JO3088B1 - مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف - Google Patents
مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهدافInfo
- Publication number
- JO3088B1 JO3088B1 JOP/2005/0188A JOP20050188A JO3088B1 JO 3088 B1 JO3088 B1 JO 3088B1 JO P20050188 A JOP20050188 A JO P20050188A JO 3088 B1 JO3088 B1 JO 3088B1
- Authority
- JO
- Jordan
- Prior art keywords
- alkyl
- alkyloxy
- hydrogen
- 5alkyl
- 2alkyl
- Prior art date
Links
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- -1 C3-6 cycloalkyl R 25 Chemical compound 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Chemical group C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
يتعلق الاختراع الحالي بمركبات ( compounds) من الصيغه باشكال N- اوكسيد( N-oxide forms) باملاح الاضافة( addition salts) المقبولة دوائيا وبالاشكال الايزومرية الكيميائية الفراغية ( stereochemically isomeric forms) منها حيث: Z يمثل NH Y يمثل C3-9 الكيل( C3-9alkyl) ، c1-5 الكيل C1-5NR13 الكيل، ( C1-5alkyl – NR13-C1-5alkyl) C1-5 الكيل C1-5-CO-NR14 الكيل- ( C1-5alkyl –NR14-CO-C1-5alkyl) C1-2 الكيل C1-3 NH-CO-CH2-NR21 الكيل – (C1-2ALKYL-NR21-CH2-CO-NH-C1-3alkyl) او C1-2 الكيل NH-CR16R17-CO-NR23 ) (C1-2alkyl-NR23-CO-CR16R17-NH X1 يمثل O او C1-2 O الكيل( O-C1-2alkyl-) X2 يمثل رابطة مباشرة ( direct bond) C1-2 الكيل ( C1-2alkyl)، c1-2 co الكيل ( -CO-C1-2alkyl) او C1-2NR12 الكيل ( NR12C1-2alkyl) R1 يمثل هيدروجين ( hydrogen ) او هالو ( halo) R2 يمثل هالو ( halo) استيلين ( acetylene) او Het1 R3 يمثل هيدروجين ( hydrogen) او سيانو ( cyano) R4 يمثل C1-4-Ar4 الكيل اوكسي ( Ar4-C1-4alkoxy) C1-4 الكيل اوكسي (C1-4alkoxy) او C1-4 الكيل اوكسي (C1-4alkoxy) مستبدل مع بديل واحد او اذا امكن مع اثنين او اكثر من بدائل مختراة من Het2 ، NR7R8 هيدروكسي ( hydroxy) و C1-4 الكيل اوكسي C1-4 الكيل اوكسي ( C1-4alkyloxy – C1-4alkyoxy) R7 يمثل هيدروجين ( hydrogen) او c1-4 الكيل( C1-4 alkyl) R8 يمثل c1-4 الكيل( c1-4alkyl) مستبدل مع NR25R26 او C1-4 الكيل سلفونيل ( C1-4 alkylsulfonyl ) R12 يمثل هيدرويجين ( hydrogen) او C1-4 الكيل –( C1-4 alkyl) R13 يمثل AR6 سلفونيل ( AR6-sulfonyl) او C1-6 الكيل اوكسي كربونيل ( C1-6 alkyloxycarbonyl) مستبدل اختياريا مع فنيل ( phenyl) R16 و R17 يمثلان هيدروجين ( hydrogen) C1-4 الكيل( C1-4 alkyl) او يؤخذ R16 و R17 معا مع ذرة الكربون ( carbon atom) المرتبطة معها لتشكيل C3-6 الكيل دائري( C3-6 cycloakyl) R23 يمثل c1-4 الكيل ( C1-4alkyl) و R23 يمثل هيدروجين ( hydrogen) عنما يؤخذ r16 و r17 معا مع ذرة الكربون ( carbon atom) المرتبطة معهما لتشكيل c3-6 الكيل دائري ( C3-6cycloalkyl) R27,R26,R25 و R28 كل منهم على حدة يمثل هيدروجين ( hydrogen) او C1-4 الكيل كربونيل( C1-4alkylcarbonyl) Het1 يمثل 2- بورا-1، 3 ثنائي اوكسولانيل( 2-boro 1.3-dioxolanyl) Het2 يمثل بيبريدينيل ( piperidiny
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106383 | 2004-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3088B1 true JO3088B1 (ar) | 2017-03-15 |
Family
ID=34930015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2005/0188A JO3088B1 (ar) | 2004-12-08 | 2005-11-28 | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20100152174A1 (ar) |
| EP (1) | EP1828201B1 (ar) |
| JP (1) | JP5140431B2 (ar) |
| KR (1) | KR101320431B1 (ar) |
| CN (2) | CN102532163B (ar) |
| AR (1) | AR051985A1 (ar) |
| AU (1) | AU2005313350B2 (ar) |
| BR (1) | BRPI0518394B8 (ar) |
| CA (1) | CA2588764C (ar) |
| DK (1) | DK1828201T3 (ar) |
| EA (1) | EA013995B1 (ar) |
| ES (1) | ES2559305T3 (ar) |
| HU (1) | HUE027253T2 (ar) |
| JO (1) | JO3088B1 (ar) |
| MX (1) | MX2007006820A (ar) |
| MY (1) | MY148503A (ar) |
