MX347765B - Inhibidores macrociclicos de la quinasa flt3. - Google Patents
Inhibidores macrociclicos de la quinasa flt3.Info
- Publication number
- MX347765B MX347765B MX2014003807A MX2014003807A MX347765B MX 347765 B MX347765 B MX 347765B MX 2014003807 A MX2014003807 A MX 2014003807A MX 2014003807 A MX2014003807 A MX 2014003807A MX 347765 B MX347765 B MX 347765B
- Authority
- MX
- Mexico
- Prior art keywords
- kinase inhibitors
- macrocyclic
- flt3 kinase
- compounds
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a compuestos macrocíclicos y a composiciones que contienen esos compuestos, que actúan como inhibidores de quinasa, en particular, como inhibidores de FLT3 (tirosina quinasa 3, relacionada con FMS). Además, la presente invención provee procesos para la preparación de los compuestos descritos, así como métodos para usarlos, por ejemplo, como medicina; en particular para el tratamiento de trastornos de proliferación de células, tales como cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2011067084 | 2011-09-30 | ||
PCT/EP2012/069252 WO2013045653A1 (en) | 2011-09-30 | 2012-09-28 | Macrocyclic flt3 kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014003807A MX2014003807A (es) | 2015-01-12 |
MX347765B true MX347765B (es) | 2017-05-12 |
Family
ID=46980944
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014003807A MX347765B (es) | 2011-09-30 | 2012-09-28 | Inhibidores macrociclicos de la quinasa flt3. |
Country Status (14)
Country | Link |
---|---|
US (2) | US9090630B2 (es) |
JP (1) | JP6046728B2 (es) |
KR (1) | KR20140078710A (es) |
CN (1) | CN103930427B (es) |
AU (1) | AU2012314376B2 (es) |
BR (1) | BR112014007622A2 (es) |
CA (1) | CA2849999A1 (es) |
DK (1) | DK2760867T3 (es) |
EA (1) | EA025881B1 (es) |
ES (1) | ES2569048T3 (es) |
HK (1) | HK1198764A1 (es) |
HU (1) | HUE027318T2 (es) |
MX (1) | MX347765B (es) |
WO (1) | WO2013045653A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20140095477A (ko) * | 2011-09-30 | 2014-08-01 | 입센 파마 에스.에이.에스 | 마크로시클릭 lrrk2 키나제 억제제 |
GB201204384D0 (en) | 2012-03-13 | 2012-04-25 | Univ Dundee | Anti-flammatory agents |
WO2014140235A1 (en) * | 2013-03-15 | 2014-09-18 | Ipsen Pharma S.A.S. | Macrocyclic lrrk2 kinase inhibitors |
AU2014230125A1 (en) * | 2013-03-15 | 2015-10-29 | Oncodesign S.A. | Macrocyclic salt-inducible kinase inhibitors |
AU2014230111A1 (en) * | 2013-03-15 | 2015-10-29 | Oncodesign S.A | Macrocyclic RIP2 kinase inhibitors |
AU2014264973B2 (en) * | 2013-05-06 | 2018-01-18 | Merck Patent Gmbh | Macrocycles as kinase inhibitors |
DK3636649T3 (da) | 2014-01-24 | 2024-05-21 | Turning Point Therapeutics Inc | Diarylmakrocykler som modulatorer af proteinkinaser |
WO2015136073A1 (en) * | 2014-03-14 | 2015-09-17 | Oncodesign Sa | Macrocyclic tgf-br2 kinase inhibitors |
DK3172213T3 (da) * | 2014-07-21 | 2021-12-13 | Dana Farber Cancer Inst Inc | Makrocykliske kinasehæmmere og anvendelser deraf |
US10287268B2 (en) | 2014-07-21 | 2019-05-14 | Dana-Farber Cancer Institute, Inc. | Imidazolyl kinase inhibitors and uses thereof |
US20170224700A1 (en) | 2014-08-08 | 2017-08-10 | Dana-Farber Cancer Institute, Inc. | Uses of salt-inducible kinase (sik) inhibitors |
