RU2006135205A - Применение антагонистов рецептора ангиотензина ii для лечения острого инфаркта миокарда - Google Patents
Применение антагонистов рецептора ангиотензина ii для лечения острого инфаркта миокарда Download PDFInfo
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- RU2006135205A RU2006135205A RU2006135205/15A RU2006135205A RU2006135205A RU 2006135205 A RU2006135205 A RU 2006135205A RU 2006135205/15 A RU2006135205/15 A RU 2006135205/15A RU 2006135205 A RU2006135205 A RU 2006135205A RU 2006135205 A RU2006135205 A RU 2006135205A
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- treatment
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- angiotensin
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- 238000011282 treatment Methods 0.000 title claims abstract 7
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title claims abstract 4
- 206010000891 acute myocardial infarction Diseases 0.000 title claims abstract 3
- 208000010125 myocardial infarction Diseases 0.000 claims abstract 8
- 239000004480 active ingredient Substances 0.000 claims abstract 6
- 230000001154 acute effect Effects 0.000 claims abstract 6
- -1 silazapril Chemical compound 0.000 claims abstract 6
- 229960000830 captopril Drugs 0.000 claims abstract 4
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 claims abstract 4
- 239000003814 drug Substances 0.000 claims abstract 4
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 claims abstract 3
- BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 claims abstract 2
- XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 claims abstract 2
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims abstract 2
- IFYLTXNCFVRALQ-OALUTQOASA-N Ceronapril Chemical compound O([C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)P(O)(=O)CCCCC1=CC=CC=C1 IFYLTXNCFVRALQ-OALUTQOASA-N 0.000 claims abstract 2
- 108010061435 Enalapril Proteins 0.000 claims abstract 2
- 108010066671 Enalaprilat Proteins 0.000 claims abstract 2
- 108010007859 Lisinopril Proteins 0.000 claims abstract 2
- VXFJYXUZANRPDJ-WTNASJBWSA-N Trandopril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@H]2CCCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 VXFJYXUZANRPDJ-WTNASJBWSA-N 0.000 claims abstract 2
- 229960004530 benazepril Drugs 0.000 claims abstract 2
- 229960004067 benazeprilat Drugs 0.000 claims abstract 2
- MADRIHWFJGRSBP-ROUUACIJSA-N benazeprilat Chemical compound C([C@H](N[C@H]1CCC2=CC=CC=C2N(C1=O)CC(=O)O)C(O)=O)CC1=CC=CC=C1 MADRIHWFJGRSBP-ROUUACIJSA-N 0.000 claims abstract 2
- 229950005749 ceronapril Drugs 0.000 claims abstract 2
- 229960005227 delapril Drugs 0.000 claims abstract 2
- WOUOLAUOZXOLJQ-MBSDFSHPSA-N delapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N(CC(O)=O)C1CC2=CC=CC=C2C1)CC1=CC=CC=C1 WOUOLAUOZXOLJQ-MBSDFSHPSA-N 0.000 claims abstract 2
- 229960000873 enalapril Drugs 0.000 claims abstract 2
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 claims abstract 2
- 229960002680 enalaprilat Drugs 0.000 claims abstract 2
- LZFZMUMEGBBDTC-QEJZJMRPSA-N enalaprilat (anhydrous) Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 LZFZMUMEGBBDTC-QEJZJMRPSA-N 0.000 claims abstract 2
- 229960002490 fosinopril Drugs 0.000 claims abstract 2
- 229960001195 imidapril Drugs 0.000 claims abstract 2
- KLZWOWYOHUKJIG-BPUTZDHNSA-N imidapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1C(N(C)C[C@H]1C(O)=O)=O)CC1=CC=CC=C1 KLZWOWYOHUKJIG-BPUTZDHNSA-N 0.000 claims abstract 2
- 229960002394 lisinopril Drugs 0.000 claims abstract 2
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 229960002582 perindopril Drugs 0.000 claims abstract 2
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 claims abstract 2
- 238000011321 prophylaxis Methods 0.000 claims abstract 2
- 229960003401 ramipril Drugs 0.000 claims abstract 2
- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 230000009863 secondary prevention Effects 0.000 claims abstract 2
- 229960002909 spirapril Drugs 0.000 claims abstract 2
- 108700035424 spirapril Proteins 0.000 claims abstract 2
- HRWCVUIFMSZDJS-SZMVWBNQSA-N spirapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2(C1)SCCS2)C(O)=O)CC1=CC=CC=C1 HRWCVUIFMSZDJS-SZMVWBNQSA-N 0.000 claims abstract 2
