DE602004011574D1 - Glycosylierte steroidderivate mit antimigratorischer wirkung - Google Patents

Glycosylierte steroidderivate mit antimigratorischer wirkung

Info

Publication number
DE602004011574D1
DE602004011574D1 DE602004011574T DE602004011574T DE602004011574D1 DE 602004011574 D1 DE602004011574 D1 DE 602004011574D1 DE 602004011574 T DE602004011574 T DE 602004011574T DE 602004011574 T DE602004011574 T DE 602004011574T DE 602004011574 D1 DE602004011574 D1 DE 602004011574D1
Authority
DE
Germany
Prior art keywords
steroid derivatives
glycosylated steroid
antimigratory
effect
antimigratory effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004011574T
Other languages
English (en)
Other versions
DE602004011574T2 (de
Inventor
Jean-Claude Braekman
Laurent Ingrassia
Prosper Nshimyumukiza
Quaquebeke Eric Van
Welle Janique De
Den Hove Laurent Van
Robert Kiss
Francis Darro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unibioscreen SA
Universite Libre de Bruxelles ULB
Original Assignee
Unibioscreen SA
Universite Libre de Bruxelles ULB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2003/014567 external-priority patent/WO2004055039A1/en
Application filed by Unibioscreen SA, Universite Libre de Bruxelles ULB filed Critical Unibioscreen SA
Publication of DE602004011574D1 publication Critical patent/DE602004011574D1/de
Application granted granted Critical
Publication of DE602004011574T2 publication Critical patent/DE602004011574T2/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0095—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 carbon in position 21 is part of carboxylic group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
DE602004011574T 2003-12-18 2004-12-17 Glycosylierte steroidderivate mit antimigratorischer wirkung Expired - Fee Related DE602004011574T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/EP2003/014567 WO2004055039A1 (en) 2002-12-18 2003-12-18 Steroid compounds with anti-tumor activity
WOPCT/EP03/14567 2003-12-18
EP2004006486 2004-06-16
WOPCT/EP2004/006 2004-06-16
PCT/EP2004/014408 WO2005058934A2 (en) 2003-12-18 2004-12-17 Glycosylated steroid derivatives with anti-migratory activity

Publications (2)

Publication Number Publication Date
DE602004011574D1 true DE602004011574D1 (de) 2008-03-13
DE602004011574T2 DE602004011574T2 (de) 2009-01-29

Family

ID=34702157

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004011574T Expired - Fee Related DE602004011574T2 (de) 2003-12-18 2004-12-17 Glycosylierte steroidderivate mit antimigratorischer wirkung

Country Status (10)

Country Link
EP (1) EP1709063B1 (de)
AU (1) AU2004299267A1 (de)
CA (1) CA2549074A1 (de)
DE (1) DE602004011574T2 (de)
DK (1) DK1709063T3 (de)
ES (1) ES2300877T3 (de)
MX (1) MXPA06006901A (de)
PL (1) PL1709063T3 (de)
PT (1) PT1709063E (de)
WO (1) WO2005058934A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI373473B (en) * 2005-09-02 2012-10-01 Otsuka Pharma Co Ltd Anticancer agent
WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
EP2794626B3 (de) 2011-12-22 2020-08-05 GlycoMimetics, Inc. E-selectin-antagonistenverbindungen
EP2914610A2 (de) * 2012-10-31 2015-09-09 GlycoMimetics, Inc. Galactopyranosyl-cyclohexylderivate als e-selectin-antagonisten
US9867841B2 (en) 2012-12-07 2018-01-16 Glycomimetics, Inc. Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
ES2754549T3 (es) 2014-12-03 2020-04-20 Glycomimetics Inc Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
AU2017341065B2 (en) 2016-10-07 2023-04-06 Glycomimetics, Inc. Highly potent multimeric E-selectin antagonists
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
AU2018395417B2 (en) 2017-12-29 2023-07-13 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
EP3761994A1 (de) 2018-03-05 2021-01-13 GlycoMimetics, Inc. Verfahren zur behandlung akuter myeloischer leukämie und verwandter zustände
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0940690A (ja) * 1995-05-23 1997-02-10 Yutaka Sashita ステロイド配糖体及びこれを有効成分とする医薬
JP2001002698A (ja) * 1999-06-16 2001-01-09 Kanegafuchi Chem Ind Co Ltd 新規腫瘍細胞増殖抑制剤

Also Published As

Publication number Publication date
PL1709063T3 (pl) 2008-06-30
CA2549074A1 (en) 2005-06-30
WO2005058934A2 (en) 2005-06-30
ES2300877T3 (es) 2008-06-16
EP1709063B1 (de) 2008-01-23
PT1709063E (pt) 2008-04-09
DE602004011574T2 (de) 2009-01-29
AU2004299267A1 (en) 2005-06-30
WO2005058934A3 (en) 2005-10-06
EP1709063A2 (de) 2006-10-11
MXPA06006901A (es) 2006-09-04
DK1709063T3 (da) 2008-06-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee