MX2009013218A - Derivados de quinoxalina como inhibidores de la actividad de cinasa de tirosina de las cinasas janus. - Google Patents

Derivados de quinoxalina como inhibidores de la actividad de cinasa de tirosina de las cinasas janus.

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Publication number
MX2009013218A
MX2009013218A MX2009013218A MX2009013218A MX2009013218A MX 2009013218 A MX2009013218 A MX 2009013218A MX 2009013218 A MX2009013218 A MX 2009013218A MX 2009013218 A MX2009013218 A MX 2009013218A MX 2009013218 A MX2009013218 A MX 2009013218A
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MX
Mexico
Prior art keywords
tyrosine kinase
kinase activity
inhibitors
janus kinases
quinoxaline derivatives
Prior art date
Application number
MX2009013218A
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English (en)
Inventor
Marc Gerspacher
Eric Vangrevelinghe
Pascal Furet
Carole Pissot Soldermann
Philipp Holzer
Christoph Gaul
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2009013218A publication Critical patent/MX2009013218A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Health & Medical Sciences (AREA)
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  • Neurology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un compuesto de quinoxalina de la Fórmula (I): (ver fórmula (I)) en donde: R1 es carbociclilo o heterociclilo, cualquiera de los cuales está opcionalmente sustituido con 1, 2, 3, 4, ó 5 R7; R2 es arilo o heterociclilo, cualquiera de los cuales está opcionalmente sustituido con 1, 2, 3, 4, ó 5 R8; R3, R4, y R5, son cada uno independientemente hidrógeno o R9; R6 es hidrógeno; y R7, R8, y R9 se seleccionan cada uno independientemente a partir de sustituyentes orgánicos e inorgánicos, a su uso en terapia de enfermedades, en particular las enfermedades mediadas por la actividad de la cinasa de tirosina de las cinasas Janus, incluyendo las cinasas JAK-2 y JAK-3.
MX2009013218A 2007-06-08 2008-06-06 Derivados de quinoxalina como inhibidores de la actividad de cinasa de tirosina de las cinasas janus. MX2009013218A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07109880 2007-06-08
EP07150266 2007-12-20
PCT/EP2008/057058 WO2008148867A2 (en) 2007-06-08 2008-06-06 Quinoxaline derivatives as inhibitors of the tyrosine kinase activity of janus kinases

Publications (1)

Publication Number Publication Date
MX2009013218A true MX2009013218A (es) 2010-01-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013218A MX2009013218A (es) 2007-06-08 2008-06-06 Derivados de quinoxalina como inhibidores de la actividad de cinasa de tirosina de las cinasas janus.

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Country Link
US (1) US8193189B2 (es)
EP (1) EP2155201B1 (es)
JP (1) JP5574957B2 (es)
KR (1) KR20100020465A (es)
CN (1) CN101678020B (es)
AR (1) AR066879A1 (es)
AU (1) AU2008258486B2 (es)
BR (1) BRPI0812893A2 (es)
CA (1) CA2690288A1 (es)
CL (1) CL2008001659A1 (es)
EA (1) EA200901608A1 (es)
ES (1) ES2392570T3 (es)
MX (1) MX2009013218A (es)
PA (1) PA8783501A1 (es)
TW (1) TW200904814A (es)
UY (1) UY31126A1 (es)
WO (1) WO2008148867A2 (es)

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TW200904814A (en) 2009-02-01
US8193189B2 (en) 2012-06-05
JP2010529088A (ja) 2010-08-26
AR066879A1 (es) 2009-09-16
JP5574957B2 (ja) 2014-08-20
PA8783501A1 (es) 2009-01-23
CN101678020B (zh) 2012-08-15
BRPI0812893A2 (pt) 2014-12-09
AU2008258486A1 (en) 2008-12-11
CA2690288A1 (en) 2008-12-11
WO2008148867A3 (en) 2009-04-09
KR20100020465A (ko) 2010-02-22
CN101678020A (zh) 2010-03-24
EA200901608A1 (ru) 2010-06-30
CL2008001659A1 (es) 2009-02-20
AU2008258486B2 (en) 2011-11-10
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WO2008148867A2 (en) 2008-12-11
UY31126A1 (es) 2009-01-30

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