NO329092B1 - 3-azabicyklo (3.1.0) heksanderivater som opioidreseptorantagonister samt farmasoytisk sammensetning - Google Patents
3-azabicyklo (3.1.0) heksanderivater som opioidreseptorantagonister samt farmasoytisk sammensetning Download PDFInfo
- Publication number
- NO329092B1 NO329092B1 NO20041626A NO20041626A NO329092B1 NO 329092 B1 NO329092 B1 NO 329092B1 NO 20041626 A NO20041626 A NO 20041626A NO 20041626 A NO20041626 A NO 20041626A NO 329092 B1 NO329092 B1 NO 329092B1
- Authority
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- Norway
- Prior art keywords
- aza
- ethyl
- phenyl
- hydroxy
- exo
- Prior art date
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- 229940123257 Opioid receptor antagonist Drugs 0.000 title description 2
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- 238000006722 reduction reaction Methods 0.000 description 1
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- 150000004760 silicates Chemical class 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33851101P | 2001-10-22 | 2001-10-22 | |
| PCT/IB2002/003668 WO2003035622A1 (fr) | 2001-10-22 | 2002-09-09 | Derives 3-azabicyclo (3.1.0) hexane en tant qu'antagonistes de recepteur opioide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20041626L NO20041626L (no) | 2004-05-26 |
| NO329092B1 true NO329092B1 (no) | 2010-08-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20041626A NO329092B1 (no) | 2001-10-22 | 2004-04-21 | 3-azabicyklo (3.1.0) heksanderivater som opioidreseptorantagonister samt farmasoytisk sammensetning |
Country Status (42)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6867222B2 (en) | 2001-04-18 | 2005-03-15 | Euro-Celtique, S.A. | Nociceptin analogs |
| SI1440059T1 (sl) * | 2001-10-22 | 2008-08-31 | Pfizer Prod Inc | Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja |
| JP3984281B2 (ja) * | 2003-04-14 | 2007-10-03 | ファイザー・プロダクツ・インク | ３−アザビシクロ〔３，２，１〕オクタン誘導体 |
| US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US7153976B2 (en) * | 2003-10-06 | 2006-12-26 | Pfizer Inc. | Purification process for an azabicyclo[3.1.0]hexane compound |
| NZ546012A (en) * | 2003-10-14 | 2009-12-24 | Pfizer Prod Inc | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors |
| BRPI0415459A (pt) * | 2003-10-16 | 2006-12-19 | Pfizer Prod Inc | preparação de derivados de 3-azabiciclo[3.1.0]hexano |
| TW200538113A (en) | 2004-02-23 | 2005-12-01 | Glaxo Group Ltd | Compounds |
| JPWO2005085228A1 (ja) * | 2004-03-05 | 2008-01-17 | 萬有製薬株式会社 | シクロアルカノピリジン誘導体 |
| WO2006064779A1 (fr) * | 2004-12-14 | 2006-06-22 | Shionogi & Co., Ltd. | Derive de l’indolomorphinane avec carboxy en position 6' |
| GB0512099D0 (en) * | 2005-06-14 | 2005-07-20 | Glaxo Group Ltd | Compounds |
| GB0517191D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| US7592461B2 (en) * | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| MY145633A (en) * | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| WO2008075162A2 (fr) * | 2006-12-15 | 2008-06-26 | Pfizer Limited | Composés pour le traitement d'un dysfonctionnement sexuel |
| TWI409067B (zh) | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
| WO2009029253A1 (fr) * | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Composés d'hétéroarylalkyl-8-azabicyclo[3.2.1]octane comme antagonistes des récepteurs opioïdes mu |
| TWI423801B (zh) * | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物 |
| EP2195314B1 (fr) * | 2007-08-27 | 2011-03-23 | Theravance, Inc. | Composes d'alkyl-8-azabicyclo[3.2.1.]octane disubstitutes utilises en tant qu'antagonistes du recepteur opioide mu |
| ES2390195T3 (es) * | 2007-08-27 | 2012-11-07 | Theravance, Inc. | Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu |
| WO2012042539A2 (fr) | 2010-09-28 | 2012-04-05 | Panacea Biotec Ltd | Nouveaux composés bicycliques |
| MX2016006482A (es) * | 2013-11-20 | 2016-12-09 | Sanwa Kagaku Kenkyusho Co | Derivado novedoso de 3-azabiciclo[3.1.0]hexano y uso del mismo para proposito medico. |
| CA2985327A1 (fr) * | 2015-05-20 | 2016-11-24 | Sanwa Kagaku Kenkyusho Co., Ltd. | Cristal de sel de nouveau derive de 3-azabicyclo[3.1.0]hexane et son utilisation pharmaceutique |
| WO2018159716A1 (fr) | 2017-03-02 | 2018-09-07 | 株式会社 三和化学研究所 | Agent thérapeutique pour troubles liés à la consommation d'alcool |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2099214A (en) * | 1937-11-16 | Process fob forming the sulphuric | ||
