HUP0300686A2 - Szívtranszplantátumok kilökődésének kezelésére szolgáló gyógyszerkészítmény, mely nem-peptid CCR1 receptor antagonista és ciklosporin A kombinációját tartalmazza - Google Patents

Szívtranszplantátumok kilökődésének kezelésére szolgáló gyógyszerkészítmény, mely nem-peptid CCR1 receptor antagonista és ciklosporin A kombinációját tartalmazza

Info

Publication number
HUP0300686A2
HUP0300686A2 HU0300686A HUP0300686A HUP0300686A2 HU P0300686 A2 HUP0300686 A2 HU P0300686A2 HU 0300686 A HU0300686 A HU 0300686A HU P0300686 A HUP0300686 A HU P0300686A HU P0300686 A2 HUP0300686 A2 HU P0300686A2
Authority
HU
Hungary
Prior art keywords
cyclosporin
treatment
transplant rejection
combination
pharmaceutical composition
Prior art date
Application number
HU0300686A
Other languages
English (en)
Inventor
Richard Horuk
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of HUP0300686A2 publication Critical patent/HUP0300686A2/hu
Publication of HUP0300686A3 publication Critical patent/HUP0300686A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány gyógyászati készítményekre vonatkozik, melyek emlősökben aszívtranszplantátumok kilökődésének kezelésében hasznosak ésgyógyszerészetileg elfogadható hordozót, nempeptid CCR1 receptorantagonista hatásos mennyiségét, és szub-nephrotoxikus meny- nyiségűciklosporin A-t tartalmaz. A találmány kiterjed a készítményekalkalmazására is. Ó
HU0300686A 2000-07-31 2001-07-31 Pharmaceutical composition containing non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection HUP0300686A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22205300P 2000-07-31 2000-07-31
US23128200P 2000-09-08 2000-09-08
US09/915,411 US6740636B2 (en) 2000-07-31 2001-07-25 Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection
PCT/US2001/023862 WO2002009762A2 (en) 2000-07-31 2001-07-31 Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection

Publications (2)

Publication Number Publication Date
HUP0300686A2 true HUP0300686A2 (hu) 2003-08-28
HUP0300686A3 HUP0300686A3 (en) 2005-03-29

Family

ID=27397025

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300686A HUP0300686A3 (en) 2000-07-31 2001-07-31 Pharmaceutical composition containing non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection

Country Status (28)

Country Link
US (1) US6740636B2 (hu)
EP (1) EP1305047B1 (hu)
JP (1) JP2004530630A (hu)
KR (1) KR20030048000A (hu)
CN (1) CN1655818A (hu)
AT (1) ATE330634T1 (hu)
AU (2) AU2001278073B2 (hu)
BG (1) BG107502A (hu)
BR (1) BR0113140A (hu)
CA (1) CA2417636A1 (hu)
CY (1) CY1105321T1 (hu)
DE (1) DE60120986T2 (hu)
DK (1) DK1305047T3 (hu)
EE (1) EE200300047A (hu)
ES (1) ES2261447T3 (hu)
HR (1) HRP20030121A2 (hu)
HU (1) HUP0300686A3 (hu)
IL (1) IL153933A0 (hu)
LV (1) LV13033B (hu)
MX (1) MXPA03000836A (hu)
NO (1) NO20030475L (hu)
NZ (1) NZ523688A (hu)
PL (1) PL364521A1 (hu)
PT (1) PT1305047E (hu)
SI (1) SI21123A (hu)
SK (1) SK1222003A3 (hu)
WO (1) WO2002009762A2 (hu)
YU (1) YU6703A (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0413846A (pt) * 2003-08-22 2006-10-24 Schering Aktiengellschaft derivados de piperazina inibidores de quimiocina e seu uso para tratar miocardite
US7917195B2 (en) 2004-03-05 2011-03-29 Lifesciences Solutions LLC Systems, methods and computer program products for heart monitoring
US10499828B2 (en) * 2004-03-05 2019-12-10 Lifescience Solutions, Llc System and method for heart monitoring
US8103065B2 (en) * 2006-01-05 2012-01-24 Lifescience Solutions Llc Assessment of medical conditions
US20110009758A1 (en) * 2009-07-10 2011-01-13 Lifescience Solutions Llc System and method for heart monitoring

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
DK0966443T3 (da) 1997-02-26 2009-03-09 Pfizer Heteroaryl-hexansyre amidderivater, deres fremstilling og deres anvendelse som selektive inhibitorer af MIP-1-alfa binding til dens CCR1 receptor
US6207665B1 (en) 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
IL137266A0 (en) 1998-01-21 2001-07-24 Millennium Pharm Inc Heterocyclic chemokine receptor antagonists and pharmaceutical compositions containing the same
US6433165B1 (en) 1998-01-21 2002-08-13 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
EA003137B1 (ru) 1998-02-05 2003-02-27 Пфайзер Продактс Инк Новые производные дигидроксигексановой кислоты
EP1000626A1 (en) 1998-09-18 2000-05-17 Applied Research Systems ARS Holding N.V. Chemokine receptor antagonist and cyclosporin in combined therapy
CA2360672A1 (en) 1999-01-29 2000-08-03 Wayne W. Hancock Methods for preventing graft rejection and ischemia-reperfusion injury

Also Published As

Publication number Publication date
SK1222003A3 (en) 2003-09-11
DK1305047T3 (da) 2006-10-23
DE60120986T2 (de) 2006-11-23
EE200300047A (et) 2004-10-15
EP1305047B1 (en) 2006-06-21
ES2261447T3 (es) 2006-11-16
BR0113140A (pt) 2003-06-24
AU7807301A (en) 2002-02-13
WO2002009762A2 (en) 2002-02-07
LV13033B (en) 2004-02-20
YU6703A (sh) 2006-05-25
PL364521A1 (en) 2004-12-13
SI21123A (sl) 2003-08-31
ATE330634T1 (de) 2006-07-15
IL153933A0 (en) 2003-07-31
NZ523688A (en) 2005-04-29
US20020039997A1 (en) 2002-04-04
MXPA03000836A (es) 2003-06-06
BG107502A (en) 2003-07-31
HUP0300686A3 (en) 2005-03-29
CY1105321T1 (el) 2010-03-03
HRP20030121A2 (en) 2005-02-28
JP2004530630A (ja) 2004-10-07
US6740636B2 (en) 2004-05-25
CA2417636A1 (en) 2002-02-07
WO2002009762A3 (en) 2003-01-09
NO20030475D0 (no) 2003-01-30
CN1655818A (zh) 2005-08-17
NO20030475L (no) 2003-03-28
EP1305047A2 (en) 2003-05-02
DE60120986D1 (de) 2006-08-03
AU2001278073B2 (en) 2005-06-30
PT1305047E (pt) 2006-11-30
KR20030048000A (ko) 2003-06-18

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