DK1501826T3 - Substituerede indoler som alpha-1-agonister - Google Patents
Substituerede indoler som alpha-1-agonisterInfo
- Publication number
- DK1501826T3 DK1501826T3 DK03714714T DK03714714T DK1501826T3 DK 1501826 T3 DK1501826 T3 DK 1501826T3 DK 03714714 T DK03714714 T DK 03714714T DK 03714714 T DK03714714 T DK 03714714T DK 1501826 T3 DK1501826 T3 DK 1501826T3
- Authority
- DK
- Denmark
- Prior art keywords
- agonists
- alpha
- substituted indoles
- indoles
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Nutrition Science (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35350802P | 2002-02-01 | 2002-02-01 | |
| US41849202P | 2002-10-15 | 2002-10-15 | |
| PCT/EP2003/000644 WO2003064387A2 (en) | 2002-02-01 | 2003-01-23 | Substituted indoles as alpha-1 agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1501826T3 true DK1501826T3 (da) | 2007-01-29 |
Family
ID=27669110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03714714T DK1501826T3 (da) | 2002-02-01 | 2003-01-23 | Substituerede indoler som alpha-1-agonister |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6852726B2 (da) |
| EP (1) | EP1501826B1 (da) |
| JP (1) | JP4209332B2 (da) |
| KR (1) | KR100656037B1 (da) |
| CN (1) | CN100378095C (da) |
| AR (1) | AR038341A1 (da) |
| AT (1) | ATE340792T1 (da) |
| AU (1) | AU2003218962B2 (da) |
| BR (1) | BR0307406A (da) |
| CA (1) | CA2473803A1 (da) |
| DE (1) | DE60308670T2 (da) |
| DK (1) | DK1501826T3 (da) |
| ES (1) | ES2271551T3 (da) |
| MX (1) | MXPA04007414A (da) |
| PL (1) | PL373410A1 (da) |
| PT (1) | PT1501826E (da) |
| RU (1) | RU2337909C2 (da) |
| WO (1) | WO2003064387A2 (da) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
| TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
| SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| DE60332769D1 (de) | 2002-11-07 | 2010-07-08 | Organon Nv | Indole, die sich zur behandlung von mit dem androgenrezeptor in zusammenhang stehenden krankheiten eignen |
| UA79504C2 (en) * | 2002-11-07 | 2007-06-25 | Organon Nv | Indols for treating diseases associated with androgen receptors |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| JP4454622B2 (ja) * | 2003-05-09 | 2010-04-21 | エフ．ホフマン−ラ ロシュ アーゲー | アルファ−１アドレナリン作動性アゴニストとしてのメチルインドール及びメチルピロロピリジン |
| SE0301569D0 (sv) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
| SE0302232D0 (sv) * | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| RU2006109108A (ru) * | 2003-10-14 | 2007-11-20 | Оксаген Лимитед (GB) | Соединения, обладающие активностью антагонистов crth2 рецепторов |
| JP4448730B2 (ja) * | 2004-04-20 | 2010-04-14 | 富士フイルム株式会社 | 感光性組成物、該感光性組成物に用いられる化合物及び該感光性組成物を用いたパターン形成方法 |
| TW200602317A (en) | 2004-04-23 | 2006-01-16 | Akzo Nobel Nv | Novel androgens |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| JP5208510B2 (ja) | 2004-11-23 | 2013-06-12 | アストラゼネカ・アクチエボラーグ | 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 |
| CA2588953A1 (en) | 2004-11-30 | 2006-06-08 | Plexxikon, Inc. | Ppar active compounds |
| US20060135540A1 (en) * | 2004-11-30 | 2006-06-22 | Jack Lin | PPAR active compounds |
| GB0500604D0 (en) | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
| DK2839830T3 (da) * | 2005-01-14 | 2019-08-19 | Urigen Inc | Kits og sammensætninger til behandling af lidelser i de nedre urinveje |
| US8475647B2 (en) * | 2005-08-22 | 2013-07-02 | Shell Oil Company | Diesel fuel and a method of operating a diesel engine |
| JP5155171B2 (ja) | 2005-10-06 | 2013-02-27 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| CN101460458A (zh) * | 2006-02-15 | 2009-06-17 | 阿勒根公司 | 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物 |
| BRPI0707873A2 (pt) * | 2006-02-15 | 2011-05-10 | Allergan Inc | compostos amida, Éster, tioamida e tiol Éster do Ácido indol-3-carboxÍlico carregando grupos arila ou heteroarila tendo atividade biolàgica antagonista de recptor de esfingosina-1-fosfato (s1p) |
| US7741360B2 (en) | 2006-05-26 | 2010-06-22 | Astrazeneca Ab | Bi-aryl or aryl-heteroaryl substituted indoles |
| PE20090159A1 (es) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| AU2009243730B2 (en) * | 2008-05-05 | 2013-07-18 | Polypeptide Laboratories Holding (Ppl) Ab | Indolesulfonyl protecting groups for protection of guanidino and amino groups |
| EP2246326A1 (de) * | 2009-05-02 | 2010-11-03 | Bayer CropScience AG | Verfahren zur Herstellung von Oxindolen und ortho-substituierten Anilinen und ihre Verwendung als Zwischenprodukte für Synthesen |
| CN102917707A (zh) * | 2010-05-06 | 2013-02-06 | 默沙东公司 | 可用作faah调节剂的氮杂吲哚衍生物 |
| TWI695831B (zh) * | 2014-09-13 | 2020-06-11 | 香港商南北兄弟藥業投資有限公司 | Ｃｒｔｈ２拮抗劑化合物及其用途 |
| CN106674081A (zh) * | 2016-12-18 | 2017-05-17 | 南京理工大学 | 一种3‑甲硫基吲哚衍生物合成方法 |
| WO2020180876A1 (en) * | 2019-03-04 | 2020-09-10 | Beth Israel Deaconess Medical Center, Inc. | Orai channel inhibitors |
| CN114835677A (zh) * | 2021-02-02 | 2022-08-02 | 广东东阳光药业有限公司 | 吲哚衍生物的盐及其用途 |
| WO2023183394A1 (en) * | 2022-03-24 | 2023-09-28 | Curasen Therapeutics, Inc. | Alpha 1a-adrenergic receptor agonists and methods of use |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3404156A (en) | 1966-02-23 | 1968-10-01 | Sterling Drug Inc | Imidazolin-2-yl-alkyl-substituted indoles |
| US3689655A (en) | 1970-12-07 | 1972-09-05 | Sterling Drug Inc | Rodenticidal and rodent repellent compositions |
| US4654360A (en) | 1984-06-01 | 1987-03-31 | Syntex (U.S.A.) Inc. | 1,2,3-trisubstituted indoles for treatment of inflammation |
| US5095031A (en) | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
| US5334597A (en) | 1991-10-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Indole carbamates as leukotriene antagonists |
| ZA939516B (en) | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
| US6175013B1 (en) | 1994-06-10 | 2001-01-16 | Eli Lilly And Company | Imidazolinyl tachykinin receptor antagonists |
| DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
| FR2735774B1 (fr) | 1995-06-21 | 1997-09-12 | Sanofi Sa | Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant |
| TR199700334T1 (tr) | 1995-09-01 | 1997-08-21 | Lilly Co Eli | Indolil nöropeptid y reseptör antagonistleri. |
| SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
| DE69814012T2 (de) | 1997-12-19 | 2004-04-01 | Eli Lilly And Co., Indianapolis | Hypoglykàmische imidazoline derivate |
| GB9910110D0 (en) * | 1999-04-30 | 1999-06-30 | Glaxo Group Ltd | Chemical compounds |
| US6323231B1 (en) | 2000-02-17 | 2001-11-27 | Abbott Laboratories | Use of α1A adrenoceptor agonists with α1B and α1D antagonism for the treatment of stress urinary incontinence |
-
2003
- 2003-01-23 PL PL03373410A patent/PL373410A1/xx not_active Application Discontinuation
- 2003-01-23 EP EP03714714A patent/EP1501826B1/en not_active Expired - Lifetime
- 2003-01-23 BR BR0307406-4A patent/BR0307406A/pt not_active IP Right Cessation
- 2003-01-23 ES ES03714714T patent/ES2271551T3/es not_active Expired - Lifetime
- 2003-01-23 PT PT03714714T patent/PT1501826E/pt unknown