| US2099216A (en) * | 1934-05-04 | 1937-11-16 | Frederick H Nass | Metal testing machine |
| US3004340A (en) * | 1959-09-24 | 1961-10-17 | Bernice L Collins | Kitchen utensil |
| US3078282A (en) * | 1960-01-02 | 1963-02-19 | Bayer Ag | Anthraquinone dyestuffs |
| EP0287339B1 (fr) | 1987-04-16 | 1994-08-17 | Eli Lilly And Company | Pipéridines comme antagonistes d'opioids |
| JPH04155522A (ja) * | 1990-10-19 | 1992-05-28 | Nec Corp | ファースト・イン・ランダム・アウト回路 |
| US5159081A (en) | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| ZA922180B (en) | 1991-03-29 | 1993-09-27 | Lilly Co Eli | Piperidine derivatives |
| GB9725114D0 (en) * | 1997-11-28 | 1998-01-28 | Pfizer Ltd | Treatment of pruritus |
| GB9810671D0 (en) * | 1998-05-18 | 1998-07-15 | Pfizer Ltd | Anti-pruritic agents |
| TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| GB9912413D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912415D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912410D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| US20020064825A1 (en) * | 2000-05-19 | 2002-05-30 | Lewis Marilyn Evelyn | Novel polypeptide |
| GB0015562D0 (en) * | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
| US20030207876A1 (en) * | 2000-06-23 | 2003-11-06 | Banks Bernard Joseph | 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy |
| US20020025948A1 (en) * | 2000-06-23 | 2002-02-28 | Banks Bernard Joseph | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| DE10042885A1 (de) * | 2000-08-31 | 2002-03-14 | Heidelberger Druckmasch Ag | Bogentransportzylinder |
| SI1440059T1 (sl) | 2001-10-22 | 2008-08-31 | Pfizer Prod Inc | Derivati 3-azabiciklo(3.1.0)heksana kot antagonisti opioidnega receptorja |
| WO2003101963A1 (fr) | 2002-05-30 | 2003-12-11 | Eli Lilly And Company | Antagonistes de recepteur d'opioides |
| US7056930B2 (en) * | 2003-04-14 | 2006-06-06 | Pfizer Inc. | 2-Azabicyclo[3.3.1]nonane derivatives |
| US20040204453A1 (en) * | 2003-04-14 | 2004-10-14 | Pfizer Inc | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors |
| US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US7153976B2 (en) * | 2003-10-06 | 2006-12-26 | Pfizer Inc. | Purification process for an azabicyclo[3.1.0]hexane compound |
-
2002
- 2002-09-09 SI SI200230688T patent/SI1440059T1/sl unknown
- 2002-09-09 MX MXPA04003730A patent/MXPA04003730A/es active IP Right Grant
- 2002-09-09 CN CNB028208854A patent/CN100368398C/zh not_active Expired - Fee Related
- 2002-09-09 HU HU0401884A patent/HUP0401884A2/hu unknown
- 2002-09-09 AT AT02765197T patent/ATE392415T1/de not_active IP Right Cessation
- 2002-09-09 EA EA200400467A patent/EA006708B1/ru not_active IP Right Cessation
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- 2002-09-09 GE GEAP20028173A patent/GEP20084300B/en unknown
- 2002-09-09 PT PT02765197T patent/PT1440059E/pt unknown
- 2002-09-09 DE DE60226161T patent/DE60226161T2/de not_active Expired - Lifetime
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- 2002-09-09 EP EP02765197A patent/EP1440059B1/fr not_active Expired - Lifetime
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- 2002-09-09 CA CA002463264A patent/CA2463264C/fr not_active Expired - Fee Related
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- 2002-09-09 ES ES02765197T patent/ES2302839T3/es not_active Expired - Lifetime
- 2002-09-09 JP JP2003538138A patent/JP4155522B2/ja not_active Expired - Fee Related
- 2002-09-09 NZ NZ531807A patent/NZ531807A/xx unknown
- 2002-09-09 WO PCT/IB2002/003668 patent/WO2003035622A1/fr active IP Right Grant
- 2002-09-09 BR BR0213464-0A patent/BR0213464A/pt not_active IP Right Cessation
- 2002-09-09 UA UA20040402979A patent/UA75714C2/uk unknown
- 2002-09-09 AU AU2002329557A patent/AU2002329557B2/en not_active Ceased
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- 2002-10-18 HN HN2002000299A patent/HN2002000299A/es unknown
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2004
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2005
- 2005-02-24 US US11/066,095 patent/US20050171178A1/en not_active Abandoned
- 2005-06-08 HK HK05104840A patent/HK1072052A1/xx not_active IP Right Cessation
-
2006
- 2006-03-01 US US11/366,903 patent/US20070054950A1/en not_active Abandoned
-
2007
- 2007-10-19 JP JP2007272602A patent/JP2008069169A/ja active Pending
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