- 229960004084 temocapril Drugs 0.000 claims abstract 2
- FIQOFIRCTOWDOW-BJLQDIEVSA-N temocapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C[C@H](SC1)C=1SC=CC=1)=O)CC1=CC=CC=C1 FIQOFIRCTOWDOW-BJLQDIEVSA-N 0.000 claims abstract 2
- 229960002051 trandolapril Drugs 0.000 claims abstract 2
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims abstract 2
- 229960004699 valsartan Drugs 0.000 claims abstract 2
- 102000008873 Angiotensin II receptor Human genes 0.000 claims 1
- 108050000824 Angiotensin II receptor Proteins 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1. Применение антагониста рецептора ангиотензина II в сочетании с другим принятым действующим веществом для приготовления лекарственного средства для лечения острого инфаркта миокарда (МИ) и для вторичной профилактики острого МИ.2. Применение по п.1 для приготовления лекарственного средства для лечения пациентов из группы высокого риска.3. Применение по п.1 или 2, где антагонистом рецептора ангиотензина II является валсартан формулыили его фармацевтически приемлемая соль.4. Применение по любому из пп.2-4, где другой принятый активный ингредиент для лечения острого МИ и для вторичной профилактики острого МИ выбирают из группы, включающей алацеприл, беназеприл, беназеприлат, каптоприл, церонаприл, силазаприл, делаприл, эналаприл, эналаприлат, фосиноприл, имидаприл, лизиноприл, мовелтоприл, периндоприл, хинаприл, рамиприл, спираприл, темокаприл и трандолаприл.5. Применение по п.4, где другой принятый активный ингредиент представляет собой каптоприл.
Claims (5)
1. Применение антагониста рецептора ангиотензина II в сочетании с другим принятым действующим веществом для приготовления лекарственного средства для лечения острого инфаркта миокарда (МИ) и для вторичной профилактики острого МИ.
2. Применение по п.1 для приготовления лекарственного средства для лечения пациентов из группы высокого риска.
3. Применение по п.1 или 2, где антагонистом рецептора ангиотензина II является валсартан формулы
или его фармацевтически приемлемая соль.
4. Применение по любому из пп.2-4, где другой принятый активный ингредиент для лечения острого МИ и для вторичной профилактики острого МИ выбирают из группы, включающей алацеприл, беназеприл, беназеприлат, каптоприл, церонаприл, силазаприл, делаприл, эналаприл, эналаприлат, фосиноприл, имидаприл, лизиноприл, мовелтоприл, периндоприл, хинаприл, рамиприл, спираприл, темокаприл и трандолаприл.
5. Применение по п.4, где другой принятый активный ингредиент представляет собой каптоприл.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99810061.4 | 1999-01-26 | ||
| EP99810061 | 1999-01-26 | ||
| US46866499A | 1999-12-21 | 1999-12-21 | |
| US09/468,664 | 1999-12-21 | ||
| PCT/EP2000/000525 WO2000044378A1 (en) | 1999-01-26 | 2000-01-24 | Use of angiotensin ii receptor antagonists for treating acute myocardial infarction |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001122113/15A Division RU2298405C2 (ru) | 1999-01-26 | 2000-01-24 | Применение антагонистов рецептора ангиотензина ii для лечения острого инфаркта миокарда |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006135205A true RU2006135205A (ru) | 2008-04-10 |
| RU2345790C2 RU2345790C2 (ru) | 2009-02-10 |
Family
ID=26153740
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001122113/15A RU2298405C2 (ru) | 1999-01-26 | 2000-01-24 | Применение антагонистов рецептора ангиотензина ii для лечения острого инфаркта миокарда |
| RU2006135205/15A RU2345790C2 (ru) | 1999-01-26 | 2006-10-05 | Применение антагонистов рецептора ангиотензина ii для лечения острого инфаркта миокарда |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001122113/15A RU2298405C2 (ru) | 1999-01-26 | 2000-01-24 | Применение антагонистов рецептора ангиотензина ii для лечения острого инфаркта миокарда |
Country Status (25)
| Country | Link |
|---|---|
| EP (2) | EP1146872B1 (ru) |
| JP (1) | JP2002535367A (ru) |
| KR (1) | KR100674053B1 (ru) |
| CN (1) | CN1337879A (ru) |
| AT (1) | ATE330599T1 (ru) |
| AU (1) | AU766453C (ru) |
| BR (1) | BR0007686A (ru) |
| CA (1) | CA2360691A1 (ru) |
| CY (1) | CY1105257T1 (ru) |
| CZ (1) | CZ20012682A3 (ru) |
| DE (1) | DE60028928T2 (ru) |
| DK (1) | DK1146872T3 (ru) |
