BR112014008045A2 - benzilindazóis substituídos para uso como inibidores de bub1 cinase no tratamento de doenças hiperproliferativas - Google Patents
benzilindazóis substituídos para uso como inibidores de bub1 cinase no tratamento de doenças hiperproliferativasInfo
- Publication number
- BR112014008045A2 BR112014008045A2 BR112014008045A BR112014008045A BR112014008045A2 BR 112014008045 A2 BR112014008045 A2 BR 112014008045A2 BR 112014008045 A BR112014008045 A BR 112014008045A BR 112014008045 A BR112014008045 A BR 112014008045A BR 112014008045 A2 BR112014008045 A2 BR 112014008045A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- kinase inhibitors
- hyperproliferative diseases
- bub1 kinase
- benzylindazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
- A01H6/36—Ericaceae, e.g. azalea, cranberry or blueberry
- A01H6/368—Vaccinium, e.g. cranberry, blueberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
resumo patente de invenção: "benzilindazóis substituídos para uso como inibidores de bub1 cinase no tratamento de doenças hiperproliferativas". a presente invenção refere-se a compostos de fórmula (i) , que são inibidores de bub1 cinase, processos para sua produção e seu uso como produtos farmacêuticos. a presente invenção refere-se ainda a um processo de produção do referido composto de fórmula (i), seus usos no tratamento ou profilaxia de doenças hiperproliferativas e/ou distúrbios responsáveis para indução de apoptose, composições farmacêuticas e combinações compreendendo os mesmos, e compostos intermediários. 20938286v1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11184061 | 2011-10-06 | ||
PCT/EP2012/069562 WO2013050438A1 (en) | 2011-10-06 | 2012-10-04 | Substituted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases. |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014008045A2 true BR112014008045A2 (pt) | 2017-04-11 |
Family
ID=46968229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014008045A BR112014008045A2 (pt) | 2011-10-06 | 2012-10-04 | benzilindazóis substituídos para uso como inibidores de bub1 cinase no tratamento de doenças hiperproliferativas |
Country Status (38)
Country | Link |
---|---|
US (3) | US20140249133A1 (pt) |
EP (1) | EP2763982B1 (pt) |
JP (1) | JP6140170B2 (pt) |
KR (1) | KR102007056B1 (pt) |
CN (1) | CN103974948B (pt) |
AP (1) | AP3847A (pt) |
AR (1) | AR088449A1 (pt) |
AU (1) | AU2012320582B2 (pt) |
BR (1) | BR112014008045A2 (pt) |
CA (1) | CA2851037A1 (pt) |
CO (1) | CO6930363A2 (pt) |
CR (1) | CR20140161A (pt) |
CU (1) | CU20140043A7 (pt) |
CY (1) | CY1120318T1 (pt) |
DK (1) | DK2763982T3 (pt) |
DO (1) | DOP2014000062A (pt) |
EA (1) | EA201400412A1 (pt) |
EC (1) | ECSP14013284A (pt) |
ES (1) | ES2665036T3 (pt) |
GT (1) | GT201400063A (pt) |
HK (1) | HK1200449A1 (pt) |
HR (1) | HRP20180546T1 (pt) |
HU (1) | HUE037154T2 (pt) |
IL (1) | IL231591A (pt) |
LT (1) | LT2763982T (pt) |
MX (1) | MX361279B (pt) |
NO (1) | NO2763982T3 (pt) |
PE (1) | PE20141203A1 (pt) |
PL (1) | PL2763982T3 (pt) |
PT (1) | PT2763982T (pt) |
RS (1) | RS57099B1 (pt) |
SG (1) | SG11201400616YA (pt) |
SI (1) | SI2763982T1 (pt) |
TN (1) | TN2014000138A1 (pt) |
TW (1) | TWI588141B (pt) |
UA (1) | UA111754C2 (pt) |
UY (1) | UY34374A (pt) |
WO (1) | WO2013050438A1 (pt) |
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BR112017005444A2 (pt) | 2014-09-19 | 2018-04-24 | Bayer Pharma AG | indazoles substituídos por benzil como inibidores bub1. |
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EP3194381A1 (en) | 2014-09-19 | 2017-07-26 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles as bub1 kinase inhibitors |
WO2017148995A1 (en) | 2016-03-04 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | 1-(pyrimidin-2-yl)-1h-indazoles having bub1 kinase inhibiting activity |
WO2017157991A1 (en) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | 1-alkyl-pyrazoles and -indazoles as bub1 inhibitors for the treatment of hyperproliferative diseases |
WO2017157992A1 (en) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | Annulated pyrazoles as bub1 kinase inhibitors for treating proliferative disorders |
WO2018122168A1 (en) | 2016-12-29 | 2018-07-05 | Bayer Pharma Aktiengesellschaft | Combinations of bub1 kinase and parp inhibitors |
WO2018158175A1 (en) | 2017-02-28 | 2018-09-07 | Bayer Pharma Aktiengesellschaft | Combination of bub1 inhibitors |
WO2018206547A1 (en) | 2017-05-12 | 2018-11-15 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and atr inhibitors |
WO2018215282A1 (en) | 2017-05-26 | 2018-11-29 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and pi3k inhibitors |
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