| NZ (1) | NZ555496A (ar) |
| PA (1) | PA8654501A1 (ar) |
| SI (1) | SI1828201T1 (ar) |
| TW (2) | TWI432440B (ar) |
| UA (1) | UA91522C2 (ar) |
| WO (1) | WO2006061417A2 (ar) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8603801A1 (es) * | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| EP1697384B1 (en) * | 2003-12-18 | 2008-04-02 | Janssen Pharmaceutica N.V. | Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents |
| NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
| EP2044084B1 (en) * | 2006-07-13 | 2016-02-17 | Janssen Pharmaceutica NV | Mtki quinazoline derivatives |
| MX2009004436A (es) * | 2006-10-27 | 2009-05-22 | Janssen Pharmaceutica Nv | Derivados de quinazolina macrociclicos como inhibidores del factor de crecimiento endotelial vascular r3. |
| EA200970420A1 (ru) * | 2006-10-27 | 2009-12-30 | Янссен Фармацевтика Нв | Применение mtki 1 для лечения или предупреждения рака кости |
| CA2687909C (en) * | 2007-06-21 | 2015-09-15 | Janssen Pharmaceutica Nv | Indolin-2-ones and aza-indolin-2-ones |
| US8318731B2 (en) | 2007-07-27 | 2012-11-27 | Janssen Pharmaceutica Nv | Pyrrolopyrimidines |
| DK2350075T3 (da) | 2008-09-22 | 2014-05-26 | Array Biopharma Inc | Substituerede imidazo[1,2b]pyridazinforbindelser som trk-kinase-inhibitorer |
| PT3106463T (pt) | 2008-10-22 | 2018-05-18 | Array Biopharma Inc | Compostos de pirazolo[1,5-]pirimidina substituídos como inibidores de cinase trk |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| RU2735545C2 (ru) * | 2010-05-20 | 2020-11-03 | Эррэй Биофарма Инк. | Макроциклические соединения в качестве ингибиторов киназы trk |
| KR101927114B1 (ko) * | 2014-02-07 | 2018-12-10 | 엑시테라 파마슈티컬스 인코퍼레이티드 | 치료 화합물 및 조성물 |
| MA39823A (fr) | 2014-04-03 | 2018-01-09 | Janssen Pharmaceutica Nv | Dérivés de pyridine macrocyclique |
| MA39822A (fr) | 2014-04-03 | 2018-02-06 | Janssen Pharmaceutica Nv | Dérivés de pyrimidine bicycle |
| EP3218380B1 (en) | 2014-11-16 | 2021-03-17 | Array Biopharma, Inc. | Preparation of a crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
| TN2019000271A1 (en) | 2015-10-26 | 2021-01-07 | Univ Colorado Regents | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| IL304018A (en) | 2016-04-04 | 2023-08-01 | Loxo Oncology Inc | Liquid formulations of (S)-N-(5-((R)-2-(5,2-difluorophenyl)-pyrrolidine-1-yl)-pyrazolo[5,1-A]pyrimidin-3-yl)-3 -hydroxypyrrolidine-1-carboxamide |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| ES2952056T3 (es) | 2016-05-18 | 2023-10-26 | Loxo Oncology Inc | Preparación de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2423536A1 (de) * | 1974-05-15 | 1975-11-27 | Bayer Ag | 3-amino-phenylessigsaeure-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide |
| US4126688A (en) * | 1976-05-17 | 1978-11-21 | Janssen Pharmaceutica N.V. | Antiemetic 1-(benzotriazolyl-alkyl)-piperidine derivatives |
| US4442278A (en) * | 1981-12-03 | 1984-04-10 | Hughes Aircraft Company | Ethynyl-substituted s-triazine derivatives, polymers thereof and process for making the same |
| US5721237A (en) * | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
| CA2137203C (en) * | 1993-12-07 | 2006-11-28 | William Francis Heath Jr. | Protein kinase c inhibitors |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US5654307A (en) * | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| DE69502028T2 (de) * | 1994-10-31 | 1998-12-10 | Dsm N.V., Heerlen | Katalytische zusammensetzung und verfahren zur olefinpolymerisation |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| EA199800372A1 (ru) * | 1995-11-14 | 1998-10-29 | Дзе Дюпон Мерк Фармасьютикал Компани | Новые макроциклические соединения-ингибиторы |
| DE19608588A1 (de) * | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| HU228446B1 (en) * | 1996-04-12 | 2013-03-28 | Warner Lambert Co | Kinazoline derivatives as irreversible inhibitors of protein-kinase, pharmaceutical compositions containing these compounds and use thereof |
| GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6288082B1 (en) * | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| AU6998000A (en) * | 1999-08-27 | 2001-03-26 | Boehringer Ingelheim Pharma Kg | Substituted indolinones as tyrosine kinase inhibitors |
| ATE396978T1 (de) * | 1999-10-07 | 2008-06-15 | Amgen Inc | Triazin-kinase-hemmer |
| US6864255B2 (en) * | 2001-04-11 | 2005-03-08 | Amgen Inc. | Substituted triazinyl amide derivatives and methods of use |
| BR0210391A (pt) * | 2001-06-12 | 2004-06-15 | Elan Pharm Inc | Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto |
| ATE341545T1 (de) * | 2001-07-16 | 2006-10-15 | Astrazeneca Ab | Quinolin-derivate und ihre verwendung als inhibitoren der tyrosine kinase |
| US6924285B2 (en) * | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
| US7504408B2 (en) * | 2002-07-09 | 2009-03-17 | Astrazeneca Ab | Quinzoline derivatives for use in the treatment of cancer |
| DE10239042A1 (de) * | 2002-08-21 | 2004-03-04 | Schering Ag | Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel |
| US20050021480A1 (en) * | 2003-05-16 | 2005-01-27 | Hyperspace Communications, Inc. | Method and apparatus for creating and validating an encrypted digital receipt for third-party electronic commerce transactions |
| PA8603801A1 (es) * | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| ES2335216T3 (es) * | 2003-12-18 | 2010-03-23 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-quinolina con actividad antiproliferativa. |
| EP1697384B1 (en) * | 2003-12-18 | 2008-04-02 | Janssen Pharmaceutica N.V. | Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents |
| MY169441A (en) * | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
| US8778919B2 (en) * | 2005-06-30 | 2014-07-15 | Janssen Pharmaceutica Nv | Cyclic anilino—pyridinotriazines |
| EP1951729B1 (en) * | 2005-11-16 | 2014-06-25 | Cell Therapeutics, Inc. | Oxygen linked pyrimidine derivatives |
| EP2044084B1 (en) * | 2006-07-13 | 2016-02-17 | Janssen Pharmaceutica NV | Mtki quinazoline derivatives |
| CA2687909C (en) * | 2007-06-21 | 2015-09-15 | Janssen Pharmaceutica Nv | Indolin-2-ones and aza-indolin-2-ones |
| US8318731B2 (en) * | 2007-07-27 | 2012-11-27 | Janssen Pharmaceutica Nv | Pyrrolopyrimidines |
| EP2283024B1 (en) * | 2008-03-10 | 2013-05-15 | Janssen Pharmaceutica, N.V. | 4-aryl-2-anilino-pyrimidines as plk kinase inhibitors |
-
2005
- 2005-11-28 JO JOP/2005/0188A patent/JO3088B1/ar active
- 2005-12-05 PA PA20058654501A patent/PA8654501A1/es unknown
- 2005-12-06 MY MYPI20055704A patent/MY148503A/en unknown
- 2005-12-07 TW TW094143060A patent/TWI432440B/zh not_active IP Right Cessation
- 2005-12-07 AR ARP050105124A patent/AR051985A1/es not_active Application Discontinuation
- 2005-12-07 TW TW102141302A patent/TWI511970B/zh not_active IP Right Cessation
- 2005-12-08 WO PCT/EP2005/056609 patent/WO2006061417A2/en not_active Ceased
- 2005-12-08 BR BRPI0518394A patent/BRPI0518394B8/pt active IP Right Grant
- 2005-12-08 EP EP05826362.5A patent/EP1828201B1/en not_active Expired - Lifetime
- 2005-12-08 HU HUE05826362A patent/HUE027253T2/en unknown
- 2005-12-08 JP JP2007544918A patent/JP5140431B2/ja not_active Expired - Lifetime
- 2005-12-08 CA CA2588764A patent/CA2588764C/en not_active Expired - Lifetime
- 2005-12-08 EA EA200701233A patent/EA013995B1/ru not_active IP Right Cessation
- 2005-12-08 SI SI200532035T patent/SI1828201T1/sl unknown
- 2005-12-08 NZ NZ555496A patent/NZ555496A/en not_active IP Right Cessation
- 2005-12-08 CN CN201110392750.4A patent/CN102532163B/zh not_active Expired - Lifetime
- 2005-12-08 UA UAA200705396A patent/UA91522C2/ru unknown
- 2005-12-08 MX MX2007006820A patent/MX2007006820A/es active IP Right Grant
- 2005-12-08 CN CN2005800420435A patent/CN101072781B/zh not_active Expired - Lifetime
- 2005-12-08 DK DK05826362.5T patent/DK1828201T3/en active
- 2005-12-08 ES ES05826362.5T patent/ES2559305T3/es not_active Expired - Lifetime
- 2005-12-08 US US11/720,693 patent/US20100152174A1/en not_active Abandoned
- 2005-12-08 AU AU2005313350A patent/AU2005313350B2/en not_active Expired
- 2005-12-08 KR KR1020077013133A patent/KR101320431B1/ko not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JO3088B1 (ar) | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف | |
| WO2007003525A3 (en) | Cyclic anilino-pyridinotriazines as gsk-3 inhibitors | |
| CY1121051T1 (el) | Περιεχουσα αζωτο ετεροκυκλικη ενωση και γεωργικο/κηπουρικο σποριοκτονο | |
| ECSP077274A (es) | Derivados de n-2 adamantanil-2-fenoxi-acetamida como inhibidores de deshidrogenasa 11-beta hidroxiesteroide | |
| EA200501045A1 (ru) | Адамантилацетамиды как ингибиторы 11-бета гидроксистероиддегидрогеназы | |
| UA98116C2 (ru) | Изоксазолины, композиция, их применение, способы получения и промежуточные соединения | |
| MX2009008325A (es) | Herbicidas con n-oxido de piridina sustituido. | |
| HRP20080113T3 (hr) | Supstituirani piridinilni i pirimidinilni derivati kao modulatori metabolizma i liječenje bolesti koje su s tim povezane | |
| TN2012000033A1 (en) | Mixtures of mesoionic pesticides | |
| PH12013501489A1 (en) | Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof | |
| NO20056196L (no) | Makrocykliske kinazolinderivater som antiproliferative midler | |
| EA200602058A1 (ru) | Производные адамантилпирролидин-2-она в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы | |
| AR074782A1 (es) | Antranilamidas sustituidas con tetrazol como plaguicidas | |
| CR8986A (es) | Isoxazoles sustituidos como fungicidas | |
| TW200635931A (en) | 2,4(4,6)pyrimidine derivatives | |
| EA200601177A1 (ru) | Пиридо- и пиримидопиримидиновые производные в качестве антипролиферативных агентов | |
| TW200502225A (en) | Heterocyclic compounds useful as nurr-1 activators | |
| UA117151C2 (uk) | N-ациліміногетероциклічні сполуки | |
| PE20070041A1 (es) | Amidas de acido pirazolcarboxilico | |
| ATE510820T1 (de) | Alkoxy-polyester-verbindungen, zusammensetzungen und verwendungsverfahren dafür | |
| MY136824A (en) | Substituted benzoxazinones and uses thereof | |
| EA201070817A1 (ru) | ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-α]ПИРИДИН-2-КАРБОКСАМИДОВ, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ | |
| WO2009027626A3 (en) | Improvements in or relating to organic compounds | |
| PY0435702A (es) | Mezclas fungicidas a base de derivados de carbamato e insecticidas | |
| MXPA03010436A (es) | Amidas biciclicas fusionadas a piridinilo como funguicidas. |