EA201692143A1 - Производные аминопиразина в качестве ингибиторов фосфатидилинозитол-3-киназы - Google Patents

Производные аминопиразина в качестве ингибиторов фосфатидилинозитол-3-киназы

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Publication number
EA201692143A1
EA201692143A1 EA201692143A EA201692143A EA201692143A1 EA 201692143 A1 EA201692143 A1 EA 201692143A1 EA 201692143 A EA201692143 A EA 201692143A EA 201692143 A EA201692143 A EA 201692143A EA 201692143 A1 EA201692143 A1 EA 201692143A1
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EA
Eurasian Patent Office
Prior art keywords
kinase
aminopirazine
phosphatidylinositol
inhibitors
derivatives
Prior art date
Application number
EA201692143A
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English (en)
Other versions
EA032075B1 (ru
Inventor
Бенджамин Ричард Беллини
Грэм Чарльз Блумфилд
Ян БРЮС
Эндрю Джеймс КАЛШО
Эдвард Чарльз Холл
Грегори Холлингворт
Джеймс Ниф
Мэттью Спендифф
Саймон Джеймс Уотсон
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201692143A1 publication Critical patent/EA201692143A1/ru
Publication of EA032075B1 publication Critical patent/EA032075B1/ru

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Plural Heterocyclic Compounds (AREA)
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Abstract

В данном изобретении представлены соединения формулы (I)которые ингибируют активность гамма изоформы ФИ-3-киназы, которые применяют для лечения заболеваний, медиированных активацией гамма изоформы ФИ-3-киназы.
EA201692143A 2014-04-24 2014-04-24 Производные аминопиразина в качестве ингибиторов фосфатидилинозитол-3-киназы EA032075B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2014/060988 WO2015162459A1 (en) 2014-04-24 2014-04-24 Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201692143A1 true EA201692143A1 (ru) 2017-03-31
EA032075B1 EA032075B1 (ru) 2019-04-30

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EA201692143A EA032075B1 (ru) 2014-04-24 2014-04-24 Производные аминопиразина в качестве ингибиторов фосфатидилинозитол-3-киназы

Country Status (11)

Country Link
US (2) US10004732B2 (ru)
EP (1) EP3134397A1 (ru)
JP (1) JP6433509B2 (ru)
KR (1) KR20160141855A (ru)
CN (1) CN106458979B (ru)
AU (2) AU2014391608A1 (ru)
BR (1) BR112016024533A8 (ru)
CA (1) CA2945212A1 (ru)
EA (1) EA032075B1 (ru)
MX (1) MX2016013812A (ru)
WO (1) WO2015162459A1 (ru)

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JP2022526854A (ja) 2019-04-10 2022-05-26 ナンジン・ジェンシアン・ファーマシューティカルズ・カンパニー・リミテッド ホスファチジルイノシトール３－キナーゼ阻害剤
CN112409337A (zh) * 2020-12-21 2021-02-26 李寒 一种取代的吡嗪衍生物及其用途
CN112341437A (zh) * 2020-12-21 2021-02-09 李寒 一种取代的吡嗪衍生物及其应用
CN114994215A (zh) * 2022-08-03 2022-09-02 北京华大吉比爱生物技术有限公司 氯唑沙宗的应用、检测酶抑制剂类抗生素药物浓度的方法、试剂盒及应用

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US20180243297A1 (en) 2018-08-30
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