MX2015008396A - Derivados de la 2,3-dihidro-isoindol-1-ona, como inhibidores de la btk quinasa y composiciones farmacéuticas que los incluyen. - Google Patents

Derivados de la 2,3-dihidro-isoindol-1-ona, como inhibidores de la btk quinasa y composiciones farmacéuticas que los incluyen.

Info

Publication number
MX2015008396A
MX2015008396A MX2015008396A MX2015008396A MX2015008396A MX 2015008396 A MX2015008396 A MX 2015008396A MX 2015008396 A MX2015008396 A MX 2015008396A MX 2015008396 A MX2015008396 A MX 2015008396A MX 2015008396 A MX2015008396 A MX 2015008396A
Authority
MX
Mexico
Prior art keywords
compound
pharmaceutical composition
suppressant
isoindole
dihydro
Prior art date
Application number
MX2015008396A
Other languages
English (en)
Inventor
Yong Rae Hong
Jeong Eun Na
Im Sook Min
Hyun Ju Cha
Sool Ki Kwon
Seonggu Ro
Joong Myung Cho
Original Assignee
Crystalgenomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crystalgenomics Inc filed Critical Crystalgenomics Inc
Publication of MX2015008396A publication Critical patent/MX2015008396A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención provee un compuesto seleccionado a partir del grupo que consiste en un compuesto de la fórmula (I), sales farmacéuticamente aceptables, ésteres, profármacos, hidratos, solvatos e isómeros de los mismos; un uso del compuesto para el tratamiento, alivio o prevención de enfermedades provocadas por activación anómala o descontralada de la proteín quinasa, y el uso del compuesto para manufacturar un medicamento para el tratamiento, alivio o prevención de enfermedades; una composición farmacéutica que comprende el compuesto como ingrediente activo; y un método de tratamiento, alivio o prevención de enfermedades empleando el compuesto. El compuesto inventivo es útil para el tratamiento, alivio o prevención de enfermedades causadas por activación anómala o descontralada de la protein quinasa.
MX2015008396A 2012-12-28 2013-12-26 Derivados de la 2,3-dihidro-isoindol-1-ona, como inhibidores de la btk quinasa y composiciones farmacéuticas que los incluyen. MX2015008396A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261746980P 2012-12-28 2012-12-28
PCT/KR2013/012204 WO2014104757A1 (ko) 2012-12-28 2013-12-26 Btk 키나아제 억제제로서의 2,3-디하이드로-이소인돌-1-온 유도체 및 이를 함유하는 약학적 조성물

Publications (1)

Publication Number Publication Date
MX2015008396A true MX2015008396A (es) 2016-04-15

Family

ID=51021712

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015008396A MX2015008396A (es) 2012-12-28 2013-12-26 Derivados de la 2,3-dihidro-isoindol-1-ona, como inhibidores de la btk quinasa y composiciones farmacéuticas que los incluyen.
MX2021011563A MX2021011563A (es) 2012-12-28 2013-12-26 Derivados de 2,3-dihidro-isoindol-1-ona, como inhibidores de la btk quinasa y composiciones farmaceuticas que los incluyen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021011563A MX2021011563A (es) 2012-12-28 2013-12-26 Derivados de 2,3-dihidro-isoindol-1-ona, como inhibidores de la btk quinasa y composiciones farmaceuticas que los incluyen.

Country Status (16)

Country Link
US (4) US9758508B2 (es)
EP (2) EP2940014B1 (es)
JP (2) JP6325573B2 (es)
KR (1) KR102009163B1 (es)
CN (1) CN104995184B (es)
AU (3) AU2013371146C1 (es)
BR (1) BR112015015477B1 (es)
CA (1) CA2896711C (es)
DK (1) DK2940014T3 (es)
ES (2) ES2696700T3 (es)
HK (1) HK1259355A1 (es)
MX (2) MX2015008396A (es)
PL (1) PL2940014T3 (es)
PT (1) PT2940014T (es)
RU (2) RU2671847C2 (es)
WO (1) WO2014104757A1 (es)

