AR067599A1 - Derivados de indazol sustituido activos como inhibidores de quinasa - Google Patents

Derivados de indazol sustituido activos como inhibidores de quinasa

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Publication number
AR067599A1
AR067599A1 ARP080103104A ARP080103104A AR067599A1 AR 067599 A1 AR067599 A1 AR 067599A1 AR P080103104 A ARP080103104 A AR P080103104A AR P080103104 A ARP080103104 A AR P080103104A AR 067599 A1 AR067599 A1 AR 067599A1
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AR
Argentina
Prior art keywords
alkyl
heterocyclyl
aryl
substituted
heteroaryl
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ARP080103104A
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English (en)
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Nerviano Medical Sciences Srl
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39764856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR067599(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Publication of AR067599A1 publication Critical patent/AR067599A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Se describen derivados de indazol sustituido de la formula (1) y sales farmacéuticamente aceptables de estos, como se define en la especificacion, procesos para su preparacion y composiciones farmacéuticas que los comprenden. Los compuestos de la presente pueden ser utiles en terapia, en el tratamiento de enfermedades asociadas con una actividad desregulada de la proteína quinasa, como el cáncer. Reivindicacion 1: Un compuesto de la formula (1), caracterizado porque X es -CH2-, -CH(OH)-, -CH(OR')- o -C(R'Rö)-, en donde: R' es alquilo C1-6 y Rö es H o alquilo C1-6; Ar es arilo o heteroarilo opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente de halogeno, alquenilo C2-6, alquinilo C2-6, ciano, nitro, NHCOR4, COR4, NR5R6, NR5COR4, OR7, SR7, SOR10, SO2R10, NHSOR10, NHSO2R10, R8R9N-alquilo C1-6, R8O-alquilo C1-6, alquilo C1-6, cicloalquilo C3-6, heterociclilo, arilo y heteroarilo de cadena recta o ramificada opcionalmente más sustituido en donde: R4 es hidrogeno, alquenilo C2-6, alquinilo C2-6, NR5R6, OR7, SR7, R8R9N-alquilo C1-6, R8O-alquilo C1-6, alquilo C1-6, cicloalquilo C3-6, heterociclilo, arilo o heteroarilo de cadena recta o ramificada opcionalmente más sustituido; R5 y R6 son independientemente hidrogeno, alquenilo C2-6, alquinilo C2-6, R8R9N-alquilo C2-6, R8O-alquilo C2-6, alquilo C1-6, cicloalquilo C3-6, heterociclilo, arilo o heteroarilo de cadena recta o ramificada, opcionalmente más sustituido, o R5 y R6, tomados juntos con el átomo de nitrogeno al cual están unidos pueden forman un grupo heterociclilo opcionalmente sustituido; R7 es hidrogeno, alquenilo C2-6, alquinilo C2-6, COR4, SOR10, SO2R10, R8R9N-alquilo C2-6, R8O-alquilo C2-6, alquilo C1-6, cicloalquilo C3-6, heterociclilo, arilo o heteroarilo de cadena recta o ramificada, opcionalmente más sustituido, en donde R4 es como se definiera anteriormente; R8 y R9 son independientemente hidrogeno, alquenilo C2-6, alquinilo C2-6, COR4, alquilo C1-6, cicloalquilo C3-6, heterociclilo, arilo o heteroarilo de cadena recta o ramificada opcionalmente más sustituido, o R8 y R9, tomados juntos con el átomo de nitrogeno al cual están unidos, pueden formar un grupo heterociclilo opcionalmente sustituido, en donde R4 es como se definiera anteriormente; R10 es hidrogeno, alquenilo C2-6, alquinilo C2-6, NR5R6, OR7, R8R9N-alquilo C1-6, R8O-alquilo C1-6, alquilo C1-6de cadena recta o ramificado, opcionalmente más sustituido, cicloalquilo C3-6, heterociclilo, arilo o heteroarilo, en donde R5, R6, R7, R8 y R9 son como se definiera anteriormente; Res un alquilo C1-6, cicloalquilo C3-6, heterociclilo, arilo o heteroarilo de cadena recta o ramificada, opcionalmente sustituido, R1, R2 y R3 son independientemente hidrogeno, halogeno, nitro, alquilo C1-6 de cadena recta o ramificada, opcionalmente sustituido, NR5R6, u OR7, en donde R5, R6 y R7 son como se definiera anteriormente; o isomeros, tautomeros, prodrogas o sales de estos farmacéuticamente aceptables.
ARP080103104A 2007-07-20 2008-07-18 Derivados de indazol sustituido activos como inhibidores de quinasa AR067599A1 (es)

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EP07112881 2007-07-20

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AR067599A1 true AR067599A1 (es) 2009-10-14

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US (11) US8299057B2 (es)
EP (1) EP2176231B1 (es)
JP (1) JP5506674B2 (es)
KR (2) KR101567763B1 (es)
CN (2) CN101754956B (es)
AR (1) AR067599A1 (es)
AU (1) AU2008280283B2 (es)
BR (1) BRPI0814628B1 (es)
CA (1) CA2693901C (es)
CL (1) CL2008002129A1 (es)
DK (1) DK2176231T3 (es)
EA (1) EA018503B1 (es)
ES (1) ES2605230T3 (es)
FR (1) FR20C1064I2 (es)
HK (2) HK1141278A1 (es)
HU (2) HUE030929T2 (es)
IL (1) IL203292A (es)
NL (1) NL301090I2 (es)
NO (1) NO2020042I1 (es)
NZ (1) NZ583450A (es)
PL (1) PL2176231T3 (es)
PT (1) PT2176231T (es)
SG (1) SG183049A1 (es)
SI (1) SI2176231T1 (es)
TW (1) TWI421073B (es)
UA (1) UA99141C2 (es)
WO (1) WO2009013126A1 (es)
ZA (1) ZA201001086B (es)

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