PT1492789E - Derivados de tropano como moduladores ccr5 - Google Patents
Derivados de tropano como moduladores ccr5Info
- Publication number
- PT1492789E PT1492789E PT03710080T PT03710080T PT1492789E PT 1492789 E PT1492789 E PT 1492789E PT 03710080 T PT03710080 T PT 03710080T PT 03710080 T PT03710080 T PT 03710080T PT 1492789 E PT1492789 E PT 1492789E
- Authority
- PT
- Portugal
- Prior art keywords
- tropane derivatives
- ccr5 modulators
- ccr5
- modulators
- tropane
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0208071.1A GB0208071D0 (en) | 2002-04-08 | 2002-04-08 | Tropane derivatives useful in therapy |
GB0301575A GB0301575D0 (en) | 2003-01-23 | 2003-01-23 | Tropane derivatives useful in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1492789E true PT1492789E (pt) | 2006-09-29 |
Family
ID=28793308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT03710080T PT1492789E (pt) | 2002-04-08 | 2003-03-31 | Derivados de tropano como moduladores ccr5 |
Country Status (41)
Country | Link |
---|---|
EP (1) | EP1492789B1 (pt) |
JP (2) | JP3793200B2 (pt) |
KR (1) | KR100734685B1 (pt) |
CN (1) | CN1324025C (pt) |
AP (1) | AP1789A (pt) |
AR (1) | AR039383A1 (pt) |
AT (1) | ATE328882T1 (pt) |
AU (1) | AU2003214503B2 (pt) |
BR (1) | BR0309118A (pt) |
CA (1) | CA2481482C (pt) |
CR (1) | CR7514A (pt) |
CU (1) | CU23282A3 (pt) |
CY (1) | CY1106114T1 (pt) |
DE (1) | DE60305903T2 (pt) |
DK (1) | DK1492789T3 (pt) |
DO (1) | DOP2003000624A (pt) |
EA (1) | EA007590B1 (pt) |
ES (1) | ES2263960T3 (pt) |
GE (1) | GEP20074210B (pt) |
HK (1) | HK1076102A1 (pt) |
HN (1) | HN2003000114A (pt) |
HR (1) | HRP20040940A2 (pt) |
IL (1) | IL164261A0 (pt) |
IS (1) | IS2577B (pt) |
MA (1) | MA27190A1 (pt) |
MX (1) | MXPA04009220A (pt) |
MY (1) | MY134223A (pt) |
NI (1) | NI200300053A (pt) |
NO (1) | NO329674B1 (pt) |
NZ (1) | NZ535452A (pt) |
OA (1) | OA12798A (pt) |
PA (1) | PA8570801A1 (pt) |
PE (1) | PE20040082A1 (pt) |
PL (1) | PL372968A1 (pt) |
PT (1) | PT1492789E (pt) |
RS (1) | RS51550B (pt) |
SI (1) | SI1492789T1 (pt) |
TN (1) | TNSN04194A1 (pt) |
TW (1) | TWI280130B (pt) |
UY (1) | UY27752A1 (pt) |
WO (1) | WO2003084954A1 (pt) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2263960T3 (es) * | 2002-04-08 | 2006-12-16 | Pfizer Inc. | Derivados de tropano como moduladores de ccr5. |
US6855724B2 (en) | 2002-04-08 | 2005-02-15 | Agouron Pharmaceuticals, Inc. | Tropane derivatives useful in therapy |
CA2579609A1 (en) | 2003-09-10 | 2005-03-17 | Virochem Pharma Inc. | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity |
CA2540834C (en) * | 2003-10-03 | 2010-06-22 | Pfizer Inc. | Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation |
TW200533348A (en) | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
US8131026B2 (en) | 2004-04-16 | 2012-03-06 | Validity Sensors, Inc. | Method and apparatus for fingerprint image reconstruction |
US7751601B2 (en) | 2004-10-04 | 2010-07-06 | Validity Sensors, Inc. | Fingerprint sensing assemblies and methods of making |
WO2006064340A2 (en) * | 2004-12-13 | 2006-06-22 | Pfizer Limited | Process for the preparation of n-acyl beta-aminoaldehydes |
WO2008063600A2 (en) * | 2006-11-17 | 2008-05-29 | Concert Pharmaceuticals Inc. | Triazolyl tropane derivatives |
JP5194105B2 (ja) | 2007-04-13 | 2013-05-08 | ドン ファ ファーマシューティカル カンパニー リミテッド | 1−シクロプロピル−6−フルオロ−7−(8−メトキシイミノ−2,6−ジアザ−スピロ[3.4]オクト−6−イル)−4−オキソ−1,4−ジヒドロ−[1,8]ナフチリジン−3−カルボン酸のアスパラギンサン酸塩、その製造方法、およびそれを含む抗菌用薬学組成物 |
DE602008005771D1 (de) | 2007-08-27 | 2011-05-05 | Theravance Inc | Disubstituierte alkyl-8-azabicycloä3.2.1üoktan-verbindungen als mu-opioid-rezeptorantagonisten |
CN101712679B (zh) * | 2008-10-08 | 2013-04-10 | 中国科学院上海药物研究所 | 一种酰胺类化合物、其药物组合物及其制备方法和用途 |
EP2501679A1 (en) * | 2009-11-21 | 2012-09-26 | F. Hoffmann-La Roche AG | Heterocyclic antiviral compounds |
EA201200855A1 (ru) | 2009-12-23 | 2013-04-30 | Айронвуд Фармасьютикелз, Инк. | Модуляторы crth2 |
PE20130529A1 (es) | 2010-04-02 | 2013-05-14 | Phivco 1 Llc | Terapia de combinacion que comprende un antagonista de ccr5, un inhibidor de proteasa de vih-1, y un potenciador farmacocinetico |
WO2012009137A1 (en) | 2010-07-12 | 2012-01-19 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
US20130259830A1 (en) | 2010-07-12 | 2013-10-03 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
US20140271680A1 (en) | 2011-08-12 | 2014-09-18 | Universite Paris-Est Creteil Val De Marne | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
CN103159754A (zh) * | 2011-12-19 | 2013-06-19 | 中国科学院上海药物研究所 | 一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途 |
JP6146990B2 (ja) * | 2012-11-16 | 2017-06-14 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化されたcftr増強物質 |
GB201321748D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
GB201321749D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
US10196384B2 (en) | 2015-03-31 | 2019-02-05 | Vertex Pharmaceuticals (Europe) Limited | Deuterated CFTR modulators |
CA2999529A1 (en) | 2015-09-25 | 2017-03-30 | Vertex Pharmaceuticals (Europe) Limited | Deuterated cftr potentiators |
JP2017105824A (ja) * | 2017-02-10 | 2017-06-15 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化されたcftr増強物質 |
WO2019109021A1 (en) | 2017-12-01 | 2019-06-06 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
EP3768256A4 (en) | 2018-03-19 | 2021-11-24 | Emory University | PANTROPIC ENTRY INHIBITORS |
JP6654223B2 (ja) * | 2018-08-13 | 2020-02-26 | バーテックス ファーマシューティカルズ (ヨーロッパ) リミテッド | 重水素化されたcftr増強物質 |
US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20001420A1 (es) * | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
WO2001080106A1 (fr) * | 2000-04-19 | 2001-10-25 | Satoshi Yamazaki | Procede de diffusion d'outil publicitaire et support magnetique pour le logiciel |
ES2215129T3 (es) * | 2000-05-26 | 2004-10-01 | Pfizer Inc. | Derivados de triazolil tropano como modulares de ccr5. |
ES2263960T3 (es) * | 2002-04-08 | 2006-12-16 | Pfizer Inc. | Derivados de tropano como moduladores de ccr5. |
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2003
- 2003-03-31 ES ES03710080T patent/ES2263960T3/es not_active Expired - Lifetime
- 2003-03-31 BR BR0309118-0A patent/BR0309118A/pt not_active IP Right Cessation
- 2003-03-31 MX MXPA04009220A patent/MXPA04009220A/es active IP Right Grant
- 2003-03-31 KR KR1020047016104A patent/KR100734685B1/ko not_active IP Right Cessation
- 2003-03-31 PL PL03372968A patent/PL372968A1/xx unknown
- 2003-03-31 OA OA1200400262A patent/OA12798A/en unknown
- 2003-03-31 DE DE60305903T patent/DE60305903T2/de not_active Expired - Lifetime
- 2003-03-31 AT AT03710080T patent/ATE328882T1/de active
- 2003-03-31 JP JP2003582151A patent/JP3793200B2/ja not_active Expired - Lifetime
- 2003-03-31 AP APAP/P/2004/003147A patent/AP1789A/en active
- 2003-03-31 PT PT03710080T patent/PT1492789E/pt unknown
- 2003-03-31 EA EA200401167A patent/EA007590B1/ru not_active IP Right Cessation
- 2003-03-31 RS YUP-888/04A patent/RS51550B/en unknown
- 2003-03-31 WO PCT/IB2003/001220 patent/WO2003084954A1/en active IP Right Grant
- 2003-03-31 NZ NZ535452A patent/NZ535452A/en not_active IP Right Cessation
- 2003-03-31 IL IL16426103A patent/IL164261A0/xx unknown
- 2003-03-31 AU AU2003214503A patent/AU2003214503B2/en not_active Ceased
- 2003-03-31 CN CNB03807639XA patent/CN1324025C/zh not_active Expired - Fee Related
- 2003-03-31 SI SI200330319T patent/SI1492789T1/sl unknown
- 2003-03-31 DK DK03710080T patent/DK1492789T3/da active
- 2003-03-31 EP EP03710080A patent/EP1492789B1/en not_active Expired - Lifetime
- 2003-03-31 GE GEAP8437A patent/GEP20074210B/en unknown
- 2003-03-31 CA CA002481482A patent/CA2481482C/en not_active Expired - Lifetime
- 2003-04-04 DO DO2003000624A patent/DOP2003000624A/es unknown
- 2003-04-04 NI NI200300053A patent/NI200300053A/es unknown
- 2003-04-04 MY MYPI20031257A patent/MY134223A/en unknown
- 2003-04-04 PE PE2003000346A patent/PE20040082A1/es not_active Application Discontinuation
- 2003-04-07 HN HN2003000114A patent/HN2003000114A/es unknown
- 2003-04-07 TW TW092107880A patent/TWI280130B/zh not_active IP Right Cessation
- 2003-04-07 AR ARP030101205A patent/AR039383A1/es unknown
- 2003-04-07 UY UY27752A patent/UY27752A1/es unknown
- 2003-04-08 PA PA20038570801A patent/PA8570801A1/es unknown
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2004
- 2004-09-16 IS IS7453A patent/IS2577B/is unknown
- 2004-09-29 MA MA27883A patent/MA27190A1/fr unknown
- 2004-10-06 TN TNP2004000194A patent/TNSN04194A1/fr unknown
- 2004-10-07 HR HR20040940A patent/HRP20040940A2/hr not_active Application Discontinuation
- 2004-10-07 CU CU20040219A patent/CU23282A3/es unknown
- 2004-10-07 CR CR7514A patent/CR7514A/es unknown
- 2004-10-26 NO NO20044615A patent/NO329674B1/no not_active IP Right Cessation
-
2005
- 2005-09-16 HK HK05108146A patent/HK1076102A1/xx not_active IP Right Cessation
-
2006
- 2006-02-03 JP JP2006027537A patent/JP4571078B2/ja not_active Expired - Lifetime
- 2006-07-04 CY CY20061100919T patent/CY1106114T1/el unknown
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