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EP2918588B1 (en) 2010-05-20 2017-05-03 Array Biopharma, Inc. Macrocyclic compounds as TRK kinase inhibitors
AU2013371146C1 (en) * 2012-12-28 2019-01-17 Crystalgenomics, Inc. 2,3-dihydro-isoindole-1-on derivative as BTK kinase suppressant, and pharmaceutical composition including same
PT3322706T (pt) 2015-07-16 2021-03-08 Array Biopharma Inc Compostos de pirazolo[1,5-a]piridina substituídos como inibidores da quinase do ret
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
WO2018102785A2 (en) 2016-12-03 2018-06-07 Juno Therapeutics, Inc. Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors
CN110267960B (zh) 2017-01-18 2022-04-26 阿雷生物药品公司 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
CN110621665A (zh) * 2017-02-21 2019-12-27 艾普托斯生物科学公司 用于治疗患有恶性血液病的患者的方法
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
TWI812649B (zh) 2017-10-10 2023-08-21 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
JP7061195B2 (ja) 2018-01-18 2022-04-27 アレイ バイオファーマ インコーポレイテッド ＲＥＴキナーゼ阻害剤としての置換ピラゾロ［３，４－ｄ］ピリミジン化合物
JP7060694B2 (ja) 2018-01-18 2022-04-26 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物
CN111615514B (zh) 2018-01-18 2022-10-11 奥瑞生物药品公司 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物
JP2022500383A (ja) 2018-09-10 2022-01-04 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての縮合複素環式化合物
AU2019387508A1 (en) * 2018-11-30 2021-06-10 Aptose Biosciences Inc. Combination therapy with 2,3-dihydro-isoindole-1-one compounds and methods for treating patients with various mutations
US20220143049A1 (en) 2019-03-21 2022-05-12 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
EP4054579A1 (en) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
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US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
CN117295737A (zh) * 2021-03-05 2023-12-26 林伯士萨顿公司 Hpk1拮抗剂和其用途

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Also Published As

Publication number Publication date
JP2016504351A (ja) 2016-02-12
EP2940014A1 (en) 2015-11-04
MX2021011563A (es) 2022-10-10
AU2020201431B2 (en) 2021-07-22
RU2018138028A (ru) 2019-03-21
RU2015124381A (ru) 2017-02-01
AU2013371146C1 (en) 2019-01-17
US20150336934A1 (en) 2015-11-26
AU2020201431A1 (en) 2020-03-19
US20170362205A1 (en) 2017-12-21
KR20160058720A (ko) 2016-05-25
CA2896711A1 (en) 2014-07-03
RU2671847C2 (ru) 2018-11-07
CN104995184B (zh) 2018-01-02
JP2018109069A (ja) 2018-07-12
WO2014104757A1 (ko) 2014-07-03
AU2013371146A1 (en) 2015-07-16
US20210009565A1 (en) 2021-01-14
AU2018214134B2 (en) 2020-03-12
EP2940014A4 (en) 2016-06-22
EP3428161A1 (en) 2019-01-16
EP2940014B1 (en) 2018-09-26
JP6596537B2 (ja) 2019-10-23
US20220380346A1 (en) 2022-12-01
CA2896711C (en) 2019-12-31
PL2940014T3 (pl) 2019-03-29
BR112015015477A2 (pt) 2017-07-11
BR112015015477B1 (pt) 2022-07-12
KR102009163B1 (ko) 2019-08-09
AU2018214134A1 (en) 2018-08-30
ES2696700T3 (es) 2019-01-17
ES2929906T3 (es) 2022-12-02
US9758508B2 (en) 2017-09-12
PT2940014T (pt) 2018-11-28
US10604508B2 (en) 2020-03-31
EP3428161B1 (en) 2022-09-07
JP6325573B2 (ja) 2018-05-16
CN104995184A (zh) 2015-10-21
DK2940014T3 (en) 2018-12-10
US11230539B2 (en) 2022-01-25
HK1259355A1 (zh) 2019-11-29
AU2013371146B2 (en) 2018-05-10

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