EA200601176A1 - 3-цианохинолиновые производные с антипролиферативной активностью - Google Patents

3-цианохинолиновые производные с антипролиферативной активностью

Info

Publication number
EA200601176A1
EA200601176A1 EA200601176A EA200601176A EA200601176A1 EA 200601176 A1 EA200601176 A1 EA 200601176A1 EA 200601176 A EA200601176 A EA 200601176A EA 200601176 A EA200601176 A EA 200601176A EA 200601176 A1 EA200601176 A1 EA 200601176A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyanohinoline
derivatives
antiproliferative activity
compounds
formula
Prior art date
Application number
EA200601176A
Other languages
English (en)
Inventor
Эдди Жан Эдгар Фрейн
Петер Якобус Йоханнес Антониус Бейнстерс
Кристоф Ван Эмелен
Вернер Констант Йохан Эмбрехтс
Тимоти Пьетро Сурен Перера
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34684508&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200601176(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200601176A1 publication Critical patent/EA200601176A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к N-оксидным формам соединения формулы (I), их фармацевтически приемлемым солям и стереохимически изомерным формам. Соединения формулы (I) ингибируют тирозинкиназные ферменты.
EA200601176A 2003-12-18 2004-12-15 3-цианохинолиновые производные с антипролиферативной активностью EA200601176A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EPPCT/EP03/51059 2003-12-18
PCT/EP2004/053497 WO2005058318A1 (en) 2003-12-18 2004-12-15 3-cyano-quinoline derivatives with antiproliferative activity

Publications (1)

Publication Number Publication Date
EA200601176A1 true EA200601176A1 (ru) 2006-10-27

Family

ID=34684508

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601176A EA200601176A1 (ru) 2003-12-18 2004-12-15 3-цианохинолиновые производные с антипролиферативной активностью

Country Status (23)

Country Link
US (4) US7655642B2 (ru)
EP (1) EP1696914B1 (ru)
JP (1) JP4892353B2 (ru)
KR (1) KR101158440B1 (ru)
CN (1) CN1893944B (ru)
AR (1) AR047060A1 (ru)
AT (1) ATE446750T1 (ru)
AU (1) AU2004298784B2 (ru)
BR (1) BRPI0417609B8 (ru)
CA (1) CA2549728C (ru)
DE (1) DE602004023876D1 (ru)
EA (1) EA200601176A1 (ru)
ES (1) ES2335216T3 (ru)
HK (1) HK1095742A1 (ru)
IL (1) IL176358A (ru)
MX (1) MXPA06007018A (ru)
NO (1) NO337622B1 (ru)
NZ (1) NZ547795A (ru)
SG (1) SG151288A1 (ru)
TW (2) TWI389890B (ru)
UA (1) UA83880C2 (ru)
WO (1) WO2005058318A1 (ru)
ZA (1) ZA200604971B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06007018A (es) * 2003-12-18 2006-08-31 Janssen Pharmaceutica Nv Derivados de 3-ciano-quinolino con actividad anti-proliferativa.
EP1697384B1 (en) * 2003-12-18 2008-04-02 Janssen Pharmaceutica N.V. Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
JO3088B1 (ar) * 2004-12-08 2017-03-15 Janssen Pharmaceutica Nv مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف
MY169441A (en) 2004-12-08 2019-04-11 Janssen Pharmaceutica Nv 2,4, (4,6) pyrimidine derivatives
WO2007058627A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Oxygen linked pyrimidine derivatives
US10517876B2 (en) 2005-11-16 2019-12-31 Cti Biopharma Corp. Oxygen linked pyrimidine derivatives
WO2008006884A2 (en) * 2006-07-13 2008-01-17 Janssen Pharmaceutica N.V. Mtki quinazoline derivatives
WO2008087736A1 (ja) * 2007-01-19 2008-07-24 Ube Industries, Ltd. アラルキルオキシ又はヘテロアラルキルオキシ基を有する芳香族アミンの製法
ES2435454T3 (es) * 2007-06-21 2013-12-19 Janssen Pharmaceutica, N.V. Indolin-2-onas y aza-indolin-2-onas
EP2185562B1 (en) 2007-07-27 2015-12-02 Janssen Pharmaceutica, N.V. Pyrrolopyrimidines useful for the treatment of proliferative diseases
CN102127087B (zh) * 2011-01-21 2012-07-04 江苏先声药物研究有限公司 喹唑啉衍生物
MA39822A (fr) 2014-04-03 2018-02-06 Janssen Pharmaceutica Nv Dérivés de pyrimidine bicycle
MA39823A (fr) 2014-04-03 2018-01-09 Janssen Pharmaceutica Nv Dérivés de pyridine macrocyclique
BR112018006873A2 (pt) 2015-10-05 2018-11-06 The Trustees Of Columbia University In The City Of New York ativadores do fluxo autofágico e fosfolipase d e depuração de agregados de proteína incluindo tau e tratamento de proteinopatias

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028613A (en) 1990-02-16 1991-07-02 Repligen Corporation Novel pyrroloquinoline alkaloids and methods of use
UA73073C2 (ru) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Замещенные 3-циан хинолины
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
DK1117659T3 (da) 1998-09-29 2004-03-22 Wyeth Corp Substituerede 3-cyanoquinoliner som hæmmere af proteintyrosinkinaser
US6288082B1 (en) * 1998-09-29 2001-09-11 American Cyanamid Company Substituted 3-cyanoquinolines
CN1642552B (zh) 2002-03-30 2010-05-12 贝林格尔英格海姆法玛两合公司 作为酪氨酸激酶抑制剂的4-(n-苯氨基)-喹唑啉/喹啉
JO2785B1 (en) * 2003-05-27 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinazoline derivatives
MXPA06007018A (es) 2003-12-18 2006-08-31 Janssen Pharmaceutica Nv Derivados de 3-ciano-quinolino con actividad anti-proliferativa.

Also Published As

Publication number Publication date
TWI389890B (zh) 2013-03-21
JP4892353B2 (ja) 2012-03-07
BRPI0417609B8 (pt) 2021-05-25
US9040511B2 (en) 2015-05-26
BRPI0417609B1 (pt) 2019-02-19
US20140256948A1 (en) 2014-09-11
ATE446750T1 (de) 2009-11-15
NZ547795A (en) 2009-07-31
US8778920B2 (en) 2014-07-15
DE602004023876D1 (de) 2009-12-10
NO20063324L (no) 2006-07-18
KR20070005560A (ko) 2007-01-10
HK1095742A1 (en) 2007-05-18
US20100069424A1 (en) 2010-03-18
MXPA06007018A (es) 2006-08-31
TW201132628A (en) 2011-10-01
CN1893944A (zh) 2007-01-10
EP1696914B1 (en) 2009-10-28
WO2005058318A1 (en) 2005-06-30
SG151288A1 (en) 2009-04-30
US20080139601A1 (en) 2008-06-12
US9365517B2 (en) 2016-06-14
KR101158440B1 (ko) 2012-07-06
BRPI0417609A (pt) 2007-04-10
CN1893944B (zh) 2011-07-06
EP1696914A1 (en) 2006-09-06
TW200530187A (en) 2005-09-16
UA83880C2 (en) 2008-08-26
TWI374879B (en) 2012-10-21
NO337622B1 (no) 2016-05-09
ZA200604971B (en) 2009-05-27
CA2549728C (en) 2015-07-21
ES2335216T3 (es) 2010-03-23
AU2004298784B2 (en) 2011-06-09
US20130197022A1 (en) 2013-08-01
IL176358A (en) 2010-06-16
CA2549728A1 (en) 2005-06-30
AU2004298784A1 (en) 2005-06-30
US7655642B2 (en) 2010-02-02
AR047060A1 (es) 2006-01-04
IL176358A0 (en) 2006-10-05
JP2007514711A (ja) 2007-06-07

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