HK1198764A1 - 大環 激酶抑制劑 - Google Patents

大環 激酶抑制劑

Info

Publication number
HK1198764A1
HK1198764A1 HK14112275.5A HK14112275A HK1198764A1 HK 1198764 A1 HK1198764 A1 HK 1198764A1 HK 14112275 A HK14112275 A HK 14112275A HK 1198764 A1 HK1198764 A1 HK 1198764A1
Authority
HK
Hong Kong
Prior art keywords
flt3
macrocyclic
kinase inhibitors
flt3 kinase
inhibitors
Prior art date
Application number
HK14112275.5A
Other languages
English (en)
Inventor
．布羅姆
．霍夫萊克
Original Assignee
昂科迪塞恩股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 昂科迪塞恩股份有限公司 filed Critical 昂科迪塞恩股份有限公司
Publication of HK1198764A1 publication Critical patent/HK1198764A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK14112275.5A 2011-09-30 2014-12-05 大環 激酶抑制劑 HK1198764A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2011067084 2011-09-30
PCT/EP2012/069252 WO2013045653A1 (en) 2011-09-30 2012-09-28 Macrocyclic flt3 kinase inhibitors

Publications (1)

Publication Number Publication Date
HK1198764A1 true HK1198764A1 (zh) 2015-06-05

Family

ID=46980944

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14112275.5A HK1198764A1 (zh) 2011-09-30 2014-12-05 大環 激酶抑制劑

Country Status (14)

Country Link
US (2) US9090630B2 (zh)
JP (1) JP6046728B2 (zh)
KR (1) KR20140078710A (zh)
CN (1) CN103930427B (zh)
AU (1) AU2012314376B2 (zh)
BR (1) BR112014007622A2 (zh)
CA (1) CA2849999A1 (zh)
DK (1) DK2760867T3 (zh)
EA (1) EA025881B1 (zh)
ES (1) ES2569048T3 (zh)
HK (1) HK1198764A1 (zh)
HU (1) HUE027318T2 (zh)
MX (1) MX347765B (zh)
WO (1) WO2013045653A1 (zh)

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GB201204384D0 (en) 2012-03-13 2012-04-25 Univ Dundee Anti-flammatory agents
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US9586975B2 (en) * 2013-03-15 2017-03-07 Oncodesign S.A. Macrocyclic salt-inducible kinase inhibitors
MX2015012526A (es) * 2013-03-15 2016-04-26 Oncodesign Sa Inhibodores macrociclicos de cinasa rip2.
CA2911259A1 (en) * 2013-05-06 2014-11-13 Merck Patent Gmbh Macrocycles as kinase inhibitors
SG10202000191YA (en) * 2014-01-24 2020-03-30 Turning Point Therapeutics Inc Diaryl macrocycles as modulators of protein kinases
WO2015136073A1 (en) * 2014-03-14 2015-09-17 Oncodesign Sa Macrocyclic tgf-br2 kinase inhibitors
AU2015292818B2 (en) 2014-07-21 2020-01-16 Dana-Farber Cancer Institute, Inc. Imidazolyl kinase inhibitors and uses thereof
CA2954187C (en) 2014-07-21 2022-08-16 Dana-Farber Cancer Institute, Inc. Macrocyclic kinase inhibitors and uses thereof
AU2015300782B2 (en) 2014-08-08 2020-04-16 Dana-Farber Cancer Institute, Inc. Uses of salt-inducible kinase (SIK) inhibitors
BR112017004035B1 (pt) * 2014-09-17 2023-11-14 Oncodesign Precision Medicine (OPM) Inibidores macrocíclicos de rip2 quinase e composições farmacêuticas
EA032838B1 (ru) * 2014-09-17 2019-07-31 Онкодизайн С.А. Макроциклические ингибиторы lrrk2-киназы
WO2016146651A1 (en) 2015-03-16 2016-09-22 Oncodesign Sa Macrocyclic activin-like receptor kinase inhibitors
JP6871903B2 (ja) 2015-07-02 2021-05-19 ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． プロテインキナーゼのモジュレーターとしてのキラルジアリール大環状分子
US10294242B2 (en) 2015-07-06 2019-05-21 Tp Therapeutics, Inc. Diaryl macrocycle polymorph
AU2016296878B2 (en) 2015-07-21 2020-12-17 Turning Point Therapeutics, Inc. Chiral diaryl macrocycles and uses thereof
RU2630958C2 (ru) * 2015-12-29 2017-09-15 федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" (МФТИ) Новые макроциклические соединения, содержащие природное 3,7-диазабицикло[3.3.1]нонановое ядро и способ их получения
US10954242B2 (en) 2016-07-05 2021-03-23 The Broad Institute, Inc. Bicyclic urea kinase inhibitors and uses thereof
KR20190034225A (ko) 2016-07-28 2019-04-01 티피 테라퓨틱스, 인크. 거대환 키나제 억제제
US11241435B2 (en) 2016-09-16 2022-02-08 The General Hospital Corporation Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis
TWI808958B (zh) 2017-01-25 2023-07-21 美商特普醫葯公司 涉及二芳基巨環化合物之組合療法
AU2018226771B2 (en) 2017-02-28 2023-11-23 Dana-Farber Cancer Institute, Inc. Uses of pyrimidopyrimidinones as SIK inhibitors
AU2018306328B2 (en) 2017-07-28 2023-03-09 Turning Point Therapeutics, Inc. Macrocyclic compounds and uses thereof
CN111511746B (zh) 2017-12-19 2024-01-09 特普医药公司 用于治疗疾病的巨环化合物
CN110950889B (zh) * 2018-09-27 2022-04-05 北京赛林泰医药技术有限公司 一种多靶点激酶抑制剂及其制备方法和用途
JP2023504523A (ja) * 2019-12-03 2023-02-03 ターニング・ポイント・セラピューティクス・インコーポレイテッド 疾患処置に使用するための大環状分子

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KR101324804B1 (ko) * 2008-05-13 2013-11-01 아이알엠 엘엘씨 키나제 억제제로서의 질소 함유 융합 헤테로사이클 및 그의 조성물
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ES2583477T3 (es) * 2011-09-30 2016-09-21 Ipsen Pharma S.A.S. Inhibidores macrocíclicos de cinasa de LRRK2

Also Published As

Publication number Publication date
KR20140078710A (ko) 2014-06-25
ES2569048T3 (es) 2016-05-06
DK2760867T3 (en) 2016-04-11
WO2013045653A1 (en) 2013-04-04
HUE027318T2 (en) 2016-10-28
JP6046728B2 (ja) 2016-12-21
AU2012314376A1 (en) 2014-05-15
CA2849999A1 (en) 2013-04-04
AU2012314376B2 (en) 2017-04-06
US9370519B2 (en) 2016-06-21
US20140303159A1 (en) 2014-10-09
US20150283141A1 (en) 2015-10-08
CN103930427B (zh) 2016-03-09
MX347765B (es) 2017-05-12
CN103930427A (zh) 2014-07-16
JP2014528398A (ja) 2014-10-27
EA201490707A1 (ru) 2014-08-29
US9090630B2 (en) 2015-07-28
EA025881B1 (ru) 2017-02-28
BR112014007622A2 (pt) 2017-04-04
MX2014003807A (es) 2015-01-12

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200930