HUP0202414A2 - Új eljárás perindopril és analógjai, és ezek sói előállítására - Google Patents

Új eljárás perindopril és analógjai, és ezek sói előállítására

Info

Publication number
HUP0202414A2
HUP0202414A2 HU0202414A HUP0202414A HUP0202414A2 HU P0202414 A2 HUP0202414 A2 HU P0202414A2 HU 0202414 A HU0202414 A HU 0202414A HU P0202414 A HUP0202414 A HU P0202414A HU P0202414 A2 HUP0202414 A2 HU P0202414A2
Authority
HU
Hungary
Prior art keywords
compound
general formula
preparation
formula
alkyl group
Prior art date
Application number
HU0202414A
Other languages
English (en)
Inventor
Pau Cid
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8183486&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0202414(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Adir filed Critical Adir
Publication of HU0202414D0 publication Critical patent/HU0202414D0/hu
Publication of HUP0202414A2 publication Critical patent/HUP0202414A2/hu
Publication of HUP0202414A3 publication Critical patent/HUP0202414A3/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44Two oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

A találmány (IV) általános képletű vegyület vagy annak észtere, vagysója előállítására vonatkozik, oly módon, hogy 1) egy (I) általánosképletű vegyületet - ahol Ra jelentése 1-4 szénatomos alkilcsoport, Rbjelentése 1-4 szénatomos alkilcsoport, és Rc jelentése 1-6 szénatomosalkilcsoport egy X2C=O általános képletű vegyülettel - ahol a két Xegymástól függetlenül kilépőcsoportot jelent - reagáltatva egy (II)általános képletű vegyületet - ahol Ra, Rb és Rc jelentése a fentmegadott - állítanak elő; és 2) a kapott (II) általános képletűvegyületet egy (III) általános képletű vegyülettel - a képletben Rdjelentése hidrogénatom vagy védőcsoport reagáltatják. A találmány magában foglalja a (II) általános képletű vegyületeketés az (I) általános képletű vegyületek előálítására szolgáló eljárástis. Ó
HU0202414A 2001-07-24 2002-07-23 Process for the preparation of perindopril, their analogous and their salts HUP0202414A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01500197 2001-07-24

Publications (3)

Publication Number Publication Date
HU0202414D0 HU0202414D0 (hu) 2002-09-28
HUP0202414A2 true HUP0202414A2 (hu) 2003-02-28
HUP0202414A3 HUP0202414A3 (en) 2003-05-28

Family

ID=8183486

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202414A HUP0202414A3 (en) 2001-07-24 2002-07-23 Process for the preparation of perindopril, their analogous and their salts

Country Status (24)

