MX2019001579A - Composiciones farmaceuticas que comprenden inhibidores de la proteina quinasa akt. - Google Patents
Composiciones farmaceuticas que comprenden inhibidores de la proteina quinasa akt.Info
- Publication number
- MX2019001579A MX2019001579A MX2019001579A MX2019001579A MX2019001579A MX 2019001579 A MX2019001579 A MX 2019001579A MX 2019001579 A MX2019001579 A MX 2019001579A MX 2019001579 A MX2019001579 A MX 2019001579A MX 2019001579 A MX2019001579 A MX 2019001579A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical compositions
- protein kinase
- kinase inhibitors
- akt protein
- akt
- Prior art date
Links
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003909 protein kinase inhibitor Substances 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a composiciones farmacéuticas que comprenden inhibidores de la proteína quinasa Akt con actividad terapéutica contra enfermedades tales como el cáncer, así como a procesos para su preparación y su uso como un medicamento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662373252P | 2016-08-10 | 2016-08-10 | |
PCT/EP2017/070128 WO2018029226A1 (en) | 2016-08-10 | 2017-08-09 | Pharmaceutical compositions comprising akt protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019001579A true MX2019001579A (es) | 2019-06-20 |
Family
ID=59569321
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019001579A MX2019001579A (es) | 2016-08-10 | 2017-08-09 | Composiciones farmaceuticas que comprenden inhibidores de la proteina quinasa akt. |
MX2021010041A MX2021010041A (es) | 2016-08-10 | 2019-02-07 | Composiciones farmaceuticas que comprenden inhibidores de la proteina quinasa akt. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021010041A MX2021010041A (es) | 2016-08-10 | 2019-02-07 | Composiciones farmaceuticas que comprenden inhibidores de la proteina quinasa akt. |
Country Status (12)
Country | Link |
---|---|
US (2) | US11337977B2 (es) |
EP (1) | EP3496722A1 (es) |
JP (3) | JP6875501B2 (es) |
KR (3) | KR20230124110A (es) |
CN (3) | CN116172869A (es) |
AU (3) | AU2017310454B2 (es) |
BR (1) | BR112019002007B1 (es) |
CA (1) | CA3032233C (es) |
IL (3) | IL305639A (es) |
MX (2) | MX2019001579A (es) |
TW (2) | TWI736660B (es) |
WO (1) | WO2018029226A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112019002007B1 (pt) | 2016-08-10 | 2024-01-16 | F. Hoffmann-La Roche Ag | Composição farmacêutica e uso de uma composição farmacêutica |
AU2019309435A1 (en) * | 2018-07-27 | 2021-01-21 | Sandoz Ag | Process for preparing rapidly or very rapidly dissolving tablets comprising freely soluble API |
BR112022001627A2 (pt) * | 2019-07-31 | 2022-04-19 | Hoffmann La Roche | Composições farmacêuticas, minicomprimido, embalagem do tipo stickpack, kit, processo para produzir a composição farmacêutica, métodos para o tratamento de doenças e para tratar tipos específicos de câncer, método de tratamento de câncer em um paciente em necessidade do mesmo e invenção |
EP4013419A1 (en) | 2019-08-12 | 2022-06-22 | F. Hoffmann-La Roche AG | Treatment of breast cancer using combination therapies comprising an atp competitive akt inhibitor, a cdk4/6 inhibitor, and fulvestrant |
US11684582B2 (en) | 2021-03-31 | 2023-06-27 | Delta-Fly Pharma, Inc. | Method for stabilizing humidity-sensitive pharmaceutical substance and stabilized preparation thereof |
CA3221313A1 (en) * | 2021-06-09 | 2022-12-15 | Warren Miller | Mixed solvents for spray drying for preparation of amorphous solid dispersions |
KR102689151B1 (ko) * | 2021-09-06 | 2024-07-29 | 연세대학교 산학협력단 | Akt 신호경로 억제제를 유효성분으로 포함하는 아토피피부염의 예방 또는 치료용 조성물 |
KR20240093850A (ko) * | 2021-10-22 | 2024-06-24 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 개선된 안정성 프로파일을 갖는 약제학적 조성물 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2004134594A (ru) | 2002-04-29 | 2005-06-27 | Алза Корпорейшн (Us) | Способы и лекарственные формы для контролируемой доставки оксикодона |
CA2393720C (en) | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
WO2005032525A1 (en) * | 2003-10-03 | 2005-04-14 | Lifecycle Pharma A/S | A method for preparing modified release pharmaceutical compositions |
