CY1106114T1 - Παραγωγα τροπανιου σαν ρυθμιστες ccr5 - Google Patents

Παραγωγα τροπανιου σαν ρυθμιστες ccr5

Info

Publication number
CY1106114T1
CY1106114T1 CY20061100919T CY061100919T CY1106114T1 CY 1106114 T1 CY1106114 T1 CY 1106114T1 CY 20061100919 T CY20061100919 T CY 20061100919T CY 061100919 T CY061100919 T CY 061100919T CY 1106114 T1 CY1106114 T1 CY 1106114T1
Authority
CY
Cyprus
Prior art keywords
ccr5
tropane
producers
regulators
modulators
Prior art date
Application number
CY20061100919T
Other languages
English (en)
Inventor
Patricia Ann Basford
Peter Thomas Stephenson
Stefan Colin John Taylor
Anthony Wood
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0208071.1A external-priority patent/GB0208071D0/en
Priority claimed from GB0301575A external-priority patent/GB0301575D0/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of CY1106114T1 publication Critical patent/CY1106114T1/el

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    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Diabetes (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
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  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει ενώσεις του τύπου (I) όπου, τα Χ, Υ, R1, R2 και R2 είναι ως ορίζονται εδώ ανωτέρω. Οι ενώσεις της παρούσας εφεύρεσης είναι ρυθμιστές, ειδικά ανταγωνιστές, της δραστικότητας υποδοχέων CCR5 χημοκίνης. Ρυθμιστές του CCR5 υποδοχέα μπορεί να είναι χρήσιμοι στην θεραπεία διαφόρων φλεγμονωδών ασθενειών και καταστάσεων, και στη θεραπεία λοίμωξης από HIV και γενετικώς συναφείς ρετροϊούς.
CY20061100919T 2002-04-08 2006-07-04 Παραγωγα τροπανιου σαν ρυθμιστες ccr5 CY1106114T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0208071.1A GB0208071D0 (en) 2002-04-08 2002-04-08 Tropane derivatives useful in therapy
GB0301575A GB0301575D0 (en) 2003-01-23 2003-01-23 Tropane derivatives useful in therapy
PCT/IB2003/001220 WO2003084954A1 (en) 2002-04-08 2003-03-31 Tropane derivatives as ccr5 modulators

Publications (1)

Publication Number Publication Date
CY1106114T1 true CY1106114T1 (el) 2011-06-08

Family

ID=28793308

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100919T CY1106114T1 (el) 2002-04-08 2006-07-04 Παραγωγα τροπανιου σαν ρυθμιστες ccr5

Country Status (41)

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EP (1) EP1492789B1 (el)
JP (2) JP3793200B2 (el)
KR (1) KR100734685B1 (el)
CN (1) CN1324025C (el)
AP (1) AP1789A (el)
AR (1) AR039383A1 (el)
AT (1) ATE328882T1 (el)
AU (1) AU2003214503B2 (el)
BR (1) BR0309118A (el)
CA (1) CA2481482C (el)
CR (1) CR7514A (el)
CU (1) CU23282A3 (el)
CY (1) CY1106114T1 (el)
DE (1) DE60305903T2 (el)
DK (1) DK1492789T3 (el)
DO (1) DOP2003000624A (el)
EA (1) EA007590B1 (el)
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GE (1) GEP20074210B (el)
HK (1) HK1076102A1 (el)
HN (1) HN2003000114A (el)
HR (1) HRP20040940A2 (el)
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IS (1) IS2577B (el)
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PT1492789E (pt) * 2002-04-08 2006-09-29 Pfizer Derivados de tropano como moduladores ccr5
EP1786816A4 (en) 2003-09-10 2009-11-04 Virochem Pharma Inc SPIROHYDANTOIN COMPOUNDS AND METHODS FOR MODULATING CHEMOKINE RECEPTOR ACTIVITY
AU2004278158B2 (en) 2003-10-03 2009-08-13 Pfizer Inc. Imidazopyridine substituted tropane derivatives with CCR5 receptor antagonist activity for the treatment of HIV and inflammation
TW200533348A (en) 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US8131026B2 (en) 2004-04-16 2012-03-06 Validity Sensors, Inc. Method and apparatus for fingerprint image reconstruction
EP1800243B1 (en) 2004-10-04 2010-08-11 Validity Sensors, Inc. Fingerprint sensing assemblies comprising a substrate
WO2006064340A2 (en) * 2004-12-13 2006-06-22 Pfizer Limited Process for the preparation of n-acyl beta-aminoaldehydes
US7932235B2 (en) 2006-11-17 2011-04-26 Concert Pharmaceuticals, Inc. Triazolyl tropane derivatives
CA2683939C (en) * 2007-04-13 2012-06-19 Dong Wha Pharmaceutical Co. Ltd. Aspartate of 1-cyclopropyl-6-fluoro-7-(8-methoxyimino-2,6-diaza-spiro[3.4]oct-6-yl)-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid, method for preparing the same, and antimicrobial pharmaceutical composition comprising the same
US7947710B2 (en) 2007-08-27 2011-05-24 Theravance, Inc. Disubstituted alkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
CN101712679B (zh) * 2008-10-08 2013-04-10 中国科学院上海药物研究所 一种酰胺类化合物、其药物组合物及其制备方法和用途
BR112012012085A2 (pt) * 2009-11-21 2016-05-17 Hoffmann La Roche compostos antivirais heterocíclicos
EP2516416A1 (en) 2009-12-23 2012-10-31 Ironwood Pharmaceuticals, Inc. Crth2 modulators
EA201290852A1 (ru) 2010-04-02 2013-04-30 ФИВКО-1 ЭлЭлСи Комбинированная терапия, включающая антагонист ccr5, ингибитор протеазы вич-1 и фармакокинетический усилитель
US20130216552A1 (en) 2010-07-12 2013-08-22 Ironwood Pharmaceuticals, Inc. Crth2 modulators
US20130259830A1 (en) 2010-07-12 2013-10-03 Ironwood Pharmaceuticals, Inc. Crth2 modulators
HUE047354T2 (hu) 2011-05-18 2020-04-28 Vertex Pharmaceuticals Europe Ltd Ivacaftor deuterizált származékai
WO2013024022A1 (en) 2011-08-12 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of pulmonary hypertension
CN106977511B (zh) * 2011-12-19 2019-04-12 中国科学院上海药物研究所 一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途
JP6146990B2 (ja) * 2012-11-16 2017-06-14 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質
GB201321749D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321748D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
CA2981495C (en) 2015-03-31 2023-09-26 Vertex Pharmaceuticals (Europe) Limited Deuterated vx-661
CA2999529A1 (en) 2015-09-25 2017-03-30 Vertex Pharmaceuticals (Europe) Limited Deuterated cftr potentiators
JP2017105824A (ja) * 2017-02-10 2017-06-15 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化されたｃｆｔｒ増強物質
US11708331B2 (en) 2017-12-01 2023-07-25 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
WO2019183133A1 (en) 2018-03-19 2019-09-26 Emory University Pan-Tropic Entry Inhibitors
JP6654223B2 (ja) * 2018-08-13 2020-02-26 バーテックス ファーマシューティカルズ （ヨーロッパ） リミテッド 重水素化されたｃｆｔｒ増強物質
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

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PE20001420A1 (es) * 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
WO2001080106A1 (fr) * 2000-04-19 2001-10-25 Satoshi Yamazaki Procede de diffusion d'outil publicitaire et support magnetique pour le logiciel
DK1526134T3 (da) * 2000-05-26 2008-11-17 Pfizer Triazolyltropanderivater som CCR5-modulatorer
PT1492789E (pt) * 2002-04-08 2006-09-29 Pfizer Derivados de tropano como moduladores ccr5

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IS2577B (is) 2010-02-15
AP2004003147A0 (en) 2004-09-30
DK1492789T3 (da) 2006-09-11
IS7453A (is) 2004-09-16
JP3793200B2 (ja) 2006-07-05
WO2003084954A1 (en) 2003-10-16
HRP20040940A2 (en) 2005-04-30
EA007590B1 (ru) 2006-12-29
RS88804A (en) 2006-12-15
TNSN04194A1 (fr) 2007-03-12
JP4571078B2 (ja) 2010-10-27
JP2005532285A (ja) 2005-10-27
ES2263960T3 (es) 2006-12-16
PA8570801A1 (es) 2004-11-26
SI1492789T1 (sl) 2006-10-31
PT1492789E (pt) 2006-09-29
PE20040082A1 (es) 2004-03-20
AR039383A1 (es) 2005-02-16
IL164261A0 (en) 2005-12-18
EP1492789A1 (en) 2005-01-05
AU2003214503B2 (en) 2008-08-07
ATE328882T1 (de) 2006-06-15
EA200401167A1 (ru) 2005-04-28
CA2481482A1 (en) 2003-10-16
BR0309118A (pt) 2005-02-01
AP1789A (en) 2007-10-05
CN1324025C (zh) 2007-07-04
HK1076102A1 (en) 2006-01-06
PL372968A1 (en) 2005-08-08
MA27190A1 (fr) 2005-01-03
MY134223A (en) 2007-11-30
MXPA04009220A (es) 2005-09-30
NO329674B1 (no) 2010-11-29
TWI280130B (en) 2007-05-01
HN2003000114A (es) 2004-05-05
AU2003214503A1 (en) 2003-10-20
CA2481482C (en) 2009-11-10
KR20040099420A (ko) 2004-11-26
EP1492789B1 (en) 2006-06-07
OA12798A (en) 2006-07-10
NI200300053A (es) 2005-11-01
NZ535452A (en) 2006-11-30
DE60305903T2 (de) 2007-03-08
GEP20074210B (en) 2007-10-10
DOP2003000624A (es) 2003-10-15
DE60305903D1 (de) 2006-07-20
NO20044615L (no) 2004-10-26
KR100734685B1 (ko) 2007-07-02
UY27752A1 (es) 2003-11-28
CN1646526A (zh) 2005-07-27
CU23282A3 (es) 2008-06-30
JP2006182784A (ja) 2006-07-13
RS51550B (en) 2011-06-30
TW200403242A (en) 2004-03-01
CR7514A (es) 2004-11-08

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