AU2003278057A1 - Indole derivative with 5ht1a affinity - Google Patents

Indole derivative with 5ht1a affinity

Info

Publication number
AU2003278057A1
AU2003278057A1 AU2003278057A AU2003278057A AU2003278057A1 AU 2003278057 A1 AU2003278057 A1 AU 2003278057A1 AU 2003278057 A AU2003278057 A AU 2003278057A AU 2003278057 A AU2003278057 A AU 2003278057A AU 2003278057 A1 AU2003278057 A1 AU 2003278057A1
Authority
AU
Australia
Prior art keywords
5ht1a
affinity
indole derivative
indole
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003278057A
Inventor
Gerd Bartoszyk
Henning Bottcher
Timo Heinrich
Gunter Holzemann
Joachim Leibrock
Kai Schiemann
Christoph Seyfried
Christoph Van Amsterdam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2003278057A1 publication Critical patent/AU2003278057A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003278057A 2002-11-08 2003-10-08 Indole derivative with 5ht1a affinity Abandoned AU2003278057A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10252102.6 2002-11-08
DE10252102A DE10252102A1 (en) 2002-11-08 2002-11-08 New 3-(piperidino- or -piperazino-alkyl)-indole derivatives, are 5HT-1A and/or 5HT-1D agonists and 5-HT reuptake inhibitors, useful e.g. for treating anxiety, depression or neurodegenerative diseases
PCT/EP2003/011132 WO2004041815A1 (en) 2002-11-08 2003-10-08 Indole derivative with 5ht1a affinity

Publications (1)

Publication Number Publication Date
AU2003278057A1 true AU2003278057A1 (en) 2004-06-07

Family

ID=32185383

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003278057A Abandoned AU2003278057A1 (en) 2002-11-08 2003-10-08 Indole derivative with 5ht1a affinity

Country Status (3)

Country Link
AU (1) AU2003278057A1 (en)
DE (1) DE10252102A1 (en)
WO (1) WO2004041815A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1637529A1 (en) * 2004-09-20 2006-03-22 4Sc Ag Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof
EA012607B1 (en) * 2004-09-20 2009-10-30 4Сц Аг NOVEL HETEROCYCLIC NF-kB INHIBITORS
US7601745B2 (en) 2004-09-27 2009-10-13 4Sc Ag Heterocyclic NF-kB inhibitors
DE102005019670A1 (en) * 2005-04-26 2006-11-02 Merck Patent Gmbh Preparation of 5-(4-(4-(5-cyano-3-indolyl)-butyl)-1-piperazinyl)-benzofuran-2-carboxamide, comprises reacting a heterocyclic compound with a carbonitrile compound; and/or converting the obtained benzofuran compound to its salt
EP2896624B1 (en) 2007-03-28 2016-07-13 Atir Holding S.A. Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof
US9598401B2 (en) * 2013-07-29 2017-03-21 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
DK3154942T3 (en) * 2014-06-11 2019-11-18 Bayer Cropscience Ag PIPERIDIN-4-CARBOTHIOAMIDE PREPARATION
CN106065018B (en) * 2015-04-23 2020-04-21 广东东阳光药业有限公司 Substituted indole compounds, methods of use and uses thereof
WO2016182900A1 (en) * 2015-05-08 2016-11-17 Vertellus Specialties, Inc. Processes for converting carboxamides to thiocarboxamides
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
AU2018340376B2 (en) 2017-09-29 2022-09-01 Sunshine Lake Pharma Co., Ltd. Substituted pyrimidine piperazine compound and use thereof
CN111454250B (en) * 2019-01-21 2021-05-07 华东理工大学 Multi-target active compound and application thereof
CN111533738A (en) * 2020-05-27 2020-08-14 中国药科大学 Compound containing indole structure or pharmaceutically acceptable salt thereof, preparation method and application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (en) * 1959-09-25 1900-01-01
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
CA2207201A1 (en) * 1994-12-06 1996-06-13 Caroline Henry Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists

Also Published As

Publication number Publication date
WO2004041815A1 (en) 2004-05-21
DE10252102A1 (en) 2004-05-27

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase