WO1999023078A3 - Neue carbonsäurederivate, die amidseitenketten tragen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten - Google Patents

Neue carbonsäurederivate, die amidseitenketten tragen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten Download PDF

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Publication number
WO1999023078A3
WO1999023078A3 PCT/EP1998/006571 EP9806571W WO9923078A3 WO 1999023078 A3 WO1999023078 A3 WO 1999023078A3 EP 9806571 W EP9806571 W EP 9806571W WO 9923078 A3 WO9923078 A3 WO 9923078A3
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WO
WIPO (PCT)
Prior art keywords
carboxylic acid
acid derivatives
production
optionally substituted
receptor antagonists
Prior art date
Application number
PCT/EP1998/006571
Other languages
English (en)
French (fr)
Other versions
WO1999023078A2 (de
Inventor
Wilhelm Amberg
Rolf Jansen
Stefan Hergenroeder
Manfred Raschack
Liliane Unger
Original Assignee
Basf Ag
Wilhelm Amberg
Rolf Jansen
Stefan Hergenroeder
Manfred Raschack
Liliane Unger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19752904A external-priority patent/DE19752904A1/de
Priority claimed from DE1998109376 external-priority patent/DE19809376A1/de
Priority to CA002307770A priority Critical patent/CA2307770A1/en
Priority to AU22661/99A priority patent/AU2266199A/en
Priority to SK459-2000A priority patent/SK4592000A3/sk
Priority to NZ504316A priority patent/NZ504316A/xx
Priority to US09/529,860 priority patent/US6509341B1/en
Priority to IL13534798A priority patent/IL135347A0/xx
Application filed by Basf Ag, Wilhelm Amberg, Rolf Jansen, Stefan Hergenroeder, Manfred Raschack, Liliane Unger filed Critical Basf Ag
Priority to KR1020007004703A priority patent/KR20010031650A/ko
Priority to EP98966230A priority patent/EP1027338A2/de
Priority to HU0100054A priority patent/HUP0100054A3/hu
Priority to JP2000518953A priority patent/JP2001521927A/ja
Priority to BR9814951-2A priority patent/BR9814951A/pt
Publication of WO1999023078A2 publication Critical patent/WO1999023078A2/de
Publication of WO1999023078A3 publication Critical patent/WO1999023078A3/de
Priority to NO20002124A priority patent/NO20002124D0/no
Priority to BG104396A priority patent/BG104396A/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Die vorliegende Erfindung betrifft Carbonsäurederivate der Formel (I), wobei R6 eine Gruppe (a) oder (b) wobei R?13 und R14¿ gleich oder verschieden sein können und folgende Bedeutung haben; Wasserstoff mit der Maßgabe, daß R?13 und R14¿ nicht gleichzeitig Wasserstoff sein dürfen, C¿1?-C8-Alkyl, C3-C8-Cycloalkyl, C3-C8-Alkenyl, C3-C8-Alkinyl, Benzyl, Phenyl, Naphthyl, jeweils gegebenenfalls substituiert, oder R?13 und R14¿ bilden gemeinsam eine zu einem Ring geschlossene, gegebenenfalls substituierte C¿3?-C7-Alkylenkette, in der eine Alkylengruppe durch Sauerstoff, Schwefel oder Stickstoff ersetzt sein kann, oder R?13 und R14¿ bilden gemeinsam eine zu einem Ring geschlossene, gegebenenfalls substituierte C¿3?-C7-Alkylenkette oder C3-C7-Alkenylenkette, an die ein gegebenfalls substituierter Phenylring annelliert ist; und wobei die anderen Substituenten die in der Beschreibung erläuterte Bedeutung haben, die Herstellung von Verwendung als Endothelinrezeptorantagonisten.
PCT/EP1998/006571 1997-10-31 1998-10-16 Neue carbonsäurederivate, die amidseitenketten tragen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten WO1999023078A2 (de)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP2000518953A JP2001521927A (ja) 1997-10-31 1998-10-16 アミド側鎖を有する新規のカルボン酸誘導体、その製造およびエンドセリン受容体アンタゴニストとしての使用
BR9814951-2A BR9814951A (pt) 1997-10-31 1998-10-16 Derivado de ácido carboxìlico, uso do mesmo, preparação de medicamento para o uso oral, parenteral, combinação, uso de compostos, fragmento estrutural, uso do mesmo, antagonista de receptor de endotelina, e, composto
KR1020007004703A KR20010031650A (ko) 1997-10-31 1998-10-16 아마이도 측쇄를 가지는 신규한 카르복실산 유도체, 그의제법 및 엔도셀린 수용체 길항제로서의 용도
SK459-2000A SK4592000A3 (en) 1997-10-31 1998-10-16 Novel carboxylic acid derivatives which carry amide side chains, production of said carboxylic acid derivatives and their use as endothelin receptor antagonists
NZ504316A NZ504316A (en) 1997-10-31 1998-10-16 Pyrimidine substituted carboxylic acid derivatives which have amido side-chains useful as endothelin receptor antagonists
US09/529,860 US6509341B1 (en) 1997-10-31 1998-10-16 Carboxylic acid derivatives, carrying amido side-chains; production and use as endothelin receptor antagonists
IL13534798A IL135347A0 (en) 1997-10-31 1998-10-16 New carboxylic acid derivatives, carrying amido side-chains; production and use as endothelin receptor antagonists
CA002307770A CA2307770A1 (en) 1997-10-31 1998-10-16 Novel carboxylic acid derivatives which carry amide side chains, production of said carboxylic acid derivatives and their use as endothelin receptor antagonists
AU22661/99A AU2266199A (en) 1997-10-31 1998-10-16 New carboxylic acid derivatives, carrying amido side-chains; production and use as endothelin receptor antagonists
EP98966230A EP1027338A2 (de) 1997-10-31 1998-10-16 Neue carbonsäurederivate, die amidseitenketten tragen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten
HU0100054A HUP0100054A3 (en) 1997-10-31 1998-10-16 Pyrimidinyloxi carboxylic acid derivatives, carrying amido side-chains, process for producing them, their use and medicaments containing the same
NO20002124A NO20002124D0 (no) 1997-10-31 2000-04-26 Nye karboksylsyrederivater med amid-sidekjeder, deres fremstilling og anvendelse som endothelin-reseptorantagonister
BG104396A BG104396A (en) 1997-10-31 2000-05-02 New carboxylic acid derivatives, carrying amido side-chains, production and use as endothelin receptor antagonists

