DK1492789T3 - Tropanderivater som CCR5-modulatorer - Google Patents
Tropanderivater som CCR5-modulatorerInfo
- Publication number
- DK1492789T3 DK1492789T3 DK03710080T DK03710080T DK1492789T3 DK 1492789 T3 DK1492789 T3 DK 1492789T3 DK 03710080 T DK03710080 T DK 03710080T DK 03710080 T DK03710080 T DK 03710080T DK 1492789 T3 DK1492789 T3 DK 1492789T3
- Authority
- DK
- Denmark
- Prior art keywords
- tropane derivatives
- ccr5 modulators
- ccr5
- modulators
- tropane
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0208071.1A GB0208071D0 (en) | 2002-04-08 | 2002-04-08 | Tropane derivatives useful in therapy |
GB0301575A GB0301575D0 (en) | 2003-01-23 | 2003-01-23 | Tropane derivatives useful in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1492789T3 true DK1492789T3 (da) | 2006-09-11 |
Family
ID=28793308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03710080T DK1492789T3 (da) | 2002-04-08 | 2003-03-31 | Tropanderivater som CCR5-modulatorer |
Country Status (41)
Country | Link |
---|---|
EP (1) | EP1492789B1 (da) |
JP (2) | JP3793200B2 (da) |
KR (1) | KR100734685B1 (da) |
CN (1) | CN1324025C (da) |
AP (1) | AP1789A (da) |
AR (1) | AR039383A1 (da) |
AT (1) | ATE328882T1 (da) |
AU (1) | AU2003214503B2 (da) |
BR (1) | BR0309118A (da) |
CA (1) | CA2481482C (da) |
CR (1) | CR7514A (da) |
CU (1) | CU23282A3 (da) |
CY (1) | CY1106114T1 (da) |
DE (1) | DE60305903T2 (da) |
DK (1) | DK1492789T3 (da) |
DO (1) | DOP2003000624A (da) |
EA (1) | EA007590B1 (da) |
ES (1) | ES2263960T3 (da) |
GE (1) | GEP20074210B (da) |
HK (1) | HK1076102A1 (da) |
HN (1) | HN2003000114A (da) |
HR (1) | HRP20040940A2 (da) |
IL (1) | IL164261A0 (da) |
IS (1) | IS2577B (da) |
MA (1) | MA27190A1 (da) |
MX (1) | MXPA04009220A (da) |
MY (1) | MY134223A (da) |
NI (1) | NI200300053A (da) |
NO (1) | NO329674B1 (da) |
NZ (1) | NZ535452A (da) |
OA (1) | OA12798A (da) |
PA (1) | PA8570801A1 (da) |
PE (1) | PE20040082A1 (da) |
PL (1) | PL372968A1 (da) |
PT (1) | PT1492789E (da) |
RS (1) | RS51550B (da) |
SI (1) | SI1492789T1 (da) |
TN (1) | TNSN04194A1 (da) |
TW (1) | TWI280130B (da) |
UY (1) | UY27752A1 (da) |
WO (1) | WO2003084954A1 (da) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6855724B2 (en) | 2002-04-08 | 2005-02-15 | Agouron Pharmaceuticals, Inc. | Tropane derivatives useful in therapy |
BR0309118A (pt) * | 2002-04-08 | 2005-02-01 | Pfizer | Derivados de tropano úteis em terapêutica |
CA2579609A1 (en) | 2003-09-10 | 2005-03-17 | Virochem Pharma Inc. | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity |
SI1682545T1 (sl) * | 2003-10-03 | 2008-04-30 | Pfizer | Derivati tropana, substituirani z imidazopiridinom, z antagonisticno aktivnostjo receptorja CCR5 zazdravljenje HIV in vnetja |
TW200533348A (en) | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
US8131026B2 (en) | 2004-04-16 | 2012-03-06 | Validity Sensors, Inc. | Method and apparatus for fingerprint image reconstruction |
WO2006041780A1 (en) | 2004-10-04 | 2006-04-20 | Validity Sensors, Inc. | Fingerprint sensing assemblies comprising a substrate |
