PL2646448T3 - Makrocykliczne inhibitory kinazy - Google Patents
Makrocykliczne inhibitory kinazyInfo
- Publication number
- PL2646448T3 PL2646448T3 PL11794899T PL11794899T PL2646448T3 PL 2646448 T3 PL2646448 T3 PL 2646448T3 PL 11794899 T PL11794899 T PL 11794899T PL 11794899 T PL11794899 T PL 11794899T PL 2646448 T3 PL2646448 T3 PL 2646448T3
- Authority
- PL
- Poland
- Prior art keywords
- kinase inhibitors
- macrocyclic kinase
- macrocyclic
- inhibitors
- kinase
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41760110P | 2010-11-29 | 2010-11-29 | |
PCT/US2011/062290 WO2012074951A1 (en) | 2010-11-29 | 2011-11-29 | Macrocyclic kinase inhibitors |
EP11794899.2A EP2646448B1 (en) | 2010-11-29 | 2011-11-29 | Macrocyclic kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2646448T3 true PL2646448T3 (pl) | 2017-12-29 |
Family
ID=45346560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL11794899T PL2646448T3 (pl) | 2010-11-29 | 2011-11-29 | Makrocykliczne inhibitory kinazy |
Country Status (7)
Country | Link |
---|---|
US (1) | US9133224B2 (pl) |
EP (1) | EP2646448B1 (pl) |
JP (1) | JP6000273B2 (pl) |
ES (1) | ES2645508T3 (pl) |
PL (1) | PL2646448T3 (pl) |
PT (1) | PT2646448T (pl) |
WO (1) | WO2012074951A1 (pl) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
WO2012074951A1 (en) | 2010-11-29 | 2012-06-07 | OSI Pharmaceuticals, LLC | Macrocyclic kinase inhibitors |
EP3592757A2 (en) | 2017-03-09 | 2020-01-15 | ELITechGroup, Inc. | Nitrodiarylethenes as fluorescence quenchers for nucleic acid probes |
WO2023229430A1 (ko) * | 2022-05-27 | 2023-11-30 | 보로노이 주식회사 | 헤테로아릴 유도체 화합물 및 이의 용도 |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5438299A (en) | 1998-08-29 | 2000-03-21 | Astrazeneca Ab | Pyrimidine compounds |
KR20030024659A (ko) | 2000-02-17 | 2003-03-26 | 암겐 인코포레이티드 | 키나제 억제제 |
GB0004890D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
EE200200506A (et) | 2000-03-06 | 2004-02-16 | Warner-Lambert Company | 5-alküülpürido[2,3-d]pürimidiinid kui türosiinkinaasi inhibiitorid |
IL159120A0 (en) | 2001-05-29 | 2004-05-12 | Schering Ag | Cdk inhibiting pyrimidines, production thereof and their use as medicaments |
EP1408978A4 (en) | 2001-06-21 | 2005-07-13 | Ariad Pharma Inc | NOVEL PHENYLAMINO-PYRIMIDINES AND THEIR USE |
WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
DE10239042A1 (de) * | 2002-08-21 | 2004-03-04 | Schering Ag | Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel |
GEP20084357B (en) | 2002-12-20 | 2008-04-29 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
UA80767C2 (en) | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
US7109337B2 (en) | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
ATE433447T1 (de) | 2003-02-20 | 2009-06-15 | Smithkline Beecham Corp | Pyrimiidinverbindungen |
EP2476667B1 (en) | 2003-02-26 | 2014-07-16 | Sugen, Inc. | Aminoheteroaryl compounds as protein kinase inhibitors |
GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
BRPI0413616B8 (pt) | 2003-08-15 | 2021-05-25 | Irm Llc | 2,4-pirimidinadiaminas, seus usos, e composição farmacêutica |
EP1656378A4 (en) | 2003-08-15 | 2011-05-11 | Irm Llc | COMPOUNDS AND COMPOSITIONS INHIBITING TYROSINE KINASE RECEPTOR ACTIVITY |
BRPI0414059B8 (pt) | 2003-09-05 | 2021-05-25 | Pfizer Prod Inc | síntese seletiva de pirimidinas substituídas em cf3 |
EP1756090A1 (en) | 2004-05-14 | 2007-02-28 | Pfizer Products Incorporated | Pyrimidine derivatives for the treatment of abnormal cell growth |
US7521457B2 (en) | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
GB0419161D0 (en) | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
GB0419160D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
MY169441A (en) * | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
US7563781B2 (en) | 2005-01-14 | 2009-07-21 | Janssen Pharmaceutica Nv | Triazolopyrimidine derivatives |
DE102005008310A1 (de) | 2005-02-17 | 2006-08-24 | Schering Ag | Verwendung von CDKII Inhibitoren zur Fertilitätskontrolle |
US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
US8071609B2 (en) | 2005-08-11 | 2011-12-06 | Ariad Pharmaceuticals, Inc. | Unsaturated heterocyclic derivatives |
EP1966207A2 (en) | 2005-12-21 | 2008-09-10 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
