CU20140043A7 - Benzilindazoles sustituidos como inhibidores de la quinasa bub1 - Google Patents
Benzilindazoles sustituidos como inhibidores de la quinasa bub1Info
- Publication number
- CU20140043A7 CU20140043A7 CUP2014000043A CU20140043A CU20140043A7 CU 20140043 A7 CU20140043 A7 CU 20140043A7 CU P2014000043 A CUP2014000043 A CU P2014000043A CU 20140043 A CU20140043 A CU 20140043A CU 20140043 A7 CU20140043 A7 CU 20140043A7
- Authority
- CU
- Cuba
- Prior art keywords
- formula
- bub1
- compounds
- inhibitors
- drugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
- A01H6/36—Ericaceae, e.g. azalea, cranberry or blueberry
- A01H6/368—Vaccinium, e.g. cranberry, blueberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
La presente invención divulga compuestos de la fórmula (I). ESPACIO PARA FÓRMULA I que son inhibidores de la quinasa Bub1, y los procesos para su producción. Dado que la enfermedad del cáncer, expresada por procesos celulares proliferativos en tejidos de diferentes órganos del cuerpo humao o animal, aún no se considera como una enfermedad controlada a pesar del hecho que ya existen suficientes terapias con drogas, aún persiste una fuerte necesidad de proveer otras drogas nuevas terapeúticamente útiles que preferiblemente inhiban nuevos blancos y proporcionen nuevas opciones terapeúticas. Por ello, los compuestos inhibidores de la quinasa Bub1, de fórmula (I), conforme a la presente invención representan compuestos valiosos que permiten complementar las opciones terapeúticas, ya sea como agentes individuales o en combinación con otras drogas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11184061 | 2011-10-06 | ||
PCT/EP2012/069562 WO2013050438A1 (en) | 2011-10-06 | 2012-10-04 | Substituted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases. |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20140043A7 true CU20140043A7 (es) | 2014-08-28 |
Family
ID=46968229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CUP2014000043A CU20140043A7 (es) | 2011-10-06 | 2014-04-04 | Benzilindazoles sustituidos como inhibidores de la quinasa bub1 |
Country Status (38)
Country | Link |
---|---|
US (3) | US20140249133A1 (es) |
EP (1) | EP2763982B1 (es) |
JP (1) | JP6140170B2 (es) |
KR (1) | KR102007056B1 (es) |
CN (1) | CN103974948B (es) |
AP (1) | AP3847A (es) |
AR (1) | AR088449A1 (es) |
AU (1) | AU2012320582B2 (es) |
BR (1) | BR112014008045A2 (es) |
CA (1) | CA2851037A1 (es) |
CO (1) | CO6930363A2 (es) |
CR (1) | CR20140161A (es) |
CU (1) | CU20140043A7 (es) |
CY (1) | CY1120318T1 (es) |
DK (1) | DK2763982T3 (es) |
DO (1) | DOP2014000062A (es) |
EA (1) | EA201400412A1 (es) |
EC (1) | ECSP14013284A (es) |
ES (1) | ES2665036T3 (es) |
GT (1) | GT201400063A (es) |
HK (1) | HK1200449A1 (es) |
HR (1) | HRP20180546T1 (es) |
HU (1) | HUE037154T2 (es) |
IL (1) | IL231591A (es) |
LT (1) | LT2763982T (es) |
MX (1) | MX361279B (es) |
NO (1) | NO2763982T3 (es) |
PE (1) | PE20141203A1 (es) |
PL (1) | PL2763982T3 (es) |
PT (1) | PT2763982T (es) |
RS (1) | RS57099B1 (es) |
SG (1) | SG11201400616YA (es) |
SI (1) | SI2763982T1 (es) |
TN (1) | TN2014000138A1 (es) |
TW (1) | TWI588141B (es) |
UA (1) | UA111754C2 (es) |
UY (1) | UY34374A (es) |
WO (1) | WO2013050438A1 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA111754C2 (uk) | 2011-10-06 | 2016-06-10 | Байєр Фарма Акцієнгезелльшафт | Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань |
CA2859779A1 (en) | 2011-12-21 | 2013-06-27 | Bayer Intellectual Property Gmbh | Substituted benzylpyrazoles |
JP2015520143A (ja) * | 2012-05-11 | 2015-07-16 | バイエル ファーマ アクチエンゲゼルシャフト | 癌を治療するためのbub1阻害薬としての置換されているシクロアルケノピラゾール類 |
EP2976336A1 (en) * | 2013-03-21 | 2016-01-27 | Bayer Pharma Aktiengesellschaft | 3-heteroaryl substituted indazoles |
EP2976335A1 (en) * | 2013-03-21 | 2016-01-27 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted indazoles |
CA2907730A1 (en) * | 2013-03-21 | 2014-09-25 | Bayer Pharma Aktiengesellschaft | Diaminoheteroaryl substituted indazoles |
CA2916116A1 (en) * | 2013-06-21 | 2014-12-24 | Bayer Pharma Aktiengesellschaft | Substituted benzylpyrazoles |
EP3010902A1 (en) * | 2013-06-21 | 2016-04-27 | Bayer Pharma Aktiengesellschaft | Substituted benzylpyrazoles |
EP3010901B1 (en) * | 2013-06-21 | 2017-09-13 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted pyrazoles |
WO2014202588A1 (en) * | 2013-06-21 | 2014-12-24 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted pyrazoles |
EP3010907A1 (en) * | 2013-06-21 | 2016-04-27 | Bayer Pharma Aktiengesellschaft | Diaminoheteroaryl substituted pyrazoles |
JP2016536311A (ja) | 2013-10-30 | 2016-11-24 | バイエル ファーマ アクチエンゲゼルシャフト | ヘテロアリール置換ピラゾール類 |
UY36175A (es) * | 2014-06-17 | 2016-01-29 | Bayer Pharma AG | 3-amino-1,5,6,7-tetrahidro-4h-indol-4-onas |
EP3194381A1 (en) * | 2014-09-19 | 2017-07-26 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles as bub1 kinase inhibitors |
BR112017005444A2 (pt) | 2014-09-19 | 2018-04-24 | Bayer Pharma AG | indazoles substituídos por benzil como inibidores bub1. |
US20170275270A1 (en) * | 2014-09-19 | 2017-09-28 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles |
US20170305882A1 (en) * | 2014-09-19 | 2017-10-26 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles as bub1 kinase inhibitors |
GB201419264D0 (en) * | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
KR102544847B1 (ko) | 2015-01-28 | 2023-06-16 | 바이엘 파마 악티엔게젤샤프트 | 4H-피롤로[3,2-c]피리딘-4-온 유도체 |
RS59934B1 (sr) * | 2015-06-09 | 2020-03-31 | Abbvie Inc | Modulatori nuklearnih receptora (ror) za lečenje inflamatornih i autoimunih oboljenja |
CN107922389A (zh) * | 2015-06-17 | 2018-04-17 | 拜耳制药股份公司 | 3‑氨基‑1,5,6,7‑四氢‑4h‑吲哚‑4‑酮 |
CN108602820A (zh) * | 2015-12-16 | 2018-09-28 | 拜耳制药股份公司 | 杂-1,5,6,7-四氢-4h-吲哚-4-酮类化合物 |
WO2017148995A1 (en) | 2016-03-04 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | 1-(pyrimidin-2-yl)-1h-indazoles having bub1 kinase inhibiting activity |
WO2017157991A1 (en) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | 1-alkyl-pyrazoles and -indazoles as bub1 inhibitors for the treatment of hyperproliferative diseases |
WO2017157992A1 (en) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | Annulated pyrazoles as bub1 kinase inhibitors for treating proliferative disorders |
WO2018122168A1 (en) | 2016-12-29 | 2018-07-05 | Bayer Pharma Aktiengesellschaft | Combinations of bub1 kinase and parp inhibitors |
WO2018158175A1 (en) | 2017-02-28 | 2018-09-07 | Bayer Pharma Aktiengesellschaft | Combination of bub1 inhibitors |
WO2018206547A1 (en) | 2017-05-12 | 2018-11-15 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and atr inhibitors |
WO2018215282A1 (en) | 2017-05-26 | 2018-11-29 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and pi3k inhibitors |
KR102048050B1 (ko) * | 2019-08-29 | 2020-01-22 | 대한민국 | Adb-푸비나카의 대사체 합성 방법 |
CN110684016A (zh) * | 2019-09-27 | 2020-01-14 | 上海应用技术大学 | 一种含氟的azd9291衍生物及其制备方法和应用 |
AU2021347288A1 (en) | 2020-09-23 | 2023-05-04 | Scorpion Therapeutics, Inc. | Pyrrolo[3,2-c]pyridin-4-one derivatives useful in the treatment of cancer |
WO2022072645A2 (en) | 2020-09-30 | 2022-04-07 | Scorpion Therapeutics, Inc. | Methods for treating cancer |
WO2022072634A1 (en) | 2020-09-30 | 2022-04-07 | Scorpion Therapeutics, Inc. | Bicyclic compounds for use in the treatment cancer |
WO2022094271A1 (en) | 2020-10-30 | 2022-05-05 | Scorpion Therapeutics, Inc. | Methods for treating cancer |
WO2022098992A1 (en) | 2020-11-05 | 2022-05-12 | Scorpion Therapeutics, Inc. | Use of macrocyclic compounds in methods of treating cancer |
WO2022197913A1 (en) | 2021-03-18 | 2022-09-22 | Scorpion Therapeutics, Inc. | Bicyclic derivatives which can be used to treat cancer |
WO2023173083A1 (en) | 2022-03-11 | 2023-09-14 | Scorpion Therapeutics, Inc. | Tetrahydroindole derivatives as egfr and/or her2 inhibtors useful for the treatment of cancer |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
US5470862A (en) | 1995-02-03 | 1995-11-28 | Ohmeda Pharmaceutical Products Division Inc. | Substituted pyrazolyl compounds and methods employing such compounds |
ID22176A (id) | 1996-10-14 | 1999-09-09 | Bayer Ag | Turunan pirazola tersubstitusi-heterosiklilmetil yang baru |
DE19834047A1 (de) * | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
DE19846514A1 (de) * | 1998-10-09 | 2000-04-20 | Bayer Ag | Neue Heterocyclyl-methyl-substituierte Pyrazole |
AU2002359714B2 (en) | 2001-12-18 | 2006-12-21 | Merck Sharp & Dohme Corp. | Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5 |
US7166293B2 (en) | 2002-03-29 | 2007-01-23 | Carlsbad Technology, Inc. | Angiogenesis inhibitors |
BR0314196A (pt) | 2002-09-10 | 2005-07-26 | Scios Inc | Inibidores de tgf-beta |
DE10244810A1 (de) * | 2002-09-26 | 2004-04-08 | Bayer Ag | Neue Morpholin-überbrückte Indazolderivate |
WO2007038613A2 (en) | 2005-09-26 | 2007-04-05 | The Regents Of The University Of California | Selective serine/threonine kinase inhibitors |
US20080242681A1 (en) | 2004-01-22 | 2008-10-02 | Altana Pharma Ag | N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors |
WO2007065010A2 (en) * | 2005-12-02 | 2007-06-07 | Hif Bio, Inc. | Anti-angiogenesis compounds |
DE102006043443A1 (de) | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
WO2008141731A2 (en) | 2007-05-18 | 2008-11-27 | Bayer Healthcare Ag | Inhibitors of hypoxia inducible factor (hif) useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
JP2010111624A (ja) * | 2008-11-06 | 2010-05-20 | Shionogi & Co Ltd | Ttk阻害作用を有するインダゾール誘導体 |
