HUP0301244A2 - Rapamicinvegyület alkalmazása szív-és érrendszeri megbetegedések kezelésére szánt gyógyászati készítmény előállítására - Google Patents
Rapamicinvegyület alkalmazása szív-és érrendszeri megbetegedések kezelésére szánt gyógyászati készítmény előállításáraInfo
- Publication number
- HUP0301244A2 HUP0301244A2 HU0301244A HUP0301244A HUP0301244A2 HU P0301244 A2 HUP0301244 A2 HU P0301244A2 HU 0301244 A HU0301244 A HU 0301244A HU P0301244 A HUP0301244 A HU P0301244A HU P0301244 A2 HUP0301244 A2 HU P0301244A2
- Authority
- HU
- Hungary
- Prior art keywords
- rapamycin
- preparation
- pharmaceutical composition
- cardiovascular diseases
- subject
- Prior art date
Links
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002930 sirolimus Drugs 0.000 title abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 title abstract 2
- 208000019622 heart disease Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
- -1 rapamycin compound Chemical class 0.000 abstract 2
- ILPUOPPYSQEBNJ-UHFFFAOYSA-N 2-methyl-2-phenoxypropanoic acid Chemical class OC(=O)C(C)(C)OC1=CC=CC=C1 ILPUOPPYSQEBNJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000005541 ACE inhibitor Substances 0.000 abstract 1
- 229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 239000002876 beta blocker Substances 0.000 abstract 1
- 229940030611 beta-adrenergic blocking agent Drugs 0.000 abstract 1
- 239000000480 calcium channel blocker Substances 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 229940125753 fibrate Drugs 0.000 abstract 1
- 238000002657 hormone replacement therapy Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgya rapamicinvegyület alkalmazása emlősökben szív- ésérrendszeri, agyérrendszeri vagy periferiális érrendszeri megbetegedéskezelésére vagy meggátolására szánt gyógyászati készítményelőállítására. A talámány tárgya továbbá kombinációs készítmény, amelyrapamicinvegyületet és egy vagy több szert tartalmaz az alábbiakközül: ACE-inhibitorok, angiotenzin II receptor antagonisták,fibrinsav-származékok, HMG Co-A reduktáz inhibitorok, béta-adrenergblokkoló szerek, kalciumcsatorna blokkolók, antioxidánsok;antikoagulánsok vagy ösztrogént tartalmazó, hormonpótló terápiábanhasznos szerek. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21211700P | 2000-06-16 | 2000-06-16 | |
PCT/US2001/019179 WO2001097809A2 (en) | 2000-06-16 | 2001-06-14 | Method of treating cardiovascular disease using rapamycin |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0301244A2 true HUP0301244A2 (hu) | 2003-08-28 |
HUP0301244A3 HUP0301244A3 (en) | 2005-01-28 |
Family
ID=22789625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301244A HUP0301244A3 (en) | 2000-06-16 | 2001-06-14 | Use of rapamycin for preparation of pharmaceutical composition to treat heart and cardiovascular diseases |
Country Status (19)
Country | Link |
---|---|
US (1) | US20020013335A1 (hu) |
EP (1) | EP1292302A2 (hu) |
JP (1) | JP2003535899A (hu) |
KR (1) | KR20030010710A (hu) |
CN (1) | CN1436076A (hu) |
AR (1) | AR028959A1 (hu) |
AU (2) | AU2001268446B2 (hu) |
BR (1) | BR0111601A (hu) |
CA (1) | CA2412636A1 (hu) |
CZ (1) | CZ20024115A3 (hu) |
EA (1) | EA200300027A1 (hu) |
HU (1) | HUP0301244A3 (hu) |
IL (1) | IL153405A0 (hu) |
MX (1) | MXPA02012410A (hu) |
NO (1) | NO20026008D0 (hu) |
NZ (1) | NZ523114A (hu) |
PL (1) | PL365455A1 (hu) |
WO (1) | WO2001097809A2 (hu) |
ZA (1) | ZA200300418B (hu) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2269603E (pt) * | 2001-02-19 | 2015-09-09 | Novartis Ag | Tratamento de tumores da mama com um derivado de rapamicina em combinação com exemestano |
US6641611B2 (en) | 2001-11-26 | 2003-11-04 | Swaminathan Jayaraman | Therapeutic coating for an intravascular implant |
US20040137066A1 (en) * | 2001-11-26 | 2004-07-15 | Swaminathan Jayaraman | Rationally designed therapeutic intravascular implant coating |
US20030220297A1 (en) | 2002-02-01 | 2003-11-27 | Berstein David L. | Phosphorus-containing compounds and uses thereof |
US20030176455A1 (en) * | 2002-03-13 | 2003-09-18 | Wyeth | Method of inhibiting cell death |
BR0313024A (pt) | 2002-07-30 | 2005-07-12 | Wyeth Corp | Formulações parenterais contendo um hidroxiéster de rapamicina |
CN100415233C (zh) * | 2002-09-17 | 2008-09-03 | 惠氏公司 | 口服制剂 |
AU2003293529A1 (en) | 2002-12-16 | 2004-07-29 | Nitromed, Inc. | Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use |
AR042938A1 (es) | 2003-02-06 | 2005-07-06 | Wyeth Corp | Uso del cci-779 en el tratamiento de la fibrosis hepatica |
US7728033B2 (en) | 2003-05-05 | 2010-06-01 | Clinigene International Private Limited | Mycophenolate mofetil in diabetic nephropathy |
