CO5180558A1 - Derivados de n-[3-((piperidin-1-il)metil)-4-(fenil o hetero- ciclil)ciclopent-1-il]]amina utiles como moduladores de actividad del receptor de la quimioquina - Google Patents

Derivados de n-[3-((piperidin-1-il)metil)-4-(fenil o hetero- ciclil)ciclopent-1-il]]amina utiles como moduladores de actividad del receptor de la quimioquina

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Publication number
CO5180558A1
CO5180558A1 CO00042774A CO00042774A CO5180558A1 CO 5180558 A1 CO5180558 A1 CO 5180558A1 CO 00042774 A CO00042774 A CO 00042774A CO 00042774 A CO00042774 A CO 00042774A CO 5180558 A1 CO5180558 A1 CO 5180558A1
Authority
CO
Colombia
Prior art keywords
ciclopent
ciclil
chemioquine
amina
ivy
Prior art date
Application number
CO00042774A
Other languages
English (en)
Inventor
Paul E Finke
A Hilfiker Kerry
Maccoss Malcom
Kevin T Chapman
Jennifer L Loebach
G Mills Sander
Ravi N Guthikonda
K Shah Shrenrik
Kim Dooseop
Shen Dong-Ming
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CO5180558A1 publication Critical patent/CO5180558A1/es

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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

Un compuesto de la fórmula I:<EMI FILE="00042774_1" ID="1" IMF=JPEG >donde:X se selecciona a partir de: -(alquilo C0-6)- Y -(alquilo C0-6)-(alquilo C0-6)-cicloalquilo C3-8- (alquilo C0-6)-,alquenilo C2-10, y alquinilo C2-10,donde el alquilo se encuentra insustituido o sustituido por 1-7 sustitutos los cuales se seleccionan independientemente a partir de:(a) halo,(b) hidroxi,(c) -O-C1-3 alquilo, y(d) trifluorometilo;y donde Y se selecciona a partir de:un solo enlace, -O-, -SO2-, -NR10-, -NR10-SO2-, -SO2-NR10-, -S-, y -SO-,y donde R10 se selecciona independientemente a partir de: hidrógeno, alquilo C1-6, bencilo, fenilo, y alquilo C1-6-cicloalquilo C3-6,que se encuentra insustituido o sustituido por 1-3 sustitutos donde estos últimos se seleccionan independientemente a partir de: halo, alquilo C1-3, alcoxi C1-3 y trifluorometilo;R1 se selecciona a partir de:(1) -CO2H,(2) -NO2,(3) -tetrazolilo,(4) -hidroxiisoxazola,(5) -SO2NHCO-(alquilo C0-3)-R9, donde R9 se selecciona independientemente a partir de: hidrógeno, alquilo C1-6, cicloalquilo C5-6, bencilo o fenilo, el cual es insustituido o sustituido por 1-3 sustitutos los cuales se seleccionan independientemente a partir de: halo, alquilo C1-3, alcoxi C1-3 y trifluorometilo, y(6) -P(O)(OH)2;R3 se selecciona a partir del grupo conformado por:fenilo y heterociclo,que es insustituido o sustituido por 1-7 sustitutos los cuales se seleccionan independientemente a partir de:(a) halo,(b) trifluorometilo,(c) hidroxi,(d) alquilo C1-3,(e) alquilo -O-C1-3,(f) -CO2R9,(g) -NR9R10, y(h) -CONR9R10; ...
CO00042774A 1999-06-11 2000-06-08 Derivados de n-[3-((piperidin-1-il)metil)-4-(fenil o hetero- ciclil)ciclopent-1-il]]amina utiles como moduladores de actividad del receptor de la quimioquina CO5180558A1 (es)

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US33081099A 1999-06-11 1999-06-11
US13888699P 1999-06-11 1999-06-11

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CA2472682A1 (en) * 2002-01-22 2003-07-31 Merck & Co., Inc. Treating stress response with chemokine receptor ccr5 modulators
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KR20100108348A (ko) 2007-11-23 2010-10-06 레오 파마 에이/에스 질병 치료용의 신규한 사이클릭 탄화수소 화합물
RU2599788C2 (ru) * 2010-06-30 2016-10-20 Лео Фарма А/С Новая полиморфная форма кальцимиметического соединения
WO2012000498A1 (en) * 2010-06-30 2012-01-05 Leo Pharma A/S New polymorphic form of a calcimimetic compound

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WO1998031364A1 (en) * 1997-01-21 1998-07-23 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
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ATE344242T1 (de) 2006-11-15
AU772321B2 (en) 2004-04-22
JP4688381B2 (ja) 2011-05-25
PE20010236A1 (es) 2001-02-24
EP1192133B1 (en) 2006-11-02
DE60031676D1 (en) 2006-12-14
JP2003502315A (ja) 2003-01-21
CA2382880A1 (en) 2000-12-21
AU5472600A (en) 2001-01-02
CA2382880C (en) 2008-10-14
EP1192133A1 (en) 2002-04-03
DE60031676T2 (de) 2007-08-30
ES2274793T3 (es) 2007-06-01

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