WO2006064340A2 (en) * | 2004-12-13 | 2006-06-22 | Pfizer Limited | Process for the preparation of n-acyl beta-aminoaldehydes |
WO2008063600A2 (en) * | 2006-11-17 | 2008-05-29 | Concert Pharmaceuticals Inc. | Triazolyl tropane derivatives |
PL2134712T3 (pl) | 2007-04-13 | 2014-01-31 | Dong Wha Pharm Co Ltd | Asparaginian kwasu 1-cyklopropylo-6-fluoro-7-(8-metoksyimino-2,6-diaza-spiro[3.4]okt-6-ylo)-4-okso-1,4-dihydro-[1,8]naftyrydyno-3-karboksylowego, sposób jego wytwarzania i zawierająca go przeciwdrobnoustrojowa kompozycja farmaceutyczna |
WO2009029257A1 (en) * | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Disubstituted alkyl-8-azabicyclo [3.2.1.] octane compounds as mu opioid receptor antagonists |
CN101712679B (zh) * | 2008-10-08 | 2013-04-10 | 中国科学院上海药物研究所 | 一种酰胺类化合物、其药物组合物及其制备方法和用途 |
CA2778206A1 (en) * | 2009-11-21 | 2011-05-26 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
EA201200855A1 (ru) | 2009-12-23 | 2013-04-30 | Айронвуд Фармасьютикелз, Инк. | Модуляторы crth2 |
PE20130529A1 (es) | 2010-04-02 | 2013-05-14 | Phivco 1 Llc | Terapia de combinacion que comprende un antagonista de ccr5, un inhibidor de proteasa de vih-1, y un potenciador farmacocinetico |
US20130216552A1 (en) | 2010-07-12 | 2013-08-22 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
US20130259830A1 (en) | 2010-07-12 | 2013-10-03 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
EP2741777B1 (en) | 2011-08-12 | 2017-01-18 | INSERM - Institut National de la Santé et de la Recherche Médicale | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
CN103159754A (zh) * | 2011-12-19 | 2013-06-19 | 中国科学院上海药物研究所 | 一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途 |
JP6146990B2 (ja) * | 2012-11-16 | 2017-06-14 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化されたcftr増強物質 |
GB201321748D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
GB201321749D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
AU2016243171B2 (en) | 2015-03-31 | 2020-10-08 | Concert Pharmaceuticals, Inc. | Deuterated VX-661 |
US10759721B2 (en) | 2015-09-25 | 2020-09-01 | Vertex Pharmaceuticals (Europe) Limited | Deuterated CFTR potentiators |
JP2017105824A (ja) * | 2017-02-10 | 2017-06-15 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化されたcftr増強物質 |
CN117924170A (zh) | 2017-12-01 | 2024-04-26 | 弗特克斯药品有限公司 | 用于制备囊性纤维化跨膜传导调节因子的调节剂的方法 |
US11649235B2 (en) | 2018-03-19 | 2023-05-16 | Emory University | Pan-tropic entry inhibitors |
JP6654223B2 (ja) * | 2018-08-13 | 2020-02-26 | バーテックス ファーマシューティカルズ (ヨーロッパ) リミテッド | 重水素化されたcftr増強物質 |
US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20001420A1 (es) * | 1998-12-23 | 2000-12-18 | Pfizer | Moduladores de ccr5 |
WO2001080106A1 (fr) * | 2000-04-19 | 2001-10-25 | Satoshi Yamazaki | Procede de diffusion d'outil publicitaire et support magnetique pour le logiciel |
PT1526134E (pt) * | 2000-05-26 | 2008-10-28 | Pfizer | Derivados de triazoliltropano como moduladores de ccr5 |
BR0309118A (pt) * | 2002-04-08 | 2005-02-01 | Pfizer | Derivados de tropano úteis em terapêutica |
