CY1105321T1 - Μη πεπτιδικοι ανταγωνιστες υποδοχεα ccr1 σε συνδυασμο με κυκλοσπορινη α για τη θepαπεια της απορριψης καρδιακου μοσχευματος - Google Patents
Μη πεπτιδικοι ανταγωνιστες υποδοχεα ccr1 σε συνδυασμο με κυκλοσπορινη α για τη θepαπεια της απορριψης καρδιακου μοσχευματοςInfo
- Publication number
- CY1105321T1 CY1105321T1 CY20061101266T CY061101266T CY1105321T1 CY 1105321 T1 CY1105321 T1 CY 1105321T1 CY 20061101266 T CY20061101266 T CY 20061101266T CY 061101266 T CY061101266 T CY 061101266T CY 1105321 T1 CY1105321 T1 CY 1105321T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cyclosporin
- treatment
- rejection
- granplant
- cardiac
- Prior art date
Links
- 102000004500 CCR1 Receptors Human genes 0.000 title abstract 2
- 108010017319 CCR1 Receptors Proteins 0.000 title abstract 2
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
- 108010036949 Cyclosporine Proteins 0.000 title abstract 2
- 229960001265 ciclosporin Drugs 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 230000000747 cardiac effect Effects 0.000 title 1
- 206010019315 Heart transplant rejection Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η εφεύρεση αυτή κατευθύνεται προς φαρμακευτικές συνθέσεις χρήσιμες στη θεραπεία απόρριψης μοσχεύματος καρδιάς σε θηλαστικά περιλαμβάνουσα ένα φαρμακευτικά αποδεκτό έκδοχο, μια θεραπευτικά αποδεκτή ποσότητα από ένα μη πεπτιδικό ανταγωνιστή υποδοχέα CCR1 και μια υπο-νεφροτοξική ποσότητα κυκλοσπορίνης Α.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22205300P | 2000-07-31 | 2000-07-31 | |
US23128200P | 2000-09-08 | 2000-09-08 | |
US09/915,411 US6740636B2 (en) | 2000-07-31 | 2001-07-25 | Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection |
PCT/US2001/023862 WO2002009762A2 (en) | 2000-07-31 | 2001-07-31 | Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105321T1 true CY1105321T1 (el) | 2010-03-03 |
Family
ID=27397025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101266T CY1105321T1 (el) | 2000-07-31 | 2006-09-05 | Μη πεπτιδικοι ανταγωνιστες υποδοχεα ccr1 σε συνδυασμο με κυκλοσπορινη α για τη θepαπεια της απορριψης καρδιακου μοσχευματος |
Country Status (28)
Country | Link |
---|---|
US (1) | US6740636B2 (el) |
EP (1) | EP1305047B1 (el) |
JP (1) | JP2004530630A (el) |
KR (1) | KR20030048000A (el) |
CN (1) | CN1655818A (el) |
AT (1) | ATE330634T1 (el) |
AU (2) | AU7807301A (el) |
BG (1) | BG107502A (el) |
BR (1) | BR0113140A (el) |
CA (1) | CA2417636A1 (el) |
CY (1) | CY1105321T1 (el) |
DE (1) | DE60120986T2 (el) |
DK (1) | DK1305047T3 (el) |
EE (1) | EE200300047A (el) |
ES (1) | ES2261447T3 (el) |
HR (1) | HRP20030121A2 (el) |
HU (1) | HUP0300686A3 (el) |
IL (1) | IL153933A0 (el) |
LV (1) | LV13033B (el) |
MX (1) | MXPA03000836A (el) |
NO (1) | NO20030475L (el) |
NZ (1) | NZ523688A (el) |
PL (1) | PL364521A1 (el) |
PT (1) | PT1305047E (el) |
SI (1) | SI21123A (el) |
SK (1) | SK1222003A3 (el) |
WO (1) | WO2002009762A2 (el) |
YU (1) | YU6703A (el) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2006108865A (ru) * | 2003-08-22 | 2007-09-27 | Шеринг Акциенгезельшафт (De) | Производные пиперазина, которые ингибируют хемокины, и их применение для лечения миокардита |
US7917195B2 (en) | 2004-03-05 | 2011-03-29 | Lifesciences Solutions LLC | Systems, methods and computer program products for heart monitoring |
US10499828B2 (en) * | 2004-03-05 | 2019-12-10 | Lifescience Solutions, Llc | System and method for heart monitoring |
US8103065B2 (en) * | 2006-01-05 | 2012-01-24 | Lifescience Solutions Llc | Assessment of medical conditions |
US20110009758A1 (en) * | 2009-07-10 | 2011-01-13 | Lifescience Solutions Llc | System and method for heart monitoring |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6323206B1 (en) | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
CN1248968A (zh) | 1997-02-26 | 2000-03-29 | 辉瑞大药厂 | 杂芳基-己酸酰胺衍生物、其制备方法及其作为MIP-1α与其CCRI受体结合的选择性抑制剂的用途 |
US6207665B1 (en) * | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
US6433165B1 (en) | 1998-01-21 | 2002-08-13 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
BR9910144A (pt) | 1998-01-21 | 2002-04-02 | Millennium Pharm Inc | Antagonistas de receptores de quimiocinas e seu uso |
KR100385529B1 (ko) | 1998-02-05 | 2003-05-27 | 화이자 프로덕츠 인코포레이티드 | 신규 디하이드록시헥산산 유도체 |
EP1000626A1 (en) | 1998-09-18 | 2000-05-17 | Applied Research Systems ARS Holding N.V. | Chemokine receptor antagonist and cyclosporin in combined therapy |
AU2862300A (en) | 1999-01-29 | 2000-08-18 | Millennium Pharmaceuticals, Inc. | Methods for preventing graft rejection and ischemia-reperfusion injury |
-
2001
- 2001-07-25 US US09/915,411 patent/US6740636B2/en not_active Expired - Fee Related
- 2001-07-31 SK SK122-2003A patent/SK1222003A3/sk unknown
- 2001-07-31 DK DK01956035T patent/DK1305047T3/da active
- 2001-07-31 EP EP01956035A patent/EP1305047B1/en not_active Expired - Lifetime
- 2001-07-31 PT PT01956035T patent/PT1305047E/pt unknown
- 2001-07-31 JP JP2002515314A patent/JP2004530630A/ja not_active Withdrawn
- 2001-07-31 CN CNA018138004A patent/CN1655818A/zh active Pending
- 2001-07-31 IL IL15393301A patent/IL153933A0/xx unknown
- 2001-07-31 KR KR10-2003-7001483A patent/KR20030048000A/ko not_active Application Discontinuation
- 2001-07-31 CA CA002417636A patent/CA2417636A1/en not_active Abandoned
- 2001-07-31 AU AU7807301A patent/AU7807301A/xx active Pending
- 2001-07-31 PL PL01364521A patent/PL364521A1/xx not_active Application Discontinuation
- 2001-07-31 EE EEP200300047A patent/EE200300047A/xx unknown
- 2001-07-31 WO PCT/US2001/023862 patent/WO2002009762A2/en active IP Right Grant
- 2001-07-31 YU YU6703A patent/YU6703A/sh unknown
- 2001-07-31 AU AU2001278073A patent/AU2001278073B2/en not_active Expired - Fee Related
- 2001-07-31 DE DE60120986T patent/DE60120986T2/de not_active Expired - Fee Related
- 2001-07-31 AT AT01956035T patent/ATE330634T1/de not_active IP Right Cessation
- 2001-07-31 MX MXPA03000836A patent/MXPA03000836A/es unknown
- 2001-07-31 HU HU0300686A patent/HUP0300686A3/hu unknown
- 2001-07-31 SI SI200120045A patent/SI21123A/sl not_active IP Right Cessation
- 2001-07-31 ES ES01956035T patent/ES2261447T3/es not_active Expired - Lifetime
- 2001-07-31 BR BR0113140-0A patent/BR0113140A/pt not_active IP Right Cessation
- 2001-07-31 NZ NZ523688A patent/NZ523688A/en unknown
-
2003
- 2003-01-27 BG BG107502A patent/BG107502A/xx unknown
- 2003-01-30 NO NO20030475A patent/NO20030475L/no not_active Application Discontinuation
- 2003-02-19 HR HR20030121A patent/HRP20030121A2/hr not_active Application Discontinuation
- 2003-02-28 LV LVP-03-25A patent/LV13033B/en unknown
-
2006
- 2006-09-05 CY CY20061101266T patent/CY1105321T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO2002009762A2 (en) | 2002-02-07 |
WO2002009762A3 (en) | 2003-01-09 |
SI21123A (sl) | 2003-08-31 |
DE60120986D1 (de) | 2006-08-03 |
ATE330634T1 (de) | 2006-07-15 |
MXPA03000836A (es) | 2003-06-06 |
BR0113140A (pt) | 2003-06-24 |
CN1655818A (zh) | 2005-08-17 |
CA2417636A1 (en) | 2002-02-07 |
AU2001278073B2 (en) | 2005-06-30 |
SK1222003A3 (en) | 2003-09-11 |
NO20030475D0 (no) | 2003-01-30 |
DE60120986T2 (de) | 2006-11-23 |
HRP20030121A2 (en) | 2005-02-28 |
JP2004530630A (ja) | 2004-10-07 |
DK1305047T3 (da) | 2006-10-23 |
EE200300047A (et) | 2004-10-15 |
US6740636B2 (en) | 2004-05-25 |
IL153933A0 (en) | 2003-07-31 |
EP1305047A2 (en) | 2003-05-02 |
LV13033B (en) | 2004-02-20 |
US20020039997A1 (en) | 2002-04-04 |
EP1305047B1 (en) | 2006-06-21 |
NZ523688A (en) | 2005-04-29 |
HUP0300686A2 (hu) | 2003-08-28 |
PT1305047E (pt) | 2006-11-30 |
HUP0300686A3 (en) | 2005-03-29 |
ES2261447T3 (es) | 2006-11-16 |
PL364521A1 (en) | 2004-12-13 |
BG107502A (en) | 2003-07-31 |
AU7807301A (en) | 2002-02-13 |
NO20030475L (no) | 2003-03-28 |
KR20030048000A (ko) | 2003-06-18 |
YU6703A (sh) | 2006-05-25 |
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