ES2491140T3 - Derivados de flavona enantioméricamente puros para el tratamiento de trastornos proliferativos y procesos para su preparación - Google Patents

Derivados de flavona enantioméricamente puros para el tratamiento de trastornos proliferativos y procesos para su preparación Download PDF

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ES2491140T3
ES2491140T3 ES06765803.9T ES06765803T ES2491140T3 ES 2491140 T3 ES2491140 T3 ES 2491140T3 ES 06765803 T ES06765803 T ES 06765803T ES 2491140 T3 ES2491140 T3 ES 2491140T3
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enantiomerically pure
processes
preparation
treatment
proliferative disorders
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Inventor
Meenakshi Sivakumar
Malcolm Mascarenhas
Ankush Sarde
Pramod Kumar Jadhav
Manoj Shukla
Kalpana Joshi
Maggie Rathos
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Piramal Enterprises Ltd
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Piramal Enterprises Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compuesto enantiomericamente puro representado por la siguiente formula (I), y una sal farmaceuticamente aceptable del mismo; en que, R1 es fenilo, que es sustituido por 2 sustituyentes distintos: cloro o, trifluorometilo; R2 y R3 se seleccionan cada uno independientemente de: hidroxilo y OR8; en que R8 es Ci-Cio-alquilo no sustituido; R4 es Ci-C4 alquilenehidroxi; y R9 es CI-Ca alquilo; en que el termino "enantiomericamente puro" se refiere a un compuesto que se encuentra presente en un exceso enantiornerico superior al 95%.

Description

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Claims (1)

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ES06765803.9T 2006-06-21 2006-06-21 Derivados de flavona enantioméricamente puros para el tratamiento de trastornos proliferativos y procesos para su preparación Active ES2491140T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2006/052002 WO2007148158A1 (en) 2006-06-21 2006-06-21 Enantiomerically pure flavone derivatives for the treatment of poliferative disorders and processes for their preparation

Publications (1)

Publication Number Publication Date
ES2491140T3 true ES2491140T3 (es) 2014-09-05

Family

ID=37744533

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06765803.9T Active ES2491140T3 (es) 2006-06-21 2006-06-21 Derivados de flavona enantioméricamente puros para el tratamiento de trastornos proliferativos y procesos para su preparación

Country Status (18)