CA2669111C (en) | 2006-10-23 | 2016-04-12 | Cephalon, Inc. | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors |
GEP20156282B (en) | 2006-12-08 | 2015-05-11 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
WO2008079073A1 (en) | 2006-12-22 | 2008-07-03 | Astrazeneca Ab | Indazolyl sulphonamide derivatives for the treatment of glucocorticoid receptor mediated disorders |
WO2008094737A2 (en) | 2007-01-26 | 2008-08-07 | Irm Llc | Purine compounds and compositions as kinase inhibitors for the treatment of plasmodium related diseases |
JP2010532312A (ja) | 2007-01-30 | 2010-10-07 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 1−h−ピラゾロ(3,4b)ピリミジン誘導体および有糸分裂キナーゼの調節剤としてのその使用 |
WO2008116139A2 (en) | 2007-03-22 | 2008-09-25 | Vertex Pharmaceuticals Incorporated | N-heterocyclic compounds useful as inhibitors of janus kinases |
CN101678215B (zh) | 2007-04-18 | 2014-10-01 | 辉瑞产品公司 | 用于治疗异常细胞生长的磺酰胺衍生物 |
US20100305113A1 (en) | 2007-05-09 | 2010-12-02 | Hans-Georg Capraro | Substituted Imidazopyridazines as Lipid Kinase Inhibitors |
AR068054A1 (es) | 2007-08-08 | 2009-11-04 | Smithkline Beecham Corp | Compuestos de pirrolopirimidina |
CA2707653A1 (en) | 2007-12-03 | 2009-06-11 | Boehringer Ingelheim International Gmbh | Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation |
EP2249650A4 (en) * | 2008-02-19 | 2012-01-11 | Glaxosmithkline Llc | ANILINOPYRIDINE AS A FAK HEMMER |
US8871753B2 (en) | 2008-04-24 | 2014-10-28 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
KR101781605B1 (ko) | 2008-05-21 | 2017-09-25 | 어리어드 파마슈티칼스, 인코포레이티드 | 키나아제 억제제로서 포스포러스 유도체 |
MX2011002470A (es) * | 2008-09-08 | 2011-04-05 | Merck Patent Gmbh | Pirimidinas macrociclicas como inhibidores de aurora cinasa. |
TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
WO2012074951A1 (en) | 2010-11-29 | 2012-06-07 | OSI Pharmaceuticals, LLC | Macrocyclic kinase inhibitors |
EA201391626A1 (ru) | 2011-05-04 | 2014-03-31 | Ариад Фармасьютикалз, Инк. | Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака |
CN103596956A (zh) | 2011-06-07 | 2014-02-19 | 辉瑞大药厂 | 吡唑并[3,4-d]嘧啶化合物及其作为PDE2抑制剂和/或CYP3A4抑制剂的用途 |
-
2011
- 2011-11-29 WO PCT/US2011/062290 patent/WO2012074951A1/en active Application Filing
- 2011-11-29 PT PT117948992T patent/PT2646448T/pt unknown
- 2011-11-29 EP EP11794899.2A patent/EP2646448B1/en active Active
- 2011-11-29 JP JP2013542087A patent/JP6000273B2/ja not_active Expired - Fee Related
- 2011-11-29 ES ES11794899.2T patent/ES2645508T3/es active Active
- 2011-11-29 PL PL11794899T patent/PL2646448T3/pl unknown
- 2011-11-29 US US13/990,045 patent/US9133224B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20130261086A1 (en) | 2013-10-03 |
JP2013545769A (ja) | 2013-12-26 |
ES2645508T3 (es) | 2017-12-05 |
WO2012074951A1 (en) | 2012-06-07 |
EP2646448B1 (en) | 2017-08-30 |
JP6000273B2 (ja) | 2016-09-28 |
EP2646448A1 (en) | 2013-10-09 |
PT2646448T (pt) | 2017-10-04 |
US9133224B2 (en) | 2015-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1198764A1 (zh) | 大環 激酶抑制劑 | |
EP2552208A4 (en) | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS | |
HK1199838A1 (en) | Macrocyclic lrrk2 kinase inhibitors lrrk2 | |
HK1222647A1 (zh) | 激酶抑制劑 | |
HK1179477A1 (en) | Kinase inhibitors | |
EP2552214A4 (en) | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | |
ZA201203842B (en) | Kinase inhibitors | |
EP2552211A4 (en) | INDAZOLYL-PYRIMIDINE AS KINASEHEMMER | |
PL2710007T3 (pl) | Inhibitory kinazy | |
GB201009731D0 (en) | Kinase inhibitors | |
HK1182327A1 (en) | Solid dispersions containing kinase inhibitors | |
EP2558099A4 (en) | Kinase Inhibitors | |
GB201016880D0 (en) | Phosphodiesterase inhibitors | |
IL229028A0 (en) | Kinase inhibitors | |
HK1199873A1 (en) | Kinase inhibitors | |
EP2571884A4 (en) | SELECTIVE MTOR KINASE HEMMER | |
EP2629616A4 (en) | SUBSTITUTED AMINO-TRIAZOLYL-PDE10-HEMMER | |
EP2480076A4 (en) | IMIDAZOTHIAZOLIC INHIBITORS OF KINASES | |
EP2531197A4 (en) | SOLID FORMS OF MACROCYCLIC CHINESE INHIBITORS | |
PL2646448T3 (pl) | Makrocykliczne inhibitory kinazy | |
GB0914726D0 (en) | Kinase inhibitors | |
PL2760867T3 (pl) | Makrocykliczne inhibitory kinaz FLT3 | |
GB201009730D0 (en) | Kinase inhibitor compounds | |
GB201018597D0 (en) | Inhibitors |