WO2005041968A2 (en) | 2003-10-29 | 2005-05-12 | Alza Corporation | Once-a-day, oral, controlled-release, oxycodone dosage forms |
US20070287719A1 (en) * | 2005-03-11 | 2007-12-13 | Pfizer Inc | Salts, Prodrugs and Formulations of 1-[5-(4-Amino-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonyl)-2-Methoxy-Phenyl]-3-(2,4-Dichloro-Phenyl)-Urea |
US20070232624A1 (en) | 2006-04-03 | 2007-10-04 | Palumbo Joseph M | Use of paliperidone for the treatment of sleep disturbances and/or excessive daytime sleepiness in psychiatric patients |
UA95641C2 (en) | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
MX2010010998A (es) * | 2008-04-07 | 2011-01-25 | Chelsea Therapeutics Inc | Composiciones de antifolato. |
MX2011007381A (es) | 2009-01-23 | 2011-08-12 | Hoffmann La Roche | Composicion farmaceutica que contiene aleglitazar. |
US20110086102A1 (en) * | 2009-10-13 | 2011-04-14 | Teva Pharmaceutical Industries Ltd. | Delayed release compositions |
TWI505828B (zh) * | 2010-12-20 | 2015-11-01 | 葛蘭素史克智慧財產(第二)有限公司 | 新穎醫藥組成物 |
ES2582557T3 (es) | 2012-05-17 | 2016-09-13 | Array Biopharma, Inc. | Proceso para la preparación de compuestos hidroxilados de ciclopentilpirimidina |
MA37647A1 (fr) | 2012-05-17 | 2016-03-31 | Genentech Inc | Procédé de fabrication de composés de cyclopentapyrimidine hydroxylée et sels de ceux-ci |
PL2858989T3 (pl) * | 2012-05-17 | 2020-11-16 | Genentech, Inc. | Amorficzna postać inhibującego AKT związku pirymidynylo-cyklopentanu, kompozycje oraz ich sposoby |
CN104968363A (zh) * | 2012-12-07 | 2015-10-07 | 综合医院公司 | Pi3k/akt抑制剂化合物与her3/egfr抑制剂化合物的组合及使用方法 |
ES2957314T3 (es) | 2013-11-15 | 2024-01-17 | Hoffmann La Roche | Procesos para la preparación de compuestos de pirimidinilciclopentano |
WO2015097667A2 (en) * | 2013-12-23 | 2015-07-02 | Cellworks Group, Inc., | A composition, process of preparation of said composition, kit and a method of treating cancer |
KR20230136693A (ko) | 2014-07-25 | 2023-09-26 | 노파르티스 아게 | 2-플루오로-n-메틸-4-[7-(퀴놀린-6-일메틸)이미다조[1,2-b][1,2,4]트리아진-2-일]벤즈아미드의 정제 제제 |
ES2843952T3 (es) | 2014-10-23 | 2021-07-21 | Eisai R&D Man Co Ltd | Composiciones para tratar el insomnio |
TWI577042B (zh) | 2015-07-15 | 2017-04-01 | 南臺科技大學 | 發光二極體晶片及數據發射及接收裝置 |
BR112019002007B1 (pt) | 2016-08-10 | 2024-01-16 | F. Hoffmann-La Roche Ag | Composição farmacêutica e uso de uma composição farmacêutica |
-
2017
- 2017-08-09 BR BR112019002007-1A patent/BR112019002007B1/pt active IP Right Grant
- 2017-08-09 CN CN202210964541.0A patent/CN116172869A/zh active Pending
- 2017-08-09 TW TW106126958A patent/TWI736660B/zh active
- 2017-08-09 MX MX2019001579A patent/MX2019001579A/es unknown
- 2017-08-09 CA CA3032233A patent/CA3032233C/en active Active
- 2017-08-09 KR KR1020237027880A patent/KR20230124110A/ko not_active Application Discontinuation
- 2017-08-09 US US15/672,505 patent/US11337977B2/en active Active
- 2017-08-09 AU AU2017310454A patent/AU2017310454B2/en active Active
- 2017-08-09 TW TW110124994A patent/TWI777658B/zh active
- 2017-08-09 JP JP2019507119A patent/JP6875501B2/ja active Active
- 2017-08-09 CN CN202210819234.3A patent/CN115350192A/zh active Pending
- 2017-08-09 IL IL305639A patent/IL305639A/en unknown
- 2017-08-09 IL IL264593A patent/IL264593B/en unknown
- 2017-08-09 KR KR1020217022843A patent/KR102569636B1/ko active Application Filing
- 2017-08-09 EP EP17749706.2A patent/EP3496722A1/en active Pending
- 2017-08-09 IL IL293480A patent/IL293480B2/en unknown
- 2017-08-09 CN CN201780061307.4A patent/CN109789141B/zh active Active
- 2017-08-09 WO PCT/EP2017/070128 patent/WO2018029226A1/en unknown
- 2017-08-09 KR KR1020197006719A patent/KR102281695B1/ko active IP Right Grant
-
2019
- 2019-02-07 MX MX2021010041A patent/MX2021010041A/es unknown
-
2020
- 2020-06-22 AU AU2020204167A patent/AU2020204167B2/en active Active
-
2021
- 2021-04-20 JP JP2021070852A patent/JP2021120376A/ja not_active Withdrawn
- 2021-12-08 AU AU2021282472A patent/AU2021282472B2/en active Active
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2022
- 2022-04-19 US US17/724,045 patent/US11969426B2/en active Active
-
2023
- 2023-04-13 JP JP2023065459A patent/JP2023100657A/ja active Pending
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