DK3194405T3 (en) * | 2014-09-17 | 2019-04-15 | Oncodesign Sa | MACROCYCLIC LRRK2 KINase INHIBITORS |
ES2763344T3 (es) * | 2014-09-17 | 2020-05-28 | Oncodesign Sa | Inhibidores macrocíclicos de la cinasa RIP2 |
WO2016146651A1 (en) | 2015-03-16 | 2016-09-22 | Oncodesign Sa | Macrocyclic activin-like receptor kinase inhibitors |
AU2016287568B2 (en) | 2015-07-02 | 2020-08-20 | Turning Point Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
BR112018000297A2 (pt) | 2015-07-06 | 2018-09-04 | Tp Therapeutics Inc | polimorfo de macrociclo de diarila |
EP3325488B1 (en) | 2015-07-21 | 2020-06-24 | Turning Point Therapeutics, Inc. | Chiral diaryl macrocycle and use thereof in the treatment of cancer |
RU2630958C2 (ru) * | 2015-12-29 | 2017-09-15 | федеральное государственное автономное образовательное учреждение высшего образования "Московский физико-технический институт (государственный университет)" (МФТИ) | Новые макроциклические соединения, содержащие природное 3,7-диазабицикло[3.3.1]нонановое ядро и способ их получения |
AU2017291812B2 (en) | 2016-07-05 | 2023-12-14 | Dana-Farber Cancer Institute, Inc. | Bicyclic urea kinase inhibitors and uses thereof |
EP3490564A4 (en) | 2016-07-28 | 2020-02-26 | Turning Point Therapeutics, Inc. | MACRO CYCLE Kinase Inhibitors |
US11241435B2 (en) | 2016-09-16 | 2022-02-08 | The General Hospital Corporation | Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis |
TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
CN111163771B (zh) | 2017-02-28 | 2023-07-14 | 通用医疗公司 | 嘧啶并嘧啶酮类作为sik抑制剂的用途 |
WO2019023417A1 (en) | 2017-07-28 | 2019-01-31 | Tp Therapeutics, Inc. | MACROCYCLIC COMPOUNDS AND USES THEREOF |
ES2929467T3 (es) | 2017-12-19 | 2022-11-29 | Turning Point Therapeutics Inc | Compuestos macrocíclicos para tratar enfermedades |
CN110950889B (zh) * | 2018-09-27 | 2022-04-05 | 北京赛林泰医药技术有限公司 | 一种多靶点激酶抑制剂及其制备方法和用途 |
WO2021113339A1 (en) | 2019-12-03 | 2021-06-10 | Turning Point Therapeutics, Inc. | Macrocycles for use in treating disease |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
AU679789B2 (en) | 1993-10-01 | 1997-07-10 | Astra Aktiebolag | Process I |
US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
US7205308B2 (en) | 2002-09-04 | 2007-04-17 | Schering Corporation | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors |
JPWO2004039782A1 (ja) | 2002-10-29 | 2006-03-02 | 麒麟麦酒株式会社 | Flt3自己リン酸化を阻害するキノリン誘導体およびキナゾリン誘導体並びにそれらを含有する医薬組成物 |
GB0425035D0 (en) | 2004-11-12 | 2004-12-15 | Novartis Ag | Organic compounds |
DE102005042742A1 (de) * | 2005-09-02 | 2007-03-08 | Schering Ag | Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
BRPI0617489A2 (pt) | 2005-10-18 | 2011-07-26 | Janssen Pharmaceutica Nv | compostos, composiÇço e uso de ditos compostos para inibir a flt3 cinase |
WO2008016665A2 (en) | 2006-08-02 | 2008-02-07 | Xanthus Pharmaceuticals, Inc. | Imidazoacridine compounds for treating flt3 -mediated disorders |
US7517882B2 (en) * | 2006-09-18 | 2009-04-14 | Polaris Group | Protein kinase inhibitors |
RU2009115954A (ru) | 2006-09-29 | 2010-11-10 | Новартис АГ (CH) | Пиразолопиримидины в качестве ингибиторов липидной киназы р13к |
SG176461A1 (en) * | 2006-11-06 | 2011-12-29 | Supergen Inc | Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors |
WO2008060248A1 (en) * | 2006-11-15 | 2008-05-22 | S*Bio Pte Ltd. | Indole sustituted pyrimidines and use thereof in the treatment of cancer |
WO2009017795A1 (en) | 2007-08-02 | 2009-02-05 | Xanthus Pharmaceuticals, Inc. | Indazole compounds for treating inflammatory disorders, demyelinating disorders and cancers |
ES2494365T3 (es) | 2008-01-30 | 2014-09-15 | Genentech, Inc. | Compuestos de pirazolopirimidina que inhiben PI3K y métodos de uso |
CN101239978A (zh) | 2008-03-05 | 2008-08-13 | 南方医科大学 | 一种咪唑并吡啶类化合物 |
ES2548135T3 (es) * | 2008-05-13 | 2015-10-14 | Novartis Ag | Heterociclos condensados que contienen nitrógeno y composiciones de los mismos como inhibidores de quinasa |
JP5731978B2 (ja) | 2008-09-26 | 2015-06-10 | インテリカイン, エルエルシー | 複素環キナーゼ阻害剤 |
GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
UA110324C2 (en) | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
WO2013001310A1 (en) * | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
KR20140095477A (ko) * | 2011-09-30 | 2014-08-01 | 입센 파마 에스.에이.에스 | 마크로시클릭 lrrk2 키나제 억제제 |
-
2012
- 2012-09-28 WO PCT/EP2012/069252 patent/WO2013045653A1/en active Application Filing
- 2012-09-28 JP JP2014532414A patent/JP6046728B2/ja not_active Expired - Fee Related
- 2012-09-28 AU AU2012314376A patent/AU2012314376B2/en not_active Ceased
- 2012-09-28 EA EA201490707A patent/EA025881B1/ru not_active IP Right Cessation
- 2012-09-28 ES ES12769084.0T patent/ES2569048T3/es active Active
- 2012-09-28 BR BR112014007622A patent/BR112014007622A2/pt not_active IP Right Cessation
- 2012-09-28 HU HUE12769084A patent/HUE027318T2/en unknown
- 2012-09-28 MX MX2014003807A patent/MX347765B/es active IP Right Grant
- 2012-09-28 US US14/347,750 patent/US9090630B2/en not_active Expired - Fee Related
- 2012-09-28 CA CA2849999A patent/CA2849999A1/en not_active Abandoned
- 2012-09-28 DK DK12769084.0T patent/DK2760867T3/en active
- 2012-09-28 CN CN201280055769.2A patent/CN103930427B/zh not_active Expired - Fee Related
- 2012-09-28 KR KR1020147011451A patent/KR20140078710A/ko not_active Application Discontinuation
-
2014
- 2014-12-05 HK HK14112275.5A patent/HK1198764A1/zh not_active IP Right Cessation
-
2015
- 2015-06-19 US US14/744,154 patent/US9370519B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
MX2014003807A (es) | 2015-01-12 |
CN103930427A (zh) | 2014-07-16 |
EA025881B1 (ru) | 2017-02-28 |
CN103930427B (zh) | 2016-03-09 |
US9090630B2 (en) | 2015-07-28 |
BR112014007622A2 (pt) | 2017-04-04 |
ES2569048T3 (es) | 2016-05-06 |
HUE027318T2 (en) | 2016-10-28 |
CA2849999A1 (en) | 2013-04-04 |
EA201490707A1 (ru) | 2014-08-29 |
DK2760867T3 (en) | 2016-04-11 |
KR20140078710A (ko) | 2014-06-25 |
HK1198764A1 (zh) | 2015-06-05 |
WO2013045653A1 (en) | 2013-04-04 |
JP6046728B2 (ja) | 2016-12-21 |
US20150283141A1 (en) | 2015-10-08 |
US20140303159A1 (en) | 2014-10-09 |
US9370519B2 (en) | 2016-06-21 |
JP2014528398A (ja) | 2014-10-27 |
AU2012314376B2 (en) | 2017-04-06 |
AU2012314376A1 (en) | 2014-05-15 |
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