PL1660484T3 - Metyloindole i metylopirolopirydyny jako agoniści receptora adrenergicznego α-1 - Google Patents
Metyloindole i metylopirolopirydyny jako agoniści receptora adrenergicznego α-1Info
- Publication number
- PL1660484T3 PL1660484T3 PL04739120T PL04739120T PL1660484T3 PL 1660484 T3 PL1660484 T3 PL 1660484T3 PL 04739120 T PL04739120 T PL 04739120T PL 04739120 T PL04739120 T PL 04739120T PL 1660484 T3 PL1660484 T3 PL 1660484T3
- Authority
- PL
- Poland
- Prior art keywords
- sup
- methyl
- alpha
- pyrrolopyridines
- adrenergic agonists
- Prior art date
Links
- BHNHHSOHWZKFOX-UHFFFAOYSA-N 2-methyl-1H-indole Chemical class C1=CC=C2NC(C)=CC2=C1 BHNHHSOHWZKFOX-UHFFFAOYSA-N 0.000 title 1
- FTDBLXOLABKXNQ-UHFFFAOYSA-N 2-methyl-1h-pyrrolo[3,2-b]pyridine Chemical class C1=CC=C2NC(C)=CC2=N1 FTDBLXOLABKXNQ-UHFFFAOYSA-N 0.000 title 1
- 239000000048 adrenergic agonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000018 receptor agonist Substances 0.000 abstract 2
- 229940044601 receptor agonist Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46925503P | 2003-05-09 | 2003-05-09 | |
| PCT/EP2004/004609 WO2004099189A1 (en) | 2003-05-09 | 2004-04-30 | Methyl indoles and methyl pyrrolopyridines as alph-1 adrenergic agonists |
| EP04739120A EP1660484B1 (en) | 2003-05-09 | 2004-04-30 | Methyl indoles and methyl pyrrolopyridines as alpha-1 adrenergic agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1660484T3 true PL1660484T3 (pl) | 2009-02-27 |
Family
ID=33435226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04739120T PL1660484T3 (pl) | 2003-05-09 | 2004-04-30 | Metyloindole i metylopirolopirydyny jako agoniści receptora adrenergicznego α-1 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6979696B2 (pl) |
| EP (1) | EP1660484B1 (pl) |
| JP (1) | JP4454622B2 (pl) |
| KR (1) | KR100751163B1 (pl) |
| CN (1) | CN100378097C (pl) |
| AT (1) | ATE406363T1 (pl) |
| AU (1) | AU2004235923B2 (pl) |
| BR (1) | BRPI0410237A (pl) |
| CA (1) | CA2523253C (pl) |
| DE (1) | DE602004016177D1 (pl) |
| ES (1) | ES2313019T3 (pl) |
| MX (1) | MXPA05011841A (pl) |
| PL (1) | PL1660484T3 (pl) |
| RU (1) | RU2313524C2 (pl) |
| WO (1) | WO2004099189A1 (pl) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20050396A2 (en) * | 2002-11-07 | 2005-06-30 | Akzo Nobel N.V. | Indoles useful in the treatment of androgen-receptor related diseases |
| TW200602317A (en) * | 2004-04-23 | 2006-01-16 | Akzo Nobel Nv | Novel androgens |
| CN101309904A (zh) * | 2005-09-29 | 2008-11-19 | 惠氏公司 | 作为单胺再摄取调节剂用于治疗血管舒缩症状(vasomotorsymptoms，vms)的1－(1h－吲哚－1－基)－3－(甲基氨基)－1－苯基丙－2－醇衍生物和相关化合物 |
| EP1957488B1 (en) | 2005-11-30 | 2009-09-09 | F.Hoffmann-La Roche Ag | 3-amino-2-arylpropyl azaindoles and uses thereof |
| ES2612492T3 (es) | 2010-12-28 | 2017-05-17 | Sanofi | Nuevos derivados de piridiminas, su preparación y su utilización farmacéutica como inhibidores de fosforilación de AKT (PKB) |
| CN102702196B (zh) * | 2012-06-13 | 2015-01-14 | 南京药石药物研发有限公司 | 3-甲基-7-氮杂吲哚的合成方法 |
| KR102129842B1 (ko) * | 2013-10-02 | 2020-07-06 | 주식회사 대웅제약 | 술포닐인돌 유도체 및 이의 제조방법 |
| US10358438B2 (en) * | 2014-07-21 | 2019-07-23 | Arizona Board Of Regents On Behalf Of The University Of Arizona | [3+2] annulation to produce 5-membered heterocyclic compounds |
| AU2023360418A1 (en) * | 2022-10-14 | 2025-04-17 | Sanwa Kagaku Kenkyusho Co., Ltd. | Imidazole derivative |
| WO2024254218A2 (en) * | 2023-06-05 | 2024-12-12 | The Board Of Regents Of The University Of Texas System | Non-peptide small molecule fgf14:nav1.6 channel complex protein-protein interaction modulators |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3370063A (en) * | 1964-10-05 | 1968-02-20 | Mcneilab Inc | Substituted dimethoxy indoles and method of making the same |
| US3586695A (en) * | 1968-01-26 | 1971-06-22 | Dow Chemical Co | Substituted imidazolinyl indoles |
| GB9011335D0 (en) | 1990-05-21 | 1990-07-11 | Fujisawa Pharmaceutical Co | Indolebutyric acid derivatives and process for preparation thereof |
| ATE154935T1 (de) | 1993-06-14 | 1997-07-15 | Pfizer | Zweite amine als antidiabetische mittel und für die behandlung von fettleibigkeit |
| JPH0887346A (ja) * | 1994-09-14 | 1996-04-02 | Chino Kogyo:Kk | パソコン等デスク上を活用する為の卓上台座器具 |
| WO1998021184A1 (en) | 1996-11-14 | 1998-05-22 | Pfizer Inc. | Process for substituted pyridines |
| SG72827A1 (en) * | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
| GB9910110D0 (en) * | 1999-04-30 | 1999-06-30 | Glaxo Group Ltd | Chemical compounds |
| CA2403806A1 (en) | 2000-03-23 | 2002-09-20 | Bayer Aktiengesellschaft | Indoles for treating diseases that can be treated using thyroid hormones |
| DE10106214A1 (de) * | 2001-02-10 | 2002-08-14 | Boehringer Ingelheim Pharma | Neue Alkyl-phenylimino-imidazolidin-Derivate zur Behandlung der Harninkontinenz |
| PL373410A1 (pl) * | 2002-02-01 | 2005-08-22 | F.Hoffman-La Roche Ag | Podstawione indole jako agoniści alfa-1 |
-
2004
- 2004-04-30 AT AT04739120T patent/ATE406363T1/de active
- 2004-04-30 DE DE602004016177T patent/DE602004016177D1/de not_active Expired - Lifetime
- 2004-04-30 CA CA2523253A patent/CA2523253C/en not_active Expired - Fee Related
- 2004-04-30 WO PCT/EP2004/004609 patent/WO2004099189A1/en not_active Ceased
- 2004-04-30 RU RU2005138143/04A patent/RU2313524C2/ru not_active IP Right Cessation
- 2004-04-30 JP JP2006505343A patent/JP4454622B2/ja not_active Expired - Fee Related
- 2004-04-30 AU AU2004235923A patent/AU2004235923B2/en not_active Ceased
- 2004-04-30 CN CNB2004800122944A patent/CN100378097C/zh not_active Expired - Fee Related
- 2004-04-30 PL PL04739120T patent/PL1660484T3/pl unknown
- 2004-04-30 KR KR1020057021188A patent/KR100751163B1/ko not_active Expired - Fee Related
- 2004-04-30 BR BRPI0410237-1A patent/BRPI0410237A/pt not_active IP Right Cessation
- 2004-04-30 MX MXPA05011841A patent/MXPA05011841A/es active IP Right Grant
- 2004-04-30 ES ES04739120T patent/ES2313019T3/es not_active Expired - Lifetime
- 2004-04-30 EP EP04739120A patent/EP1660484B1/en not_active Expired - Lifetime
- 2004-05-07 US US10/841,288 patent/US6979696B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4454622B2 (ja) | 2010-04-21 |
| RU2313524C2 (ru) | 2007-12-27 |
| RU2005138143A (ru) | 2006-08-10 |
| EP1660484A1 (en) | 2006-05-31 |
| ES2313019T3 (es) | 2009-03-01 |
| US20040224973A1 (en) | 2004-11-11 |
| JP2006525970A (ja) | 2006-11-16 |
| CA2523253A1 (en) | 2004-11-18 |
| WO2004099189A1 (en) | 2004-11-18 |
| EP1660484B1 (en) | 2008-08-27 |
| DE602004016177D1 (de) | 2008-10-09 |
| CN1784397A (zh) | 2006-06-07 |
| KR100751163B1 (ko) | 2007-08-22 |
| ATE406363T1 (de) | 2008-09-15 |
| US6979696B2 (en) | 2005-12-27 |
| BRPI0410237A (pt) | 2006-05-09 |
| AU2004235923A1 (en) | 2004-11-18 |
| MXPA05011841A (es) | 2006-01-26 |
| CA2523253C (en) | 2010-06-22 |
| CN100378097C (zh) | 2008-04-02 |
| AU2004235923B2 (en) | 2008-01-24 |
| KR20060015590A (ko) | 2006-02-17 |
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