Country Link
US (1) US8563596B2 (es)
EP (1) EP2046738B1 (es)
JP (1) JP5498782B2 (es)
KR (1) KR101209397B1 (es)
CN (1) CN101472888B (es)
AR (1) AR061567A1 (es)
AU (1) AU2006344987B8 (es)
BR (1) BRPI0621777A2 (es)
CA (1) CA2655789C (es)
DK (1) DK2046738T3 (es)
ES (1) ES2491140T3 (es)
IL (1) IL195850A0 (es)
MX (1) MX2008016398A (es)
NZ (1) NZ574266A (es)
PT (1) PT2046738E (es)
TW (1) TWI461420B (es)
WO (1) WO2007148158A1 (es)
ZA (1) ZA200810756B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7915301B2 (en) 2002-07-08 2011-03-29 Piramal Life Science Limited Inhibitors of cyclin dependent kinases and their use
US7884127B2 (en) 2002-07-08 2011-02-08 Pirimal Life Sciences Ltd. Inhibitors of cyclin dependent kinases and their use
AU2006346193C1 (en) 2006-07-07 2014-02-20 Piramal Enterprises Limited An enantioselective synthesis of pyrrolidine-substituted flavones
TWI461194B (zh) * 2009-05-05 2014-11-21 Piramal Entpr Ltd 吡咯啶取代黃酮作為輻射致敏劑
WO2011097522A2 (en) 2010-02-05 2011-08-11 Whitehead Institute For Biomedical Research Combination methods for treatment of disease
KR20130027476A (ko) 2010-02-26 2013-03-15 피라말 엔터프라이지즈 리미티드 염증 질환을 치료하기 위한 피롤리딘으로 치환된 플라본
CA2794676A1 (en) 2010-03-29 2011-10-06 Piramal Enterprises Limited Cytokine inhibitors
WO2012069972A1 (en) 2010-11-19 2012-05-31 Piramal Life Sciences Limited A pharmaceutical combination for the treatment of breast cancer
TW201242597A (en) 2011-03-14 2012-11-01 Piramal Life Sciences Ltd A synergistic pharmaceutical combination for the treatment of pancreatic cancer
UY34013A (es) * 2011-04-13 2012-11-30 Astrazeneca Ab ?compuestos de cromenona con actividad anti-tumoral?.
TW201300105A (zh) * 2011-05-31 2013-01-01 Piramal Life Sciences Ltd 治療頭頸鱗狀細胞癌之相乘藥物組合物
US20140142159A1 (en) 2011-06-24 2014-05-22 Piramal Enterprises Limited Compounds for the treatment of cancers associated with human papillomavirus
US20140348950A1 (en) 2012-01-13 2014-11-27 Piramal Enterprises Limited Pyrrolidine- substituted flavone derivatives for prevention or treatment of oral mucositis
WO2014018741A1 (en) 2012-07-27 2014-01-30 Emory University Heterocyclic flavone derivatives, compositions, and methods related thereto
KR101389407B1 (ko) * 2012-08-27 2014-05-27 한림대학교 산학협력단 척추 고정용 임플란트
WO2014049515A1 (en) * 2012-09-25 2014-04-03 Piramal Enterprises Limited Pyrrolidine substituted flavones for treatment of renal cystic diseases
EP3369730B1 (en) 2012-11-05 2020-08-05 Emory University 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto
US20140199728A1 (en) 2013-01-14 2014-07-17 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
WO2014128524A1 (en) * 2013-02-19 2014-08-28 Piramal Enterprises Limited An improved process for preparation of an intermediate of the pyrrolidine substituted flavones
WO2014128523A1 (en) * 2013-02-19 2014-08-28 Piramal Enterprises Limited A process for preparation of an intermediate of the pyrrolidine substituted flavones
WO2014140695A1 (en) * 2013-03-15 2014-09-18 Piramal Enterprises Limited Solid oral formulation of a pyrrolidine substituted flavone compound
CN117731786A (zh) 2013-07-12 2024-03-22 皮拉马尔企业有限公司 用于治疗黑素瘤的药物组合
DK3148532T3 (en) 2014-05-28 2021-04-26 Piramal Entpr Ltd Pharmaceutical Combination Comprising a CDK Inhibitor and a Thioredoxin Reductase Inhibitor for the Treatment of Cancer
NZ757763A (en) 2016-03-28 2025-07-25 Presage Biosciences Inc Pharmaceutical combinations for the treatment of cancer
HUE066348T2 (hu) 2018-08-07 2024-07-28 Univ Emory Heterociklusos flavon-származékok és az ezekhez kapcsolódó készítmények és eljárások
AU2019322858A1 (en) * 2018-08-14 2021-04-01 Mei Pharma, Inc. Combination therapy
CN113195000A (zh) 2018-12-21 2021-07-30 第一三共株式会社 抗体-药物缀合物和激酶抑制剂的组合
CA3136599A1 (en) * 2019-04-11 2020-10-15 Mei Pharma, Inc. Voruciclib poly morphs and methods of making and using thereof
CN110028475B (zh) * 2019-05-13 2022-07-01 中国药科大学 基于苯并吡喃结构的新型cdk9抑制剂、其制备方法及应用
IL302925A (en) * 2020-11-19 2023-07-01 Mei Pharma Inc Treatment of kras mutant cancers
CN114957182B (zh) * 2022-03-30 2024-03-15 中国药科大学 一类含有黄酮骨架结构的usp8抑制剂及其应用

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IN164232B (es) 1986-04-11 1989-02-04 Hoechst India
JP3451099B2 (ja) 1991-12-06 2003-09-29 株式会社日立製作所 外部記憶サブシステム
TWI331034B (en) * 2002-07-08 2010-10-01 Piramal Life Sciences Ltd Inhibitors of cyclin-dependent kinases and their use
US7271193B2 (en) * 2002-07-08 2007-09-18 Nicholas Piramal India, Ltd. Inhibitors of cyclin-dependent kinases and their use
US8017651B2 (en) 2002-11-22 2011-09-13 Bionexus, Ltd. Compositions and methods for the treatment of HIV-associated fat maldistribution and hyperlipidemia

Also Published As

Publication number Publication date
AU2006344987B8 (en) 2013-07-11
PT2046738E (pt) 2014-08-29
AU2006344987A2 (en) 2009-01-29
HK1126761A1 (en) 2009-09-11
AU2006344987B2 (en) 2012-11-15
CA2655789A1 (en) 2007-12-27
NZ574266A (en) 2011-10-28
TW200813030A (en) 2008-03-16
CN101472888A (zh) 2009-07-01
MX2008016398A (es) 2009-01-21
WO2007148158A1 (en) 2007-12-27
AU2006344987A1 (en) 2007-12-27
TWI461420B (zh) 2014-11-21
KR20090023705A (ko) 2009-03-05
ZA200810756B (en) 2013-05-29
EP2046738A1 (en) 2009-04-15
CA2655789C (en) 2014-04-01
KR101209397B1 (ko) 2012-12-06
AR061567A1 (es) 2008-09-03
JP5498782B2 (ja) 2014-05-21
US20100179210A1 (en) 2010-07-15
JP2009541294A (ja) 2009-11-26
CN101472888B (zh) 2014-02-26
BRPI0621777A2 (pt) 2013-03-12
IL195850A0 (en) 2009-09-01
EP2046738B1 (en) 2014-06-11
DK2046738T3 (da) 2014-08-04
US8563596B2 (en) 2013-10-22

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