CL2017000654A1 - Indazoles sustituidos con bencilo como inhibidores de bub1. - Google Patents

Indazoles sustituidos con bencilo como inhibidores de bub1.

Info

Publication number
CL2017000654A1
CL2017000654A1 CL2017000654A CL2017000654A CL2017000654A1 CL 2017000654 A1 CL2017000654 A1 CL 2017000654A1 CL 2017000654 A CL2017000654 A CL 2017000654A CL 2017000654 A CL2017000654 A CL 2017000654A CL 2017000654 A1 CL2017000654 A1 CL 2017000654A1
Authority
CL
Chile
Prior art keywords
benzyl substituted
substituted indazoles
bub1 inhibitors
bub1
inhibitors
Prior art date
Application number
CL2017000654A
Other languages
English (en)
Inventor
Ursula Moenning
Manfred Moewes
Simon Holton
Gerhard Siemeister
Hans Briem
Wilhelm Bone
Anne Mengel
Hans Georg Lerchen
Thomas Müller
Lars Baerfacker
Marion Hitchcock
Arwed Cleve
Joachim Kuhnke
Montalvan Amaury Ernesto Fernandez
Jens Schroeder
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CL2017000654A1 publication Critical patent/CL2017000654A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>COMPUESTOS DE FÓRMULA (I) COMO SE DEFINEN EN LA PRESENTE Y SU USO COMO AGENTES FARMACÉUTICOS.</p>
CL2017000654A 2014-09-19 2017-03-17 Indazoles sustituidos con bencilo como inhibidores de bub1. CL2017000654A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14185604 2014-09-19
EP15176903 2015-07-15

Publications (1)

Publication Number Publication Date
CL2017000654A1 true CL2017000654A1 (es) 2017-12-11

Family

ID=54140475

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000654A CL2017000654A1 (es) 2014-09-19 2017-03-17 Indazoles sustituidos con bencilo como inhibidores de bub1.

Country Status (27)

Country Link
US (1) US10350206B2 (es)
EP (1) EP3194379A1 (es)
JP (1) JP6664385B2 (es)
KR (1) KR20170049604A (es)
CN (1) CN107001331A (es)
AP (1) AP2017009803A0 (es)
AU (1) AU2015316796A1 (es)
BR (1) BR112017005444A2 (es)
CA (1) CA2961589A1 (es)
CL (1) CL2017000654A1 (es)
CO (1) CO2017002532A2 (es)
CR (1) CR20170100A (es)
CU (1) CU20170029A7 (es)
DO (1) DOP2017000078A (es)
EA (1) EA032401B1 (es)
EC (1) ECSP17016797A (es)
IL (1) IL251071A0 (es)
MA (1) MA39484A (es)
MX (1) MX2017003664A (es)
NI (1) NI201700034A (es)
PE (1) PE20170697A1 (es)
PH (1) PH12017500509A1 (es)
SG (1) SG11201702082VA (es)
TN (1) TN2017000092A1 (es)
TW (1) TW201615636A (es)
UY (1) UY36311A (es)
WO (1) WO2016042084A1 (es)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10738048B2 (en) 2015-02-20 2020-08-11 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US10947230B2 (en) 2013-04-19 2021-03-16 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11053246B2 (en) 2012-06-13 2021-07-06 Incyte Corporation Substituted tricyclic compounds as FGFR inhibitors
US11174257B2 (en) 2018-05-04 2021-11-16 Incyte Corporation Salts of an FGFR inhibitor
US11173162B2 (en) 2015-02-20 2021-11-16 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US11407750B2 (en) 2019-12-04 2022-08-09 Incyte Corporation Derivatives of an FGFR inhibitor
US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
US11472801B2 (en) 2017-05-26 2022-10-18 Incyte Corporation Crystalline forms of a FGFR inhibitor and processes for preparing the same
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11607416B2 (en) 2019-10-14 2023-03-21 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11897891B2 (en) 2019-12-04 2024-02-13 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors
US11939331B2 (en) 2021-06-09 2024-03-26 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US12024517B2 (en) 2021-10-18 2024-07-02 Incyte Corporation Salts of an FGFR inhibitor