ES2630026T3 (es) | 2008-12-18 | 2017-08-17 | Nerviano Medical Sciences S.R.L. | Derivados indazólicos sustituidos activos como inhibidores de cinasa |
CN102666537A (zh) | 2009-10-20 | 2012-09-12 | 艾格尔生物制药股份有限公司 | 治疗黄病毒科病毒感染的氮杂吲唑 |
SI3415515T1 (sl) | 2009-11-27 | 2020-03-31 | Adverio Pharma Gmbh | Postopek priprave metil-(4,6-diamino-2-(1-(2-fluorobenzil)-1H-pirazolo(3,4-b)piridin-3- il)pirimidin-5-il)metilkarbamata |
WO2011115804A1 (en) | 2010-03-17 | 2011-09-22 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
JP6155187B2 (ja) | 2010-03-30 | 2017-06-28 | ヴァーセオン コーポレイション | トロンビンの阻害剤としての多置換芳香族化合物 |
CN107021951B (zh) | 2010-06-30 | 2020-10-20 | 赛克里翁治疗有限公司 | sGC刺激物 |
UA111754C2 (uk) * | 2011-10-06 | 2016-06-10 | Байєр Фарма Акцієнгезелльшафт | Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань |
CA2859779A1 (en) | 2011-12-21 | 2013-06-27 | Bayer Intellectual Property Gmbh | Substituted benzylpyrazoles |
CA2861804C (en) | 2011-12-27 | 2021-10-26 | Ironwood Pharmaceuticals, Inc. | 2-benzyl,3(pyrimidin-2-yl)substituted pyrazoles useful as sgc stimulators |
JP2015520143A (ja) | 2012-05-11 | 2015-07-16 | バイエル ファーマ アクチエンゲゼルシャフト | 癌を治療するためのbub1阻害薬としての置換されているシクロアルケノピラゾール類 |
WO2014047111A1 (en) | 2012-09-18 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
WO2014047325A1 (en) | 2012-09-19 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
WO2014047662A2 (en) | 2012-09-24 | 2014-03-27 | Whitehead Institute For Biomedical Research | Indazole derivatives and uses thereof |
EP2976336A1 (en) | 2013-03-21 | 2016-01-27 | Bayer Pharma Aktiengesellschaft | 3-heteroaryl substituted indazoles |
CA2907730A1 (en) | 2013-03-21 | 2014-09-25 | Bayer Pharma Aktiengesellschaft | Diaminoheteroaryl substituted indazoles |
EP2976335A1 (en) | 2013-03-21 | 2016-01-27 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted indazoles |
EP3010901B1 (en) | 2013-06-21 | 2017-09-13 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted pyrazoles |
EP3010907A1 (en) | 2013-06-21 | 2016-04-27 | Bayer Pharma Aktiengesellschaft | Diaminoheteroaryl substituted pyrazoles |
EP3010902A1 (en) | 2013-06-21 | 2016-04-27 | Bayer Pharma Aktiengesellschaft | Substituted benzylpyrazoles |
WO2014202588A1 (en) | 2013-06-21 | 2014-12-24 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted pyrazoles |
CA2916116A1 (en) | 2013-06-21 | 2014-12-24 | Bayer Pharma Aktiengesellschaft | Substituted benzylpyrazoles |
JP2016536311A (ja) | 2013-10-30 | 2016-11-24 | バイエル ファーマ アクチエンゲゼルシャフト | ヘテロアリール置換ピラゾール類 |
US20170305882A1 (en) | 2014-09-19 | 2017-10-26 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles as bub1 kinase inhibitors |
BR112017005444A2 (pt) | 2014-09-19 | 2018-04-24 | Bayer Pharma AG | indazoles substituídos por benzil como inibidores bub1. |
US20170275270A1 (en) | 2014-09-19 | 2017-09-28 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles |
EP3194381A1 (en) | 2014-09-19 | 2017-07-26 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles as bub1 kinase inhibitors |
WO2017148995A1 (en) | 2016-03-04 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | 1-(pyrimidin-2-yl)-1h-indazoles having bub1 kinase inhibiting activity |
WO2017157991A1 (en) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | 1-alkyl-pyrazoles and -indazoles as bub1 inhibitors for the treatment of hyperproliferative diseases |
WO2017157992A1 (en) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | Annulated pyrazoles as bub1 kinase inhibitors for treating proliferative disorders |
WO2018122168A1 (en) | 2016-12-29 | 2018-07-05 | Bayer Pharma Aktiengesellschaft | Combinations of bub1 kinase and parp inhibitors |
WO2018158175A1 (en) | 2017-02-28 | 2018-09-07 | Bayer Pharma Aktiengesellschaft | Combination of bub1 inhibitors |
WO2018206547A1 (en) | 2017-05-12 | 2018-11-15 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and atr inhibitors |
WO2018215282A1 (en) | 2017-05-26 | 2018-11-29 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and pi3k inhibitors |
-
2012
- 2012-04-10 UA UAA201404803A patent/UA111754C2/uk unknown
- 2012-10-04 DK DK12766997.6T patent/DK2763982T3/en active
- 2012-10-04 CA CA2851037A patent/CA2851037A1/en not_active Abandoned
- 2012-10-04 BR BR112014008045A patent/BR112014008045A2/pt not_active Application Discontinuation
- 2012-10-04 SG SG11201400616YA patent/SG11201400616YA/en unknown
- 2012-10-04 LT LTEP12766997.6T patent/LT2763982T/lt unknown
- 2012-10-04 US US14/350,160 patent/US20140249133A1/en active Granted
- 2012-10-04 RS RS20180403A patent/RS57099B1/sr unknown
- 2012-10-04 JP JP2014533880A patent/JP6140170B2/ja not_active Expired - Fee Related
- 2012-10-04 AU AU2012320582A patent/AU2012320582B2/en not_active Ceased
- 2012-10-04 SI SI201231274T patent/SI2763982T1/en unknown
- 2012-10-04 NO NO12766997A patent/NO2763982T3/no unknown
- 2012-10-04 PT PT127669976T patent/PT2763982T/pt unknown
- 2012-10-04 EP EP12766997.6A patent/EP2763982B1/en active Active
- 2012-10-04 AP AP2014007533A patent/AP3847A/en active
- 2012-10-04 CN CN201280059851.2A patent/CN103974948B/zh not_active Expired - Fee Related
- 2012-10-04 PL PL12766997T patent/PL2763982T3/pl unknown
- 2012-10-04 KR KR1020147011914A patent/KR102007056B1/ko active IP Right Grant
- 2012-10-04 ES ES12766997.6T patent/ES2665036T3/es active Active
- 2012-10-04 PE PE2014000471A patent/PE20141203A1/es active IP Right Grant
- 2012-10-04 HU HUE12766997A patent/HUE037154T2/hu unknown
- 2012-10-04 EA EA201400412A patent/EA201400412A1/ru unknown
- 2012-10-04 MX MX2014004122A patent/MX361279B/es active IP Right Grant
- 2012-10-04 WO PCT/EP2012/069562 patent/WO2013050438A1/en active Application Filing
- 2012-10-05 UY UY0001034374A patent/UY34374A/es not_active Application Discontinuation
- 2012-10-05 AR ARP120103719A patent/AR088449A1/es active Pending
- 2012-10-05 TW TW101137035A patent/TWI588141B/zh not_active IP Right Cessation
-
2014
- 2014-03-19 IL IL231591A patent/IL231591A/en active IP Right Grant
- 2014-04-04 CR CR20140161A patent/CR20140161A/es unknown
- 2014-04-04 CU CUP2014000043A patent/CU20140043A7/es unknown
- 2014-04-04 CO CO14073129A patent/CO6930363A2/es active IP Right Grant
- 2014-04-04 GT GT201400063A patent/GT201400063A/es unknown
- 2014-04-04 EC ECSP14013284 patent/ECSP14013284A/es unknown
- 2014-04-04 TN TNP2014000138A patent/TN2014000138A1/en unknown
- 2014-04-04 DO DO2014000062A patent/DOP2014000062A/es unknown
-
2015
- 2015-01-26 HK HK15100857.5A patent/HK1200449A1/xx not_active IP Right Cessation
-
2017
- 2017-02-21 US US15/438,254 patent/US10266548B2/en not_active Expired - Fee Related
-
2018
- 2018-04-04 HR HRP20180546TT patent/HRP20180546T1/hr unknown
- 2018-04-10 CY CY20181100391T patent/CY1120318T1/el unknown
-
2019
- 2019-03-21 US US16/360,811 patent/US10604532B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CU20140043A7 (es) | Benzilindazoles sustituidos como inhibidores de la quinasa bub1 | |
DOP2019000168A (es) | Compuestos de amino-triazolopiridina y su uso en el tratamiento del cáncer | |
CL2020002198A1 (es) | Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b. | |
CL2018002759A1 (es) | Compuestos de pirrolotriazina como inhibidores de tam. | |
DOP2015000189A (es) | Inhibidores quinazolínicos de formas mutadas activantes del receptor del factor de crecimiento epidérmico | |
CY1120939T1 (el) | Συνδυασμος ρεγοραφενιμπης και ακετυλοσαλικυλικου οξεος για τη θεραπευτικη αντιμετωπιση του ορθοκολικου καρκινου | |
CU20150163A7 (es) | DERIVADOS DE 5-HETEROARIL-4-FENIL-4,5-DIHIDROPIRROLO(3,4-c)PIRAZOL-6-ONA ACTIVOS COMO INHIBIDORES DE BET | |
CU24335B1 (es) | Piridopirimidinas sustituidas como inhibidores de la quinasa mek y útiles para el tratamiento del cáncer | |
GT201500051A (es) | Inhibidores de glucosilceramida sintasa | |
CU20150119A7 (es) | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante | |
DOP2015000241A (es) | Compuestos de biaril-amida como inhibidores de cinasa | |
CR20160035A (es) | Inhibidores de bromodominios | |
GT201600123A (es) | Inhibidores de syk | |
EA201790078A1 (ru) | Ингибиторы mnk и связанные с ними способы | |
DOP2014000188A (es) | Derivados macrocíclicos para el tratamiento de enfermedades | |
UY34974A (es) | Piridazina 1,4 disustituida, análogos de la misma y métodos para tratar las enfermedades relacionadas con deficiencia del smn | |
CU20120169A7 (es) | Compuestos pirimidinílicos como inhibidores de la cinasa atr | |
ECSP13013068A (es) | Halogenoalquil-1,3-oxazinas como inhibidores de la bace1 y/o bace2 | |
DOP2010000011A (es) | Derivados de pirimidina trisustituida para el tratamiento de enfermedades proliferativas | |
CU20140048A7 (es) | Novedosos derivados de purina útiles en el tratamiento del cáncer y trastornos neurodegenerativos | |
PE20151005A1 (es) | Composicion farmaceutica recubierta que contiene regorafenib | |
CO6640327A2 (es) | Compuestos de pirazol como inhibidores del receptor sigma | |
CL2019002900A1 (es) | Análogos de benzoazepina como agentes inhibidores de la tirosina cinasa de bruton. | |
CL2012001322A1 (es) | Compuestos derivados de piridinopiridinona, inhibidores pdgf; procedimiento de preparacion de estos; composición farmacéutica que los comprende; combinación farmacéutica; y su uso en el tratamiento del cancer, ateroesclerosis, enfermedades cardiacas, diabetes, renales, entre otras. | |
CR20170513A (es) | Derivados de pirazol útiles como inhibidores de proteína activadora de 5-li-poxigenasa (flap). |