PT1771178E - Utilização de k-252a e de inibidores de quinase para a prevenção ou o tratamento de patologias associadas a hmgb1 - Google Patents
Utilização de k-252a e de inibidores de quinase para a prevenção ou o tratamento de patologias associadas a hmgb1 Download PDFInfo
- Publication number
- PT1771178E PT1771178E PT05778429T PT05778429T PT1771178E PT 1771178 E PT1771178 E PT 1771178E PT 05778429 T PT05778429 T PT 05778429T PT 05778429 T PT05778429 T PT 05778429T PT 1771178 E PT1771178 E PT 1771178E
- Authority
- PT
- Portugal
- Prior art keywords
- prevention
- treatment
- hmgb1
- kinase inhibitors
- associated pathologies
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59188004P | 2004-07-29 | 2004-07-29 | |
US64700705P | 2005-01-27 | 2005-01-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1771178E true PT1771178E (pt) | 2009-11-12 |
Family
ID=35262096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT05778429T PT1771178E (pt) | 2004-07-29 | 2005-07-29 | Utilização de k-252a e de inibidores de quinase para a prevenção ou o tratamento de patologias associadas a hmgb1 |
Country Status (14)
Country | Link |
---|---|
US (1) | US20090191253A2 (pt) |
EP (1) | EP1771178B1 (pt) |
JP (1) | JP2008508220A (pt) |
AT (1) | ATE438404T1 (pt) |
AU (1) | AU2005266447A1 (pt) |
CA (1) | CA2575272A1 (pt) |
DE (1) | DE602005015862D1 (pt) |
DK (1) | DK1771178T3 (pt) |
ES (1) | ES2327659T3 (pt) |
MX (1) | MX2007001155A (pt) |
PL (1) | PL1771178T3 (pt) |
PT (1) | PT1771178E (pt) |
SI (1) | SI1771178T1 (pt) |
WO (1) | WO2006010628A1 (pt) |
Families Citing this family (29)
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JP2006298858A (ja) * | 2005-04-22 | 2006-11-02 | Yamaguchi Univ | 細胞内寄生性微生物に対し新規抑制効果を有するアポトーシス誘導剤 |
RS53195B2 (sr) | 2005-08-25 | 2018-08-31 | Creabilis Therapeutics Spa | Polimerni konjugati k-252a i njihovi derivati |
BRPI0615654A2 (pt) * | 2005-09-07 | 2011-05-24 | Serono Lab | inibidores da pi3k para o tratamento de endometriose |
JP5676253B2 (ja) | 2008-04-30 | 2015-02-25 | 株式会社ジェノミックス | 生体内機能的細胞の高効率採取法 |
AU2009240884B8 (en) | 2008-04-30 | 2014-03-06 | Genomix Co., Ltd. | Agent for recruitment of bone-marrow-derived pluripotent stem cell into peripheral circulation |
US8933011B2 (en) | 2008-09-24 | 2015-01-13 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Treatment of preterm labor with toll-like receptor 9 antagonists |
US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
JO3101B1 (ar) | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | مشتقات بنزوثيازول كعوامل مضادة للسرطان |
US20100267742A1 (en) * | 2009-04-17 | 2010-10-21 | Rush University Medical Center | Combination targeted therapy for lung cancer |
EP3563842A1 (en) | 2009-04-29 | 2019-11-06 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
JP5467313B2 (ja) * | 2009-09-28 | 2014-04-09 | 国立大学法人 岡山大学 | アテローム動脈硬化抑制剤 |
US11191786B2 (en) | 2009-10-28 | 2021-12-07 | StemRIM Inc. | Agents for promoting tissue regeneration by recruiting bone marrow mesenchymal stem cells and/or pluripotent stem cells into blood |
ES2413437T3 (es) * | 2010-03-10 | 2013-07-16 | Institut Pasteur | HMGB1 y anticuerpos anti-HMGB1 en pacientes infectados por VIH especialmente con trastornos neurológicos |
CA2834255C (en) | 2011-04-26 | 2021-11-02 | Genomix Co., Ltd. | Peptide for inducing regeneration of tissue and use thereof |
FI20115640A0 (fi) | 2011-06-22 | 2011-06-22 | Turun Yliopisto | Yhdistelmähoito |
US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
US10166241B2 (en) | 2012-07-13 | 2019-01-01 | Turun Yliopisto | Combination Therapy III |
WO2014065348A1 (ja) | 2012-10-25 | 2014-05-01 | 株式会社ジェノミックス | Hmgb1断片を利用した脊髄の損傷に対する新規治療法 |
CA2889275C (en) | 2012-10-25 | 2021-06-15 | Katsuto Tamai | Novel method for treating cardiac infarction using hmgb1 fragment |
JP2014162752A (ja) * | 2013-02-25 | 2014-09-08 | Dic Corp | 化合物、液晶組成物、及び表示装置 |
JP2014162751A (ja) * | 2013-02-25 | 2014-09-08 | Dic Corp | 化合物、液晶組成物、及び表示装置 |
US9964534B2 (en) * | 2014-09-12 | 2018-05-08 | The Procter & Gamble Company | Method of making a skin care composition |
EP3522881A4 (en) * | 2016-10-05 | 2020-05-27 | Afecta Pharmaceuticals, Inc. | HIGHLY MOBILE GROUP B1 PROTEIN INHIBITORS |
CN110494154B (zh) | 2017-01-27 | 2023-09-29 | 斯特姆里姆有限公司 | 心肌病、陈旧性心肌梗塞及慢性心力衰竭的治疗剂 |
TWI645083B (zh) * | 2017-08-30 | 2018-12-21 | 金立德 | 篩選抑制發炎反應及血管保護活性物質之方法 |
WO2019107530A1 (ja) | 2017-12-01 | 2019-06-06 | 株式会社ステムリム | 炎症性腸疾患の治療薬 |
US11684653B2 (en) * | 2019-03-06 | 2023-06-27 | The Cleveland Clinic Foundation | Compositions and method for reducing virulence of microorganisms |
CN112574221B (zh) * | 2019-09-30 | 2022-03-04 | 上海纽思克生物科技有限公司 | 四环嘧啶酮类化合物、其制备方法、其组合物和用途 |
CN112176066B (zh) * | 2020-10-30 | 2022-07-01 | 中国科学院合肥物质科学研究院 | 一种宫颈病变早期筛查和诊断的分子标志物及其应用 |
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JPS6041489A (ja) * | 1983-08-12 | 1985-03-05 | Kyowa Hakko Kogyo Co Ltd | 新規生理活性物質k―252 |
JPS62155284A (ja) * | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質k−252の誘導体 |
JPH0699311B2 (ja) * | 1986-11-06 | 1994-12-07 | 旭化成工業株式会社 | 抗血管レン縮剤および血管弛緩剤 |
JPH0826037B2 (ja) * | 1987-01-22 | 1996-03-13 | 協和醗酵工業株式会社 | 生理活性物質k−252の誘導体 |
US5633235A (en) * | 1991-04-19 | 1997-05-27 | Regents Of The University Of Michigan | Triciribine and analogs as antiviral drugs |
EP0541486A1 (de) * | 1991-11-07 | 1993-05-12 | Ciba-Geigy Ag | Polycyclische Konjugate |
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JPH07223958A (ja) * | 1994-02-14 | 1995-08-22 | Asahi Chem Ind Co Ltd | 血管肥厚抑制剤 |
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EP0711557A1 (de) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Pharmazeutische Formulierungsgrundlage |
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UA67725C2 (en) * | 1996-06-03 | 2004-07-15 | Cephalon Inc | K-252a derivatives and a method for improvement of functioning and cell survival enhancement |
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CA2287531A1 (en) * | 1997-03-03 | 1998-09-11 | Board Of Regents, The University Of Texas System | Supression of cyclin kinase 2 activity for prevention and treatment of dna viral infections |
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US5998386A (en) * | 1997-09-19 | 1999-12-07 | Feldman; Arthur M. | Pharmaceutical compositions and method of using same for the treatment of failing myocardial tissue |
DK1079826T3 (da) * | 1998-05-29 | 2003-06-23 | Centre Nat Rech Scient | Anvendelse af indigoide bisindolderivater til fremstilling af et medikament til inhibering af cyclinafhængige kinaser |
US6231889B1 (en) * | 1998-09-21 | 2001-05-15 | Chronorx, Llc | Unit dosage forms for the treatment of herpes simplex |
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DK1131073T3 (da) * | 1998-11-23 | 2004-02-02 | Novartis Ag | Anvendelse af staurosporinderivater til behandling af okulære neovaskulære sygdomme |
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US20040072888A1 (en) * | 1999-08-19 | 2004-04-15 | Bennett Brydon L. | Methods for treating inflammatory conditions or inhibiting JNK |
NZ517578A (en) * | 1999-08-19 | 2004-02-27 | Signal Pharm Inc | Pyrazoloanthrone and derivatives thereof as JNK inhibitors and their compositions |
US20010025059A1 (en) * | 2000-01-10 | 2001-09-27 | Kastke Floyd A. | Composition and method for treating non-bacterial prostatitis |
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WO2002057473A1 (en) * | 2001-01-17 | 2002-07-25 | Young-Mee Park | Method for inhibiting vegf and epo gene expression by quercetin |
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WO2002074242A2 (en) * | 2001-03-16 | 2002-09-26 | Tyler Curiel | Inhibition of toxoplasma gondii) replication by pyridinylimidazoles |
US6703414B2 (en) * | 2001-09-14 | 2004-03-09 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Device and method for treating restenosis |
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GB0226251D0 (en) * | 2002-11-11 | 2002-12-18 | San Raffaele Centro Fond | Acetylated protein |
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AU2003250150A1 (en) * | 2003-07-23 | 2005-02-25 | Creabilis Therapeutics S.R.L. | Topical use of tyrosine kinase inhibitors of microbial origin to prevent and treat skin disorders characterised by excessive cell proliferation |
WO2005074921A1 (en) * | 2004-02-09 | 2005-08-18 | University Of Zurich | Treatment of atherosclerosis |
-
2005
- 2005-03-11 MX MX2007001155A patent/MX2007001155A/es active IP Right Grant
- 2005-07-29 JP JP2007523023A patent/JP2008508220A/ja active Pending
- 2005-07-29 DE DE602005015862T patent/DE602005015862D1/de not_active Expired - Fee Related
- 2005-07-29 EP EP05778429A patent/EP1771178B1/en not_active Not-in-force
- 2005-07-29 ES ES05778429T patent/ES2327659T3/es active Active
- 2005-07-29 AU AU2005266447A patent/AU2005266447A1/en not_active Abandoned
- 2005-07-29 DK DK05778429T patent/DK1771178T3/da active
- 2005-07-29 WO PCT/EP2005/008258 patent/WO2006010628A1/en active Application Filing
- 2005-07-29 PT PT05778429T patent/PT1771178E/pt unknown
- 2005-07-29 US US11/658,701 patent/US20090191253A2/en not_active Abandoned
- 2005-07-29 CA CA002575272A patent/CA2575272A1/en not_active Abandoned
- 2005-07-29 AT AT05778429T patent/ATE438404T1/de not_active IP Right Cessation
- 2005-07-29 PL PL05778429T patent/PL1771178T3/pl unknown
- 2005-07-29 SI SI200530824T patent/SI1771178T1/sl unknown
Also Published As
Publication number | Publication date |
---|---|
EP1771178B1 (en) | 2009-08-05 |
US20080317809A1 (en) | 2008-12-25 |
AU2005266447A1 (en) | 2006-02-02 |
SI1771178T1 (sl) | 2010-01-29 |
JP2008508220A (ja) | 2008-03-21 |
CA2575272A1 (en) | 2006-02-02 |
ATE438404T1 (de) | 2009-08-15 |
EP1771178A1 (en) | 2007-04-11 |
US20090191253A2 (en) | 2009-07-30 |
PL1771178T3 (pl) | 2010-01-29 |
DK1771178T3 (da) | 2009-11-02 |
MX2007001155A (es) | 2007-08-14 |
DE602005015862D1 (de) | 2009-09-17 |
ES2327659T3 (es) | 2009-11-02 |
WO2006010628A1 (en) | 2006-02-02 |
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