ru)
TW (1) TW201609722A (ru)
WO (1) WO2015088868A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2931817A1 (en) 2014-01-10 2015-07-16 Eli Lilly And Company Isopropyl triazolo pyridine compounds
US9617263B2 (en) * 2014-01-10 2017-04-11 Eli Lilly And Company Phenyl-triazolo-pyridine compounds
US10106553B2 (en) 2016-04-11 2018-10-23 Janssen Pharmaceutica Nv Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
WO2017180457A1 (en) 2016-04-11 2017-10-19 Janssen Pharmaceutica Nv Gpr40 agonists in anti-diabetic drug combinations
TWI707849B (zh) 2018-02-13 2020-10-21 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
TWI712412B (zh) 2018-04-19 2020-12-11 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
WO2020014643A1 (en) 2018-07-13 2020-01-16 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN112955435A (zh) 2018-10-24 2021-06-11 吉利德科学公司 Pd-1/pd-l1抑制剂
CA3156985A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists
JP2023526625A (ja) 2020-05-19 2023-06-22 キャリーオペ，インク． Ａｍｐｋアクチベーター
AU2021297323A1 (en) 2020-06-26 2023-02-16 Kallyope, Inc. AMPK activators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003277576A1 (en) 2002-11-08 2004-06-07 Takeda Pharmaceutical Company Limited Receptor function controlling agent
US7820837B2 (en) 2003-05-30 2010-10-26 Takeda Pharmaceutical Company Limited Condensed ring compound
EP1706386A1 (en) * 2003-12-22 2006-10-04 Eli Lilly And Company Bicyclic derivatives as ppar modulators
ES2433466T3 (es) * 2004-02-27 2013-12-11 Amgen, Inc Compuestos, composiciones farmacéuticas y métodos para su uso en el tratamiento de trastornos metabólicos
US7572807B2 (en) * 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
EP2061760A1 (en) * 2006-09-07 2009-05-27 Amgen, Inc Benzo-fused compounds for use in treating metabolic disorders
WO2009153496A2 (fr) * 2008-05-26 2009-12-23 Genfit Composés agonistes ppar, préparation et utilisations
US8530413B2 (en) * 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TWI692469B (zh) * 2012-11-09 2020-05-01 南韓商Ｌｇ化學股份有限公司 Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物

Also Published As

Publication number Publication date
AU2014364224A1 (en) 2016-05-19
AR098522A1 (es) 2016-06-01
JP2016539984A (ja) 2016-12-22
US9120793B2 (en) 2015-09-01
CA2929317A1 (en) 2015-06-18
JP6152227B2 (ja) 2017-06-21
US20150166535A1 (en) 2015-06-18
ES2653522T3 (es) 2018-02-07
EP3080093A1 (en) 2016-10-19
AU2014364224B2 (en) 2017-02-16
TW201609722A (zh) 2016-03-16
EP3080093B1 (en) 2017-10-04
KR20160077207A (ko) 2016-07-01
BR112016012123A8 (pt) 2018-01-30
CN105814026B (zh) 2018-08-10
WO2015088868A1 (en) 2015-06-18
CN105814026A (zh) 2016-07-27
MX2016007567A (es) 2017-01-06

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