- 2003-01-23 JP JP2003564010A patent/JP4209332B2/ja not_active Expired - Fee Related
- 2003-01-23 MX MXPA04007414A patent/MXPA04007414A/es active IP Right Grant
- 2003-01-23 AU AU2003218962A patent/AU2003218962B2/en not_active Ceased
- 2003-01-23 DE DE60308670T patent/DE60308670T2/de not_active Expired - Lifetime
- 2003-01-23 KR KR1020047011902A patent/KR100656037B1/ko not_active IP Right Cessation
- 2003-01-23 RU RU2004126613/04A patent/RU2337909C2/ru not_active IP Right Cessation
- 2003-01-23 CN CNB038031841A patent/CN100378095C/zh not_active Expired - Fee Related
- 2003-01-23 CA CA002473803A patent/CA2473803A1/en not_active Abandoned
- 2003-01-23 WO PCT/EP2003/000644 patent/WO2003064387A2/en active IP Right Grant
- 2003-01-23 DK DK03714714T patent/DK1501826T3/da active
- 2003-01-23 AT AT03714714T patent/ATE340792T1/de active
- 2003-01-31 US US10/355,588 patent/US6852726B2/en not_active Expired - Fee Related
- 2003-01-31 AR ARP030100287A patent/AR038341A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003064387A2 (en) | 2003-08-07 |
| BR0307406A (pt) | 2004-12-28 |
| WO2003064387A3 (en) | 2004-12-02 |
| RU2004126613A (ru) | 2005-07-10 |
| JP4209332B2 (ja) | 2009-01-14 |
| ES2271551T3 (es) | 2007-04-16 |
| US6852726B2 (en) | 2005-02-08 |
| DE60308670D1 (de) | 2006-11-09 |
| RU2337909C2 (ru) | 2008-11-10 |
| JP2005522427A (ja) | 2005-07-28 |
| KR100656037B1 (ko) | 2006-12-11 |
| DE60308670T2 (de) | 2007-08-16 |
| PL373410A1 (en) | 2005-08-22 |
| US20030220319A1 (en) | 2003-11-27 |
| EP1501826B1 (en) | 2006-09-27 |
| EP1501826A2 (en) | 2005-02-02 |
| CN1628113A (zh) | 2005-06-15 |
| AR038341A1 (es) | 2005-01-12 |
| CN100378095C (zh) | 2008-04-02 |
| KR20040077927A (ko) | 2004-09-07 |
| MXPA04007414A (es) | 2004-10-11 |
| PT1501826E (pt) | 2007-01-31 |
| AU2003218962B2 (en) | 2008-09-25 |
| CA2473803A1 (en) | 2003-08-07 |
| ATE340792T1 (de) | 2006-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1501826T3 (da) | Substituerede indoler som alpha-1-agonister | |
| NO20044654L (no) | Piperidinoylpiperidiner som 5-HTIF-agonister | |
| IS7607A (is) | Ný útskipt indól | |
| DK1492785T3 (da) | 2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer | |
| NO20052887D0 (no) | Pyridazinonderivater som GSK-3Beta inhibitorer. | |
| NO20055680D0 (no) | Heksahydropyridoisokinoliner som DPP-IV-inhibitorer | |
| NO20051042L (no) | Pyrimidylsulfonamidderivater som kemokinreseptormodulatorer | |
| DE60320439D1 (de) | Indolderivate als beta-2 agonisten | |
| ATE478870T1 (de) | Spiroindolinpiperidinderivate | |
| ATE450506T1 (de) | Indol-3-schwefelderivate | |
| ATE467631T1 (de) | Chinuclidinamidderivate | |
| DK1474408T3 (da) | N-Phenyl-2-pyrimidinaminderivater | |
| DE10393374D2 (de) | Zusammensetzung | |
| SE0500163L (sv) | Sammansättning | |
| DK1438289T3 (da) | Indolderivater som cox II-inhibitorer | |
| NO20051500D0 (no) | Substituerte heterocyklylpyrimidiner. | |
| DE60305332D1 (de) | IMIDAZOi1,2-AöPYRIDINE | |
| DE60307512D1 (de) | 3h-chinazoline -4-on derivaten | |
| DK1556377T3 (da) | Cyclopropylthienylcarboxamider som fungicider | |
| ATE423771T1 (de) | Tetrahydrochinolinderivate | |
| ATE457299T1 (de) | 4-hydroxymethyl-1-aryl-cyclohexylamin-derivativ | |
| DE60324018D1 (de) | Agonisten | |
| DE50306277D1 (de) | 4-alkyl-/4-alkenyl-/4-alkinylmethyl/-1-arylcyclohexylamin-derivate | |
| NO20043610L (no) | Fenylpyrimidinaminer som IgE inhibitorer | |
| DK1487802T3 (da) | 2,3-diaryl-pyrazolidin-derivater som neurotensin-nedbrydende enzyminhibitorer |