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SG11201606269WA (en) 2014-02-06 2016-09-29 Heptares Therapeutics Ltd Bicyclic aza compounds as muscarinic m1 receptor and/or m4 receptor agonists
JP6545199B2 (ja) 2014-06-17 2019-07-17 バイエル ファーマ アクチエンゲゼルシャフト ３−アミノ−１，５，６，７−テトラヒドロ−４ｈ−インドール−４−オン類
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WO2018158175A1 (en) 2017-02-28 2018-09-07 Bayer Pharma Aktiengesellschaft Combination of bub1 inhibitors
WO2018206547A1 (en) 2017-05-12 2018-11-15 Bayer Pharma Aktiengesellschaft Combination of bub1 and atr inhibitors
WO2018215282A1 (en) 2017-05-26 2018-11-29 Bayer Pharma Aktiengesellschaft Combination of bub1 and pi3k inhibitors

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11840534B2 (en) 2012-06-13 2023-12-12 Incyte Corporation Substituted tricyclic compounds as FGFR inhibitors
US11053246B2 (en) 2012-06-13 2021-07-06 Incyte Corporation Substituted tricyclic compounds as FGFR inhibitors
US11530214B2 (en) 2013-04-19 2022-12-20 Incyte Holdings Corporation Bicyclic heterocycles as FGFR inhibitors
US10947230B2 (en) 2013-04-19 2021-03-16 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US11667635B2 (en) 2015-02-20 2023-06-06 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US11173162B2 (en) 2015-02-20 2021-11-16 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US11014923B2 (en) 2015-02-20 2021-05-25 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US10738048B2 (en) 2015-02-20 2020-08-11 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US11472801B2 (en) 2017-05-26 2022-10-18 Incyte Corporation Crystalline forms of a FGFR inhibitor and processes for preparing the same
US11174257B2 (en) 2018-05-04 2021-11-16 Incyte Corporation Salts of an FGFR inhibitor
US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11607416B2 (en) 2019-10-14 2023-03-21 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11407750B2 (en) 2019-12-04 2022-08-09 Incyte Corporation Derivatives of an FGFR inhibitor
US11897891B2 (en) 2019-12-04 2024-02-13 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11939331B2 (en) 2021-06-09 2024-03-26 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors
US12024517B2 (en) 2021-10-18 2024-07-02 Incyte Corporation Salts of an FGFR inhibitor

Also Published As

Publication number Publication date
DOP2017000078A (es) 2017-06-30
ECSP17016797A (es) 2017-05-31
CR20170100A (es) 2017-04-24
CN107001331A (zh) 2017-08-01
AP2017009803A0 (en) 2017-03-31
EA032401B1 (ru) 2019-05-31
MA39484A (fr) 2016-03-24
EP3194379A1 (en) 2017-07-26
EA201790649A1 (ru) 2017-09-29
UY36311A (es) 2016-04-29
NI201700034A (es) 2017-06-16
US10350206B2 (en) 2019-07-16
PH12017500509A1 (en) 2017-08-30
IL251071A0 (en) 2017-04-30
MX2017003664A (es) 2017-07-13
TW201615636A (zh) 2016-05-01
JP2017530962A (ja) 2017-10-19
AU2015316796A1 (en) 2017-03-30
TN2017000092A1 (en) 2018-07-04
JP6664385B2 (ja) 2020-03-13
CO2017002532A2 (es) 2017-07-11
KR20170049604A (ko) 2017-05-10
PE20170697A1 (es) 2017-06-24
CA2961589A1 (en) 2016-03-24
US20170273980A1 (en) 2017-09-28
BR112017005444A2 (pt) 2018-04-24
SG11201702082VA (en) 2017-04-27
WO2016042084A1 (en) 2016-03-24
CU20170029A7 (es) 2017-08-08

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