DE602004016177D1 - Methylindole und methylpyrrolopyridine als alpha-1-adrenerge agonisten - Google Patents
Methylindole und methylpyrrolopyridine als alpha-1-adrenerge agonistenInfo
- Publication number
- DE602004016177D1 DE602004016177D1 DE602004016177T DE602004016177T DE602004016177D1 DE 602004016177 D1 DE602004016177 D1 DE 602004016177D1 DE 602004016177 T DE602004016177 T DE 602004016177T DE 602004016177 T DE602004016177 T DE 602004016177T DE 602004016177 D1 DE602004016177 D1 DE 602004016177D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- alpha
- agonists
- methylpyrrolopyridine
- adrenerge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- BHNHHSOHWZKFOX-UHFFFAOYSA-N 2-methyl-1H-indole Chemical compound C1=CC=C2NC(C)=CC2=C1 BHNHHSOHWZKFOX-UHFFFAOYSA-N 0.000 title 1
- FTDBLXOLABKXNQ-UHFFFAOYSA-N 2-methyl-1h-pyrrolo[3,2-b]pyridine Chemical compound C1=CC=C2NC(C)=CC2=N1 FTDBLXOLABKXNQ-UHFFFAOYSA-N 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000018 receptor agonist Substances 0.000 abstract 2
- 229940044601 receptor agonist Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46925503P | 2003-05-09 | 2003-05-09 | |
| PCT/EP2004/004609 WO2004099189A1 (en) | 2003-05-09 | 2004-04-30 | Methyl indoles and methyl pyrrolopyridines as alph-1 adrenergic agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004016177D1 true DE602004016177D1 (de) | 2008-10-09 |
Family
ID=33435226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004016177T Expired - Lifetime DE602004016177D1 (de) | 2003-05-09 | 2004-04-30 | Methylindole und methylpyrrolopyridine als alpha-1-adrenerge agonisten |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6979696B2 (de) |
| EP (1) | EP1660484B1 (de) |
| JP (1) | JP4454622B2 (de) |
| KR (1) | KR100751163B1 (de) |
| CN (1) | CN100378097C (de) |
| AT (1) | ATE406363T1 (de) |
| AU (1) | AU2004235923B2 (de) |
| BR (1) | BRPI0410237A (de) |
| CA (1) | CA2523253C (de) |
| DE (1) | DE602004016177D1 (de) |
| ES (1) | ES2313019T3 (de) |
| MX (1) | MXPA05011841A (de) |
| PL (1) | PL1660484T3 (de) |
| RU (1) | RU2313524C2 (de) |
| WO (1) | WO2004099189A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7795280B2 (en) * | 2002-11-07 | 2010-09-14 | N.V. Organon | Indoles useful in the treatment of androgen-receptor related diseases |
| TW200602317A (en) * | 2004-04-23 | 2006-01-16 | Akzo Nobel Nv | Novel androgens |
| WO2007041023A1 (en) * | 2005-09-29 | 2007-04-12 | Wyeth | 1- (1h- indol- 1-yl) -3- (methylamino) -1- phenylpropan-2-ol derivatives and related compounds as modulators of the monoamine reuptake for the treatment of vasomotor symptoms (vms) |
| RU2008120141A (ru) * | 2005-11-30 | 2010-01-10 | Ф. Хоффманн-Ля Рош Аг (Ch) | 3-амино-2-арилпропилазаиндолы и их применения |
| LT2658844T (lt) | 2010-12-28 | 2017-02-10 | Sanofi | Nauji pirimidino dariniai, jų gamyba ir jų farmacinis panaudojimas kaip akt (pkb) fosforilinimo slopiklių |
| CN102702196B (zh) * | 2012-06-13 | 2015-01-14 | 南京药石药物研发有限公司 | 3-甲基-7-氮杂吲哚的合成方法 |
| KR102129842B1 (ko) * | 2013-10-02 | 2020-07-06 | 주식회사 대웅제약 | 술포닐인돌 유도체 및 이의 제조방법 |
| WO2016014426A1 (en) * | 2014-07-21 | 2016-01-28 | The Arizona Board Of Regents | Organic reactions |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3370063A (en) | 1964-10-05 | 1968-02-20 | Mcneilab Inc | Substituted dimethoxy indoles and method of making the same |
| US3586695A (en) * | 1968-01-26 | 1971-06-22 | Dow Chemical Co | Substituted imidazolinyl indoles |
| GB9011335D0 (en) | 1990-05-21 | 1990-07-11 | Fujisawa Pharmaceutical Co | Indolebutyric acid derivatives and process for preparation thereof |
| DK0703911T3 (da) | 1993-06-14 | 1997-10-06 | Pfizer | Sekundære aminer som antidiabetiske og antiobesitetsmidler |
| JPH0887346A (ja) * | 1994-09-14 | 1996-04-02 | Chino Kogyo:Kk | パソコン等デスク上を活用する為の卓上台座器具 |
| DE69735433D1 (de) | 1996-11-14 | 2006-05-04 | Pfizer | Verfahren zur herstellung von substituierten pyridinen |
| SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
| GB9910110D0 (en) * | 1999-04-30 | 1999-06-30 | Glaxo Group Ltd | Chemical compounds |
| EP1268422A1 (de) | 2000-03-23 | 2003-01-02 | Bayer Aktiengesellschaft | Indole zur behandlung von krankheiten die mit schilddrüsenhormonen behandeln werden können |
| DE10106214A1 (de) * | 2001-02-10 | 2002-08-14 | Boehringer Ingelheim Pharma | Neue Alkyl-phenylimino-imidazolidin-Derivate zur Behandlung der Harninkontinenz |
| AU2003218962B2 (en) * | 2002-02-01 | 2008-09-25 | F. Hoffmann-La Roche Ag | Substituted indoles as alpha-1 agonists |
-
2004
- 2004-04-30 AU AU2004235923A patent/AU2004235923B2/en not_active Ceased
- 2004-04-30 JP JP2006505343A patent/JP4454622B2/ja not_active Expired - Fee Related
- 2004-04-30 RU RU2005138143/04A patent/RU2313524C2/ru not_active IP Right Cessation
- 2004-04-30 KR KR1020057021188A patent/KR100751163B1/ko not_active IP Right Cessation
- 2004-04-30 MX MXPA05011841A patent/MXPA05011841A/es active IP Right Grant
- 2004-04-30 DE DE602004016177T patent/DE602004016177D1/de not_active Expired - Lifetime
- 2004-04-30 WO PCT/EP2004/004609 patent/WO2004099189A1/en active IP Right Grant
- 2004-04-30 AT AT04739120T patent/ATE406363T1/de active
- 2004-04-30 ES ES04739120T patent/ES2313019T3/es not_active Expired - Lifetime
- 2004-04-30 CN CNB2004800122944A patent/CN100378097C/zh not_active Expired - Fee Related
- 2004-04-30 CA CA2523253A patent/CA2523253C/en not_active Expired - Fee Related
- 2004-04-30 PL PL04739120T patent/PL1660484T3/pl unknown
- 2004-04-30 EP EP04739120A patent/EP1660484B1/de not_active Expired - Lifetime
- 2004-04-30 BR BRPI0410237-1A patent/BRPI0410237A/pt not_active IP Right Cessation
- 2004-05-07 US US10/841,288 patent/US6979696B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0410237A (pt) | 2006-05-09 |
| KR20060015590A (ko) | 2006-02-17 |
| EP1660484B1 (de) | 2008-08-27 |
| US20040224973A1 (en) | 2004-11-11 |
| CN100378097C (zh) | 2008-04-02 |
| RU2313524C2 (ru) | 2007-12-27 |
| EP1660484A1 (de) | 2006-05-31 |
| US6979696B2 (en) | 2005-12-27 |
| CA2523253A1 (en) | 2004-11-18 |
| AU2004235923A1 (en) | 2004-11-18 |
| KR100751163B1 (ko) | 2007-08-22 |
| ES2313019T3 (es) | 2009-03-01 |
| MXPA05011841A (es) | 2006-01-26 |
| JP2006525970A (ja) | 2006-11-16 |
| CN1784397A (zh) | 2006-06-07 |
| WO2004099189A1 (en) | 2004-11-18 |
| RU2005138143A (ru) | 2006-08-10 |
| PL1660484T3 (pl) | 2009-02-27 |
| CA2523253C (en) | 2010-06-22 |
| ATE406363T1 (de) | 2008-09-15 |
| JP4454622B2 (ja) | 2010-04-21 |
| AU2004235923B2 (en) | 2008-01-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20025641D0 (no) | Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptor-antagonister | |
| MXPA04007414A (es) | Indoles sustituidos como agonistas alfa-1. | |
| NO20025640D0 (no) | Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptor-antagonister | |
| HK1070054A1 (en) | Arylsulfonyl derivatives with5-ht6 receptor affinity | |
| DE60208568D1 (de) | Prostaglandinanaloga als ep4-rezeptoragonisten | |
| MXPA03011638A (es) | Nuevos derivados de 4-piperazinil indol con afinidad por el receptor 5-ht6. | |
| ATE360630T1 (de) | Azabicyclische heterocyclen als modulatoren des cannabinoidrezeptors | |
| SE0302760D0 (sv) | New compounds | |
| MXPA05011710A (es) | Derivados de pirimidina con actividad de crf. | |
| DE60305484D1 (de) | Verbindungen und deren verwendung als 5-ht inhibitore | |
| DE602004009200D1 (de) | Tetrahydrochinazolinderivate als cfr-antagonisten | |
| ATE386725T1 (de) | Heterocyclylverbindungen | |
| SE0403171D0 (sv) | New compounds | |
| YU53100A (sh) | Derivati 2-ariletil-(piperidin-4-ilmetil)amina kao antagonisti muskarinskih receptora | |
| PL374019A1 (en) | Benzoxazine derivatives as 5-ht6 modulators and uses thereof | |
| DE60313350D1 (de) | Pyrimidin-2,4-dion-derivate als matrix-metalloproteinase-hemmer | |
| NO20060191L (no) | 1-(alkylaminoalkyl-pyrolidin-/piperidinyl)2,2-difenylacetamidderivater som muskarinreceptoragonister | |
| MXPA04005076A (es) | Derivados de 4-piperidinil alquilamina como antagonistas del receptor muscarinico. | |
| MXPA04005313A (es) | Derivados de aminotetralin como antagonistas del receptor muscarinico. | |
| MXPA04005426A (es) | Derivados de pirazol de anillos fuisionados. | |
| DE60208694D1 (de) | Piperidinylmorpholinylderivate als modulatoren der aktivität des chemokinrezeptors | |
| DE602004016177D1 (de) | Methylindole und methylpyrrolopyridine als alpha-1-adrenerge agonisten | |
| MXPA05011476A (es) | Imidazolin-2-il-aminofenil-amidas como antagonistas de prostaglandina i2. | |
| ATE465151T1 (de) | 4-aryloxy-chinolin-derivate als 5-ht6-modulatoren | |
| SE0403118D0 (sv) | New compounds 2 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |