MXPA04007414A - Indoles sustituidos como agonistas alfa-1. - Google Patents

Indoles sustituidos como agonistas alfa-1.

Info

Publication number
MXPA04007414A
MXPA04007414A MXPA04007414A MXPA04007414A MXPA04007414A MX PA04007414 A MXPA04007414 A MX PA04007414A MX PA04007414 A MXPA04007414 A MX PA04007414A MX PA04007414 A MXPA04007414 A MX PA04007414A MX PA04007414 A MXPA04007414 A MX PA04007414A
Authority
MX
Mexico
Prior art keywords
alpha
agonists
alkyl
compounds
substituted indoles
Prior art date
Application number
MXPA04007414A
Other languages
English (en)
Inventor
Raptova Lubica
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MXPA04007414A publication Critical patent/MXPA04007414A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

La presente invencion se refiere a compuestos que son agonistas de receptores alfa-1, preferentemente agonistas de receptores alfa-1A/L, y que estan representados por la formula general(Ver formula I)en la cual X es -S(O)n- o -C(O)-, A es alquilo (C1-6), arilo, heteroarilo, hidroxialquilo (C1-6), o -(CH2)P-NRaRb, y los demas substituyentes son tal como se han definido en la memoria descriptiva; o a isomeros individuales, mezclas racemicas y no racemicas de isomeros, o sales o solvatos farmaceuticamente aceptables de los mismos. La invencion tambien se refiere a composiciones farmaceuticas que contienen dichos compuestos, a su preparacion y al empleo de las mismas como agentes terapeuticos.
MXPA04007414A 2002-02-01 2003-01-23 Indoles sustituidos como agonistas alfa-1. MXPA04007414A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35350802P 2002-02-01 2002-02-01
US41849202P 2002-10-15 2002-10-15
PCT/EP2003/000644 WO2003064387A2 (en) 2002-02-01 2003-01-23 Substituted indoles as alpha-1 agonists

Publications (1)

Publication Number Publication Date
MXPA04007414A true MXPA04007414A (es) 2004-10-11

Family

ID=27669110

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04007414A MXPA04007414A (es) 2002-02-01 2003-01-23 Indoles sustituidos como agonistas alfa-1.

Country Status (18)

Country Link
US (1) US6852726B2 (es)
EP (1) EP1501826B1 (es)
JP (1) JP4209332B2 (es)
KR (1) KR100656037B1 (es)
CN (1) CN100378095C (es)
AR (1) AR038341A1 (es)
AT (1) ATE340792T1 (es)
AU (1) AU2003218962B2 (es)
BR (1) BR0307406A (es)
CA (1) CA2473803A1 (es)
DE (1) DE60308670T2 (es)
DK (1) DK1501826T3 (es)
ES (1) ES2271551T3 (es)
MX (1) MXPA04007414A (es)
PL (1) PL373410A1 (es)
PT (1) PT1501826E (es)
RU (1) RU2337909C2 (es)
WO (1) WO2003064387A2 (es)

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SE0201635D0 (sv) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
DE60332769D1 (de) 2002-11-07 2010-07-08 Organon Nv Indole, die sich zur behandlung von mit dem androgenrezeptor in zusammenhang stehenden krankheiten eignen
UA79504C2 (en) * 2002-11-07 2007-06-25 Organon Nv Indols for treating diseases associated with androgen receptors
SE0301010D0 (sv) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
AU2004235923B2 (en) * 2003-05-09 2008-01-24 F. Hoffmann-La Roche Ag Methyl indoles and methyl pyrrolopyridines as alpha-1 adrenergic agonists
SE0301569D0 (sv) 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
SA04250253B1 (ar) 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
JP2007508363A (ja) * 2003-10-14 2007-04-05 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
JP4448730B2 (ja) * 2004-04-20 2010-04-14 富士フイルム株式会社 感光性組成物、該感光性組成物に用いられる化合物及び該感光性組成物を用いたパターン形成方法
TW200602317A (en) 2004-04-23 2006-01-16 Akzo Nobel Nv Novel androgens
GB0415320D0 (en) 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
EP1817282B1 (en) 2004-11-23 2011-07-20 AstraZeneca AB Phenoxyacetic acid derivatives useful for treating respiratory diseases
US7531568B2 (en) 2004-11-30 2009-05-12 Plexxikon, Inc. PPAR active compounds
EP1833787A2 (en) * 2004-11-30 2007-09-19 Plexxikon, Inc. Indole derivatives for use as ppar active compounds
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
DK2839830T3 (da) * 2005-01-14 2019-08-19 Urigen Inc Kits og sammensætninger til behandling af lidelser i de nedre urinveje
WO2007024747A2 (en) * 2005-08-22 2007-03-01 Shell Internationale Research Maatschappij B.V. A diesel fuel and a method of operating a diesel engine
TW200745003A (en) 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
US8148572B2 (en) 2005-10-06 2012-04-03 Astrazeneca Ab Compounds
NZ570528A (en) * 2006-02-15 2011-09-30 Allergan Inc Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity
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CN102558021A (zh) 2006-05-26 2012-07-11 阿斯利康(瑞典)有限公司 联芳基或芳基-杂芳基取代的吲哚类化合物
PE20090159A1 (es) 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
UA100983C2 (ru) 2007-07-05 2013-02-25 Астразенека Аб Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты
BRPI0912355A2 (pt) * 2008-05-05 2015-07-28 Lonza Ag Grupos de proteção de indolsulfonil para proteção dos grupamentos guanidino e amino
EP2246326A1 (de) * 2009-05-02 2010-11-03 Bayer CropScience AG Verfahren zur Herstellung von Oxindolen und ortho-substituierten Anilinen und ihre Verwendung als Zwischenprodukte für Synthesen
EP2566481A4 (en) * 2010-05-06 2014-01-22 Merck Sharp & Dohme AS FAAH MODULATORS SUITABLE AZA-INDOL DERIVATIVES
TWI695831B (zh) * 2014-09-13 2020-06-11 香港商南北兄弟藥業投資有限公司 Ｃｒｔｈ２拮抗劑化合物及其用途
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Also Published As

Publication number Publication date
AR038341A1 (es) 2005-01-12
CA2473803A1 (en) 2003-08-07
EP1501826A2 (en) 2005-02-02
WO2003064387A2 (en) 2003-08-07
PT1501826E (pt) 2007-01-31
CN1628113A (zh) 2005-06-15
DK1501826T3 (da) 2007-01-29
PL373410A1 (en) 2005-08-22
US20030220319A1 (en) 2003-11-27
KR100656037B1 (ko) 2006-12-11
DE60308670T2 (de) 2007-08-16
KR20040077927A (ko) 2004-09-07
BR0307406A (pt) 2004-12-28
US6852726B2 (en) 2005-02-08
EP1501826B1 (en) 2006-09-27
JP2005522427A (ja) 2005-07-28
ATE340792T1 (de) 2006-10-15
DE60308670D1 (de) 2006-11-09
RU2337909C2 (ru) 2008-11-10
ES2271551T3 (es) 2007-04-16
WO2003064387A3 (en) 2004-12-02
RU2004126613A (ru) 2005-07-10
AU2003218962B2 (en) 2008-09-25
JP4209332B2 (ja) 2009-01-14
CN100378095C (zh) 2008-04-02

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