DK1771178T3 - Anvendelse af K-252A og kinaseinhibitorer til forebyggelse eller behandling af HMGB1-assocuerede patologiske tilstande - Google Patents
Anvendelse af K-252A og kinaseinhibitorer til forebyggelse eller behandling af HMGB1-assocuerede patologiske tilstandeInfo
- Publication number
- DK1771178T3 DK1771178T3 DK05778429T DK05778429T DK1771178T3 DK 1771178 T3 DK1771178 T3 DK 1771178T3 DK 05778429 T DK05778429 T DK 05778429T DK 05778429 T DK05778429 T DK 05778429T DK 1771178 T3 DK1771178 T3 DK 1771178T3
- Authority
- DK
- Denmark
- Prior art keywords
- prevention
- treatment
- hmgb1
- kinase inhibitors
- pathological conditions
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59188004P | 2004-07-29 | 2004-07-29 | |
US64700705P | 2005-01-27 | 2005-01-27 | |
PCT/EP2005/008258 WO2006010628A1 (en) | 2004-07-29 | 2005-07-29 | Use of k-252a and kinase inhibitors for the prevention or treatment of hmgb1-associated pathologies |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1771178T3 true DK1771178T3 (da) | 2009-11-02 |
Family
ID=35262096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05778429T DK1771178T3 (da) | 2004-07-29 | 2005-07-29 | Anvendelse af K-252A og kinaseinhibitorer til forebyggelse eller behandling af HMGB1-assocuerede patologiske tilstande |
Country Status (14)
Country | Link |
---|---|
US (1) | US20090191253A2 (da) |
EP (1) | EP1771178B1 (da) |
JP (1) | JP2008508220A (da) |
AT (1) | ATE438404T1 (da) |
AU (1) | AU2005266447A1 (da) |
CA (1) | CA2575272A1 (da) |
DE (1) | DE602005015862D1 (da) |
DK (1) | DK1771178T3 (da) |
ES (1) | ES2327659T3 (da) |
MX (1) | MX2007001155A (da) |
PL (1) | PL1771178T3 (da) |
PT (1) | PT1771178E (da) |
SI (1) | SI1771178T1 (da) |
WO (1) | WO2006010628A1 (da) |
Families Citing this family (29)
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JP2006298858A (ja) * | 2005-04-22 | 2006-11-02 | Yamaguchi Univ | 細胞内寄生性微生物に対し新規抑制効果を有するアポトーシス誘導剤 |
SI1919979T2 (sl) | 2005-08-25 | 2017-07-31 | Creabilis Therapeutics S.P.A. | Polimerni konjugati K-252A in njihovi derivati |
EP1931424A2 (en) * | 2005-09-07 | 2008-06-18 | Laboratoires Serono S.A. | P13k inhibitors for the treatment of endometriosis |
AU2009240884B8 (en) | 2008-04-30 | 2014-03-06 | Genomix Co., Ltd. | Agent for recruitment of bone-marrow-derived pluripotent stem cell into peripheral circulation |
CN102083962B (zh) | 2008-04-30 | 2013-03-27 | 吉诺米克斯股份有限公司 | 生物体内功能性细胞的高效采集方法 |
WO2010034779A2 (en) * | 2008-09-24 | 2010-04-01 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Composition and method for treatment of preterm labor |
US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
JO3101B1 (ar) | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | مشتقات بنزوثيازول كعوامل مضادة للسرطان |
US20100267742A1 (en) * | 2009-04-17 | 2010-10-21 | Rush University Medical Center | Combination targeted therapy for lung cancer |
NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
JP5467313B2 (ja) * | 2009-09-28 | 2014-04-09 | 国立大学法人 岡山大学 | アテローム動脈硬化抑制剤 |
WO2011052668A1 (ja) | 2009-10-28 | 2011-05-05 | 株式会社ジェノミックス | 骨髄間葉系および/または多能性幹細胞の血中動員による組織再生促進剤 |
ES2413437T3 (es) * | 2010-03-10 | 2013-07-16 | Institut Pasteur | HMGB1 y anticuerpos anti-HMGB1 en pacientes infectados por VIH especialmente con trastornos neurológicos |
PT2703487T (pt) | 2011-04-26 | 2018-10-11 | Genomix Co Ltd | Péptido para induzir a regeneração de um tecido e a sua utilização |
FI20115640A0 (fi) | 2011-06-22 | 2011-06-22 | Turun Yliopisto | Yhdistelmähoito |
WO2013082458A1 (en) | 2011-12-02 | 2013-06-06 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
WO2014009609A1 (en) | 2012-07-13 | 2014-01-16 | Turun Yliopisto | Combination therapy iii |
JP6253590B2 (ja) | 2012-10-25 | 2017-12-27 | 株式会社ジェノミックス | Hmgb1断片を利用した脊髄の損傷に対する新規治療法 |
JP6253589B2 (ja) | 2012-10-25 | 2017-12-27 | 株式会社ジェノミックス | Hmgb1断片を利用した新規心筋梗塞の治療法 |
JP2014162752A (ja) * | 2013-02-25 | 2014-09-08 | Dic Corp | 化合物、液晶組成物、及び表示装置 |
JP2014162751A (ja) * | 2013-02-25 | 2014-09-08 | Dic Corp | 化合物、液晶組成物、及び表示装置 |
