ATE446750T1 - 3-cyano-chinolin-derivate mit antiproliferativer wirkung - Google Patents

3-cyano-chinolin-derivate mit antiproliferativer wirkung

Info

Publication number
ATE446750T1
ATE446750T1 AT04804849T AT04804849T ATE446750T1 AT E446750 T1 ATE446750 T1 AT E446750T1 AT 04804849 T AT04804849 T AT 04804849T AT 04804849 T AT04804849 T AT 04804849T AT E446750 T1 ATE446750 T1 AT E446750T1
Authority
AT
Austria
Prior art keywords
cyano
quinoline derivatives
antiproliferative effect
antiproliferative
effect
Prior art date
Application number
AT04804849T
Other languages
English (en)
Inventor
Eddy Jean Edgard Freyne
Peter Jacobus Johan Buijnsters
Emelen Kristof Van
Werner Constant Johah Embrechts
Timothy Pietro Suren Perera
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34684508&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE446750(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE446750T1 publication Critical patent/ATE446750T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT04804849T 2003-12-18 2004-12-15 3-cyano-chinolin-derivate mit antiproliferativer wirkung ATE446750T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EPPCT/EP03/51059 2003-12-18
PCT/EP2004/053497 WO2005058318A1 (en) 2003-12-18 2004-12-15 3-cyano-quinoline derivatives with antiproliferative activity

Publications (1)

Publication Number Publication Date
ATE446750T1 true ATE446750T1 (de) 2009-11-15

Family

ID=34684508

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04804849T ATE446750T1 (de) 2003-12-18 2004-12-15 3-cyano-chinolin-derivate mit antiproliferativer wirkung

Country Status (22)

Country Link
US (4) US7655642B2 (de)
EP (1) EP1696914B1 (de)
JP (1) JP4892353B2 (de)
KR (1) KR101158440B1 (de)
CN (1) CN1893944B (de)
AR (1) AR047060A1 (de)
AT (1) ATE446750T1 (de)
AU (1) AU2004298784B2 (de)
BR (1) BRPI0417609B8 (de)
CA (1) CA2549728C (de)
DE (1) DE602004023876D1 (de)
EA (1) EA200601176A1 (de)
ES (1) ES2335216T3 (de)
IL (1) IL176358A (de)
MX (1) MXPA06007018A (de)
NO (1) NO337622B1 (de)
NZ (1) NZ547795A (de)
SG (1) SG151288A1 (de)
TW (2) TWI389890B (de)
UA (1) UA83880C2 (de)
WO (1) WO2005058318A1 (de)
ZA (1) ZA200604971B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2335216T3 (es) 2003-12-18 2010-03-23 Janssen Pharmaceutica Nv Derivados de 3-ciano-quinolina con actividad antiproliferativa.
EP1697384B1 (de) * 2003-12-18 2008-04-02 Janssen Pharmaceutica N.V. Pyrido- und pyrimidopyrimidinderivate als anti-proliferative mittel
MY169441A (en) 2004-12-08 2019-04-11 Janssen Pharmaceutica Nv 2,4, (4,6) pyrimidine derivatives
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
JO3088B1 (ar) * 2004-12-08 2017-03-15 Janssen Pharmaceutica Nv مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف
EP1951729B1 (de) * 2005-11-16 2014-06-25 Cell Therapeutics, Inc. Sauerstoffgebundene pyrimidinderivate
US10517876B2 (en) 2005-11-16 2019-12-31 Cti Biopharma Corp. Oxygen linked pyrimidine derivatives
EP2044084B1 (de) 2006-07-13 2016-02-17 Janssen Pharmaceutica NV Mtki-derivate des chinazolins
JPWO2008087736A1 (ja) * 2007-01-19 2010-05-06 宇部興産株式会社 アラルキルオキシ又はヘテロアラルキルオキシ基を有する芳香族アミンの製法
CA2687909C (en) * 2007-06-21 2015-09-15 Janssen Pharmaceutica Nv Indolin-2-ones and aza-indolin-2-ones
US8318731B2 (en) 2007-07-27 2012-11-27 Janssen Pharmaceutica Nv Pyrrolopyrimidines
CN102127087B (zh) * 2011-01-21 2012-07-04 江苏先声药物研究有限公司 喹唑啉衍生物
MA39823A (fr) 2014-04-03 2018-01-09 Janssen Pharmaceutica Nv Dérivés de pyridine macrocyclique
MA39822A (fr) 2014-04-03 2018-02-06 Janssen Pharmaceutica Nv Dérivés de pyrimidine bicycle
WO2017062500A2 (en) 2015-10-05 2017-04-13 The Trustees Of Columbia University In The City Of New York Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028613A (en) 1990-02-16 1991-07-02 Repligen Corporation Novel pyrroloquinoline alkaloids and methods of use
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
UA73073C2 (uk) * 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6288082B1 (en) * 1998-09-29 2001-09-11 American Cyanamid Company Substituted 3-cyanoquinolines
PL201475B1 (pl) 1998-09-29 2009-04-30 Wyeth Corp Podstawione 3-cyjanochinoliny jako inhibitory białkowych kinaz tyrozynowych
KR101064530B1 (ko) * 2002-03-30 2011-09-14 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 티로신 키나아제 억제제로서의 4-(ｎ-페닐아미노)-퀴나졸린/퀴놀린, 이를 함유하는 약제학적 조성물 및 이의 제조방법
PA8603801A1 (es) * 2003-05-27 2004-12-16 Janssen Pharmaceutica Nv Derivados de la quinazolina
ES2335216T3 (es) * 2003-12-18 2010-03-23 Janssen Pharmaceutica Nv Derivados de 3-ciano-quinolina con actividad antiproliferativa.

