BR112014007622A2 - inibidores de flt3 cinase macrocíclicos - Google Patents

inibidores de flt3 cinase macrocíclicos

Info

Publication number
BR112014007622A2
BR112014007622A2 BR112014007622A BR112014007622A BR112014007622A2 BR 112014007622 A2 BR112014007622 A2 BR 112014007622A2 BR 112014007622 A BR112014007622 A BR 112014007622A BR 112014007622 A BR112014007622 A BR 112014007622A BR 112014007622 A2 BR112014007622 A2 BR 112014007622A2
Authority
BR
Brazil
Prior art keywords
macrocyclic
kinase inhibitors
flt3 kinase
flt3
compounds
Prior art date
Application number
BR112014007622A
Other languages
English (en)
Inventor
Marie Cyriel Jozef Hoflack Jan
Marcella Françoise Blom Petra
Original Assignee
Oncodesign Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncodesign Sa filed Critical Oncodesign Sa
Publication of BR112014007622A2 publication Critical patent/BR112014007622A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Abstract

resumo patente de invenção: "inibidores de flt3 cinase macrocíclicos". a presente invenção refere-se a compostos macrocíclicos e composições contendo os referidos compostos agindo como inibidores de cinase, em particular como inibidores de flt3 (tirosina cinase 3 relacionada com fms). além disso, a presente invenção fornece processos para a preparação de compostos descritos, bem como métodos de utilizá-los, por exemplo, como um medicamento, em particular para o tratamento de distúrbios proliferativos celulares, tal como câncer.
BR112014007622A 2011-09-30 2012-09-28 inibidores de flt3 cinase macrocíclicos BR112014007622A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2011067084 2011-09-30
PCT/EP2012/069252 WO2013045653A1 (en) 2011-09-30 2012-09-28 Macrocyclic flt3 kinase inhibitors

Publications (1)

Publication Number Publication Date
BR112014007622A2 true BR112014007622A2 (pt) 2017-04-04

Family

ID=46980944

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014007622A BR112014007622A2 (pt) 2011-09-30 2012-09-28 inibidores de flt3 cinase macrocíclicos

Country Status (14)

Country Link
US (2) US9090630B2 (pt)
JP (1) JP6046728B2 (pt)
KR (1) KR20140078710A (pt)
CN (1) CN103930427B (pt)
AU (1) AU2012314376B2 (pt)
BR (1) BR112014007622A2 (pt)
CA (1) CA2849999A1 (pt)
DK (1) DK2760867T3 (pt)
EA (1) EA025881B1 (pt)
ES (1) ES2569048T3 (pt)
HK (1) HK1198764A1 (pt)
HU (1) HUE027318T2 (pt)
MX (1) MX347765B (pt)
WO (1) WO2013045653A1 (pt)

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WO2016014542A1 (en) 2014-07-21 2016-01-28 Dana-Farber Cancer Institute, Inc. Imidazolyl kinase inhibitors and uses thereof
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WO2016146651A1 (en) 2015-03-16 2016-09-22 Oncodesign Sa Macrocyclic activin-like receptor kinase inhibitors
CN107735399B (zh) 2015-07-02 2021-01-26 特普医药公司 作为蛋白质激酶的调节剂的手性二芳基大环
CN113354653A (zh) 2015-07-06 2021-09-07 特普医药公司 二芳基大环多晶型物及其制备方法
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RU2630958C2 (ru) * 2015-12-29 2017-09-15 федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" (МФТИ) Новые макроциклические соединения, содержащие природное 3,7-диазабицикло[3.3.1]нонановое ядро и способ их получения
KR20190075043A (ko) 2016-07-05 2019-06-28 더 브로드 인스티튜트, 인코퍼레이티드 비시클릭 우레아 키나제 억제제 및 그의 용도
TW201815799A (zh) 2016-07-28 2018-05-01 美商Ｔｐ生物醫藥公司 巨環激酶抑制劑
WO2018053373A1 (en) 2016-09-16 2018-03-22 The General Hospital Corporation Uses of satl-inducible kinase (sik) inhibitors for treating osteoporosis
TWI808958B (zh) 2017-01-25 2023-07-21 美商特普醫葯公司 涉及二芳基巨環化合物之組合療法
RU2019129727A (ru) 2017-02-28 2021-03-30 Зэ Дженерал Хоспитал Корпорэйшн Применения пиримидопиримидинонов в качестве ингибиторов sik
KR102645316B1 (ko) 2017-07-28 2024-03-07 터닝 포인트 테라퓨틱스, 인크. 거대환형 화합물 및 이의 용도
JOP20200152A1 (ar) 2017-12-19 2022-10-30 Turning Point Therapeutics Inc مركبات حلقية كبرى لعلاج مرض
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Also Published As

Publication number Publication date
JP6046728B2 (ja) 2016-12-21
US20150283141A1 (en) 2015-10-08
US20140303159A1 (en) 2014-10-09
EA201490707A1 (ru) 2014-08-29
WO2013045653A1 (en) 2013-04-04
AU2012314376A1 (en) 2014-05-15
MX347765B (es) 2017-05-12
HK1198764A1 (zh) 2015-06-05
KR20140078710A (ko) 2014-06-25
JP2014528398A (ja) 2014-10-27
HUE027318T2 (en) 2016-10-28
DK2760867T3 (en) 2016-04-11
AU2012314376B2 (en) 2017-04-06
US9370519B2 (en) 2016-06-21
EA025881B1 (ru) 2017-02-28
MX2014003807A (es) 2015-01-12
ES2569048T3 (es) 2016-05-06
CN103930427A (zh) 2014-07-16
US9090630B2 (en) 2015-07-28
CN103930427B (zh) 2016-03-09
CA2849999A1 (en) 2013-04-04

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 6A ANUIDADE.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2481 DE 24-07-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.