DE60120986D1 - Nicht-peptidische ccr1 rezeptor-antagonisten in kombination mit cyclosporin a zur behandlung von herztransplantatabstossung - Google Patents

Nicht-peptidische ccr1 rezeptor-antagonisten in kombination mit cyclosporin a zur behandlung von herztransplantatabstossung

Info

Publication number
DE60120986D1
DE60120986D1 DE60120986T DE60120986T DE60120986D1 DE 60120986 D1 DE60120986 D1 DE 60120986D1 DE 60120986 T DE60120986 T DE 60120986T DE 60120986 T DE60120986 T DE 60120986T DE 60120986 D1 DE60120986 D1 DE 60120986D1
Authority
DE
Germany
Prior art keywords
cyclosporin
peptidic
discharge
heart transplant
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60120986T
Other languages
English (en)
Other versions
DE60120986T2 (de
Inventor
Richard Horuk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of DE60120986D1 publication Critical patent/DE60120986D1/de
Application granted granted Critical
Publication of DE60120986T2 publication Critical patent/DE60120986T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60120986T 2000-07-31 2001-07-31 Nicht-peptidische ccr1 rezeptor-antagonisten in kombination mit cyclosporin a zur behandlung von herztransplantatabstossung Expired - Fee Related DE60120986T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US22205300P 2000-07-31 2000-07-31
US222053P 2000-07-31
US23128200P 2000-09-08 2000-09-08
US231282P 2000-09-08
US09/915,411 US6740636B2 (en) 2000-07-31 2001-07-25 Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection
US915411 2001-07-25
PCT/US2001/023862 WO2002009762A2 (en) 2000-07-31 2001-07-31 Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection

Publications (2)

Publication Number Publication Date
DE60120986D1 true DE60120986D1 (de) 2006-08-03
DE60120986T2 DE60120986T2 (de) 2006-11-23

Family

ID=27397025

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60120986T Expired - Fee Related DE60120986T2 (de) 2000-07-31 2001-07-31 Nicht-peptidische ccr1 rezeptor-antagonisten in kombination mit cyclosporin a zur behandlung von herztransplantatabstossung

Country Status (28)

Country Link
US (1) US6740636B2 (de)
EP (1) EP1305047B1 (de)
JP (1) JP2004530630A (de)
KR (1) KR20030048000A (de)
CN (1) CN1655818A (de)
AT (1) ATE330634T1 (de)
AU (2) AU7807301A (de)
BG (1) BG107502A (de)
BR (1) BR0113140A (de)
CA (1) CA2417636A1 (de)
CY (1) CY1105321T1 (de)
DE (1) DE60120986T2 (de)
DK (1) DK1305047T3 (de)
EE (1) EE200300047A (de)
ES (1) ES2261447T3 (de)
HR (1) HRP20030121A2 (de)
HU (1) HUP0300686A3 (de)
IL (1) IL153933A0 (de)
LV (1) LV13033B (de)
MX (1) MXPA03000836A (de)
NO (1) NO20030475L (de)
NZ (1) NZ523688A (de)
PL (1) PL364521A1 (de)
PT (1) PT1305047E (de)
SI (1) SI21123A (de)
SK (1) SK1222003A3 (de)
WO (1) WO2002009762A2 (de)
YU (1) YU6703A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0413846A (pt) * 2003-08-22 2006-10-24 Schering Aktiengellschaft derivados de piperazina inibidores de quimiocina e seu uso para tratar miocardite
US7917195B2 (en) 2004-03-05 2011-03-29 Lifesciences Solutions LLC Systems, methods and computer program products for heart monitoring
US10499828B2 (en) * 2004-03-05 2019-12-10 Lifescience Solutions, Llc System and method for heart monitoring
US8103065B2 (en) * 2006-01-05 2012-01-24 Lifescience Solutions Llc Assessment of medical conditions
US20110009758A1 (en) * 2009-07-10 2011-01-13 Lifescience Solutions Llc System and method for heart monitoring

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
DE69840519D1 (de) 1997-02-26 2009-03-19 Pfizer Heteroaryl-hexansäureamid-derivate, ihre herstellung und ihre verwendung als selektive inhibitoren der bindung von mip-1-alpha an seinen ccr1 rezeptor
US6207665B1 (en) 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
EP1049700B9 (de) 1998-01-21 2006-05-10 Millennium Pharmaceuticals, Inc. Chemokin rezeptor antagonisten und verwndung
JP2002501052A (ja) 1998-01-21 2002-01-15 ミレニアム・ファーマシューティカルズ・インコーポレイテッド ケモカイン受容体アンタゴニストおよびその使用方法
IL137330A0 (en) 1998-02-05 2001-07-24 Pfizer Prod Inc Novel dihydroxyhexanoic acid derivatives
EP1000626A1 (de) 1998-09-18 2000-05-17 Applied Research Systems ARS Holding N.V. Kombination von chemokin-rezeptor antagonisten und cyclosporin zur therapie
JP2002535358A (ja) 1999-01-29 2002-10-22 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 移植片拒絶反応及び虚血−再灌流障害の予防方法

Also Published As

Publication number Publication date
DK1305047T3 (da) 2006-10-23
KR20030048000A (ko) 2003-06-18
HUP0300686A2 (hu) 2003-08-28
EP1305047A2 (de) 2003-05-02
CN1655818A (zh) 2005-08-17
MXPA03000836A (es) 2003-06-06
ES2261447T3 (es) 2006-11-16
PT1305047E (pt) 2006-11-30
CA2417636A1 (en) 2002-02-07
BR0113140A (pt) 2003-06-24
BG107502A (en) 2003-07-31
SK1222003A3 (en) 2003-09-11
SI21123A (sl) 2003-08-31
ATE330634T1 (de) 2006-07-15
NO20030475D0 (no) 2003-01-30
PL364521A1 (en) 2004-12-13
EP1305047B1 (de) 2006-06-21
CY1105321T1 (el) 2010-03-03
WO2002009762A2 (en) 2002-02-07
EE200300047A (et) 2004-10-15
IL153933A0 (en) 2003-07-31
AU2001278073B2 (en) 2005-06-30
NO20030475L (no) 2003-03-28
NZ523688A (en) 2005-04-29
YU6703A (sh) 2006-05-25
HRP20030121A2 (en) 2005-02-28
JP2004530630A (ja) 2004-10-07
US6740636B2 (en) 2004-05-25
US20020039997A1 (en) 2002-04-04
AU7807301A (en) 2002-02-13
LV13033B (en) 2004-02-20
DE60120986T2 (de) 2006-11-23
WO2002009762A3 (en) 2003-01-09
HUP0300686A3 (en) 2005-03-29

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE

8339 Ceased/non-payment of the annual fee