DE602004010708D1 - Imidazopyridinsubstituierte tropanderivate mit ccr5-rezeptorantagonistischer wirkung zur behandlung von hiv und entzündungen - Google Patents

Imidazopyridinsubstituierte tropanderivate mit ccr5-rezeptorantagonistischer wirkung zur behandlung von hiv und entzündungen

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Publication number
DE602004010708D1
DE602004010708D1 DE602004010708T DE602004010708T DE602004010708D1 DE 602004010708 D1 DE602004010708 D1 DE 602004010708D1 DE 602004010708 T DE602004010708 T DE 602004010708T DE 602004010708 T DE602004010708 T DE 602004010708T DE 602004010708 D1 DE602004010708 D1 DE 602004010708D1
Authority
DE
Germany
Prior art keywords
tropanderivates
receptorantagonistic
imidazopyridine
ccr5
hiv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004010708T
Other languages
English (en)
Other versions
DE602004010708T2 (de
Inventor
Paul Anthony Stupple
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0323236.0A external-priority patent/GB0323236D0/en
Priority claimed from GB0325020A external-priority patent/GB0325020D0/en
Priority claimed from GB0418566A external-priority patent/GB0418566D0/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE602004010708D1 publication Critical patent/DE602004010708D1/de
Application granted granted Critical
Publication of DE602004010708T2 publication Critical patent/DE602004010708T2/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DE602004010708T 2003-10-03 2004-09-28 Imidazopyridinsubstituierte tropanderivate mit ccr5-rezeptorantagonistischer wirkung zur behandlung von hiv und entzündungen Active DE602004010708T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB0323236.0A GB0323236D0 (en) 2003-10-03 2003-10-03 Chemical compounds
GB0323236 2003-10-03
GB0325020A GB0325020D0 (en) 2003-10-27 2003-10-27 Chemical compounds
GB0325020 2003-10-27
GB0418566A GB0418566D0 (en) 2004-08-19 2004-08-19 Tropane derivatives
GB0418566 2004-08-19
PCT/IB2004/003153 WO2005033107A1 (en) 2003-10-03 2004-09-28 Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation

Publications (2)

Publication Number Publication Date
DE602004010708D1 true DE602004010708D1 (de) 2008-01-24
DE602004010708T2 DE602004010708T2 (de) 2008-12-04

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DE602004010708T Active DE602004010708T2 (de) 2003-10-03 2004-09-28 Imidazopyridinsubstituierte tropanderivate mit ccr5-rezeptorantagonistischer wirkung zur behandlung von hiv und entzündungen

Country Status (35)

Country Link
US (2) US7309790B2 (de)
EP (1) EP1682545B1 (de)
JP (1) JP4874107B2 (de)
KR (1) KR100777885B1 (de)
AP (1) AP2174A (de)
AR (1) AR045856A1 (de)
AT (1) ATE380813T1 (de)
AU (1) AU2004278158B2 (de)
BR (1) BRPI0414862A (de)
CA (1) CA2540834C (de)
CY (1) CY1107281T1 (de)
DE (1) DE602004010708T2 (de)
DK (1) DK1682545T3 (de)
EA (1) EA009941B1 (de)
EC (1) ECSP066475A (de)
ES (1) ES2295924T3 (de)
GE (1) GEP20084417B (de)
HN (1) HN2004000383A (de)
HR (1) HRP20080052T3 (de)
IL (1) IL174208A0 (de)
MA (1) MA28080A1 (de)
MX (1) MXPA06003749A (de)
MY (1) MY137609A (de)
NO (1) NO20061978L (de)
NZ (1) NZ545837A (de)
OA (1) OA13266A (de)
PA (1) PA8614301A1 (de)
PE (1) PE20050961A1 (de)
PL (1) PL1682545T3 (de)
PT (1) PT1682545E (de)
RS (1) RS20060198A (de)
SI (1) SI1682545T1 (de)
TW (1) TWI280244B (de)
UY (1) UY28546A1 (de)
WO (1) WO2005033107A1 (de)

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TW201300360A (zh) 2010-11-01 2013-01-01 Portola Pharm Inc 做為ｊａｋ激酶調節劑之菸鹼醯胺
EP2741777B1 (de) 2011-08-12 2017-01-18 INSERM - Institut National de la Santé et de la Recherche Médicale Verfahren und pharmazeutische zusammensetzungen zur behandlung von pulmonaler hypertonie
BR112014012396B1 (pt) 2011-11-23 2020-08-25 Portola Pharmaceuticals, Inc inibidores de pirazina quinase, composição, método in vitro para inibição de quinase syk ou via de transdução de sinal, uso dos referidos inibidores e kit
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US20050131011A1 (en) 2005-06-16
TW200519112A (en) 2005-06-16
TWI280244B (en) 2007-05-01
DE602004010708T2 (de) 2008-12-04
NO20061978L (no) 2006-07-03
IL174208A0 (en) 2006-08-01
ATE380813T1 (de) 2007-12-15
AU2004278158B2 (en) 2009-08-13
EP1682545B1 (de) 2007-12-12
CA2540834A1 (en) 2005-04-14
HRP20080052T3 (en) 2008-02-29
OA13266A (en) 2007-01-31
WO2005033107A1 (en) 2005-04-14
KR100777885B1 (ko) 2007-11-28
NZ545837A (en) 2009-12-24
DK1682545T3 (da) 2008-03-17
PA8614301A1 (es) 2005-05-10
PT1682545E (pt) 2008-02-11
US20080045563A1 (en) 2008-02-21
CY1107281T1 (el) 2012-11-21
ECSP066475A (es) 2006-10-10
JP4874107B2 (ja) 2012-02-15
SI1682545T1 (sl) 2008-04-30
CA2540834C (en) 2010-06-22
MY137609A (en) 2009-02-27
MA28080A1 (fr) 2006-08-01
ES2295924T3 (es) 2008-04-16
EA009941B1 (ru) 2008-04-28
US7309790B2 (en) 2007-12-18
RS20060198A (en) 2008-09-29
PL1682545T3 (pl) 2008-04-30
AU2004278158A1 (en) 2005-04-14
AP2006003580A0 (en) 2006-04-30
GEP20084417B (en) 2008-07-10
EP1682545A1 (de) 2006-07-26
EA200600480A1 (ru) 2006-08-25
HN2004000383A (es) 2008-10-14
AP2174A (en) 2010-11-20
MXPA06003749A (es) 2006-06-14
AR045856A1 (es) 2005-11-16
PE20050961A1 (es) 2005-11-29
JP2007507483A (ja) 2007-03-29
KR20060070571A (ko) 2006-06-23
UY28546A1 (es) 2005-05-31
US7790740B2 (en) 2010-09-07
BRPI0414862A (pt) 2006-11-28

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