NO20002124L - Nye karboksylsyrederivater med amid-sidekjeder, deres fremstilling og anvendelse som endothelin-reseptorantagonister - Google Patents

Nye karboksylsyrederivater med amid-sidekjeder, deres fremstilling og anvendelse som endothelin-reseptorantagonister

Info

Publication number
NO20002124L
NO20002124L NO20002124A NO20002124A NO20002124L NO 20002124 L NO20002124 L NO 20002124L NO 20002124 A NO20002124 A NO 20002124A NO 20002124 A NO20002124 A NO 20002124A NO 20002124 L NO20002124 L NO 20002124L
Authority
NO
Norway
Prior art keywords
carboxylic acid
acid derivatives
receptor antagonists
preparation
endothelin receptor
Prior art date
Application number
NO20002124A
Other languages
English (en)
Other versions
NO20002124D0 (no
Inventor
Wilhelm Amberg
Rolf Jansen
Stefan Hergenroeder
Manfred Raschack
Liliane Unger
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19752904A external-priority patent/DE19752904A1/de
Priority claimed from DE1998109376 external-priority patent/DE19809376A1/de
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO20002124L publication Critical patent/NO20002124L/no
Publication of NO20002124D0 publication Critical patent/NO20002124D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Karboksylsyrederivater med formel l R° H R ¿C¿W ¿ C----C- R* K *=<, hvor substituentene har betydningene som er forklart i beskrivelsen, blir anvendt som endotelinreseptorantagonister.
NO20002124A 1997-10-31 2000-04-26 Nye karboksylsyrederivater med amid-sidekjeder, deres fremstilling og anvendelse som endothelin-reseptorantagonister NO20002124D0 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19748238 1997-10-31
DE19752904A DE19752904A1 (de) 1997-10-31 1997-11-28 Neue Carbonsäurederivate, die Amidseitenketten tragen, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten
DE1998109376 DE19809376A1 (de) 1998-03-05 1998-03-05 Neue Carbonsäurederivate, die Amidseitenketten tragen, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten
PCT/EP1998/006571 WO1999023078A2 (de) 1997-10-31 1998-10-16 Neue carbonsäurederivate, die amidseitenketten tragen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten

Publications (2)

Publication Number Publication Date
NO20002124L true NO20002124L (no) 2000-04-26
NO20002124D0 NO20002124D0 (no) 2000-04-26

Family

ID=27217881

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20002124A NO20002124D0 (no) 1997-10-31 2000-04-26 Nye karboksylsyrederivater med amid-sidekjeder, deres fremstilling og anvendelse som endothelin-reseptorantagonister

Country Status (18)

Country Link
US (1) US6509341B1 (no)
EP (1) EP1027338A2 (no)
JP (1) JP2001521927A (no)
CN (1) CN1278251A (no)
AU (1) AU2266199A (no)
BG (1) BG104396A (no)
BR (1) BR9814951A (no)
CA (1) CA2307770A1 (no)
HR (1) HRP980560A2 (no)
HU (1) HUP0100054A3 (no)
ID (1) ID24278A (no)
IL (1) IL135347A0 (no)
NO (1) NO20002124D0 (no)
NZ (1) NZ504316A (no)
PL (1) PL340871A1 (no)
SK (1) SK4592000A3 (no)
TR (1) TR200001182T2 (no)
WO (1) WO1999023078A2 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19806438A1 (de) * 1998-02-17 1999-08-19 Basf Ag Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung
DE19933164A1 (de) * 1999-07-20 2001-01-25 Basf Ag Neue Carbonsäurederivate mit 5,6 substituiertem Pyrimidinring, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten
CA2408343A1 (en) * 2000-05-11 2002-11-07 Banyu Pharmaceutical Co., Ltd. N-acyltetrahydroisoquinoline derivatives
DE10025728A1 (de) * 2000-05-25 2001-11-29 Basf Ag Neue Carbamate und Harnstoffe, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten
WO2002064573A1 (de) * 2001-02-14 2002-08-22 Abbott Gmbh & Co. Kg Neue carbonsäurederivate mit alkylsubstituierten triazinen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten
ATE327744T1 (de) 2001-03-20 2006-06-15 Sanol Arznei Schwarz Gmbh Neue verwendung von peptidverbindungen bei der behandlung von nicht-neuropathischem entzündungsschmerz
PT1243263E (pt) 2001-03-21 2003-03-31 Sanol Arznei Schwarz Gmbh Nova utilizacao de uma classe peptidica de composto para o tratamento de alodinia ou de outros tipos diferentes de dor cronica ou fantasma
CN1950101B (zh) 2004-04-16 2011-03-30 舒沃茨药物股份公司 肽化合物用于预防和治疗慢性头痛的用途
EP1604656A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS)
WO2006021412A2 (en) 2004-08-27 2006-03-02 Schwarz Pharma Ag Use of peptide compounds for treating bone cancer pain, chemotherapy-and nucleoside-induced pain
AU2007237874A1 (en) * 2006-04-13 2007-10-25 Actelion Pharmaceuticals Ltd Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
SI2462990T1 (sl) 2006-06-15 2014-04-30 Ucb Pharma Gmbh Farmacevtski sestavek, ki obsega lakozamid in levetiracetam, s sinergističnim antikonvulzivnim učinkom

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4313413A1 (de) * 1993-04-23 1994-10-27 Basf Ag 3-(Het)aryloxy(thio)-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung
DE4313412A1 (de) * 1993-04-23 1994-10-27 Basf Ag 3-(Het)aryl-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung
DE4411225A1 (de) 1994-03-31 1995-10-05 Basf Ag Verwendung von Carbonsäurederivaten als Arzneimittel
DE19533023B4 (de) * 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19614534A1 (de) 1996-04-12 1997-10-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung

Also Published As

Publication number Publication date
WO1999023078A3 (de) 1999-09-10
NZ504316A (en) 2002-12-20
SK4592000A3 (en) 2000-12-11
CN1278251A (zh) 2000-12-27
ID24278A (id) 2000-07-13
HUP0100054A1 (hu) 2002-02-28
TR200001182T2 (tr) 2000-11-21
EP1027338A2 (de) 2000-08-16
NO20002124D0 (no) 2000-04-26
PL340871A1 (en) 2001-03-12
JP2001521927A (ja) 2001-11-13
HUP0100054A3 (en) 2002-03-28
CA2307770A1 (en) 1999-05-14
WO1999023078A2 (de) 1999-05-14
IL135347A0 (en) 2001-05-20
HRP980560A2 (en) 1999-08-31
US6509341B1 (en) 2003-01-21
BR9814951A (pt) 2000-10-03
AU2266199A (en) 1999-05-24
BG104396A (en) 2001-02-28

Similar Documents

Publication Publication Date Title
CY1107281T1 (el) Παραγωγα τροπανιου υποκατεστημενα με ιδιδαζοπυριδινη με ενεργοτητα ανταγωνιστη ccr5 υποδοχεα για τη θεραπεια hiv και φλεγμονης
NO20006282L (no) Nye cyklosporiner
AU2003226572A1 (en) Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors
NO20002124L (no) Nye karboksylsyrederivater med amid-sidekjeder, deres fremstilling og anvendelse som endothelin-reseptorantagonister
NO20070532L (no) Substituerte 2-alkyl-kinazolinonderivater som PARP-inhibitorer
CY1117029T1 (el) Συνεργιστικοι μυκητοκτονοι συνδυασμοι δραστικων ουσιων
YU41801A (sh) Derivati fenilglicina
NO20025590D0 (no) Fenylglycin-derivater
DE60226469D1 (de) Biphenylkarbonsäureamidderivate als p38 kinase-inhibitoren
DE60230127D1 (de) Inhibitoren von integrin alpha-v-beta-6
NO20054848L (no) Substituerte p-diaminobenzenderivater
NO990662L (no) Trombin-inhibitorer
NO20064415L (no) Nye amido-substituerte hydroksy-6-fenylfenantridiner og deres anvendelse som PDE4-inhibitorer
NO20021502L (no) Kinazolinoner
MXPA05009282A (es) Derivados de anilina sustituidos.
NO20071111L (no) Kynurensyreamidderivater som NR2B-reseptorantagonister
EA200601176A1 (ru) 3-цианохинолиновые производные с антипролиферативной активностью
NO20060702L (no) Aminokinolinderivater og deres anvendelse som adenosin A3 ligander
NO20052520L (no) Nye sulfamider
ATE259813T1 (de) Triazolopyrimidinderivate
CA2292775A1 (en) Cyanoguanidines as cell proliferation inhibitors
TR199901416T2 (xx) Heterosiklik karbonikasit t�revleri.
NO20002154L (no) Nye heterocykliske substituerte alfa-hydroksykarboksylsyre- derivater
NO20001077L (no) Nye karboksylsyrederivater, deres fremstilling og anvendelse som blandete ETA/ETB-endothelin-reseptorantagonister
TR199903159T2 (xx) Yeni �-Amino ve �-Azido karbonik asit t�revleri.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application