ATE340792T1 - Substituierte indole als alpha-1 agonisten - Google Patents
Substituierte indole als alpha-1 agonistenInfo
- Publication number
- ATE340792T1 ATE340792T1 AT03714714T AT03714714T ATE340792T1 AT E340792 T1 ATE340792 T1 AT E340792T1 AT 03714714 T AT03714714 T AT 03714714T AT 03714714 T AT03714714 T AT 03714714T AT E340792 T1 ATE340792 T1 AT E340792T1
- Authority
- AT
- Austria
- Prior art keywords
- agonists
- alpha
- substituted indoles
- indoles
- substituted
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35350802P | 2002-02-01 | 2002-02-01 | |
| US41849202P | 2002-10-15 | 2002-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE340792T1 true ATE340792T1 (de) | 2006-10-15 |
Family
ID=27669110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03714714T ATE340792T1 (de) | 2002-02-01 | 2003-01-23 | Substituierte indole als alpha-1 agonisten |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6852726B2 (de) |
| EP (1) | EP1501826B1 (de) |
| JP (1) | JP4209332B2 (de) |
| KR (1) | KR100656037B1 (de) |
| CN (1) | CN100378095C (de) |
| AR (1) | AR038341A1 (de) |
| AT (1) | ATE340792T1 (de) |
| AU (1) | AU2003218962B2 (de) |
| BR (1) | BR0307406A (de) |
| CA (1) | CA2473803A1 (de) |
| DE (1) | DE60308670T2 (de) |
| DK (1) | DK1501826T3 (de) |
| ES (1) | ES2271551T3 (de) |
| MX (1) | MXPA04007414A (de) |
| PL (1) | PL373410A1 (de) |
| PT (1) | PT1501826E (de) |
| RU (1) | RU2337909C2 (de) |
| WO (1) | WO2003064387A2 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
| TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
| SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| MXPA05004929A (es) | 2002-11-07 | 2005-08-18 | Akzo Nobel Nv | Indoles utiles en el tratamiento de enfermedades relacionadas a receptor de androgeno. |
| UA79504C2 (en) * | 2002-11-07 | 2007-06-25 | Organon Nv | Indols for treating diseases associated with androgen receptors |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| CA2523253C (en) * | 2003-05-09 | 2010-06-22 | F. Hoffmann-La Roche Ag | Methyl indoles and methyl pyrrolopyridines as alpha-1 adrenergic agonists |
| SE0301569D0 (sv) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
| SE0302232D0 (sv) * | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| JP2007508363A (ja) * | 2003-10-14 | 2007-04-05 | オキサジェン リミテッド | Ｃｒｔｈ２アンタゴニスト活性を有する化合物 |
| JP4448730B2 (ja) * | 2004-04-20 | 2010-04-14 | 富士フイルム株式会社 | 感光性組成物、該感光性組成物に用いられる化合物及び該感光性組成物を用いたパターン形成方法 |
| TW200602317A (en) * | 2004-04-23 | 2006-01-16 | Akzo Nobel Nv | Novel androgens |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| ATE517085T1 (de) | 2004-11-23 | 2011-08-15 | Astrazeneca Ab | Zur behandlung von atemwegserkrankungen geeignete phenoxyessigsäurederivate |
| US7531568B2 (en) | 2004-11-30 | 2009-05-12 | Plexxikon, Inc. | PPAR active compounds |
| JP2008521831A (ja) * | 2004-11-30 | 2008-06-26 | プレキシコン，インコーポレーテッド | Ｐｐａｒ活性化合物 |
| GB0500604D0 (en) | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
| DK2839830T3 (da) * | 2005-01-14 | 2019-08-19 | Urigen Inc | Kits og sammensætninger til behandling af lidelser i de nedre urinveje |
| EP1917330A2 (de) * | 2005-08-22 | 2008-05-07 | Shell Internationale Researchmaatschappij B.V. | Dieseltreibstoff und verfahren für den betrieb eines dieselmotors |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| WO2007039736A1 (en) | 2005-10-06 | 2007-04-12 | Astrazeneca Ab | Novel compounds |
| CN101460458A (zh) * | 2006-02-15 | 2009-06-17 | 阿勒根公司 | 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物 |
| CA2642668C (en) * | 2006-02-15 | 2013-01-08 | Allergan, Inc. | Indole-3-carboxylic acid amide and ester compounds bearing phenyl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity |
| JP2009538289A (ja) | 2006-05-26 | 2009-11-05 | アストラゼネカ・アクチエボラーグ | ビアリールまたはヘテロアリール置換インドール |
| PE20090159A1 (es) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| KR101493554B1 (ko) * | 2008-05-05 | 2015-02-16 | 론자 아게 (론자 엘티디.) | 구아니디노 및 아미노기 보호용 인돌술포닐 보호기 |
| CA2797281A1 (en) * | 2010-05-06 | 2011-11-10 | Merck Sharp & Dohme Corp. | Aza-indole derivatives useful as modulators of faah |
| TWI695831B (zh) * | 2014-09-13 | 2020-06-11 | 香港商南北兄弟藥業投資有限公司 | Ｃｒｔｈ２拮抗劑化合物及其用途 |
| CN106674081A (zh) * | 2016-12-18 | 2017-05-17 | 南京理工大学 | 一种3‑甲硫基吲哚衍生物合成方法 |
| WO2020150439A1 (en) * | 2019-01-17 | 2020-07-23 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| US12459938B2 (en) | 2019-03-04 | 2025-11-04 | Beth Israel Deaconess Medical Center, Inc. | ORAI channel inhibitors |
