NO20021502L - Kinazolinoner - Google Patents

Kinazolinoner

Info

Publication number
NO20021502L
NO20021502L NO20021502A NO20021502A NO20021502L NO 20021502 L NO20021502 L NO 20021502L NO 20021502 A NO20021502 A NO 20021502A NO 20021502 A NO20021502 A NO 20021502A NO 20021502 L NO20021502 L NO 20021502L
Authority
NO
Norway
Prior art keywords
quinazolinones
zolinones
solvates
china
salts
Prior art date
Application number
NO20021502A
Other languages
English (en)
Other versions
NO20021502D0 (no
Inventor
Werner Mederski
Ralf Devant
Gerhard Barnickel
Sabine Bernotat-Danielowski
Guido Melzer
Daljit Dhanoa
Bao-Ping Zhao
James Rinker
Mark Player
Richard M Soll
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20021502D0 publication Critical patent/NO20021502D0/no
Publication of NO20021502L publication Critical patent/NO20021502L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Kinazolinoner med formel (I) hvor R, R1, R2, R3, R4, Y, Z, n og m har betydningene angitt i patentkrav l, og deres salter eller solvater som glyko- protein iblX-antagonister.
NO20021502A 1999-09-28 2002-03-26 Kinazolinoner NO20021502L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40795899A 1999-09-28 1999-09-28
PCT/EP2000/008940 WO2001023365A1 (en) 1999-09-28 2000-09-13 Quinazolinones

Publications (2)

Publication Number Publication Date
NO20021502D0 NO20021502D0 (no) 2002-03-26
NO20021502L true NO20021502L (no) 2002-03-26

Family

ID=23614261

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021502A NO20021502L (no) 1999-09-28 2002-03-26 Kinazolinoner

Country Status (8)

Country Link
EP (1) EP1216235A1 (no)
KR (1) KR20020047186A (no)
AR (1) AR025797A1 (no)
AU (1) AU7654800A (no)
BR (1) BR0014294A (no)
CA (1) CA2385921A1 (no)
NO (1) NO20021502L (no)
WO (1) WO2001023365A1 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
WO2003106435A1 (en) * 2002-06-18 2003-12-24 Sankyo Company, Limited Fused-ring pyrimidin-4(3h)-one derivatives, processes for the preparation and uses thereof
US20040152696A1 (en) * 2002-08-01 2004-08-05 Euro-Celtique S.A. 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers
CA2502302A1 (en) * 2002-11-04 2004-05-21 Nps Pharmaceuticals, Inc. Quinazolinone compounds as calcilytics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670416A1 (de) * 1966-12-30 1971-02-11 Chem Fab Von Heyden Gmbh Muenc Verfahren zur Herstellung von aminosubstituierten Chinazolinonderivaten
JPS6136273A (ja) * 1984-07-26 1986-02-20 Mitsubishi Yuka Yakuhin Kk ２−フエニルアルキル−４（３ｈ）−キナゾリノン誘導体
WO1995024410A1 (fr) * 1994-03-08 1995-09-14 Otsuka Pharmaceutical Factory, Inc. Derive de diester phosphonique
US5783577A (en) * 1995-09-15 1998-07-21 Trega Biosciences, Inc. Synthesis of quinazolinone libraries and derivatives thereof

Also Published As

Publication number Publication date
KR20020047186A (ko) 2002-06-21
CA2385921A1 (en) 2001-04-05
AR025797A1 (es) 2002-12-11
EP1216235A1 (en) 2002-06-26
NO20021502D0 (no) 2002-03-26
AU7654800A (en) 2001-04-30
BR0014294A (pt) 2002-05-21
WO2001023365A1 (en) 2001-04-05

Similar Documents

Publication Publication Date Title
TR199801255T2 (xx) Vitronektin resept�r antagonistleri.
DE60236600D1 (de) Substituierte 1h-dihydropyrazole, ihre herstellung und verwendung
NO20054848L (no) Substituerte p-diaminobenzenderivater
DE60230127D1 (de) Inhibitoren von integrin alpha-v-beta-6
NO20021503L (no) Kinazolinoner
NO20050666L (no) 2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorer
NO991761L (no) Nye piperidin-kotokarbonsyre-derivater, deres fremstilling og anvendelse
SE9702773D0 (sv) Novel compounds
NO20023161L (no) Substituerte piperidiner, legemidler inneholdende disse forbindelser og fremgangsmåter for fremstilling av dem
NO20040881L (no) Orale antidiabetes midler.
ATE258930T1 (de) Dihydrobenzifurane
PT1086096E (pt) Benzamidas com substituintes etra-hidrofuraniloxi como inibidores da fosfodiesterase 4
NO20054721L (no) Substituerte anilinderivater
MY136297A (en) Piperazine derivatives having sst1 antagonistic activity
NO20022123L (no) Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII
NO20001934L (no) 3-Substituerte tetrahydropyridopyrimidinon-derivater, deres fremstilling og anvendelse
NO20021502L (no) Kinazolinoner
NO20002124L (no) Nye karboksylsyrederivater med amid-sidekjeder, deres fremstilling og anvendelse som endothelin-reseptorantagonister
PT1204659E (pt) Benzofuranos serotoninergicos
NO20020885L (no) <alfa>v<beta>3-integrininhibitorer
TR199901416T2 (xx) Heterosiklik karbonikasit t�revleri.
TR199903159T2 (xx) Yeni �-Amino ve �-Azido karbonik asit t�revleri.
DE50004731D1 (de) Substituierte benzimidazole, ihre herstellung und ihre verwendung als mittel gegen parasitäre protozoen
NO20001077L (no) Nye karboksylsyrederivater, deres fremstilling og anvendelse som blandete ETA/ETB-endothelin-reseptorantagonister
DK1104419T3 (da) N-substituerede azabicyloheptan-derivater, deres fremstilling og anvendelse

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application