BR112017005444A2 - indazoles substituídos por benzil como inibidores bub1. - Google Patents

indazoles substituídos por benzil como inibidores bub1.

Info

Publication number
BR112017005444A2
BR112017005444A2 BR112017005444A BR112017005444A BR112017005444A2 BR 112017005444 A2 BR112017005444 A2 BR 112017005444A2 BR 112017005444 A BR112017005444 A BR 112017005444A BR 112017005444 A BR112017005444 A BR 112017005444A BR 112017005444 A2 BR112017005444 A2 BR 112017005444A2
Authority
BR
Brazil
Prior art keywords
benzyl substituted
substituted indazoles
bub1 inhibitors
bub1
inhibitors
Prior art date
Application number
BR112017005444A
Other languages
English (en)
Inventor
Ernesto Fernandez-Montalvan Amaury
Mengel Anne
Cleve Arwed
Siemeister Gerhard
Briem Hans
Lerchen Hans-Georg
Schröder Jens
Kuhnke Joachim
Bärfacker Lars
Möwes Manfred
Hitchcock Marion
Holton Simon
Müller Thomas
Mönning Ursula
Bone Wilhelm
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of BR112017005444A2 publication Critical patent/BR112017005444A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Abstract

compostos da fórmula (i) conforme definidos neste documento e seu uso como produtos farmacêuticos.
BR112017005444A 2014-09-19 2015-09-17 indazoles substituídos por benzil como inibidores bub1. BR112017005444A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14185604 2014-09-19
EP15176903 2015-07-15
PCT/EP2015/071340 WO2016042084A1 (en) 2014-09-19 2015-09-17 Benzyl substituted indazoles as bub1 inhibitors

Publications (1)

Publication Number Publication Date
BR112017005444A2 true BR112017005444A2 (pt) 2018-04-24

Family

ID=54140475

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017005444A BR112017005444A2 (pt) 2014-09-19 2015-09-17 indazoles substituídos por benzil como inibidores bub1.

Country Status (27)

Country Link
US (1) US10350206B2 (pt)
EP (1) EP3194379A1 (pt)
JP (1) JP6664385B2 (pt)
KR (1) KR20170049604A (pt)
CN (1) CN107001331A (pt)
AP (1) AP2017009803A0 (pt)
AU (1) AU2015316796A1 (pt)
BR (1) BR112017005444A2 (pt)
CA (1) CA2961589A1 (pt)
CL (1) CL2017000654A1 (pt)
CO (1) CO2017002532A2 (pt)
CR (1) CR20170100A (pt)
CU (1) CU20170029A7 (pt)
DO (1) DOP2017000078A (pt)
EA (1) EA032401B1 (pt)
EC (1) ECSP17016797A (pt)
IL (1) IL251071A0 (pt)
MA (1) MA39484A (pt)
MX (1) MX2017003664A (pt)
NI (1) NI201700034A (pt)
PE (1) PE20170697A1 (pt)
PH (1) PH12017500509A1 (pt)
SG (1) SG11201702082VA (pt)
TN (1) TN2017000092A1 (pt)
TW (1) TW201615636A (pt)
UY (1) UY36311A (pt)
WO (1) WO2016042084A1 (pt)

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CN108727340B (zh) 2017-04-11 2020-12-29 广东东阳光药业有限公司 氟取代的吲唑类化合物及其用途
WO2018206547A1 (en) 2017-05-12 2018-11-15 Bayer Pharma Aktiengesellschaft Combination of bub1 and atr inhibitors
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
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MA52494A (fr) 2018-05-04 2021-03-10 Incyte Corp Formes solides d'un inhibiteur de fgfr et leurs procédés de préparation
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
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WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
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TW202313611A (zh) 2021-06-09 2023-04-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之三環雜環

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Also Published As

Publication number Publication date
EA032401B1 (ru) 2019-05-31
CN107001331A (zh) 2017-08-01
CU20170029A7 (es) 2017-08-08
US10350206B2 (en) 2019-07-16
TN2017000092A1 (en) 2018-07-04
PE20170697A1 (es) 2017-06-24
MX2017003664A (es) 2017-07-13
US20170273980A1 (en) 2017-09-28
CL2017000654A1 (es) 2017-12-11
AU2015316796A1 (en) 2017-03-30
MA39484A (fr) 2016-03-24
SG11201702082VA (en) 2017-04-27
PH12017500509A1 (en) 2017-08-30
ECSP17016797A (es) 2017-05-31
AP2017009803A0 (en) 2017-03-31
CR20170100A (es) 2017-04-24
JP2017530962A (ja) 2017-10-19
DOP2017000078A (es) 2017-06-30
IL251071A0 (en) 2017-04-30
NI201700034A (es) 2017-06-16
CA2961589A1 (en) 2016-03-24
JP6664385B2 (ja) 2020-03-13
CO2017002532A2 (es) 2017-07-11
WO2016042084A1 (en) 2016-03-24
EP3194379A1 (en) 2017-07-26
EA201790649A1 (ru) 2017-09-29
TW201615636A (zh) 2016-05-01
KR20170049604A (ko) 2017-05-10
UY36311A (es) 2016-04-29

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