| CN114835678A (zh) * | 2021-02-02 | 2022-08-02 | 广东东阳光药业有限公司 | 吲哚衍生物的盐及其用途 |
| CN114989136A (zh) * | 2021-02-02 | 2022-09-02 | 广东东阳光药业有限公司 | 吲哚衍生物的盐及其用途 |
| WO2022166638A1 (zh) * | 2021-02-02 | 2022-08-11 | 广东东阳光药业有限公司 | 吲哚衍生物的盐及其用途 |
| AU2023240170A1 (en) * | 2022-03-24 | 2024-10-31 | Curasen Therapeutics, Inc. | Alpha 1a-adrenergic receptor agonists and methods of use |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3404156A (en) | 1966-02-23 | 1968-10-01 | Sterling Drug Inc | Imidazolin-2-yl-alkyl-substituted indoles |
| US3689655A (en) | 1970-12-07 | 1972-09-05 | Sterling Drug Inc | Rodenticidal and rodent repellent compositions |
| US4654360A (en) | 1984-06-01 | 1987-03-31 | Syntex (U.S.A.) Inc. | 1,2,3-trisubstituted indoles for treatment of inflammation |
| US5095031A (en) | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
| US5334597A (en) | 1991-10-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Indole carbamates as leukotriene antagonists |
| ZA939516B (en) | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
| US6175013B1 (en) | 1994-06-10 | 2001-01-16 | Eli Lilly And Company | Imidazolinyl tachykinin receptor antagonists |
| DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
| FR2735774B1 (fr) | 1995-06-21 | 1997-09-12 | Sanofi Sa | Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant |
| AU717422B2 (en) | 1995-09-01 | 2000-03-23 | Eli Lilly And Company | Indolyl neuropeptide Y receptor antagonists |
| GB9600235D0 (en) * | 1996-01-05 | 1996-03-06 | Pfizer Ltd | Therapeutic agents |
| SG72827A1 (en) | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
| AU2201699A (en) | 1997-12-19 | 1999-07-12 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
| GB9910110D0 (en) * | 1999-04-30 | 1999-06-30 | Glaxo Group Ltd | Chemical compounds |
| US6323231B1 (en) | 2000-02-17 | 2001-11-27 | Abbott Laboratories | Use of α1A adrenoceptor agonists with α1B and α1D antagonism for the treatment of stress urinary incontinence |
-
2003
- 2003-01-23 EP EP03714714A patent/EP1501826B1/de not_active Expired - Lifetime
- 2003-01-23 AU AU2003218962A patent/AU2003218962B2/en not_active Ceased
- 2003-01-23 DK DK03714714T patent/DK1501826T3/da active
- 2003-01-23 KR KR1020047011902A patent/KR100656037B1/ko not_active Expired - Fee Related
- 2003-01-23 AT AT03714714T patent/ATE340792T1/de active
- 2003-01-23 CN CNB038031841A patent/CN100378095C/zh not_active Expired - Fee Related
- 2003-01-23 JP JP2003564010A patent/JP4209332B2/ja not_active Expired - Fee Related
- 2003-01-23 WO PCT/EP2003/000644 patent/WO2003064387A2/en not_active Ceased
- 2003-01-23 MX MXPA04007414A patent/MXPA04007414A/es active IP Right Grant
- 2003-01-23 DE DE60308670T patent/DE60308670T2/de not_active Expired - Lifetime
- 2003-01-23 BR BR0307406-4A patent/BR0307406A/pt not_active IP Right Cessation
- 2003-01-23 ES ES03714714T patent/ES2271551T3/es not_active Expired - Lifetime
- 2003-01-23 CA CA002473803A patent/CA2473803A1/en not_active Abandoned
- 2003-01-23 RU RU2004126613/04A patent/RU2337909C2/ru not_active IP Right Cessation
- 2003-01-23 PT PT03714714T patent/PT1501826E/pt unknown
- 2003-01-23 PL PL03373410A patent/PL373410A1/xx not_active Application Discontinuation
- 2003-01-31 US US10/355,588 patent/US6852726B2/en not_active Expired - Fee Related
- 2003-01-31 AR ARP030100287A patent/AR038341A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60308670D1 (de) | 2006-11-09 |
| KR100656037B1 (ko) | 2006-12-11 |
| US20030220319A1 (en) | 2003-11-27 |
| MXPA04007414A (es) | 2004-10-11 |
| PT1501826E (pt) | 2007-01-31 |
| CA2473803A1 (en) | 2003-08-07 |
| AU2003218962B2 (en) | 2008-09-25 |
| JP2005522427A (ja) | 2005-07-28 |
| CN100378095C (zh) | 2008-04-02 |
| EP1501826A2 (de) | 2005-02-02 |
| RU2004126613A (ru) | 2005-07-10 |
| AR038341A1 (es) | 2005-01-12 |
| US6852726B2 (en) | 2005-02-08 |
| WO2003064387A2 (en) | 2003-08-07 |
| EP1501826B1 (de) | 2006-09-27 |
| DE60308670T2 (de) | 2007-08-16 |
| DK1501826T3 (da) | 2007-01-29 |
| WO2003064387A3 (en) | 2004-12-02 |
| BR0307406A (pt) | 2004-12-28 |
| ES2271551T3 (es) | 2007-04-16 |
| JP4209332B2 (ja) | 2009-01-14 |
| KR20040077927A (ko) | 2004-09-07 |
| RU2337909C2 (ru) | 2008-11-10 |
| CN1628113A (zh) | 2005-06-15 |
| PL373410A1 (en) | 2005-08-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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