CN101678020B - 作为Janus激酶的酪氨酸激酶活性抑制剂的喹喔啉衍生物 - Google Patents

作为Janus激酶的酪氨酸激酶活性抑制剂的喹喔啉衍生物 Download PDF

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Publication number
CN101678020B
CN101678020B CN2008800193524A CN200880019352A CN101678020B CN 101678020 B CN101678020 B CN 101678020B CN 2008800193524 A CN2008800193524 A CN 2008800193524A CN 200880019352 A CN200880019352 A CN 200880019352A CN 101678020 B CN101678020 B CN 101678020B
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phenyl
quinoxaline
morpholine
methyl
ylmethyl
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Expired - Fee Related
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CN101678020A (zh
Inventor
M·格施帕赫
P·菲雷
E·范格莱维灵格
C·皮索特索德曼
C·高尔
P·霍尔策
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Novartis AG
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Novartis AG
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
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  • Organic Chemistry (AREA)
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  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2008800193524A 2007-06-08 2008-06-06 作为Janus激酶的酪氨酸激酶活性抑制剂的喹喔啉衍生物 Expired - Fee Related CN101678020B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP07109880.0 2007-06-08
EP07109880 2007-06-08
EP07150266.0 2007-12-20
EP07150266 2007-12-20
PCT/EP2008/057058 WO2008148867A2 (en) 2007-06-08 2008-06-06 Quinoxaline derivatives as inhibitors of the tyrosine kinase activity of janus kinases

Publications (2)

Publication Number Publication Date
CN101678020A CN101678020A (zh) 2010-03-24
CN101678020B true CN101678020B (zh) 2012-08-15

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CN2008800193524A Expired - Fee Related CN101678020B (zh) 2007-06-08 2008-06-06 作为Janus激酶的酪氨酸激酶活性抑制剂的喹喔啉衍生物

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US (1) US8193189B2 (es)
EP (1) EP2155201B1 (es)
JP (1) JP5574957B2 (es)
KR (1) KR20100020465A (es)
CN (1) CN101678020B (es)
AR (1) AR066879A1 (es)
AU (1) AU2008258486B2 (es)
BR (1) BRPI0812893A2 (es)
CA (1) CA2690288A1 (es)
CL (1) CL2008001659A1 (es)
EA (1) EA200901608A1 (es)
ES (1) ES2392570T3 (es)
MX (1) MX2009013218A (es)
PA (1) PA8783501A1 (es)
TW (1) TW200904814A (es)
UY (1) UY31126A1 (es)
WO (1) WO2008148867A2 (es)

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JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
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CN110981819B (zh) * 2019-12-24 2022-07-01 广西师范大学 一种喹喔啉类信号通路抑制剂及其制备方法和应用
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