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2003
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- 2003-03-31 AU AU2003214503A patent/AU2003214503B2/en not_active Ceased
- 2003-03-31 SI SI200330319T patent/SI1492789T1/sl unknown
- 2003-03-31 PT PT03710080T patent/PT1492789E/pt unknown
- 2003-03-31 MX MXPA04009220A patent/MXPA04009220A/es active IP Right Grant
- 2003-03-31 AP APAP/P/2004/003147A patent/AP1789A/en active
- 2003-03-31 IL IL16426103A patent/IL164261A0/xx unknown
- 2003-03-31 PL PL03372968A patent/PL372968A1/xx unknown
- 2003-03-31 KR KR1020047016104A patent/KR100734685B1/ko not_active IP Right Cessation
- 2003-03-31 AT AT03710080T patent/ATE328882T1/de active
- 2003-03-31 CA CA002481482A patent/CA2481482C/en not_active Expired - Lifetime
- 2003-03-31 WO PCT/IB2003/001220 patent/WO2003084954A1/en active IP Right Grant
- 2003-03-31 DE DE60305903T patent/DE60305903T2/de not_active Expired - Lifetime
- 2003-03-31 OA OA1200400262A patent/OA12798A/en unknown
- 2003-03-31 ES ES03710080T patent/ES2263960T3/es not_active Expired - Lifetime
- 2003-03-31 NZ NZ535452A patent/NZ535452A/en not_active IP Right Cessation
- 2003-03-31 EA EA200401167A patent/EA007590B1/ru not_active IP Right Cessation
- 2003-03-31 DK DK03710080T patent/DK1492789T3/da active
- 2003-03-31 RS YUP-888/04A patent/RS51550B/en unknown
- 2003-03-31 GE GEAP8437A patent/GEP20074210B/en unknown
- 2003-03-31 JP JP2003582151A patent/JP3793200B2/ja not_active Expired - Lifetime
- 2003-03-31 CN CNB03807639XA patent/CN1324025C/zh not_active Expired - Fee Related
- 2003-03-31 EP EP03710080A patent/EP1492789B1/en not_active Expired - Lifetime
- 2003-04-04 NI NI200300053A patent/NI200300053A/es unknown
- 2003-04-04 MY MYPI20031257A patent/MY134223A/en unknown
- 2003-04-04 PE PE2003000346A patent/PE20040082A1/es not_active Application Discontinuation
- 2003-04-04 DO DO2003000624A patent/DOP2003000624A/es unknown
- 2003-04-07 UY UY27752A patent/UY27752A1/es unknown
- 2003-04-07 HN HN2003000114A patent/HN2003000114A/es unknown
- 2003-04-07 AR ARP030101205A patent/AR039383A1/es unknown
- 2003-04-07 TW TW092107880A patent/TWI280130B/zh not_active IP Right Cessation
- 2003-04-08 PA PA20038570801A patent/PA8570801A1/es unknown
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2004
- 2004-09-16 IS IS7453A patent/IS2577B/is unknown
- 2004-09-29 MA MA27883A patent/MA27190A1/fr unknown
- 2004-10-06 TN TNP2004000194A patent/TNSN04194A1/fr unknown
- 2004-10-07 HR HR20040940A patent/HRP20040940A2/hr not_active Application Discontinuation
- 2004-10-07 CU CU20040219A patent/CU23282A3/es unknown
- 2004-10-07 CR CR7514A patent/CR7514A/es unknown
- 2004-10-26 NO NO20044615A patent/NO329674B1/no not_active IP Right Cessation
-
2005
- 2005-09-16 HK HK05108146A patent/HK1076102A1/xx not_active IP Right Cessation
-
2006
- 2006-02-03 JP JP2006027537A patent/JP4571078B2/ja not_active Expired - Lifetime
- 2006-07-04 CY CY20061100919T patent/CY1106114T1/el unknown
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