NO20061978L - Imidazopyridinsubstituerte tropanderivater med CCR5-reseptorantagonist aktivitet for behandling av HIV og inflammasjon - Google Patents

Imidazopyridinsubstituerte tropanderivater med CCR5-reseptorantagonist aktivitet for behandling av HIV og inflammasjon

Info

Publication number
NO20061978L
NO20061978L NO20061978A NO20061978A NO20061978L NO 20061978 L NO20061978 L NO 20061978L NO 20061978 A NO20061978 A NO 20061978A NO 20061978 A NO20061978 A NO 20061978A NO 20061978 L NO20061978 L NO 20061978L
Authority
NO
Norway
Prior art keywords
treatment
hiv
imidazopyridine
inflammation
receptor antagonist
Prior art date
Application number
NO20061978A
Other languages
English (en)
Inventor
Paul Anthony Stupple
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0323236.0A external-priority patent/GB0323236D0/en
Priority claimed from GB0325020A external-priority patent/GB0325020D0/en
Priority claimed from GB0418566A external-priority patent/GB0418566D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of NO20061978L publication Critical patent/NO20061978L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • AIDS & HIV (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer forbindelser med formel (I) hvori R1 og R2 er som definert ovenfor. Forbindelsene ifølge oppfinnelsen er modulatorer, særlig antagonister av aktiviteten til kjemokin CCR5-reseptorer. Modulatorer av CCR5-reseptoren kan være anvendelig ved behandling av forskjellige inflammasjonssykdommer og tilstander og ved behandling av infeksjon ved HIV og genetisk relaterte retroviruser.
NO20061978A 2003-10-03 2006-05-03 Imidazopyridinsubstituerte tropanderivater med CCR5-reseptorantagonist aktivitet for behandling av HIV og inflammasjon NO20061978L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB0323236.0A GB0323236D0 (en) 2003-10-03 2003-10-03 Chemical compounds
GB0325020A GB0325020D0 (en) 2003-10-27 2003-10-27 Chemical compounds
GB0418566A GB0418566D0 (en) 2004-08-19 2004-08-19 Tropane derivatives
PCT/IB2004/003153 WO2005033107A1 (en) 2003-10-03 2004-09-28 Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation

Publications (1)

Publication Number Publication Date
NO20061978L true NO20061978L (no) 2006-07-03

Family

ID=34426592

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061978A NO20061978L (no) 2003-10-03 2006-05-03 Imidazopyridinsubstituerte tropanderivater med CCR5-reseptorantagonist aktivitet for behandling av HIV og inflammasjon

Country Status (35)

Country Link
US (2) US7309790B2 (no)
EP (1) EP1682545B1 (no)
JP (1) JP4874107B2 (no)
KR (1) KR100777885B1 (no)
AP (1) AP2174A (no)
AR (1) AR045856A1 (no)
AT (1) ATE380813T1 (no)
AU (1) AU2004278158B2 (no)
BR (1) BRPI0414862A (no)
CA (1) CA2540834C (no)
CY (1) CY1107281T1 (no)
DE (1) DE602004010708T2 (no)
DK (1) DK1682545T3 (no)
EA (1) EA009941B1 (no)
EC (1) ECSP066475A (no)
ES (1) ES2295924T3 (no)
GE (1) GEP20084417B (no)
HN (1) HN2004000383A (no)
HR (1) HRP20080052T3 (no)
IL (1) IL174208A0 (no)
MA (1) MA28080A1 (no)
MX (1) MXPA06003749A (no)
MY (1) MY137609A (no)
NO (1) NO20061978L (no)
NZ (1) NZ545837A (no)
OA (1) OA13266A (no)
PA (1) PA8614301A1 (no)
PE (1) PE20050961A1 (no)
PL (1) PL1682545T3 (no)
PT (1) PT1682545E (no)
RS (1) RS20060198A (no)
SI (1) SI1682545T1 (no)
TW (1) TWI280244B (no)
UY (1) UY28546A1 (no)
WO (1) WO2005033107A1 (no)

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WO2005033107A1 (en) 2005-04-14
CA2540834C (en) 2010-06-22
ES2295924T3 (es) 2008-04-16
US7309790B2 (en) 2007-12-18
HRP20080052T3 (en) 2008-02-29
US20050131011A1 (en) 2005-06-16
US20080045563A1 (en) 2008-02-21
AP2174A (en) 2010-11-20
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CA2540834A1 (en) 2005-04-14
MXPA06003749A (es) 2006-06-14
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US7790740B2 (en) 2010-09-07
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MA28080A1 (fr) 2006-08-01
ATE380813T1 (de) 2007-12-15
DE602004010708T2 (de) 2008-12-04
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PT1682545E (pt) 2008-02-11
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DK1682545T3 (da) 2008-03-17
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MY137609A (en) 2009-02-27
BRPI0414862A (pt) 2006-11-28
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