NI201700034A - Indazoles sustituidos con benzilo como inhibidores de bub1. - Google Patents

Indazoles sustituidos con benzilo como inhibidores de bub1.

Info

Publication number
NI201700034A
NI201700034A NI201700034A NI201700034A NI201700034A NI 201700034 A NI201700034 A NI 201700034A NI 201700034 A NI201700034 A NI 201700034A NI 201700034 A NI201700034 A NI 201700034A NI 201700034 A NI201700034 A NI 201700034A
Authority
NI
Nicaragua
Prior art keywords
benzyl
indazoles substituted
bub1 inhibitors
bub1
inhibitors
Prior art date
Application number
NI201700034A
Other languages
English (en)
Inventor
Mengel Anne
Lerchen Hans-Georg
Möwes Manfred
Müller Thomas
Bärfacker Lars
Hitchcock Marion
Cleve Arwed
Kuhnke Joachim
Briem Hans
Siemeister Gerhard
Bone Wilhelm
Ernesto Fernández-Montalván Amaury
Schröder Jens
Mönning Ursula
Holton Simon
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of NI201700034A publication Critical patent/NI201700034A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compuestos de fórmula (I) como se definen en la presente y su uso como agentes farmacéuticos.
NI201700034A 2014-09-19 2017-03-17 Indazoles sustituidos con benzilo como inhibidores de bub1. NI201700034A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14185604 2014-09-19
EP15176903 2015-07-15

Publications (1)

Publication Number Publication Date
NI201700034A true NI201700034A (es) 2017-06-16

Family

ID=54140475

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201700034A NI201700034A (es) 2014-09-19 2017-03-17 Indazoles sustituidos con benzilo como inhibidores de bub1.

Country Status (27)

Country Link
US (1) US10350206B2 (es)
EP (1) EP3194379A1 (es)
JP (1) JP6664385B2 (es)
KR (1) KR20170049604A (es)
CN (1) CN107001331A (es)
AP (1) AP2017009803A0 (es)
AU (1) AU2015316796A1 (es)
BR (1) BR112017005444A2 (es)
CA (1) CA2961589A1 (es)
CL (1) CL2017000654A1 (es)
CO (1) CO2017002532A2 (es)
CR (1) CR20170100A (es)
CU (1) CU20170029A7 (es)
DO (1) DOP2017000078A (es)
EA (1) EA032401B1 (es)
EC (1) ECSP17016797A (es)
IL (1) IL251071A0 (es)
MA (1) MA39484A (es)
MX (1) MX2017003664A (es)
NI (1) NI201700034A (es)
PE (1) PE20170697A1 (es)
PH (1) PH12017500509A1 (es)
SG (1) SG11201702082VA (es)
TN (1) TN2017000092A1 (es)
TW (1) TW201615636A (es)
UY (1) UY36311A (es)
WO (1) WO2016042084A1 (es)

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AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
AU2019262195B2 (en) 2018-05-04 2024-09-12 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
MA52493A (fr) 2018-05-04 2021-03-10 Incyte Corp Sels d'un inhibiteur de fgfr
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN115835908A (zh) 2019-10-14 2023-03-21 因赛特公司 作为fgfr抑制剂的双环杂环
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
US11407750B2 (en) 2019-12-04 2022-08-09 Incyte Corporation Derivatives of an FGFR inhibitor
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CA3215903A1 (en) 2021-04-12 2022-10-20 Incyte Corporation Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
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Also Published As

Publication number Publication date
CA2961589A1 (en) 2016-03-24
UY36311A (es) 2016-04-29
US10350206B2 (en) 2019-07-16
PH12017500509A1 (en) 2017-08-30
MX2017003664A (es) 2017-07-13
CU20170029A7 (es) 2017-08-08
JP6664385B2 (ja) 2020-03-13
KR20170049604A (ko) 2017-05-10
TW201615636A (zh) 2016-05-01
CR20170100A (es) 2017-04-24
IL251071A0 (en) 2017-04-30
EA032401B1 (ru) 2019-05-31
WO2016042084A1 (en) 2016-03-24
ECSP17016797A (es) 2017-05-31
DOP2017000078A (es) 2017-06-30
AP2017009803A0 (en) 2017-03-31
TN2017000092A1 (en) 2018-07-04
AU2015316796A1 (en) 2017-03-30
PE20170697A1 (es) 2017-06-24
MA39484A (fr) 2016-03-24
JP2017530962A (ja) 2017-10-19
US20170273980A1 (en) 2017-09-28
CN107001331A (zh) 2017-08-01
CO2017002532A2 (es) 2017-07-11
EP3194379A1 (en) 2017-07-26
SG11201702082VA (en) 2017-04-27
EA201790649A1 (ru) 2017-09-29
CL2017000654A1 (es) 2017-12-11
BR112017005444A2 (pt) 2018-04-24

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