US7220755B2 (en) | 2003-11-12 | 2007-05-22 | Biosensors International Group, Ltd. | 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same |
DE102004019845A1 (de) * | 2004-03-29 | 2005-10-20 | Krka Tovarna Zdravil D D | Verfahren zur Herstellung einer festen pharmazeutischen Zusammensetzung |
US20050232965A1 (en) * | 2004-04-15 | 2005-10-20 | Robert Falotico | Local administration of a combination of rapamycin and 17 beta-estradiol for the treatment of vulnerable plaque |
PL1750862T3 (pl) * | 2004-06-04 | 2011-06-30 | Teva Pharma | Kompozycja farmaceutyczna zawierająca irbesartan |
CN100435755C (zh) * | 2004-07-27 | 2008-11-26 | 微创医疗器械(上海)有限公司 | 药物洗脱支架 |
EP1656941A1 (en) * | 2004-11-09 | 2006-05-17 | Clinigene International Private Limited | Compositions for the treatment of diabetic nephropathy |
GB0503936D0 (en) | 2005-02-25 | 2005-04-06 | San Raffaele Centro Fond | Method |
CN100384416C (zh) * | 2006-03-20 | 2008-04-30 | 杨军 | 一种用于治疗心血管疾病的药物组合物 |
US20080175887A1 (en) * | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
WO2011115695A1 (en) | 2010-03-15 | 2011-09-22 | Exxonmobil Chemical Patents Inc. | Processes for the production of alcohols |
EP2906214A1 (en) * | 2012-10-12 | 2015-08-19 | The Board of Regents of The University of Texas System | Use of mtor inhibitors to treat vascular cognitive impairment |
US10098871B2 (en) * | 2013-03-15 | 2018-10-16 | Leslie B. Gordon | Combination therapies for treatment of laminopathies, cellular aging, and atherosclerosis |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
EP3089737B1 (en) | 2013-12-31 | 2021-11-03 | Rapamycin Holdings, LLC | Oral rapamycin nanoparticle preparations and use |
CN105997940A (zh) * | 2016-05-11 | 2016-10-12 | 中国人民解放军第三军医大学 | 炎症微环境响应性纳米药物、其制备方法及应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5516781A (en) * | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
US5373014A (en) * | 1993-10-08 | 1994-12-13 | American Home Products Corporation | Rapamycin oximes |
US5563145A (en) * | 1994-12-07 | 1996-10-08 | American Home Products Corporation | Rapamycin 42-oximes and hydroxylamines |
GB9606452D0 (en) * | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
PT994697E (pt) * | 1997-06-13 | 2005-02-28 | Wyeth Corp | Formulacoes de rapamicina para administracao oral |
US6015809A (en) * | 1998-08-17 | 2000-01-18 | American Home Products Corporation | Photocyclized rapamycin |
-
2001
- 2001-06-13 US US09/880,295 patent/US20020013335A1/en not_active Abandoned
- 2001-06-14 EP EP01946387A patent/EP1292302A2/en not_active Ceased
- 2001-06-14 PL PL01365455A patent/PL365455A1/xx not_active Application Discontinuation
- 2001-06-14 CN CN01811212A patent/CN1436076A/zh active Pending
- 2001-06-14 WO PCT/US2001/019179 patent/WO2001097809A2/en not_active Application Discontinuation
- 2001-06-14 NZ NZ523114A patent/NZ523114A/en unknown
- 2001-06-14 KR KR1020027017036A patent/KR20030010710A/ko not_active Application Discontinuation
- 2001-06-14 CA CA002412636A patent/CA2412636A1/en not_active Abandoned
- 2001-06-14 IL IL15340501A patent/IL153405A0/xx unknown
- 2001-06-14 CZ CZ20024115A patent/CZ20024115A3/cs unknown
- 2001-06-14 EA EA200300027A patent/EA200300027A1/ru unknown
- 2001-06-14 HU HU0301244A patent/HUP0301244A3/hu unknown
- 2001-06-14 MX MXPA02012410A patent/MXPA02012410A/es not_active Application Discontinuation
- 2001-06-14 BR BR0111601-0A patent/BR0111601A/pt not_active IP Right Cessation
- 2001-06-14 AU AU2001268446A patent/AU2001268446B2/en not_active Ceased
- 2001-06-14 AU AU6844601A patent/AU6844601A/xx active Pending
- 2001-06-14 JP JP2002503293A patent/JP2003535899A/ja active Pending
- 2001-06-15 AR ARP010102877A patent/AR028959A1/es not_active Application Discontinuation
-
2002
- 2002-12-13 NO NO20026008A patent/NO20026008D0/no not_active Application Discontinuation
-
2003
- 2003-01-15 ZA ZA200300418A patent/ZA200300418B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JP2003535899A (ja) | 2003-12-02 |
WO2001097809A2 (en) | 2001-12-27 |
CA2412636A1 (en) | 2001-12-27 |
ZA200300418B (en) | 2004-04-15 |
US20020013335A1 (en) | 2002-01-31 |
PL365455A1 (en) | 2005-01-10 |
EA200300027A1 (ru) | 2003-06-26 |
NZ523114A (en) | 2004-07-30 |
CZ20024115A3 (cs) | 2003-06-18 |
IL153405A0 (en) | 2003-07-06 |
MXPA02012410A (es) | 2003-04-25 |
NO20026008L (no) | 2002-12-13 |
AU6844601A (en) | 2002-01-02 |
AU2001268446B2 (en) | 2005-08-11 |
BR0111601A (pt) | 2003-07-01 |
KR20030010710A (ko) | 2003-02-05 |
NO20026008D0 (no) | 2002-12-13 |
AR028959A1 (es) | 2003-05-28 |
EP1292302A2 (en) | 2003-03-19 |
HUP0301244A3 (en) | 2005-01-28 |
CN1436076A (zh) | 2003-08-13 |
WO2001097809A3 (en) | 2002-05-10 |
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