JP6513795B2 (ja) * | 2014-09-12 | 2019-05-15 | ザ プロクター アンド ギャンブル カンパニー | スキンケア組成物の製造方法 |
US20200039922A1 (en) * | 2016-10-05 | 2020-02-06 | Afecta Pharmaceuticals, Inc. | High mobility group b1 protein inhibitors |
KR102559262B1 (ko) | 2017-01-27 | 2023-07-25 | 가부시키가이샤 스템림 | 심근증, 진구성 심근경색 및 만성심부전의 치료약 |
TWI645083B (zh) * | 2017-08-30 | 2018-12-21 | 金立德 | 篩選抑制發炎反應及血管保護活性物質之方法 |
EP3718561A4 (en) | 2017-12-01 | 2021-07-21 | Stemrim Inc. | Therapy for inflammatory bowel disease |
US11684653B2 (en) * | 2019-03-06 | 2023-06-27 | The Cleveland Clinic Foundation | Compositions and method for reducing virulence of microorganisms |
CN112574221B (zh) * | 2019-09-30 | 2022-03-04 | 上海纽思克生物科技有限公司 | 四环嘧啶酮类化合物、其制备方法、其组合物和用途 |
CN112176066B (zh) * | 2020-10-30 | 2022-07-01 | 中国科学院合肥物质科学研究院 | 一种宫颈病变早期筛查和诊断的分子标志物及其应用 |
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JPS6041489A (ja) * | 1983-08-12 | 1985-03-05 | Kyowa Hakko Kogyo Co Ltd | 新規生理活性物質k―252 |
JPS62155284A (ja) * | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質k−252の誘導体 |
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WO2000021531A1 (fr) * | 1998-10-13 | 2000-04-20 | Kyowa Hakko Kogyo Co., Ltd. | Medicaments pour maladies oculaires |
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DE19917990A1 (de) * | 1999-04-20 | 2000-11-02 | Florian Lang | Arzneimittel enthaltend Hemmstoffe der zellvolumenregulierten humanen Kinase h-sgk |
US20040072888A1 (en) * | 1999-08-19 | 2004-04-15 | Bennett Brydon L. | Methods for treating inflammatory conditions or inhibiting JNK |
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US20010025059A1 (en) * | 2000-01-10 | 2001-09-27 | Kastke Floyd A. | Composition and method for treating non-bacterial prostatitis |
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GB0226251D0 (en) * | 2002-11-11 | 2002-12-18 | San Raffaele Centro Fond | Acetylated protein |
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TWI324604B (en) * | 2003-06-18 | 2010-05-11 | Novartis Ag | New use of staurosporine derivatives |
WO2005014003A1 (en) * | 2003-07-23 | 2005-02-17 | Creabilis Therapeutics S.R.L. | Topical use of tyrosine kinase inhibitors of microbial origin to prevent and treat skin disorders characterised by excessive cell proliferation |
WO2005074921A1 (en) * | 2004-02-09 | 2005-08-18 | University Of Zurich | Treatment of atherosclerosis |
-
2005
- 2005-03-11 MX MX2007001155A patent/MX2007001155A/es active IP Right Grant
- 2005-07-29 US US11/658,701 patent/US20090191253A2/en not_active Abandoned
- 2005-07-29 PT PT05778429T patent/PT1771178E/pt unknown
- 2005-07-29 DK DK05778429T patent/DK1771178T3/da active
- 2005-07-29 JP JP2007523023A patent/JP2008508220A/ja active Pending
- 2005-07-29 EP EP05778429A patent/EP1771178B1/en not_active Not-in-force
- 2005-07-29 ES ES05778429T patent/ES2327659T3/es active Active
- 2005-07-29 PL PL05778429T patent/PL1771178T3/pl unknown
- 2005-07-29 CA CA002575272A patent/CA2575272A1/en not_active Abandoned
- 2005-07-29 DE DE602005015862T patent/DE602005015862D1/de not_active Expired - Fee Related
- 2005-07-29 SI SI200530824T patent/SI1771178T1/sl unknown
- 2005-07-29 AT AT05778429T patent/ATE438404T1/de not_active IP Right Cessation
- 2005-07-29 WO PCT/EP2005/008258 patent/WO2006010628A1/en active Application Filing
- 2005-07-29 AU AU2005266447A patent/AU2005266447A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2327659T3 (es) | 2009-11-02 |
DE602005015862D1 (de) | 2009-09-17 |
EP1771178B1 (en) | 2009-08-05 |
JP2008508220A (ja) | 2008-03-21 |
SI1771178T1 (sl) | 2010-01-29 |
ATE438404T1 (de) | 2009-08-15 |
CA2575272A1 (en) | 2006-02-02 |
MX2007001155A (es) | 2007-08-14 |
US20090191253A2 (en) | 2009-07-30 |
PL1771178T3 (pl) | 2010-01-29 |
US20080317809A1 (en) | 2008-12-25 |
EP1771178A1 (en) | 2007-04-11 |
WO2006010628A1 (en) | 2006-02-02 |
AU2005266447A1 (en) | 2006-02-02 |
PT1771178E (pt) | 2009-11-12 |
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