| ES (1) | ES2265910T3 (ru) |
| HK (1) | HK1041808B (ru) |
| HU (1) | HUP0105199A3 (ru) |
| ID (1) | ID29818A (ru) |
| IL (2) | IL144216A0 (ru) |
| NO (1) | NO20013459L (ru) |
| NZ (1) | NZ513039A (ru) |
| PL (1) | PL197161B1 (ru) |
| PT (1) | PT1146872E (ru) |
| RU (2) | RU2298405C2 (ru) |
| SI (1) | SI1146872T1 (ru) |
| SK (1) | SK10522001A3 (ru) |
| WO (1) | WO2000044378A1 (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2351357A1 (en) | 1998-12-23 | 2000-07-06 | Novartis Ag | Use of at-1 receptor antagonist or at-2 receptor modulator for treating diseases associated with an increase of at-1 or at-2 receptors |
| CA2420844A1 (en) * | 2000-08-30 | 2003-02-28 | Sankyo Company, Limited | Medicinal compositions for preventing or treating heart failure |
| US7076287B2 (en) | 2000-12-29 | 2006-07-11 | Ge Medical Systems Information Technologies, Inc. | System and method for detecting new left bundle branch block for accelerating treatment of acute myocardial infarction |
| WO2003035046A2 (en) * | 2001-10-18 | 2003-05-01 | Novartis Ag | Salts formed of an at1-receptor antagonist and a cardiovascular agent |
| EG24716A (en) | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
| RU2004137109A (ru) * | 2002-05-17 | 2005-10-10 | Новартис АГ (CH) | Комбинация блокатора рецептора ангиотензина ii и бетаблокатора для вторичной профилактики инфаркта миокарда |
| SE0302331D0 (sv) * | 2003-08-29 | 2003-08-29 | Astrazeneca Ab | New use II |
| WO2005030202A1 (en) * | 2003-09-26 | 2005-04-07 | Novartis Ag | Use of angiotensin ii receptor antagonists for treating cerebrovascular disorders |
| WO2005053687A1 (en) * | 2003-11-25 | 2005-06-16 | Novartis Ag | Combination of organic compounds |
| WO2009087116A1 (en) * | 2008-01-11 | 2009-07-16 | Novartis Ag | Use of spp100 for the treatment of acute mi |
| CN104086623B (zh) * | 2014-07-02 | 2017-05-24 | 牡丹江友搏药业有限责任公司 | 一种新的具有降压和细胞保护作用的化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9027208D0 (en) * | 1990-12-14 | 1991-02-06 | Smithkline Beecham Plc | Medicaments |
| EP0577025A3 (de) * | 1992-07-01 | 1998-02-04 | Hoechst Aktiengesellschaft | Angiotensin-II-Rezeptorantagonisten zur Behandlung und Prophylaxe von koronaren Herzerkrankungen |
| FR2716882B1 (fr) * | 1994-03-04 | 1996-04-05 | Roussel Uclaf | Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques. |
| DE4432860A1 (de) * | 1994-09-15 | 1996-03-21 | Merck Patent Gmbh | Imidazopyridine |
| GB9613470D0 (en) * | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
| US5795904A (en) * | 1996-12-06 | 1998-08-18 | Merck & Co., Inc. | Enhanced functional recovery of the heart by losartan treatment after an ischemic attach |
-
2000
- 2000-01-24 PT PT00902628T patent/PT1146872E/pt unknown
- 2000-01-24 IL IL14421600A patent/IL144216A0/xx active IP Right Grant
- 2000-01-24 WO PCT/EP2000/000525 patent/WO2000044378A1/en active Application Filing
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- 2000-01-24 DE DE60028928T patent/DE60028928T2/de not_active Revoked
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- 2000-01-24 CN CN00803157A patent/CN1337879A/zh active Pending
- 2000-01-24 AU AU24397/00A patent/AU766453C/en not_active Ceased
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- 2000-01-24 CA CA002360691A patent/CA2360691A1/en not_active Abandoned
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- 2000-01-24 RU RU2001122113/15A patent/RU2298405C2/ru not_active IP Right Cessation
- 2000-01-24 SK SK1052-2001A patent/SK10522001A3/sk not_active Application Discontinuation
- 2000-01-24 EP EP06009525A patent/EP1714651A1/en not_active Withdrawn
- 2000-01-24 BR BR0007686-4A patent/BR0007686A/pt not_active Application Discontinuation
- 2000-01-24 ID IDW00200101602A patent/ID29818A/id unknown
- 2000-01-24 DK DK00902628T patent/DK1146872T3/da active
- 2000-01-24 HU HU0105199A patent/HUP0105199A3/hu unknown
- 2000-01-24 AT AT00902628T patent/ATE330599T1/de not_active IP Right Cessation
- 2000-01-24 ES ES00902628T patent/ES2265910T3/es not_active Expired - Lifetime
- 2000-01-24 JP JP2000595681A patent/JP2002535367A/ja not_active Withdrawn
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2001
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20100125 |