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE19748238 1997-10-31
DE19748238.4 1997-10-31
DE19752904A DE19752904A1 (de) 1997-10-31 1997-11-28 Neue Carbonsäurederivate, die Amidseitenketten tragen, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten
DE19752904.6 1997-11-28
DE19809376.4 1998-03-05
DE1998109376 DE19809376A1 (de) 1998-03-05 1998-03-05 Neue Carbonsäurederivate, die Amidseitenketten tragen, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten

Publications (2)

Publication Number Publication Date
WO1999023078A2 WO1999023078A2 (de) 1999-05-14
WO1999023078A3 true WO1999023078A3 (de) 1999-09-10

Family

ID=27217881

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/006571 WO1999023078A2 (de) 1997-10-31 1998-10-16 Neue carbonsäurederivate, die amidseitenketten tragen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten

Country Status (18)

Country Link
US (1) US6509341B1 (de)
EP (1) EP1027338A2 (de)
JP (1) JP2001521927A (de)
CN (1) CN1278251A (de)
AU (1) AU2266199A (de)
BG (1) BG104396A (de)
BR (1) BR9814951A (de)
CA (1) CA2307770A1 (de)
HR (1) HRP980560A2 (de)
HU (1) HUP0100054A3 (de)
ID (1) ID24278A (de)
IL (1) IL135347A0 (de)
NO (1) NO20002124D0 (de)
NZ (1) NZ504316A (de)
PL (1) PL340871A1 (de)
SK (1) SK4592000A3 (de)
TR (1) TR200001182T2 (de)
WO (1) WO1999023078A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19806438A1 (de) * 1998-02-17 1999-08-19 Basf Ag Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung
DE19933164A1 (de) * 1999-07-20 2001-01-25 Basf Ag Neue Carbonsäurederivate mit 5,6 substituiertem Pyrimidinring, ihre Herstellung und Verwendung als Endothelin Rezeptorantagonisten
AU779266B2 (en) * 2000-05-11 2005-01-13 Banyu Pharmaceutical Co., Ltd. N-acyltetrahydroisoquinoline derivatives
DE10025728A1 (de) * 2000-05-25 2001-11-29 Basf Ag Neue Carbamate und Harnstoffe, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten
WO2002064573A1 (de) * 2001-02-14 2002-08-22 Abbott Gmbh & Co. Kg Neue carbonsäurederivate mit alkylsubstituierten triazinen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten
DE60120104T2 (de) 2001-03-20 2006-09-21 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz
DE60100055T2 (de) 2001-03-21 2003-07-24 Sanol Arznei Schwarz Gmbh Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen
EP1734980A1 (de) 2004-04-16 2006-12-27 Schwarz Pharma Ag Verwendung peptidähnlicher verbindungen zur vorbeugung und behandlung chronischer kopfschmerzen
EP1604656A1 (de) 2004-06-09 2005-12-14 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen zur Behandlung von amyotropher Lateralsklerose (ALS)
PL1781276T3 (pl) 2004-08-27 2010-11-30 Ucb Pharma Gmbh Zastosowanie związków peptydowych do leczenia bólu związanego z rakiem kości, bólu indukowanego przez chemioterapię oraz nukleozydy
RU2435585C2 (ru) * 2006-04-13 2011-12-10 Актелион Фармасьютиклз Лтд Антагонисты рецептора эндотелина, предназначенные для ранней стадии идиопатического фиброза легких
EP2037965B1 (de) 2006-06-15 2017-08-30 UCB Pharma GmbH Pharmazeutische zusammensetzung mit synergistischer antikonvulsiver wirkung

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19614534A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4313412A1 (de) * 1993-04-23 1994-10-27 Basf Ag 3-(Het)aryl-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung
DE4313413A1 (de) * 1993-04-23 1994-10-27 Basf Ag 3-(Het)aryloxy(thio)-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung
DE4411225A1 (de) 1994-03-31 1995-10-05 Basf Ag Verwendung von Carbonsäurederivaten als Arzneimittel
DE19533023B4 (de) * 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19614534A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
WO1997038980A1 (de) * 1996-04-12 1997-10-23 Basf Aktiengesellschaft Neue carbonsäurederivate, ihre herstellung und verwendung

Also Published As

Publication number Publication date
CN1278251A (zh) 2000-12-27
HRP980560A2 (en) 1999-08-31
NO20002124L (no) 2000-04-26
NZ504316A (en) 2002-12-20
HUP0100054A1 (hu) 2002-02-28
WO1999023078A2 (de) 1999-05-14
HUP0100054A3 (en) 2002-03-28
CA2307770A1 (en) 1999-05-14
SK4592000A3 (en) 2000-12-11
JP2001521927A (ja) 2001-11-13
BR9814951A (pt) 2000-10-03
EP1027338A2 (de) 2000-08-16
NO20002124D0 (no) 2000-04-26
PL340871A1 (en) 2001-03-12
AU2266199A (en) 1999-05-24
ID24278A (id) 2000-07-13
IL135347A0 (en) 2001-05-20
US6509341B1 (en) 2003-01-21
TR200001182T2 (tr) 2000-11-21
BG104396A (en) 2001-02-28

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