Country Link
US (1) US20040248814A1 (hu)
EP (1) EP1279665B1 (hu)
JP (1) JP4083118B2 (hu)
KR (1) KR100694528B1 (hu)
CN (1) CN100503568C (hu)
AR (1) AR036187A1 (hu)
AT (1) ATE386717T1 (hu)
AU (1) AU2002328954B2 (hu)
BR (1) BR0211422A (hu)
CY (1) CY1107403T1 (hu)
DE (1) DE60225092T2 (hu)
DK (1) DK1279665T3 (hu)
EA (1) EA007000B1 (hu)
ES (1) ES2300402T3 (hu)
HK (1) HK1067129A1 (hu)
HU (1) HUP0202414A3 (hu)
MX (1) MXPA04000649A (hu)
NO (1) NO20040278L (hu)
NZ (1) NZ530578A (hu)
PL (1) PL355161A1 (hu)
PT (1) PT1279665E (hu)
SI (1) SI1279665T1 (hu)
WO (1) WO2003010142A2 (hu)
ZA (1) ZA200400323B (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2289060T3 (es) 2002-01-30 2008-02-01 Les Laboratoires Servier Proceso para la preparacion de perindopril de alta pureza y de intermedios utiles en su sintesis.
ES2307923T3 (es) 2003-02-28 2008-12-01 Les Laboratoires Servier S.A. Procedimiento de preparacion de perindopril y sales del mismo.
ES2386161T3 (es) 2003-04-16 2012-08-10 Bristol-Myers Squibb Company Proceso para separar una mezcla de enantiómeros de éster alquílico usando una enzima
SI21506A (sl) * 2003-05-08 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo perindoprila
SI21507A (sl) * 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
AU2003263584A1 (en) * 2003-08-21 2005-03-10 Hetero Drugs Limited Process for pure perindopril tert-butylamine salt
AU2003300689B2 (en) * 2003-10-21 2009-01-29 Les Laboratoires Servier Novel method for preparation of crystalline perindopril erbumine
SI21703A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
US7291745B2 (en) 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
WO2006137082A1 (en) * 2005-06-23 2006-12-28 Ramesh Babu Potluri Process for industrially viable preparation of perindopril erbumine
FR2894825B1 (fr) * 2005-12-21 2010-12-03 Servier Lab Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent
US7960558B2 (en) 2006-05-12 2011-06-14 Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag Pharmaceutical intermediate for synthesizing ACE inhibitors and the use thereof
JP2008019214A (ja) * 2006-07-13 2008-01-31 Shiono Chemical Co Ltd ペリンドプリルまたはその誘導体の製造方法
EP2150538B1 (en) 2007-06-06 2012-03-28 DSM Sinochem Pharmaceuticals Netherlands B.V. Novel 5-substituted hydantoins
FR2985512B1 (fr) 2012-01-05 2014-06-20 Servier Lab Procede de preparation du sel de l-arginine du perindopril
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
CN111116709B (zh) * 2019-12-31 2022-06-24 北京鑫开元医药科技有限公司 一种培哚普利制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
LU88621I2 (fr) * 1980-10-23 1995-09-01 Schering Corp Sandopril
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4558038A (en) 1981-03-30 1985-12-10 Usv Pharmaceutical Corp. N-Substituted-amindo-amino acids
US4496542A (en) * 1981-03-30 1985-01-29 Usv Pharmaceutical Corporation N-substituted-amido-amino acids
US4686295A (en) * 1982-03-10 1987-08-11 Usv Pharmaceutical Corporation N-carboxy anhydride intermediates
US4885293A (en) * 1984-09-24 1989-12-05 Schering Corporation Antiglaucoma agents
JPS6248696A (ja) 1985-08-27 1987-03-03 Kanegafuchi Chem Ind Co Ltd N−〔1(s)−エトキシカルボニル−3−フエニルプロピル〕−l−アラニル−l−プロリンの製造法
ES2004804A6 (es) * 1987-08-13 1989-02-01 Pharma Investi S A Un procedimiento para preparar derivados de carboxialquildipeptidos
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
US5258525A (en) * 1991-03-27 1993-11-02 Mcneilab, Inc. Processes for preparing [2S-(2α,3aβ,7aβ)]octahydro-1H-indole-2-carboxylic acid and esters
SI9200213A (en) * 1992-09-16 1994-03-31 Krka Process for preparing alkyl-l-alanil-l-proline derivates
IN184759B (hu) 1997-07-22 2000-09-23 Kaneka Corp
SE0000382D0 (sv) * 2000-02-07 2000-02-07 Astrazeneca Ab New process

Also Published As

Publication number Publication date
JP4083118B2 (ja) 2008-04-30
HK1067129A1 (en) 2005-04-01
NO20040278L (no) 2004-01-21
WO2003010142A2 (en) 2003-02-06
BR0211422A (pt) 2004-08-17
AR036187A1 (es) 2004-08-18
NZ530578A (en) 2007-02-23
ATE386717T1 (de) 2008-03-15
EP1279665B1 (en) 2008-02-20
ZA200400323B (en) 2005-03-30
JP2005501829A (ja) 2005-01-20
KR100694528B1 (ko) 2007-03-13
AU2002328954B2 (en) 2007-10-04
DE60225092T2 (de) 2009-02-19
KR20040029378A (ko) 2004-04-06
DK1279665T3 (da) 2008-06-23
CN100503568C (zh) 2009-06-24
CN1529694A (zh) 2004-09-15
US20040248814A1 (en) 2004-12-09
HU0202414D0 (hu) 2002-09-28
HUP0202414A3 (en) 2003-05-28
PT1279665E (pt) 2008-03-28
PL355161A1 (en) 2003-01-13
CY1107403T1 (el) 2012-12-19
WO2003010142A3 (en) 2003-08-28
EP1279665A3 (en) 2003-03-12
EP1279665A2 (en) 2003-01-29
SI1279665T1 (sl) 2008-06-30
MXPA04000649A (es) 2004-10-27
DE60225092D1 (de) 2008-04-03
ES2300402T3 (es) 2008-06-16
EA007000B1 (ru) 2006-06-30
EA200400129A1 (ru) 2004-08-26

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished