BR112019002007A2 - composições farmacêuticas, processo para a fabricação de grânulos, processo para a fabricação de uma composição farmacêutica, processo para a preparação de monocloridrato de ipatasertib amorfo, método para o tratamento de distúrbios hiperproliferativos, utilização de uma composição farmacêutica e presente invenção - Google Patents

composições farmacêuticas, processo para a fabricação de grânulos, processo para a fabricação de uma composição farmacêutica, processo para a preparação de monocloridrato de ipatasertib amorfo, método para o tratamento de distúrbios hiperproliferativos, utilização de uma composição farmacêutica e presente invenção

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Publication number
BR112019002007A2
BR112019002007A2 BR112019002007-1A BR112019002007A BR112019002007A2 BR 112019002007 A2 BR112019002007 A2 BR 112019002007A2 BR 112019002007 A BR112019002007 A BR 112019002007A BR 112019002007 A2 BR112019002007 A2 BR 112019002007A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
manufacturing
present
hyperproliferative disorders
pharmaceutical compositions
Prior art date
Application number
BR112019002007-1A
Other languages
English (en)
Other versions
BR112019002007B1 (pt
Inventor
Reents Reinhard
Hidber Pirmin
Hell André
Steidle Peter
Wunderlich Martin
Pepelnjak Marie
Gosselin Francis
Yost Edward
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of BR112019002007A2 publication Critical patent/BR112019002007A2/pt
Publication of BR112019002007B1 publication Critical patent/BR112019002007B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

a presente invenção se refere às composições farmacêuticas que compreendem os inibidores da proteína quinase akt com atividade terapêutica contra as doenças, tais como o câncer, bem como aos processos para a sua preparação e sua utilização como medicamento.
BR112019002007-1A 2016-08-10 2017-08-09 Composição farmacêutica e uso de uma composição farmacêutica BR112019002007B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662373252P 2016-08-10 2016-08-10
US62/373,252 2016-08-10
PCT/EP2017/070128 WO2018029226A1 (en) 2016-08-10 2017-08-09 Pharmaceutical compositions comprising akt protein kinase inhibitors

Publications (2)

Publication Number Publication Date
BR112019002007A2 true BR112019002007A2 (pt) 2019-05-07
BR112019002007B1 BR112019002007B1 (pt) 2024-01-16

Family

ID=59569321

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019002007-1A BR112019002007B1 (pt) 2016-08-10 2017-08-09 Composição farmacêutica e uso de uma composição farmacêutica

Country Status (12)

Country Link
US (2) US11337977B2 (pt)
EP (1) EP3496722A1 (pt)
JP (3) JP6875501B2 (pt)
KR (3) KR102281695B1 (pt)
CN (3) CN109789141B (pt)
AU (3) AU2017310454B2 (pt)
BR (1) BR112019002007B1 (pt)
CA (1) CA3032233C (pt)
IL (3) IL264593B (pt)
MX (2) MX2019001579A (pt)
TW (3) TWI736660B (pt)
WO (1) WO2018029226A1 (pt)

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* Cited by examiner, † Cited by third party
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JP6875501B2 (ja) 2016-08-10 2021-05-26 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Ａｋｔプロテインキナーゼ阻害剤を含む薬学的組成物
CA3099888A1 (en) * 2018-07-27 2020-01-30 Sandoz Ag Process for preparing rapidly or very rapidly dissolving tablets comprising freely soluble api
EP4003309A1 (en) * 2019-07-31 2022-06-01 F. Hoffmann-La Roche AG New pharmaceutical formulation
EP4091614B1 (en) 2021-03-31 2023-09-06 Delta-Fly Pharma, Inc. Method for stabilizing medicinal substance sensitive to humidity (dfp-11207), and stable preparation thereof
EP4351522A1 (en) * 2021-06-09 2024-04-17 Lonza Bend Inc. Mixed solvents for spray drying for preparation of amorphous solid dispersions
WO2023069733A1 (en) * 2021-10-22 2023-04-27 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced stability profiles

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WO2005032525A1 (en) * 2003-10-03 2005-04-14 Lifecycle Pharma A/S A method for preparing modified release pharmaceutical compositions
KR20060108690A (ko) 2003-10-29 2006-10-18 알자 코포레이션 1일 1회 경구용의 서방성 옥시코돈 제형
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Also Published As

Publication number Publication date
JP2021120376A (ja) 2021-08-19
MX2019001579A (es) 2019-06-20
KR20190038619A (ko) 2019-04-08
MX2021010041A (es) 2022-06-14
US20180055845A1 (en) 2018-03-01
US20220241279A1 (en) 2022-08-04
US11969426B2 (en) 2024-04-30
KR102281695B1 (ko) 2021-07-28
KR20210094667A (ko) 2021-07-29
US11337977B2 (en) 2022-05-24
AU2020204167B2 (en) 2021-10-21
IL264593A (en) 2019-02-28
TW202329972A (zh) 2023-08-01
JP2019524804A (ja) 2019-09-05
CN116172869A (zh) 2023-05-30
AU2017310454A1 (en) 2019-02-14
IL305639A (en) 2023-11-01
CN109789141B (zh) 2022-08-26
EP3496722A1 (en) 2019-06-19
JP6875501B2 (ja) 2021-05-26
TWI736660B (zh) 2021-08-21
AU2020204167A1 (en) 2020-07-09
BR112019002007B1 (pt) 2024-01-16
KR20230124110A (ko) 2023-08-24
AU2021282472B2 (en) 2024-02-22
KR102569636B1 (ko) 2023-08-23
JP2023100657A (ja) 2023-07-19
AU2021282472A1 (en) 2022-01-06
IL293480A (en) 2022-08-01
CN109789141A (zh) 2019-05-21
IL293480B1 (en) 2023-10-01
IL264593B (en) 2022-07-01
CN115350192A (zh) 2022-11-18
AU2017310454B2 (en) 2020-06-04
CA3032233A1 (en) 2018-02-15
CA3032233C (en) 2021-09-14
WO2018029226A1 (en) 2018-02-15
TWI777658B (zh) 2022-09-11
TW201808337A (zh) 2018-03-16
TW202214299A (zh) 2022-04-16
IL293480B2 (en) 2024-02-01

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