DE60037597D1 - Imidazol- Derivate - Google Patents
Imidazol- DerivateInfo
- Publication number
- DE60037597D1 DE60037597D1 DE60037597T DE60037597T DE60037597D1 DE 60037597 D1 DE60037597 D1 DE 60037597D1 DE 60037597 T DE60037597 T DE 60037597T DE 60037597 T DE60037597 T DE 60037597T DE 60037597 D1 DE60037597 D1 DE 60037597D1
- Authority
- DE
- Germany
- Prior art keywords
- imidazole derivatives
- occurred
- excessive
- inappropriate
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16688699P | 1999-11-22 | 1999-11-22 | |
US16681499P | 1999-11-22 | 1999-11-22 | |
US16689599P | 1999-11-22 | 1999-11-22 | |
US16688599P | 1999-11-22 | 1999-11-22 | |
US166886P | 1999-11-22 | ||
US166814P | 1999-11-22 | ||
US166895P | 1999-11-22 | ||
US166885P | 1999-11-22 | ||
PCT/US2000/031791 WO2001037835A1 (en) | 1999-11-22 | 2000-11-20 | Novel compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60037597D1 true DE60037597D1 (de) | 2008-02-07 |
DE60037597T2 DE60037597T2 (de) | 2008-12-11 |
Family
ID=27496721
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60037597T Expired - Fee Related DE60037597T2 (de) | 1999-11-22 | 2000-11-20 | Imidazol- Derivate |
DE60015594T Expired - Fee Related DE60015594T2 (de) | 1999-11-22 | 2000-11-20 | Imidazolderivate und deren verwendung als raf kinase inhibitoren |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60015594T Expired - Fee Related DE60015594T2 (de) | 1999-11-22 | 2000-11-20 | Imidazolderivate und deren verwendung als raf kinase inhibitoren |
Country Status (21)
Country | Link |
---|---|
US (3) | US7026336B1 (de) |
EP (2) | EP1232153B1 (de) |
JP (2) | JP2003514906A (de) |
KR (1) | KR20020050294A (de) |
CN (1) | CN1543346A (de) |
AT (2) | ATE382044T1 (de) |
AU (2) | AU1623601A (de) |
BR (1) | BR0015532A (de) |
CA (1) | CA2395564A1 (de) |
CZ (1) | CZ20021746A3 (de) |
DE (2) | DE60037597T2 (de) |
ES (2) | ES2228629T3 (de) |
HK (1) | HK1050190A1 (de) |
HU (1) | HUP0203403A3 (de) |
IL (2) | IL149150A0 (de) |
MX (1) | MXPA02005106A (de) |
NO (1) | NO20022318D0 (de) |
NZ (1) | NZ518032A (de) |
PL (1) | PL355912A1 (de) |
TR (1) | TR200201364T2 (de) |
WO (2) | WO2001037835A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
JP2003514906A (ja) | 1999-11-22 | 2003-04-22 | スミスクライン ビーチャム パブリック リミテッド カンパニー | イミダゾール誘導体およびrafキナーゼ阻害剤としてのその使用 |
GB0004888D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004886D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0005357D0 (en) | 2000-03-06 | 2000-04-26 | Smithkline Beecham Plc | Compounds |
GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
GB0021726D0 (en) * | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
AU2002236476A1 (en) | 2000-11-20 | 2002-05-27 | Smith Kline Beecham Corporation | Novel compounds |
GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
US7446106B2 (en) | 2001-09-05 | 2008-11-04 | Smithkline Beecham Plc | Pyridylfurans and pyrroles as Raf kinase inhibitors |
GB0121488D0 (en) * | 2001-09-05 | 2001-10-24 | Smithkline Beecham Plc | Compounds |
US7375105B2 (en) | 2001-09-05 | 2008-05-20 | Smithkline Beecham P.L.C. | Pyridine substituted furan derivatives as Raf kinase inhibitors |
GB0205693D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
AU2003208479A1 (en) * | 2002-03-09 | 2003-09-22 | Astrazeneca Ab | 4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity |
GB0205690D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
GB0205688D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
DE60304718T2 (de) | 2002-08-06 | 2007-04-26 | Astrazeneca Ab | Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität |
JP2006508051A (ja) | 2002-08-29 | 2006-03-09 | サイオス インク. | 骨形成を促進する方法 |
EP2426122A1 (de) * | 2002-10-24 | 2012-03-07 | Merck Patent GmbH | Methylenharnstoffderivate als Inhibitoren von RAF Kinase |
US7589112B2 (en) * | 2002-10-24 | 2009-09-15 | Merck Patent Gmbh | Methylene urea derivatives |
GB0230089D0 (en) * | 2002-12-24 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
WO2004060362A2 (en) * | 2003-01-02 | 2004-07-22 | Millennium Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING TGF-β |
GB0311274D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
GB0311276D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
AR045037A1 (es) | 2003-07-10 | 2005-10-12 | Aventis Pharma Sa | Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion. |
WO2005030091A2 (en) | 2003-09-25 | 2005-04-07 | Scios Inc. | Stents and intra-luminal prostheses containing map kinase inhibitors |
EP1670780A4 (de) * | 2003-10-02 | 2008-12-17 | Irm Llc | Verbindungen und zusammensetzungen als proteinkinaseinhibitoren |
WO2005063716A1 (en) | 2003-12-22 | 2005-07-14 | Janssen Pharmaceutica, N.V. | Imidazoles and their use cck-1 receptor modulators |
TW200528101A (en) | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
EP1727800A1 (de) * | 2004-02-26 | 2006-12-06 | MERCK PATENT GmbH | Semicarbazidderivate als kinaseinhibitoren |
EP1676574A3 (de) | 2004-12-30 | 2006-07-26 | Johnson & Johnson Vision Care, Inc. | Verfahren zur Förderung des Überlebens von Zell- und Gewebe-Transplantaten |
WO2007016286A1 (en) * | 2005-07-28 | 2007-02-08 | Janssen Pharmaceutica N.V. | Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine |
AU2006296386A1 (en) | 2005-09-30 | 2007-04-05 | Astrazeneca Ab | Imidazo [1,2-a] pyridine having anti-cell-proliferation activity |
US7989461B2 (en) | 2005-12-23 | 2011-08-02 | Amgen Inc. | Substituted quinazolinamine compounds for the treatment of cancer |
CN101490046A (zh) | 2006-05-09 | 2009-07-22 | 辉瑞产品公司 | 环烷基氨基酸衍生物及其药物组合物 |
WO2008153947A2 (en) | 2007-06-07 | 2008-12-18 | Amgen Inc. | Heterocyclic compounds as raf kinase modulators |
BRPI0814423B1 (pt) | 2007-07-17 | 2022-04-19 | Plexxikon, Inc | Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos |
CA2718936A1 (en) | 2008-03-21 | 2009-09-24 | Novartis Ag | Novel heterocyclic compounds and uses therof |
US8865732B2 (en) | 2008-03-21 | 2014-10-21 | Novartis Ag | Heterocyclic compounds and uses thereof |
UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
AU2009262199B2 (en) | 2008-06-27 | 2012-08-09 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
EP2485593B1 (de) * | 2009-10-08 | 2015-01-07 | GlaxoSmithKline LLC | Kombination |
PT3560498T (pt) | 2009-10-16 | 2022-11-03 | Novartis Ag | Combinação que compreende um inibidor de mek e um inibidor de b-raf |
EP2516668B1 (de) * | 2009-12-22 | 2016-04-06 | Csir | Hemmung der aktivität von kinase- und synthetaseenzymen |
CN103159735B (zh) * | 2011-12-10 | 2015-12-09 | 通化济达医药有限公司 | 取代的咪唑激酶抑制剂 |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
US10605785B2 (en) * | 2017-06-07 | 2020-03-31 | General Electric Company | Sensor system and method |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3707475A (en) | 1970-11-16 | 1972-12-26 | Pfizer | Antiinflammatory imidazoles |
US3940486A (en) | 1971-05-10 | 1976-02-24 | Ciba-Geigy Corporation | Imidazole derivatives in the treatment of pain |
US4447413A (en) * | 1980-05-08 | 1984-05-08 | Aviation Chemical, Inc. | Drift influencing composition |