Also Published As

Publication number Publication date
TWI374879B (en) 2012-10-21
AU2004298784B2 (en) 2011-06-09
US20080139601A1 (en) 2008-06-12
HK1095742A1 (en) 2007-05-18
ZA200604971B (en) 2009-05-27
JP4892353B2 (ja) 2012-03-07
AU2004298784A1 (en) 2005-06-30
WO2005058318A1 (en) 2005-06-30
US9040511B2 (en) 2015-05-26
EP1696914A1 (de) 2006-09-06
US20140256948A1 (en) 2014-09-11
TWI389890B (zh) 2013-03-21
IL176358A (en) 2010-06-16
US20130197022A1 (en) 2013-08-01
US9365517B2 (en) 2016-06-14
TW200530187A (en) 2005-09-16
JP2007514711A (ja) 2007-06-07
NO20063324L (no) 2006-07-18
DE602004023876D1 (de) 2009-12-10
SG151288A1 (en) 2009-04-30
MXPA06007018A (es) 2006-08-31
US7655642B2 (en) 2010-02-02
CN1893944A (zh) 2007-01-10
UA83880C2 (en) 2008-08-26
CA2549728A1 (en) 2005-06-30
CA2549728C (en) 2015-07-21
TW201132628A (en) 2011-10-01
AR047060A1 (es) 2006-01-04
KR20070005560A (ko) 2007-01-10
IL176358A0 (en) 2006-10-05
ES2335216T3 (es) 2010-03-23
BRPI0417609B1 (pt) 2019-02-19
US8778920B2 (en) 2014-07-15
EP1696914B1 (de) 2009-10-28
BRPI0417609A (pt) 2007-04-10
BRPI0417609B8 (pt) 2021-05-25
NZ547795A (en) 2009-07-31
KR101158440B1 (ko) 2012-07-06
NO337622B1 (no) 2016-05-09
US20100069424A1 (en) 2010-03-18
CN1893944B (zh) 2011-07-06
EA200601176A1 (ru) 2006-10-27

Similar Documents

Publication Publication Date Title
DE602004029705D1 (de) 5,7-diaminopyrazoloä4,3-düpyrimidine mit pde-5-hemmender wirkung
ATE386743T1 (de) Pyrimidoverbindungen mit antiproliferativer wirkung
DE60332125D1 (de) Indole mit antidiabetischer wirkung
DE602004009089D1 (de) Pyrrolderivate mit antibakterieller wirkung
DE60320033D1 (de) Benzoazolylpiperazinderivate mit vr1-antagonistischer wirkung
ATE340782T1 (de) Piperidinbenzolsulfonamidderivate
ATE352550T1 (de) Chinazolinderivate
ATE478870T1 (de) Spiroindolinpiperidinderivate
ATE460418T1 (de) Heterocyclocarboxamidderivate
ATE450506T1 (de) Indol-3-schwefelderivate
ATE467631T1 (de) Chinuclidinamidderivate
ATE420066T1 (de) Amidoacetonitrilderivate
ATE485267T1 (de) Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung
ATE395345T1 (de) Imidazol-4-yl-ethynyl-pyridin-derivate
ATE473985T1 (de) Tricyclische tetrahydrochinoline mit antibakterieller wirkung
ATE446750T1 (de) 3-cyano-chinolin-derivate mit antiproliferativer wirkung
ATE361282T1 (de) Indazol-aminoacetonitrilderivate mit pestizider wirkung
ATE354365T1 (de) N-thiazol-2-yl-benzamid-derivate
ATE518876T1 (de) Macrolid-konjugate mit entzündungshemmender wirkung
DE602004011574D1 (de) Glycosylierte steroidderivate mit antimigratorischer wirkung
ATE423771T1 (de) Tetrahydrochinolinderivate
DE60328272D1 (de) Diazabicycloalkan-derivate mit nk1-antagonistischer wirkung
ATE449064T1 (de) Amidoacetonitrilderivate
DE602004027792D1 (de) Indazolamide mit analgetischer wirkung
ATE420086T1 (de) Chinolinthiazolinone mit cdk-1 antiproliferativer wirkung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties