ATE330634T1 - Nicht-peptidische ccr1 rezeptor-antagonisten in kombination mit cyclosporin a zur behandlung von herztransplantatabstossung - Google Patents

Nicht-peptidische ccr1 rezeptor-antagonisten in kombination mit cyclosporin a zur behandlung von herztransplantatabstossung

Info

Publication number
ATE330634T1
ATE330634T1 AT01956035T AT01956035T ATE330634T1 AT E330634 T1 ATE330634 T1 AT E330634T1 AT 01956035 T AT01956035 T AT 01956035T AT 01956035 T AT01956035 T AT 01956035T AT E330634 T1 ATE330634 T1 AT E330634T1
Authority
AT
Austria
Prior art keywords
cyclosporin
transplant rejection
peptidic
heart transplant
treatment
Prior art date
Application number
AT01956035T
Other languages
English (en)
Inventor
Richard Horuk
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of ATE330634T1 publication Critical patent/ATE330634T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01956035T 2000-07-31 2001-07-31 Nicht-peptidische ccr1 rezeptor-antagonisten in kombination mit cyclosporin a zur behandlung von herztransplantatabstossung ATE330634T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22205300P 2000-07-31 2000-07-31
US23128200P 2000-09-08 2000-09-08
US09/915,411 US6740636B2 (en) 2000-07-31 2001-07-25 Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection

Publications (1)

Publication Number Publication Date
ATE330634T1 true ATE330634T1 (de) 2006-07-15

Family

ID=27397025

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01956035T ATE330634T1 (de) 2000-07-31 2001-07-31 Nicht-peptidische ccr1 rezeptor-antagonisten in kombination mit cyclosporin a zur behandlung von herztransplantatabstossung

Country Status (28)

Country Link
US (1) US6740636B2 (de)
EP (1) EP1305047B1 (de)
JP (1) JP2004530630A (de)
KR (1) KR20030048000A (de)
CN (1) CN1655818A (de)
AT (1) ATE330634T1 (de)
AU (2) AU7807301A (de)
BG (1) BG107502A (de)
BR (1) BR0113140A (de)
CA (1) CA2417636A1 (de)
CY (1) CY1105321T1 (de)
DE (1) DE60120986T2 (de)
DK (1) DK1305047T3 (de)
EE (1) EE200300047A (de)
ES (1) ES2261447T3 (de)
HR (1) HRP20030121A2 (de)
HU (1) HUP0300686A3 (de)
IL (1) IL153933A0 (de)
LV (1) LV13033B (de)
MX (1) MXPA03000836A (de)
NO (1) NO20030475L (de)
NZ (1) NZ523688A (de)
PL (1) PL364521A1 (de)
PT (1) PT1305047E (de)
SI (1) SI21123A (de)
SK (1) SK1222003A3 (de)
WO (1) WO2002009762A2 (de)
YU (1) YU6703A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2006108865A (ru) * 2003-08-22 2007-09-27 Шеринг Акциенгезельшафт (De) Производные пиперазина, которые ингибируют хемокины, и их применение для лечения миокардита
US7917195B2 (en) 2004-03-05 2011-03-29 Lifesciences Solutions LLC Systems, methods and computer program products for heart monitoring
US10499828B2 (en) * 2004-03-05 2019-12-10 Lifescience Solutions, Llc System and method for heart monitoring
US8103065B2 (en) * 2006-01-05 2012-01-24 Lifescience Solutions Llc Assessment of medical conditions
US20110009758A1 (en) * 2009-07-10 2011-01-13 Lifescience Solutions Llc System and method for heart monitoring

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CN1248968A (zh) 1997-02-26 2000-03-29 辉瑞大药厂 杂芳基-己酸酰胺衍生物、其制备方法及其作为MIP-1α与其CCRI受体结合的选择性抑制剂的用途
US6207665B1 (en) * 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
US6433165B1 (en) 1998-01-21 2002-08-13 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
BR9910144A (pt) 1998-01-21 2002-04-02 Millennium Pharm Inc Antagonistas de receptores de quimiocinas e seu uso
KR100385529B1 (ko) 1998-02-05 2003-05-27 화이자 프로덕츠 인코포레이티드 신규 디하이드록시헥산산 유도체
EP1000626A1 (de) 1998-09-18 2000-05-17 Applied Research Systems ARS Holding N.V. Kombination von chemokin-rezeptor antagonisten und cyclosporin zur therapie
AU2862300A (en) 1999-01-29 2000-08-18 Millennium Pharmaceuticals, Inc. Methods for preventing graft rejection and ischemia-reperfusion injury

Also Published As

Publication number Publication date
WO2002009762A2 (en) 2002-02-07
WO2002009762A3 (en) 2003-01-09
SI21123A (sl) 2003-08-31
DE60120986D1 (de) 2006-08-03
MXPA03000836A (es) 2003-06-06
BR0113140A (pt) 2003-06-24
CN1655818A (zh) 2005-08-17
CA2417636A1 (en) 2002-02-07
AU2001278073B2 (en) 2005-06-30
SK1222003A3 (en) 2003-09-11
NO20030475D0 (no) 2003-01-30
DE60120986T2 (de) 2006-11-23
HRP20030121A2 (en) 2005-02-28
JP2004530630A (ja) 2004-10-07
DK1305047T3 (da) 2006-10-23
EE200300047A (et) 2004-10-15
CY1105321T1 (el) 2010-03-03
US6740636B2 (en) 2004-05-25
IL153933A0 (en) 2003-07-31
EP1305047A2 (de) 2003-05-02
LV13033B (en) 2004-02-20
US20020039997A1 (en) 2002-04-04
EP1305047B1 (de) 2006-06-21
NZ523688A (en) 2005-04-29
HUP0300686A2 (hu) 2003-08-28
PT1305047E (pt) 2006-11-30
HUP0300686A3 (en) 2005-03-29
ES2261447T3 (es) 2006-11-16
PL364521A1 (en) 2004-12-13
BG107502A (en) 2003-07-31
AU7807301A (en) 2002-02-13
NO20030475L (no) 2003-03-28
KR20030048000A (ko) 2003-06-18
YU6703A (sh) 2006-05-25

Similar Documents

Publication Publication Date Title
ATE293989T1 (de) Verwendung von eph-rezeptor-antagonisten und agonisten zur behandlung von vaskulären krankheiten
DE60318891D1 (de) Cyclopropylverbindungen als ccr5 antagonisten
ATE376832T1 (de) Verzögert freisetzende formulierungen von oxymorphon
DE60323133D1 (de) Cyclohexylverbindungen als ccr5-antagonisten
DE69533174D1 (de) Pyridopyrimidinone, chinoline und anellierte n-heterozyklen als bradykinin-antagonisten
ATE402176T1 (de) Pyrrolidin- und azetidinverbindungen alsccr5- antagonisten
HUP0400553A2 (hu) Gyógyászati készítmények
MXPA01008993A (es) Tratamiento de combinacion para depresion y ansiedad.
CY1105321T1 (el) Μη πεπτιδικοι ανταγωνιστες υποδοχεα ccr1 σε συνδυασμο με κυκλοσπορινη α για τη θepαπεια της απορριψης καρδιακου μοσχευματος
ATE319473T1 (de) Melagatran zur behandlung von entzündungen
EA200400302A1 (ru) Способ лечения первичной бессонницы
DE60028928D1 (de) Verwendung von angiotensin ii rezeptorantagonisten zur behandlung von akutem myokardischen infarkt
DK1147105T3 (da) Optisk aktivt pyridyl-4H-1,2,4-oxadiazinderivat og anvendelse af dette til behandling af karsygdomme
CY1105302T1 (el) Μη-πεπτιδιο ανταγωνιστες υποδοχεα ccr1 για την θepαπεια προϊουσης νεφρικης ινωσης
BG105984A (bg) Използване на озанетант за приготвяне на лекарствени средства полезни за лечение на разстройства на настроението
LT2003015A (en) Non-peptide ccr1 receptor antagonists in combination with cyclosporin a for the treatment of heart transplant rejection
DE60009315D1 (de) Verwendung von cyamemazin zur behandlung von entwöhnungserscheinungen der benzodiazepinbehandlung
ATE454153T1 (de) 5-ht4 antagonisten zur behandlung von herzversagen
ATE288756T1 (de) Verwendung von nk-1 rezeptorantagonisten zur behandlung von schweren depressionen, die von angstzuständen begleitet werden
AR018825A1 (es) Antagonistas del receptor de bradiquinina no peptidica para uso en el tratamiento de trastornos y enfermedades oftalmicas
HUP0300032A2 (en) Use of compounds useful for the treatment or prevention of a disease mediated by the alpha-2b-adrenoreceptor for preparation of pharmaceutical composition
SE9902596D0 (sv) Pharmaceutically active compounds

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1305047

Country of ref document: EP

REN Ceased due to non-payment of the annual fee