US4348404A (en) | 1980-07-21 | 1982-09-07 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-α-polyfluoroalkyl-1H-imidazole-2-methanamines |
CA1175431A (en) | 1980-07-25 | 1984-10-02 | Alfred Sallmann | Tri-substituted imidazole derivatives, processes for their manufacture, pharmaceutical preparations containing them, and their use |
US5166214A (en) | 1988-12-05 | 1992-11-24 | Du Pont Merck Pharmaceutical Company | Use of imidazoles for the treatment of atherosclerosis |
US5236917A (en) | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
US5179117A (en) | 1991-12-20 | 1993-01-12 | Du Pont Merck Pharmaceutical Company | Antihypercholesterolemic 2-substituted imidazoles |
US5656644A (en) | 1994-07-20 | 1997-08-12 | Smithkline Beecham Corporation | Pyridyl imidazoles |
US5310748A (en) | 1992-05-11 | 1994-05-10 | The Du Pont Merck Pharmaceutical Company | Imidazoles for the treatment of atherosclerosis |
EP0653421B1 (de) | 1993-11-12 | 1997-01-15 | Ishihara Sangyo Kaisha Ltd. | Verfahren zur Herstellung 2-cyanoimidazol Derivate |
US5620999A (en) | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
US5514505A (en) | 1995-05-15 | 1996-05-07 | Xerox Corporation | Method for obtaining improved image contrast in migration imaging members |
US6342510B1 (en) | 1995-06-12 | 2002-01-29 | G. D. Searle & Co. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist |
US5717100A (en) | 1995-10-06 | 1998-02-10 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
EP0889887A4 (de) | 1996-03-25 | 2003-06-11 | Smithkline Beecham Corp | Behandlung von verletzungen des zentralen nervensystems |
JP2000504023A (ja) | 1996-04-03 | 2000-04-04 | メルク エンド カンパニー インコーポレーテッド | 癌治療方法 |
ES2239357T3 (es) | 1996-06-10 | 2005-09-16 | MERCK & CO., INC. | Imidazoles sustituidos que tienen actividad inhibidora de citoquinas. |
ATE271385T1 (de) | 1996-10-15 | 2004-08-15 | Searle Llc | Verwendung von cyclooxygenase-2 inhibitoren zur behandlung und verbeugung von neoplasia |
CN100443481C (zh) | 1997-06-12 | 2008-12-17 | 艾文蒂斯药品有限公司 | 咪唑基-环缩醛类 |
GB9713726D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
CA2295021A1 (en) | 1997-06-30 | 1999-01-28 | Ortho-Mcneil Pharmaceutical, Inc. | 2-substituted imidazoles useful in the treatment of inflammatory diseases |
WO1999021555A2 (en) | 1997-10-27 | 1999-05-06 | Takeda Chemical Industries, Ltd. | Adenosine a3 receptor antagonists |
TR200100918T2 (tr) * | 1997-12-22 | 2001-06-21 | Bayer Corporation | Aril ve heteroaril sübstitüentli üreler kullanılarak RAF kinazın inhibe edilmesi |
IL136690A0 (en) * | 1997-12-22 | 2001-06-14 | Bayer Ag | Inhibition of raf kinase using symmetrical and unsymmetrical substituted diphenyl ureas |
PL344330A1 (en) * | 1998-05-22 | 2001-10-22 | Smithkline Beecham Corp | Novel 2-alkyl substituted imidazole compounds |
WO2000001688A1 (fr) | 1998-07-02 | 2000-01-13 | Sankyo Company, Limited | Composes heteroaryle a cinq elements |
US6207687B1 (en) | 1998-07-31 | 2001-03-27 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
AU6476599A (en) | 1998-11-03 | 2000-05-22 | Novartis Ag | Anti-inflammatory 4-phenyl-5-pyrimidinyl-imidazoles |
AU2164300A (en) | 1998-12-04 | 2000-06-26 | N.V. Organon | Substituted thiazoles for treatment of human diseases involving modulators of p-, l- and e- selectin |
AU4556800A (en) | 1999-04-27 | 2000-11-10 | Smithkline Beecham Plc | Novel treatment |
JP2003514906A (ja) | 1999-11-22 | 2003-04-22 | スミスクライン ビーチャム パブリック リミテッド カンパニー | イミダゾール誘導体およびrafキナーゼ阻害剤としてのその使用 |
EP1263753B1 (de) | 2000-03-06 | 2004-05-06 | SmithKline Beecham plc | Imidazol derivate als raf kinase inhibitoren |
GB0005357D0 (en) | 2000-03-06 | 2000-04-26 | Smithkline Beecham Plc | Compounds |
WO2002024680A1 (en) | 2000-09-21 | 2002-03-28 | Smithkline Beecham P.L.C. | Imidazole derivatives as raf kinase inhibitors |
AU2002236476A1 (en) | 2000-11-20 | 2002-05-27 | Smith Kline Beecham Corporation | Novel compounds |
GB0112348D0 (en) | 2001-05-19 | 2001-07-11 | Smithkline Beecham Plc | Compounds |
GB0121494D0 (en) | 2001-09-05 | 2001-10-24 | Smithkline Beecham Plc | Compounds |
US7446106B2 (en) | 2001-09-05 | 2008-11-04 | Smithkline Beecham Plc | Pyridylfurans and pyrroles as Raf kinase inhibitors |
GB0121490D0 (en) | 2001-09-05 | 2001-10-24 | Smithkline Beecham Plc | Ciompounds |
WO2003022837A1 (en) | 2001-09-05 | 2003-03-20 | Smithkline Beecham P.L.C. | Heterocycle-carboxamide derivatives as raf kinase inhibitors |
GB0121488D0 (en) | 2001-09-05 | 2001-10-24 | Smithkline Beecham Plc | Compounds |
US7375105B2 (en) | 2001-09-05 | 2008-05-20 | Smithkline Beecham P.L.C. | Pyridine substituted furan derivatives as Raf kinase inhibitors |
-
2000
- 2000-11-20 JP JP2001540087A patent/JP2003514906A/ja not_active Withdrawn
- 2000-11-20 MX MXPA02005106A patent/MXPA02005106A/es unknown
- 2000-11-20 NZ NZ518032A patent/NZ518032A/en unknown
- 2000-11-20 US US10/130,019 patent/US7026336B1/en not_active Expired - Fee Related
- 2000-11-20 US US10/130,018 patent/US7189745B1/en not_active Expired - Fee Related
- 2000-11-20 ES ES00977660T patent/ES2228629T3/es not_active Expired - Lifetime
- 2000-11-20 WO PCT/US2000/031791 patent/WO2001037835A1/en active Search and Examination
- 2000-11-20 DE DE60037597T patent/DE60037597T2/de not_active Expired - Fee Related
- 2000-11-20 TR TR2002/01364T patent/TR200201364T2/xx unknown
- 2000-11-20 CN CNA008159491A patent/CN1543346A/zh active Pending
- 2000-11-20 DE DE60015594T patent/DE60015594T2/de not_active Expired - Fee Related
- 2000-11-20 JP JP2001539450A patent/JP2003514860A/ja active Pending
- 2000-11-20 CZ CZ20021746A patent/CZ20021746A3/cs unknown
- 2000-11-20 AU AU16236/01A patent/AU1623601A/en not_active Abandoned
- 2000-11-20 CA CA002395564A patent/CA2395564A1/en not_active Abandoned
- 2000-11-20 ES ES00978816T patent/ES2298165T3/es not_active Expired - Lifetime
- 2000-11-20 AU AU15299/01A patent/AU1529901A/en not_active Abandoned
- 2000-11-20 WO PCT/GB2000/004413 patent/WO2001038324A2/en active IP Right Grant
- 2000-11-20 PL PL00355912A patent/PL355912A1/xx not_active Application Discontinuation
- 2000-11-20 EP EP00977660A patent/EP1232153B1/de not_active Expired - Lifetime
- 2000-11-20 EP EP00978816A patent/EP1233769B1/de not_active Expired - Lifetime
- 2000-11-20 KR KR1020027006476A patent/KR20020050294A/ko not_active Application Discontinuation
- 2000-11-20 AT AT00978816T patent/ATE382044T1/de not_active IP Right Cessation
- 2000-11-20 BR BR0015532-2A patent/BR0015532A/pt not_active Application Discontinuation
- 2000-11-20 HU HU0203403A patent/HUP0203403A3/hu unknown
- 2000-11-20 AT AT00977660T patent/ATE281451T1/de not_active IP Right Cessation
- 2000-11-20 IL IL14915000A patent/IL149150A0/xx active IP Right Grant
-
2002
- 2002-04-15 IL IL149150A patent/IL149150A/en not_active IP Right Cessation
- 2002-05-15 NO NO20022318A patent/NO20022318D0/no not_active Application Discontinuation
-
2003
- 2003-01-29 HK HK03100744.6A patent/HK1050190A1/zh unknown
-
2006
- 2006-09-19 US US11/533,034 patent/US20070010534A1/en not_active Abandoned
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