CY1107281T1 - Παραγωγα τροπανιου υποκατεστημενα με ιδιδαζοπυριδινη με ενεργοτητα ανταγωνιστη ccr5 υποδοχεα για τη θεραπεια hiv και φλεγμονης - Google Patents

Παραγωγα τροπανιου υποκατεστημενα με ιδιδαζοπυριδινη με ενεργοτητα ανταγωνιστη ccr5 υποδοχεα για τη θεραπεια hiv και φλεγμονης

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Publication number
CY1107281T1
CY1107281T1 CY20081100178T CY081100178T CY1107281T1 CY 1107281 T1 CY1107281 T1 CY 1107281T1 CY 20081100178 T CY20081100178 T CY 20081100178T CY 081100178 T CY081100178 T CY 081100178T CY 1107281 T1 CY1107281 T1 CY 1107281T1
Authority
CY
Cyprus
Prior art keywords
hiv
tropani
ididazopyridine
antagonist activity
ccr5 antagonist
Prior art date
Application number
CY20081100178T
Other languages
English (en)
Inventor
Paul Anthony Stupple
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0323236.0A external-priority patent/GB0323236D0/en
Priority claimed from GB0325020A external-priority patent/GB0325020D0/en
Priority claimed from GB0418566A external-priority patent/GB0418566D0/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of CY1107281T1 publication Critical patent/CY1107281T1/el

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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

Η παρούσα εφεύρεση εξασφαλίζει ενώσεις του τύπου (Ι) όπου R1 και R2 είναι όπως ορίστηκαν ανωτέρω. Οι ενώσεις της παρούσας εφεύρεσης είναι διαμορφωτές, ειδικότερα ανταγωνιστές, της ενεργότητας των υποδοχέων των CCR5 χημοκινών. Οι διαμορφωτές του CCR5 υποδοχέα μπορούν να είναι χρήσιμοι στην θεραπεία διαφόρων φλεγμονωδών ασθενειών και καταστάσεων, και στη θεραπεία της μόλυνσης από ΗIV και γενετικά συναφών ρετροϊών.
CY20081100178T 2003-10-03 2008-02-14 Παραγωγα τροπανιου υποκατεστημενα με ιδιδαζοπυριδινη με ενεργοτητα ανταγωνιστη ccr5 υποδοχεα για τη θεραπεια hiv και φλεγμονης CY1107281T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0323236.0A GB0323236D0 (en) 2003-10-03 2003-10-03 Chemical compounds
GB0325020A GB0325020D0 (en) 2003-10-27 2003-10-27 Chemical compounds
GB0418566A GB0418566D0 (en) 2004-08-19 2004-08-19 Tropane derivatives
EP04769496A EP1682545B1 (en) 2003-10-03 2004-09-28 Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation

Publications (1)

Publication Number Publication Date
CY1107281T1 true CY1107281T1 (el) 2012-11-21

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US (2) US7309790B2 (el)
EP (1) EP1682545B1 (el)
JP (1) JP4874107B2 (el)
KR (1) KR100777885B1 (el)
AP (1) AP2174A (el)
AR (1) AR045856A1 (el)
AT (1) ATE380813T1 (el)
AU (1) AU2004278158B2 (el)
BR (1) BRPI0414862A (el)
CA (1) CA2540834C (el)
CY (1) CY1107281T1 (el)
DE (1) DE602004010708T2 (el)
DK (1) DK1682545T3 (el)
EA (1) EA009941B1 (el)
EC (1) ECSP066475A (el)
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GE (1) GEP20084417B (el)
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