MX2018003564A - 1,4-benzodiazepinas biheteroarilo sustituidas y usos de las mismas para el tratamiento del cancer. - Google Patents

1,4-benzodiazepinas biheteroarilo sustituidas y usos de las mismas para el tratamiento del cancer.

Info

Publication number
MX2018003564A
MX2018003564A MX2018003564A MX2018003564A MX2018003564A MX 2018003564 A MX2018003564 A MX 2018003564A MX 2018003564 A MX2018003564 A MX 2018003564A MX 2018003564 A MX2018003564 A MX 2018003564A MX 2018003564 A MX2018003564 A MX 2018003564A
Authority
MX
Mexico
Prior art keywords
cancer
treatment
benzodiazepines
heteroaryl substituted
compounds
Prior art date
Application number
MX2018003564A
Other languages
English (en)
Inventor
Patrick René Angibaud
Alexis Georges Querolle Olivier
Vermeulen Wim
Anna HOSTYN Steven
Fernando Domenico Broggini Diego
Albert C CUYCKENS Filip
MARK JONES Russell
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2018003564A publication Critical patent/MX2018003564A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La invención se refiere a nuevos compuestos derivados de quinolina, piridopirazina, naftiridina y quinazolinona, a composiciones farmacéuticas que comprenden dichos compuestos, a procesos para la preparación de dichos compuestos y al uso de dichos compuestos en el tratamiento de enfermedades, por ejemplo cáncer.
MX2018003564A 2015-09-23 2016-09-22 1,4-benzodiazepinas biheteroarilo sustituidas y usos de las mismas para el tratamiento del cancer. MX2018003564A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15186478 2015-09-23
PCT/EP2016/072501 WO2017050865A1 (en) 2015-09-23 2016-09-22 Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2018003564A true MX2018003564A (es) 2018-06-18

Family

ID=54251305

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018003564A MX2018003564A (es) 2015-09-23 2016-09-22 1,4-benzodiazepinas biheteroarilo sustituidas y usos de las mismas para el tratamiento del cancer.

Country Status (17)

Country Link
US (2) US11542247B2 (es)
EP (1) EP3353164B1 (es)
JP (1) JP6896711B2 (es)
KR (1) KR20180052631A (es)
CN (1) CN108137546B (es)
AU (1) AU2016328693B2 (es)
BR (1) BR112018005625B1 (es)
CA (1) CA2996989C (es)
DK (1) DK3353164T3 (es)
ES (1) ES2904513T3 (es)
HR (1) HRP20220012T1 (es)
HU (1) HUE057090T2 (es)
LT (1) LT3353164T (es)
MX (1) MX2018003564A (es)
RU (1) RU2747644C2 (es)
SI (1) SI3353164T1 (es)
WO (1) WO2017050865A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021207554A1 (en) * 2020-04-08 2021-10-14 Remix Therapeutics Inc. Compounds and methods for modulating splicing

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